List of works by Alexander M. M. Eggermont

20 years experience of TNF-based isolated limb perfusion for in-transit melanoma metastases: TNF dose matters

scientific article

5'-Deoxy-5-fluorouridine increases daunorubicin uptake in multidrug-resistant cells and its activity is related with P-gp 170 expression.

scientific article

A BRCA1/2 mutation, high breast density and prominent pushing margins of a tumor independently contribute to a frequent false-negative mammography

article

A MAGE-3 peptide presented by HLA-DR1 to CD4+ T cells that were isolated from a melanoma patient vaccinated with a MAGE-3 protein

scientific article published on July 2003

A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents

scientific article published on 11 November 2016

A clinical development paradigm for cancer vaccines and related biologics

scientific article

A dose escalation phase 1 study of radiotherapy (RT) in combination with anti-cytotoxic-T-lymphocyte-associated antigen 4 (CTLA-4) monoclonal antibody ipilimumab in patients (pts) with metastatic melanoma

scientific article published on 20 May 2017

A multicentre epidemiological study on sunbed use and cutaneous melanoma in Europe.

scientific article published in September 2005

A novel two-step mild hyperthermia for advanced liposomal chemotherapy

scientific article published on 22 November 2013

A retrospective comparative study evaluating the results of a single-perfusion versus double-perfusion schedule with melphalan in patients with recurrent melanoma of the lower limb

scientific article published on 01 May 1993

A retrospective comparative study evaluating the results of mild hyperthermic versus controlled normothermic perfusion for recurrent melanoma of the extremities ⬇️

scientific article published on 01 January 1995

A ring barrier-based migration assay to assess cell migration in vitro

scientific article published on 21 May 2015

A roadmap for restoring trust in Big Data

article by Mark Lawler et al published August 2018 in Lancet Oncology Commission

A simplified interventional mapping system (SIMS) for the selection of combinations of targeted treatments in non-small cell lung cancer

scientific article

A systematic review examining factors influencing health related quality of life among melanoma cancer survivors

scientific article

Absence of severe systemic toxicity after leakage-controlled isolated limb perfusion with tumor necrosis factor-alpha and melphalan

scientific article

Abstract 311: Diverse biological mechanisms drive resistance to Lorlatinib in ALK-rearranged Lung Cancer

scholarly article

Acute-phase response patterns in isolated hepatic perfusion with tumour necrosis factor alpha (TNF-alpha) and melphalan in patients with colorectal liver metastases.

scientific article published in June 1999

Addition of low-dose tumor necrosis factor-alpha to systemic treatment with STEALTH liposomal doxorubicin (Doxil) improved anti-tumor activity in osteosarcoma-bearing rats

scientific article

Adjuvant Pembrolizumab in Resected Stage III Melanoma

scientific article published on 01 August 2018

Adjuvant Pembrolizumab versus Placebo in Resected Stage III Melanoma.

scientific article published on 15 April 2018

Adjuvant ganglioside GM2-KLH/QS-21 vaccination versus observation after resection of primary tumor > 1.5 mm in patients with stage II melanoma: results of the EORTC 18961 randomized phase III trial

scientific article

Adjuvant immunotherapy: the sting in the tail

scientific article published on 05 May 2020

Adjuvant interferon-alpha for melanoma revisited: news from old and new studies

scientific article

Adjuvant interferon-α for the treatment of high-risk melanoma: An individual patient data meta-analysis

scientific article published on 07 July 2017

Adjuvant ipilimumab in stage III melanoma: New landscape, new questions

scientific article published on 3 November 2016

Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial

scientific article published on 31 March 2015

Adjuvant ipilimumab versus placebo after complete resection of stage III melanoma: long-term follow-up results of the European Organisation for Research and Treatment of Cancer 18071 double-blind phase 3 randomised trial

scientific article published on 07 August 2019

Adjuvant regional isolated perfusion with melphalan for patients with Clark V melanoma of the extremities

scientific article published on 01 April 1993

Adjuvant therapy for high-risk melanoma

scientific article published on September 2013

Adjuvant therapy of malignant melanoma and the role of sentinel node mapping

scientific article published in January 2000

Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: final results of EORTC 18991, a randomised phase III trial

scientific article

Adjuvant therapy with pegylated interferon alfa-2b versus observation in resected stage III melanoma: a phase III randomized controlled trial of health-related quality of life and symptoms by the European Organisation for Research and Treatment of C

