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List of works by Charles Timchalk

1,2-Dichloropropane: investigation of the mechanism of mercapturic acid formation in the rat.

scientific article published in October 1990

2, 4 - Dichlorophenoxyacetic acid (2, 4-D) transport across an in vitro salivary acinar cell system: a novel approach to biomonitoring ⬇️

abstract published in 2016

A Physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans

scientific article published in March 2002

A cellular model to evaluate salivary gland uptake and clearance of pesticides: a novel non-invasive biomonitoring strategy ⬇️

abstract published in 2014

A novel immunochromatographic electrochemical biosensor for highly sensitive and selective detection of trichloropyridinol, a biomarker of exposure to chlorpyrifos

journal article published in 2011

Assessing the impact of human PON1 polymorphisms: sensitivity and Monte Carlo analyses using a physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model for chlorpyrifos ⬇️

abstract published in 2002

Biomonitoring of organophosphorus agent exposure by reactivation of cholinesterase enzyme based on carbon nanotube-enhanced flow-injection amperometric detection

journal article published in 2009

Biomonitoring of pesticides: pharmacokinetics of organophosphorus and carbamate insecticides

chapter published in 2011

Carbon nanotube-based electrochemical sensor for assay of salivary cholinesterase enzyme activity: an exposure biomarker of organophosphorus pesticides ⬇️

abstract published in 2009

Carbon nanotube-based electrochemical sensor for cholinesterase enzyme activity: an organophosphorus insecticide and nerve agent exposure monitor ⬇️

abstract published in 2008

Characterization and normalization of cholinesterase activity in rat saliva ⬇️

abstract published in 2010

Characterization of the in vitro kinetic interaction of chlorpyrifos-oxon with rat salivary cholinesterase: a potential biomonitoring matrix

journal article published in 2007

Cholinesterase inhibition in chlorpyrifos workers: characterization of biomarkers of exposure and response in relation to urinary TCPy

journal article published in 2009

Comparative changes in rat liver cytosolic proteins by mirex, diethylnitrosamine, and dimethylnitrosamine exposure.

scientific article published in November 1985

Comparative chlorpyrifos pharmacokinetics via multiple routes of exposure and vehicles of administration ⬇️

abstract published in 2009

Comparative chlorpyrifos pharmacokinetics via multiple routes of exposure and vehicles of administration in the adult rat

journal article published in 2009

Comparative metabolism of ortho-phenylphenol in mouse, rat and man.

scientific article published in June 1998

Comparative pharmacokinetics of chlorpyrifos versus its major metabolites following oral administration in the rat

journal article published in 2010

Comparative pharmacokinetics of chlorpyrifos versus its major metabolites following oral administration in the rat ⬇️

abstract published in 2010

Comparative pharmacokinetics of the organophosphorus insecticide chlorpyrifos and its major metabolites diethylphosphate, diethylthiophosphate and 3,5,6-trichloro-2-pyridinol in the rat

journal article published in 2007

Comparison of chlorpyrifos-oxon and paraoxon acetylcholinesterase inhibition dynamics: potential role of a peripheral binding site ⬇️

abstract published in 2004

Complex mixture modeling organophosphate pesticides

final grant report published in 2006

Computational strategy for quantifying human pesticide exposure based upon a saliva measurement

journal article published in 2015

Coupling in vitro and computational methods to investigate the transport of herbicide/insecticide mixtures into saliva ⬇️

abstract published in 2018

Detection of Cd, Pb, and Cu in non-pretreated natural waters and urine with thiol functionalized mesoporous silica and Nafion composite electrodes

journal article published in 2008

Development of a computational model describing and extrapolating salivary acinar cell in vitro pesticide transport ⬇️

abstract published in 2015

Development of a magnetic immunosensor to biomonitor for the chlorpyrifos metabolite trichloropyridinol ⬇️

abstract published in 2007

Development of a neonatal rat physiologically based pharmokinetic/pharmacodynamic (PBPK/PD) model for chlorpyrifos ⬇️

abstract published in 2003

Development of a non-invasive biomonitoring approach to determine exposure to the organophosphorus insecticide chlorpyrifos in rat saliva

journal article published in 2007

Development of a physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model to quantitate biomarkers of exposure to organophosphorus insecticides ⬇️

conference abstract published in 2004

Development of a physiologically based pharmokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate pesticide, diazinon ⬇️

abstract published in 2003

Development of an in vitro screening assay for noninvasive biomonitoring ⬇️

abstract published in 2015

Development of an integrated microanalytical system for analysis of lead in saliva and linkage to a physiologically based pharmacokinetic model describing lead saliva secretion

