List of works - Pavel Savitsky

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

scientific article

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells

scientific article

Assessing histone demethylase inhibitors in cells: lessons learned.

scientific article

Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations

scientific article

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

scientific article

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

scientific article

Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies

scientific article published on 9 January 2017

Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF.

scientific article published on 14 May 2015

Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation

scientific article published on 19 October 2011

Expression and purification of recombinant human inward rectifier K+ (KCNJ) channels in Saccharomyces cerevisiae

scientific article

Frapid: achieving full automation of FRAP for chemical probe validation

scientific article published on 11 January 2016

High throughput production of recombinant human proteins for crystallography

scientific article published in January 2008

In Vivo Biotinylation of Antigens in E. coli

scientific article published in January 2017

Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.

scientific article published on 18 January 2017

Large-scale structural analysis of the classical human protein tyrosine phosphatome

scientific article

Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin

scientific article published on December 2016

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

scientific article

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

scientific article

Selective targeting of Bromodomains of the Bromodomain-PHD Fingers family impairs osteoclast differentiation

scientific article published on 29 August 2017

Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4

scientific article

Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions

scientific article

Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition

scientific article

Type II Inhibitors Targeting CDK2

scientific article

List of works by Pavel Savitsky

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells

Assessing histone demethylase inhibitors in cells: lessons learned.

Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies

Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF.

Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation

Expression and purification of recombinant human inward rectifier K+ (KCNJ) channels in Saccharomyces cerevisiae

Frapid: achieving full automation of FRAP for chemical probe validation

High throughput production of recombinant human proteins for crystallography

In Vivo Biotinylation of Antigens in E. coli

Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.

Large-scale structural analysis of the classical human protein tyrosine phosphatome

Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

Selective targeting of Bromodomains of the Bromodomain-PHD Fingers family impairs osteoclast differentiation

Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4

Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions

Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition

Type II Inhibitors Targeting CDK2