scientific article published on 11 May 2009

Adjuvant therapy with pegylated interferon-alfa2b vs observation in stage II B/C patients with ulcerated primary: Results of the European Organisation for Research and Treatment of Cancer 18081 randomised trial

scientific article published on 26 May 2020

Administration of BiMAb-retargeted T cells in a rat hepatic metastases colon tumour model results in T-cell tumour infiltration independent of the route of administration

scientific article published on 01 March 2001

Advances in immuno-oncology. Foreword

scientific article published on 01 September 2012

Age as a predictor of sentinel node metastasis among patients with localized melanoma: an inverse correlation of melanoma mortality and incidence of sentinel node metastasis among young and old patients

scientific article

Age as a prognostic factor in patients with localized melanoma and regional metastases

scientific article

An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells

scientific article published on 16 December 2019

An interview with Alexander Eggermont

scientific article published on 19 April 2009

Analysis of surrogate gene expression markers in peripheral blood of melanoma patients to predict treatment outcome of adjuvant pegylated interferon alpha 2b (EORTC 18991 side study).

scientific article published on 27 April 2013

Angiogenesis: a prognostic determinant in pancreatic cancer?

scientific article published on 28 September 2011

Anti-CTLA-4 antibody adjuvant therapy in melanoma

scientific article published on October 2010

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

scientific article published on 5 November 2015

Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25.

scientific article

Association Between Immune-Related Adverse Events and Recurrence-Free Survival Among Patients With Stage III Melanoma Randomized to Receive Pembrolizumab or Placebo: A Secondary Analysis of a Randomized Clinical Trial

scientific article published on 02 January 2020

Association of TIMP3 expression with vessel density, macrophage infiltration and prognosis in human malignant melanoma

scientific article published on 17 December 2015

Autoimmune antibodies and recurrence-free interval in melanoma patients treated with adjuvant interferon

scientific article

Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab

scientific article published on 27 March 2017

Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab

scientific article published on 01 December 2019

Bcl-2 associated anthanogen-1 (Bag-1) expression and prognostic value in pancreatic head and periampullary cancer.

scientific article

Biodistribution and tumor localization of stealth liposomal tumor necrosis factor-alpha in soft tissue sarcoma bearing rats

scientific article published on September 1998

Biodistribution of lymphokine-activated killer (LAK) cells in Wag rats after hepatic-artery or jugular-vein infusion

scientific article published on 01 September 1992

Biosimilars: a position paper of the European Society for Medical Oncology, with particular reference to oncology prescribers.

scientific article

Boosting the social impact of innovative cancer research - towards a mission-oriented approach to cancer

scientific article published on 27 February 2019

C8-glycosphingolipids preferentially insert into tumor cell membranes and promote chemotherapeutic drug uptake.

scientific article published on 24 April 2015

Cancer Core Europe: A European cancer research alliance realizing a research infrastructure with critical mass and programmatic approach to cure cancer in the 21st century

scientific article published on 18 September 2018

Cancer Core Europe: A translational research infrastructure for a European mission on cancer

Cancer Core Europe: a consortium to address the cancer care-cancer research continuum challenge

scientific article published on 25 September 2014

Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

scientific article

Cancer immunotherapy: Opportunities and challenges in the rapidly evolving clinical landscape.

scientific article

Career opportunities and benefits for young oncologists in the European Society for Medical Oncology (ESMO).

scientific article

Cationic thermosensitive liposomes: a novel dual targeted heat-triggered drug delivery approach for endothelial and tumor cells

scientific article published on 13 June 2012

Challenges in initiating and conducting personalized cancer therapy trials: perspectives from WINTHER, a Worldwide Innovative Network (WIN) Consortium trial

scientific article published on 23 April 2015

Changes of ferritin and CRP levels in melanoma patients treated with adjuvant interferon-α (EORTC 18952) and prognostic value on treatment outcome

scientific article published on 01 August 2011

Changing the pathophysiology of solid tumours: the potential of TNF and other vasoactive agents

scientific article

Characteristics of tumor infiltration by adoptively transferred and endogenous natural-killer cells in a syngeneic rat model: implications for the mechanism behind anti-tumor responses

scientific article published on 01 December 1998

Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma.

