List of works - Els Pardon

Crystal structure of the β2 adrenergic receptor-Gs protein complex

scientific article

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

scientific article

Activation and allosteric modulation of a muscarinic acetylcholine receptor

scientific article

A general protocol for the generation of Nanobodies for structural biology

scientific article

Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex

scientific article

Crystal Structure of the N-Terminal Domain of the Secretin GspD from ETEC Determined with the Assistance of a Nanobody

scientific article

Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes

scientific article

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

scientific article

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

scientific article published on 13 July 2016

Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

scientific article published on 29 June 2016

Structure and properties of a complex of α-synuclein and a single-domain camelid antibody

scientific article

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.

scientific article published on 3 January 2018

Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport

scientific article

Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11

scientific article

Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.

scientific article published on 06 December 2013

Structural and Functional Studies on the Interaction of GspC and GspD in the Type II Secretion System

scientific article

Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic 2-microglobulin variant

scientific article

Structure of a bacterial type IV secretion core complex at subnanometre resolution

scientific article

SbsB structure and lattice reconstruction unveil Ca2+ triggered S-layer assembly

scientific article

Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family

scientific article

Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus

scientific article

Structural basis for GABAA receptor potentiation by neurosteroids.

scientific article

Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling

scientific article published on 17 January 2018

An intrabody based on a llama single-domain antibody targeting the N-terminal alpha-helical multimerization domain of HIV-1 rev prevents viral production.

scientific article

Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages

scientific article published on 01 April 2013

Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody

scientific article

Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies

scientific article

Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation

scientific article published on 19 October 2016

Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody

scientific article

Structural insights into binding specificity, efficacy and bias of a βAR partial agonist

scientific article

The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier

scientific article published on 02 January 2019

Structure of PINK1 in complex with its substrate ubiquitin.

scientific article published on 30 October 2017

A Nanobody Binding to Non-Amyloidogenic Regions of the Protein Human Lysozyme Enhances Partial Unfolding but Inhibits Amyloid Fibril Formation

scientific article

Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain

scientific article published on 09 December 2014

SAXS analysis of the tRNA-modifying enzyme complex MnmE/MnmG reveals a novel interaction mode and GTP-induced oligomerization

scientific article

Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport.

scientific article published on 21 July 2017

Combining in-situ proteolysis and microseed matrix screening to promote crystallization of PrPc-nanobody complexes

scientific article published on 01 May 2011

The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA-editing ligase L2

scientific article

Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor

scientific article

Structures of influenza A virus RNA polymerase offer insight into viral genome replication

scientific article published on 04 September 2019

Nanobody mediated crystallization of an archeal mechanosensitive channel.

scientific article

The Molecular Mechanism of Shiga Toxin Stx2e Neutralization by a Single-domain Antibody Targeting the Cell Receptor-binding Domain

scientific article published on July 22, 2014

Allosteric inhibition of VIM metallo-β-lactamases by a camelid nanobody

scientific article

Nanobody-Enabled Reverse Pharmacology on G-Protein-Coupled Receptors

scientific article published on 22 February 2018

Structural insight in the inhibition of adherence of F4 fimbriae producing enterotoxigenic Escherichia coli by llama single domain antibodies

scientific article published on 24 February 2015

Crystal Structure of a ligand-bound LacY-Nanobody Complex

article published in the Proceedings of the National Academy of Sciences of the United States of America

L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction

scientific article published on 18 April 2019

A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo.

scientific article

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism

scientific article published on 23 September 2019

Structure of an early native-like intermediate of β2-microglobulin amyloidogenesis

scientific article

List of works by Els Pardon

Crystal structure of the β2 adrenergic receptor-Gs protein complex

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

Activation and allosteric modulation of a muscarinic acetylcholine receptor

A general protocol for the generation of Nanobodies for structural biology

Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex

Crystal Structure of the N-Terminal Domain of the Secretin GspD from ETEC Determined with the Assistance of a Nanobody

Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

Structure and properties of a complex of α-synuclein and a single-domain camelid antibody

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.

Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport

Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11

Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.

Structural and Functional Studies on the Interaction of GspC and GspD in the Type II Secretion System

Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic 2-microglobulin variant

Structure of a bacterial type IV secretion core complex at subnanometre resolution

SbsB structure and lattice reconstruction unveil Ca2+ triggered S-layer assembly

Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family

Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus

Structural basis for GABAA receptor potentiation by neurosteroids.

Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling

An intrabody based on a llama single-domain antibody targeting the N-terminal alpha-helical multimerization domain of HIV-1 rev prevents viral production.

Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages

Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody

Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies

Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation

Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody

Structural insights into binding specificity, efficacy and bias of a βAR partial agonist

The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier

Structure of PINK1 in complex with its substrate ubiquitin.

A Nanobody Binding to Non-Amyloidogenic Regions of the Protein Human Lysozyme Enhances Partial Unfolding but Inhibits Amyloid Fibril Formation

Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain

SAXS analysis of the tRNA-modifying enzyme complex MnmE/MnmG reveals a novel interaction mode and GTP-induced oligomerization

Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport.

Combining in-situ proteolysis and microseed matrix screening to promote crystallization of PrPc-nanobody complexes

The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA-editing ligase L2

Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor

Structures of influenza A virus RNA polymerase offer insight into viral genome replication

Nanobody mediated crystallization of an archeal mechanosensitive channel.

The Molecular Mechanism of Shiga Toxin Stx2e Neutralization by a Single-domain Antibody Targeting the Cell Receptor-binding Domain

Allosteric inhibition of VIM metallo-β-lactamases by a camelid nanobody

Nanobody-Enabled Reverse Pharmacology on G-Protein-Coupled Receptors

Structural insight in the inhibition of adherence of F4 fimbriae producing enterotoxigenic Escherichia coli by llama single domain antibodies

Crystal Structure of a ligand-bound LacY-Nanobody Complex

L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction

A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo.

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism

Structure of an early native-like intermediate of β2-microglobulin amyloidogenesis