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List of works by Herwig Schüler

14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface

scientific article published in Nature Communications

A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition

scientific article published on 01 June 2018

A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD+-Dependent Enzymes

scientific article published on 19 March 2019

A Plasmodium actin-depolymerizing factor that binds exclusively to actin monomers

scientific article published on 22 June 2005

A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity

scientific article published on 18 October 2018

ATPase activity and conformational changes in the regulation of actin

scientific article

Actin regulation in the malaria parasite

scientific article published on 21 January 2011

Actin/myosin-based gliding motility in apicomplexan parasites

scientific article published on January 2008

Arp1, an actin-related protein, in Plasmodium berghei

scientific article (publication date: October 2010)

Biochemical Discrimination between Selenium and Sulfur 1: A Single Residue Provides Selenium Specificity to Human Selenocysteine Lyase

scientific article

Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3

scientific article

Comparative Structural Analysis of Human DEAD-Box RNA Helicases

scientific article

Comparative structural analysis of lipid binding START domains

scientific article published in 2011

Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family

scientific article published on January 2015

Correction to "Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors"

scientific article published on 19 June 2019

Covalent binding of ATPgammaS to the nucleotide-binding site in S14C-actin

scholarly article by Herwig Schüler published in July 2000

Critical role for a stage-specific actin in male exflagellation of the malaria parasite

scientific article published on 11 August 2011

Crystal Structure of Human ADP-ribose Transferase ARTD15/PARP16 Reveals a Novel Putative Regulatory Domain

scientific article

Crystal Structures Explain Functional Differences in the Two Actin Depolymerization Factors of the Malaria Parasite

scientific article

Crystal Structures of the ATPase Domains of Four Human Hsp70 Isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78

scientific article

Crystal structure of human RNA helicase A (DHX9): structural basis for unselective nucleotide base binding in a DEAD-box variant protein

scientific article

Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T.

scientific article

Crystal structure of the ATPase domain of the human AAA+ protein paraplegin/SPG7

scientific article

Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888

scientific article

Crystallization and preliminary structural characterization of the two actin-depolymerization factors of the malaria parasite

scientific article published on 30 April 2010

DNA binding to SMC ATPases-trapped for release.

scientific article

Design and synthesis of potent inhibitors of the mono(ADP-ribosyl)transferase, PARP14.

scientific article published on 29 April 2017

Design, Synthesis, Crystallographic Studies, and Preliminary Biological Appraisal of New Substituted Triazolo[4,3- b ]pyridazin-8-amine Derivatives as Tankyrase Inhibitors

scientific article

Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14

scientific article published on 03 May 2018

Discovery of ligands for ADP-ribosyltransferases via docking-based virtual screening

scientific article

Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins

scientific article published on 15 October 2020

Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

scientific article

Identification of Inhibitors of Pseudomonas aeruginosa Exotoxin-S ADP-Ribosyltransferase Activity

scientific article published on 5 February 2016

Identification of Poly(ADP-Ribose) Polymerase Macrodomain Inhibitors Using an AlphaScreen Protocol

scientific article published on 09 January 2018

Identification of structure-activity relationships from screening a structurally compact DNA-encoded chemical library

scientific article published on 3 February 2015

MacroGreen, a simple tool for detection of ADP-ribosylated proteins

publication published on 28 July 2021

Mutational analysis of arginine 177 in the nucleotide binding site of beta-actin

article

PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3

scientific article

PARP inhibitors: polypharmacology versus selective inhibition

scientific article published on 24 May 2013

PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA

scientific article

PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.: FIGURE 2

scientific article published in Journal of Biological Chemistry

Pharmacology of ADP-ribosylation

scientific article published on 5 July 2013

Pivotal and distinct role for Plasmodium actin capping protein alpha during blood infection of the malaria parasite

scientific article (publication date: April 2015)

Plasmodium motility: actin not actin' like actin

scientific article published on 24 February 2006

Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains

scientific article

Regulation of apicomplexan microfilament dynamics by a minimal set of actin-binding proteins

scientific article published on October 2006

Sirtuins are Unaffected by PARP Inhibitors Containing Planar Nicotinamide Bioisosteres

scientific article

Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis

scientific article

Small Molecule Microarray Based Discovery of PARP14 Inhibitors

scientific article published on 5 December 2016

Sound attenuation of polymerizing actin reflects supramolecular structures: viscoelastic properties of actin gels modified by cytochalasin D, profilin and alpha-actinin.

scientific article

Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors.

scientific article published on 21 December 2016

Structural and functional characterization of human Iba proteins

scientific article

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

scientific article

Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein

scientific article

Structural basis for parasite-specific functions of the divergent profilin of Plasmodium falciparum

scientific article published on 12 November 2008

Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism

scientific article

Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor

scientific article

Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling

scientific article published on 28 February 2013

Structure and Function of a G-actin Sequestering Protein with a Vital Role in Malaria Oocyst Development inside the Mosquito Vector

scientific article

Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy

scientific article published on 10 June 2006

Structure-activity relationships for inhibitors of Pseudomonas aeruginosa exoenzyme S ADP-ribosyltransferase activity.

scientific article published on 21 November 2017

Structure-function analysis of the filamentous actin binding domain of the neuronal scaffolding protein spinophilin

scientific article

Structures of the hydrolase domain of human 10-formyltetrahydrofolate dehydrogenase and its complex with a substrate analogue

scientific article published on 18 October 2006

System-wide identification and prioritization of enzyme substrates by thermal analysis

scientific article published on 26 February 2021

Tankyrase 1 Inhibitors with Drug-like Properties Identified by Screening a DNA-Encoded Chemical Library

scientific article published on 10 June 2015

The Corky Root Rot Pathogen Pyrenochaeta lycopersici Secretes a Proteinaceous Inducer of Cell Death Affecting Host Plants Differentially

article

The DEXD/H-box RNA Helicase DDX19 Is Regulated by an  -Helical Switch

scientific article

The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site

scientific article

The role of MeH73 in actin polymerization and ATP hydrolysis

scientific article published in April 2002

Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

scientific article published on 26 January 2010

Towards small molecule inhibitors of mono-ADP-ribosyltransferases

scientific article published on April 2015

Unusual properties of Plasmodium falciparum actin: new insights into microfilament dynamics of apicomplexan parasites

scientific article published in January 2005

Vital role for the Plasmodium actin capping protein (CP) beta-subunit in motility of malaria sporozoites

scientific article (publication date: December 2009)

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