scientific article published in May 2001

Development of pharmacokinetic and non-invasive biomonitoring approaches to determine dosimetry and assess risk in potentially sensitive sub-populations following exposure to individual chemicals and mixtures

abstract published in 2003

Development of physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD models to determine dosimetry and cholinesterase inhibition following exposure to binary mixtures of organophosphorus insecticides ⬇️

abstract published in 2007

Development of physiologically based pharmacokinetic and pharmacodynamic models to determine dosimetry, dynamic response, and to assess risk following exposure to organophosphorous insecticides ⬇️

abstract published in 2005

Direct analysis of trichloropyridinol in human saliva using an Au nanoparticles-based immunochromatographic test strip for biomonitoring of exposure to chlorpyrifos

journal article published in 2013

Direct detection of Pb in urine and Cd, Pb, Cu, and Ag in natural waters using electrochemical sensors immobilized with DMSA functionalized magnetic nanoparticles

journal article published in 2008

Disposition of lead (Pb) in saliva and blood of Sprague-Dawley rats following a single or repeated oral exposure to Pb-acetate

scientific article published on 28 February 2006

Effect of in vivo nicotine exposure on chlorpyrifos pharmacokinetics and pharmacodynamics in rats

journal article published in 2010

Effect of nicotine exposure on in vitro CYP450s-mediated metabolism of chlorpyrifos (CPF) in Sprague-Dawley (S-D) rats ⬇️

abstract published in 2008

Electrochemical sensors for the detection of lead and other toxic heavy metals: the next generation of personal exposure biomonitors

journal article published in 2007

Enzyme-linked immunosorbent assay for detection of organophosphorylated butyrylcholinesterase: a biomarker of exposure to organophosphate agents

journal article published in 2011

Evaluation of non-invasive biomonitoring of 2,4-Dichlorophenoxyacetic acid (2,4-D) in saliva

journal article published in 2018

Extrapolating salivary acinar cell in vitro pesticide transport to whole animals using computational modeling ⬇️

abstract published in 2016

Gas chromatographic/tandem mass spectrometric identification and quantitation of metabolic 4-acetyltoluene-2,4-diamine from the F344 rat

scientific article published on 01 March 1993

Immunoassays of phosphorylated cholinesterase as biomarkers for rapid diagnosis of exposure to organophosphorous agents ⬇️

abstract published in 2009

Implications of protein binding for predicting pesticide salivary transport using a combination experimental and computational approach ⬇️

abstract published in 2017

In vitro interactions between organophosporous pesticides and consequences of pre-treatment with nicotine and alcohol on in vitro pesticide metabolism in rats ⬇️

conference abstract published in 2004

In vitro to in vivo translation of salivary concentrations for non-invasive biomonitoring of 2,4-dichlorophenoxyacetic acid (2,4-D) ⬇️

abstract published in 2019

Inhibition of diazinon metabolism by chlorpyrifos in rat liver microsomes ⬇️

abstract published in 2004

Intestinal metabolism of organophosphate insecticides: potential first-pass metabolism ⬇️

abstract published in 2003

Magnetic electrochemical immunoassays with quantum dot labels for detection of phosphorylated acetylcholinesterase in plasma

journal article published in 2008

Magnetic electrochemical sensing platform for biomonitoring of exposure to organophosphorus pesticides and nerve agents based on simultaneous measurement of total enzyme amount and enzyme activity

journal article published in 2011

Metabolism and cholinesterase inhibition in lungs of rats following in vitro chlorpyrifos exposure ⬇️

abstract published in 2009

Modeling cholinesterase inhibition

chapter published in 2010

Monte Carlo analysis of the human chlorpyrifos-oxonase (PON1) polymorphism using a physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model

journal article published in 2002

Nanoparticle-based disposable electrochemical immunosensor for simple and sensitive diagnosis of exposure to organophosphorus pesticides and nerve agents

abstract published in 2010

Nanoparticle-based electrochemical immunosensor for detection of phosphorylated acetylcholinesterase adduct: an exposure biomarker of organophosphate pesticides and nerve agents ⬇️

abstract published in 2008

Nanoparticle-based electrochemical immunosensor for the detection of phosphorylated acetylcholinesterase: an exposure biomarker of organophosphate pesticides and nerve agents