scientific article

Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

scientific article published on 25 May 2020

Circulating Cell-Free Tumor DNA Analysis of 50 Genes by Next-Generation Sequencing in the Prospective MOSCATO Trial

scientific article published on 12 January 2016

Circulating melanoma cells and distant metastasis-free survival in stage III melanoma patients with or without adjuvant interferon treatment (EORTC 18991 side study).

scientific article published on 28 September 2009

Classification of current anticancer immunotherapies

scientific article

Clinical and immunological evaluation of 20 patients with advanced colorectal cancer treated with high dose recombinant leukocyte interferon-alpha A (rIFN alpha A).

scientific article published on January 1986

Clinical cancer research: the past, present and the future

scientific article published on 23 September 2014

Clinical experience with the combined use of recombinant interleukin-2 (IL2) and interferon alfa-2a (IFN alpha) in metastatic melanoma

scientific article published on October 1991

Combination Immunotherapy Development in Melanoma

article

Combined Treatment of Colon Adenocarcinoma in Rats with Tumor Necrosis Factor and the Interferon Inducer ABPP ⬇️

scientific article published on 01 June 1988

Comment on 'Diagnosis and treatment of basal cell carcinoma: European consensus-based interdisciplinary guidelines'

scientific article published on 30 March 2020

Comparing the therapeutic potential of thermosensitive liposomes and hyperthermia in two distinct subtypes of breast cancer

scientific article published on 04 May 2017

Comparison of the influence of xenon vs. isoflurane on ventilation-perfusion relationships in patients undergoing simultaneous aortocaval occlusion.

scientific article

Completion lymph node dissection after a positive sentinel node: no longer a must?

scientific article

Corrigendum to "Cost-effectiveness analysis in melanoma detection: A transition model applied to dermoscopy" [Eur J Cancer 67 (2016) 38-45].

scientific article

Cost-effectiveness analysis in melanoma detection: A transition model applied to dermoscopy.

scientific article

Critical appraisal of IFN-alpha-based adjuvant therapy in stage II-III malignant melanoma

scientific article published in October 2002

Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage

scientific article published on 01 August 2020

Curbing tobacco's toll starts with the professionals: World No Tobacco Day

scientific article published in The Lancet

Current status of interferon-alpha in the treatment of melanoma

scientific article

Current uses of isolated limb perfusion in the clinic and a model system for new strategies

scientific article

Cutaneous Malignant Melanoma

scientific article published in 2010

Cutaneous melanoma

scientific article published in The Lancet

Cyclosporin A enhances locoregional metastasis of the CC531 rat colon tumour

scientific article published on 01 January 1997

Dacarbazine, cisplatin, and interferon-alfa-2b with or without interleukin-2 in metastatic melanoma: a randomized phase III trial (18951) of the European Organisation for Research and Treatment of Cancer Melanoma Group

scientific article published in September 2005

Decrease of CD117 expression as possible prognostic marker for recurrence in the resected specimen after imatinib treatment in patients with initially unresectable gastrointestinal stromal tumors: a clinicopathological analysis

scientific article

Decreased response rates by the combination of histamine and IL-2 in melphalan-based isolated limb perfusion

scientific article

Delivering affordable cancer care in high-income countries

article

Delivering precision medicine in oncology today and in future-the promise and challenges of personalised cancer medicine: a position paper by the European Society for Medical Oncology (ESMO).

scientific article

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC.

scientific article published on 12 August 2015

Dendritic cell-derived exosomes for cancer therapy

scientific article published on April 2016

Deselecting Melanoma Patients for Sentinel Lymph Node Biopsy During COVID-19: Clinical Utility of Tumor Molecular Profiling

scientific article published on 17 July 2020

Detection of melanoma micrometastases in sentinel nodes - the cons

scientific article

Development and evaluation of an isolated limb infusion model for investigation of drug delivery kinetics to solid tumors by thermosensitive liposomes and hyperthermia

scientific article

Diagnosis and treatment of Kaposi's sarcoma: European consensus-based interdisciplinary guideline (EDF/EADO/EORTC)

scientific article published on 13 May 2019

Diagnosis and treatment of basal cell carcinoma: European consensus-based interdisciplinary guidelines

scientific article published on 06 July 2019

Diagnosis and treatment of melanoma. European consensus-based interdisciplinary guideline - Update 2016.

scientific article published on 28 June 2016

Diagnosis and treatment of melanoma. European consensus-based interdisciplinary guideline – Update 2012

scientific article published on 13 September 2012

Diagnosis and treatment of melanoma: European consensus-based interdisciplinary guideline

scientific article published on December 2009

Differential TIMP3 expression affects tumor progression and angiogenesis in melanomas through regulation of directionally persistent endothelial cell migration

scientific article published on 25 September 2013

Differential effects of matrix and growth factors on endothelial and fibroblast motility: application of a modified cell migration assay

scientific article

Differential expression and prognostic value of HMGA1 in pancreatic head and periampullary cancer ⬇️

scientific article published on August 17, 2010

Differential regulation of breast tumor cell proliferation by stromal fibroblasts of various breast tissue sources

scientific article published on January 1996

Diverse Resistance Mechanisms to the Third-Generation ALK Inhibitor Lorlatinib in ALK-Rearranged Lung Cancer

scientific article published on 04 October 2019

Does adjuvant interferon-alpha for high-risk melanoma provide a worthwhile benefit? A meta-analysis of the randomised trials

scientific article

Does adjuvant systemic therapy with interferon-alpha for stage II-III melanoma prolong survival?

scientific article published in January 2003

Doubling the blockade for melanoma immunotherapy

scientific article published on 29 October 2015

Dramatic response to radiotherapy combined with vemurafenib. Is vemurafenib a radiosensitizer?

scientific article

Drug of the year: programmed death-1 receptor/programmed death-1 ligand-1 receptor monoclonal antibodies

scientific article published on 29 July 2013

Drug resistance in rat colon cancer cell lines is associated with minor changes in susceptibility to cytotoxic cells

scientific article published on October 1993

E-cadherin promotor methylation and mutation are inversely related to motility capacity of breast cancer cells

scientific article

EANM-EORTC general recommendations for sentinel node diagnostics in melanoma

scientific article

EMAP-II facilitates TNF-R1 apoptotic signalling in endothelial cells and induces TRADD mobilization

scientific article

EORTC Melanoma Group sentinel node protocol identifies high rate of submicrometastases according to Rotterdam Criteria.

scientific article published in September 2010

Early destruction of tumor vasculature in tumor necrosis factor-alpha-based isolated limb perfusion is responsible for tumor response

scientific article

Early endothelium activation and polymorphonuclear cell invasion precede specific necrosis of human melanoma and sarcoma treated by intravascular high-dose tumour necrosis factor alpha (rTNF alpha)

scientific article published on 01 June 1994

Effect of L-NAME, an inhibitor of nitric oxide synthesis, on plasma levels of IL-6, IL-8, TNF alpha and nitrite/nitrate in human septic shock.

scientific article

Effect of bevacizumab added preoperatively to oxaliplatin on liver injury and complications after resection of colorectal liver metastases

scientific article

Effect of low-dose tumor necrosis factor-alpha in combination with STEALTH liposomal cisplatin (SPI-077) on soft-tissue- and osteosarcoma-bearing rats.

scientific article

Effects of recombinant tumour necrosis factor (rTNF-alpha) in cancer. Observations on the acute phase protein reaction and immunoglobulin synthesis after high dose recombinant TNF-alpha administration in isolated limb perfusions in cancer patients

scientific article published on 01 December 1993

Effects of simultaneous aortocaval occlusion on oxygen consumption in patients

scientific article published in September 2003

Effects of the interferon-inducer ABPP on colon cancer in rats; importance of tumor load and tumor site

scientific article published on 01 January 1986

Effects of time interval between primary melanoma excision and sentinel node biopsy on positivity rate and survival.

scientific article published on 23 September 2016

Efficacy of repeat isolated limb perfusions with tumor necrosis factor alpha and melphalan for multiple in-transit metastases in patients with prior isolated limb perfusion failure

scientific article

Electron microscopic observations on the accumulation of large granular lymphocytes (pit cells) and Kupffer cells in the liver of rats treated with continuous infusion of interleukin-2

scientific article published on 01 December 1990

Endogenous natural killer cells do not play a role in antitumor effects induced by interleukin-2 in a syngeneic rat colon tumor model

scientific article published on 01 January 2000

Endothelial P-selectin expression is reduced in advanced primary melanoma and melanoma metastasis.