journal article published in 2008

Non-invasive biological monitoring of pesticides

final grant report published in 2017

Non-invasive biomonitoring approaches to determine dosimetry and risk following chemical exposure: analysis of lead and organophosphate insecticide in saliva ⬇️

abstract published in 2006

Non-invasive biomonitoring of pesticides

final grant report published in 2012

Non-invasive saliva human biomonitoring: development of a transwell assay to support exposure science assessment and health impacts ⬇️

abstract published in 2016

Noninvasive biomonitoring approaches to determine dosimetry and risk following acute chemical exposure: analysis of lead or organophosphate insecticide in saliva

journal article published in 2004

Organophosphorus insecticide pharmacokinetics ⬇️

chapter published in 2010

PBPK modeling of the major chlorpyrifos metabolite trichloropyridinol: a potential biomonitoring strategy ⬇️

abstract published in 2008

PBPK/PD modeling of chlorpyrifos in sensitive populations: implications for biomonitoring of exposure ⬇️

abstract published in 2008

Paraoxonase 1 (PON1) status affects the metabolism of drugs and insecticides ⬇️

conference abstract published in 2005

Paraoxonase 1 (PON1) status and risk of insecticide exposure

journal article published in 2005

Pharmacokinetic and pharmacodynamic interactions of a binary mixture of chlorpyrifos and diazinon in the rat ⬇️

abstract published in 2004

Pharmacokinetics and metabolism of triclopyr 3,5,6-trichloro-2-pyridinyloxyacetic acid) in Fischer 344 rats

scientific article published in May 1990

Pharmacokinetics of 3, 5, 6-trichloro-2-pyridinol (TCPY), a chlorpyrifos metabolite, in rat saliva ⬇️

abstract published in 2010

Pharmacokinetics of triclopyr (3,5,6-trichloro-2-pyridinyloxyacetic acid) in the beagle dog and rhesus monkey: perspective on the reduced capacity of dogs to excrete this organic acid relative to the rat, monkey, and human

scientific article published on 01 June 1997

Pharmacokinetics of vhlorpyrifos metabolites in saliva ⬇️

abstract published in 2008

Physiologically based pharmacokinetic modeling of organophosphorus and carbamate pesticides

chapter published in 2006

Physiologically based pharmacokinetic modeling of salivary concentrations for noninvasive biomonitoring of 2,4-dichlorophenoxyacetic acid (2,4-D)

journal article published in 2019

Portable analyzer for on-site monitoring of worker exposure to toxic metals

final grant report published in 2009

Potential utility of saliva biomonitoring for organophosphate insecticide dosimetry and esterase inhibition ⬇️

abstract published in 2003

Predicting transport of 3,5,6-trichloro-2-pyridinol into saliva using a combination experimental and computational approach

journal article published in 2017

Quantum dot-based immunochromatographic fluorescent biosensor for biomonitoring trichloropyridinol, a biomarker of exposure to chlorpyrifos

journal article published in 2010

Quantum-dots-based electrochemical immunoassay for the chlorpyrifos and trichlopyr metabolite trichloropyridinol ⬇️

abstract published in 2008

Rapid feasibility screening to microsensor platforms for non-invasive human biomonitoring ⬇️

abstract published in 2017

Regional brain dosimetry for the organophosphorus insecticide chlorpyrifos in the preweanling rat ⬇️

abstract published in 2012

Removal of heavy metals from aqueous systems with thiol functionalized superparamagnetic nanoparticles

journal article published in 2007

Route-dependent comparative metabolism of [14C]toluene 2,4-diisocyanate and [14C]toluene 2,4-diamine in Fischer 344 rats

scientific article published on 01 February 1994

The effect of plasma lipids on the pharmacokinetics of chlorpyrifos and the impact on interpretation of blood biomonitoring data

journal article published in 2009

The impact of nicotine exposure on the pharmacokinetics and pharmacodynamics of chlorpyrifos: implications for drug/chemical mixtures ⬇️

abstract published in 2009

The impact of repeated nicotine and alcohol co-exposure on the in vivo chlorpyrifos pharmacokinetics and pharmacodynamics ⬇️

abstract published in 2010

The in vivo quantitation of diazinon, chlorpyrifos, and their major metabolites in rat blood for the refinement of a physiologically-based pharmacokinetic/pharmacodynamic models ⬇️

journal article published in 2004

The need for non- or minimally-invasive biomonitoring strategies and the development of pharmacokinetic/pharmacodynamic models for quantification

journal article published in 2017

The virtual body workshop: current and future application of human biology models in environmental health research

scientific article

Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism ⬇️

journal article published in 2005

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