scientific article published on March 1998

Endothelial monocyte-activating polypeptide-II and its functions in (patho)physiological processes

scientific article

Enhanced Specificity and Drug Delivery in Tumors by cRGD-Anchoring Thermosensitive Liposomes

scientific article

Enriching lipid nanovesicles with short‐chain glucosylceramide improves doxorubicin delivery and efficacy in solid tumors ⬇️

scientific article published on September 27, 2010

Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects

scientific article

Epidemiological evidence that UVA radiation is involved in the genesis of cutaneous melanoma

scientific article published on March 2011

Erratum: anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25.

scientific article published in March 2015

Estimation of Distant Metastasis-free Survival in Trials of Adjuvant Therapy for Melanoma

scientific article published on 01 April 2019

European Academy of Cancer Sciences - position paper

article

European Academy of Cancer Sciences-Designation of Comprehensive Cancer Centres of Excellence

scientific article published on 2 February 2018

European Organization for Research and Treatment of Cancer (EORTC)-Melanoma Cooperative Group (MCG) meeting. San Miniato, 23-24 April 1993

scientific article published on 01 October 1993

European approach to adjuvant treatment of intermediate- and high-risk malignant melanoma

scientific article published in August 2002

European approach to the treatment of malignant melanoma

scientific article published in March 2002

European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics - Update 2019

scientific article published on 09 January 2020

European consensus-based interdisciplinary guideline for melanoma. Part 2: Treatment - Update 2019

scientific article published on 19 December 2019

European interdisciplinary guideline on invasive squamous cell carcinoma of the skin: Part 1. epidemiology, diagnostics and prevention

scientific article published on 26 February 2020

European interdisciplinary guideline on invasive squamous cell carcinoma of the skin: Part 2. Treatment

scientific article published on 26 February 2020

Evaluating the potential of relapse-free survival as a surrogate for overall survival in the adjuvant therapy of melanoma with checkpoint inhibitors

scientific article published on 07 August 2020

Evaluation of the efficacy of immunotherapy for non-resectable mucosal melanoma

scientific article published on 07 June 2019

Exomics and immunogenics: Bridging mutational load and immune checkpoints efficacy

scientific article published on 16 January 2014

Expanded access programmes: patient interests versus clinical trial integrity

scientific article published on 29 December 2014

Expert opinion in melanoma: the sentinel node; EORTC Melanoma Group recommendations on practical methodology of the measurement of the microanatomic location of metastases and metastatic tumour burden

scientific article

Exposing endothelial cells to tumor necrosis factor-α and peripheral blood mononuclear cells damage endothelial integrity via interleukin-1ß by degradation of vascular endothelial-cadherin.

scientific article

Extended schedule, escalated dose temozolomide versus dacarbazine in stage IV melanoma: final results of a randomised phase III study (EORTC 18032).

scientific article

Factors Influencing Prognosis After Initial Inadequate Excision (IIE) for Soft Tissue Sarcoma

scientific article

Feasibility and first reports of the MATCH-R repeated biopsy trial at Gustave Roussy

scientific article published on 08 September 2020

Fifty tumor necrosis factor-based isolated limb perfusions for limb salvage in patients older than 75 years with limb-threatening soft tissue sarcomas and other extremity tumors

scientific article published in January 2003

Final results of phase III SYMMETRY study: randomized, double-blind trial of elesclomol plus paclitaxel versus paclitaxel alone as treatment for chemotherapy-naive patients with advanced melanoma

scientific article

Fine needle aspiration cytology of palpable and nonpalpable lymph nodes to detect metastatic melanoma

scientific article published on 21 September 2011

Frontiers in adjuvant therapy in stage II-III melanoma.

scientific article published in July 2001

Future perspectives in melanoma research : Meeting report from the "Melanoma Bridge". Napoli, December 1st-4th 2015.

scientific article

Future perspectives in melanoma research. Meeting report from the "Melanoma Bridge. Napoli, December 2nd-4th 2012".

scientific article published on 3 June 2013

Future perspectives in melanoma research: meeting report from the "Melanoma Bridge", Napoli, December 5th-8th 2013.

scientific article

Gender differences in melanoma survival: female patients have a decreased risk of metastasis.

scientific article published on 9 December 2010

Gene expression profiling of human angiotropic primary melanoma: selection of 15 differentially expressed genes potentially involved in extravascular migratory metastasis

scientific article published on 19 February 2011

Gene therapy in in vivo isolated perfusion models

scientific article

Germline CDKN2A/P16INK4A mutations contribute to genetic determinism of sarcoma ⬇️

scientific article published on 7 June 2017

Giant solitary fibrous tumour of the liver

scientific article

Global cancer surgery: delivering safe, affordable, and timely cancer surgery.

scientific article published on September 2015

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors

scientific article published on 2 November 2017

Harnessing the immune system to provide long-term survival in patients with melanoma and other solid tumors

scientific article published on 3 January 2014

Health-related quality of life with adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): secondary outcomes of a multinational, randomised, double-blind, phase 3 trial

scientific article published on 2 February 2017

Hereditary breast cancer growth rates and its impact on screening policy

scientific article

High-Throughput Genomics and Clinical Outcome in Hard-to-Treat Advanced Cancers: Results of the MOSCATO 01 Trial

scientific article published on 01 April 2017

Highlights from the perspectives in melanoma XII conference

scientific article published on 01 April 2009

Histamine combined with melphalan in isolated limb perfusion for the treatment of locally advanced soft tissue sarcomas: preclinical studies in rats

scientific article

How should we use anti-CTLA-4 antibodies?

scientific article published on 01 November 2015

Human preprocalcitonin self-antigen generates TAP-dependent and -independent epitopes triggering optimised T-cell responses toward immune-escaped tumours

scientific article published in Nature Communications

Hyperprogressive Disease Is a New Pattern of Progression in Cancer Patients Treated by Anti-PD-1/PD-L1.

scientific article

Hyperthermia and thermosensitive liposomes for improved delivery of chemotherapeutic drugs to solid tumors

scientific article published on 28 April 2010

Hyperthermic isolated limb perfusion with tumor necrosis factor alpha, interferon gamma, and melphalan for locally advanced nonmelanoma skin tumors of the extremities: a multicenter study

scientific article published on 01 March 1999

Hyperthermic isolated limb perfusion with tumor necrosis factor is a useful therapy for advanced melanoma of the limbs

scientific article published on 01 April 2007

Hyperthermic isolated limb perfusion with tumour necrosis factor and melphalan as treatment of locally advanced or recurrent soft tissue sarcomas of the extremities

scientific article published on 01 July 1998

Hyperthermic pelvic perfusion with tumor necrosis factor-α for locally advanced cancers: encouraging results of a phase II study

scientific article published in February 2012

Immune biomarkers for prognosis and prediction of responses to immune checkpoint blockade in cutaneous melanoma.

scientific article published on 7 March 2017

Immune checkpoint inhibitors in melanoma provide the cornerstones for curative therapies

scientific article published on 14 February 2015

Immune infiltrates are prognostic factors in localized gastrointestinal stromal tumors

scientific article

Immunologic functions as prognostic indicators in melanoma

scientific article

Immunophenotyping of Stage III Melanoma Reveals Parameters Associated with Patient Prognosis

scientific article published on 29 January 2016

Immunostimulation versus immunosuppression after multiple vaccinations: the woes of therapeutic vaccine development

scientific article

Immunotherapy Bridge 2017 and Melanoma Bridge 2017: meeting abstracts

scientific article published on 15 January 2018

Immunotherapy and the concept of a clinical cure

scientific article

Immunotherapy in a human ovarian cancer xenograft model with two bispecific monoclonal antibodies: OV-TL 3/CD3 and OC/TR

scientific article published on 01 February 1994

Immunotherapy: Vaccine trials in melanoma -- time for reflection

scientific article

Impact of Precision Medicine in Diverse Cancers: A Meta-Analysis of Phase II Clinical Trials

scientific article published on 24 August 2015

Impact of a Biomarker-Based Strategy on Oncology Drug Development: A Meta-analysis of Clinical Trials Leading to FDA Approval

scientific article published on 15 September 2015

Impact of molecular staging methods in primary melanoma: reverse-transcriptase polymerase chain reaction (RT-PCR) of ultrasound-guided aspirate of the sentinel node does not improve diagnostic accuracy, but RT-PCR of peripheral blood does predict su

scientific article

Importance of tumor load in the sentinel node in melanoma: clinical dilemmas

scientific article

Improved Endpoints for Cancer Immunotherapy Trials ⬇️

scientific article published on September 8, 2010

Improved intratumoral nanoparticle extravasation and penetration by mild hyperthermia.

scientific article published on 4 February 2013

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

scientific article

Improving intracellular doxorubicin delivery through nanoliposomes equipped with selective tumor cell membrane permeabilizing short-chain sphingolipids

scientific article published on 11 May 2013

In depth study on thermosensitive liposomes: Optimizing formulations for tumor specific therapy and in vitro to in vivo relations

scientific article published on 22 December 2015

In vitro and in vivo chemosensitizing effect of cyclosporin A on an intrinsic multidrug-resistant rat colon tumour.

scientific article

In vivo generation of lymphokine activated killer cell activity by ABPP and interleukin-2 and their antitumor effects against immunogenic and nonimmunogenic tumors in murine tumor models

scientific article published on 01 January 1988

Incorporating immune-checkpoint inhibitors into systemic therapy of NSCLC

scientific article

Increased sampling will lead to an increase in detection, but is it clinically relevant?

scientific article published on 13 June 2012

Induction of lymphokine-activated killer activity in rat splenocyte cultures: the importance of 2-mercaptoethanol and indomethacin

scientific article published on 01 January 1991

Interferon alfa-2a and interleukin-2 with or without cisplatin in metastatic melanoma: a randomized trial of the European Organization for Research and Treatment of Cancer Melanoma Cooperative Group ⬇️

scientific article published on 01 July 1997

Interferon-alpha in oncology patients: fewer psychiatric side effects than anticipated

scientific article published on 01 January 2008

Interferon-alpha induced Raynaud's syndrome

scientific article

Interferon-alpha influences tryptophan metabolism without inducing psychiatric side effects

scientific article published on 17 September 2007

Interleukin-2-induced thyroid dysfunction is correlated with treatment duration but not with tumor response

scientific article published on May 1993

Intraperitoneal immunotherapy of cancer: a review of options for treatment.

scientific article published on January 1996

Intrapleural administration of interleukin 2 in pleural mesothelioma: a phase I-II study ⬇️

scientific article published on November 1, 1995

Intrapleural administration of tumour necrosis factor-alpha (TNFalpha) in patients with mesothelioma: cytokine patterns and acute-phase protein response

scientific article published in April 2000

Intratumoural expression of TNF-R1 and EMAP-II in relation to response of patients treated with TNF-based isolated limb perfusion

scientific article

Introducing new strategies in...

scientific article published on 23 February 2010

Investigation of Factors Determining the Enhanced Permeability and Retention Effect in Subcutaneous Xenografts.

scientific article published on 30 December 2015

Investigation of Particle Accumulation, Chemosensitivity and Thermosensitivity for Effective Solid Tumor Therapy Using Thermosensitive Liposomes and Hyperthermia

scientific article

Is restaging with chest and abdominal CT scan after neoadjuvant chemoradiotherapy for locally advanced rectal cancer necessary?

scientific article

Is the clinical risk score for patients with colorectal liver metastases still useable in the era of effective neoadjuvant chemotherapy?

scientific article

Is ulceration in cutaneous melanoma just a prognostic and predictive factor or is ulcerated melanoma a distinct biologic entity?

scientific article published on March 2012

Isolated hepatic perfusion for the treatment of liver tumors: sunset or sunrise?

scientific article

Isolated hepatic perfusion in the pig with TNF-alpha with and without melphalan

scientific article published on January 1997

Isolated hepatic perfusion with tumor necrosis factor alpha and melphalan: experimental studies in pigs and phase I data from humans.

scientific article

Isolated hepatic perfusion: experimental evidence and clinical utility

scientific article

Isolated hypoxic hepatic perfusion with orthograde or retrograde flow in patients with irresectable liver metastases using percutaneous balloon catheter techniques: a phase I and II study

scientific article

Isolated hypoxic hepatic perfusion with retrograde outflow in patients with irresectable liver metastases; a new simplified technique in isolated hepatic perfusion

scientific article

Isolated limb perfusion based anti-p21ras gene therapy in a rat rhabdomyosarcoma

scientific article

Isolated limb perfusion for an irresectable melanoma recurrence in a Jehovah's witness

scientific article

Isolated limb perfusion for local gene delivery: efficient and targeted adenovirus-mediated gene transfer into soft tissue sarcomas

scientific article published in December 2000

Isolated limb perfusion for unresectable melanoma of the extremities

scientific article published on 01 November 2004

Isolated limb perfusion in primary and recurrent melanoma: indications and results

scientific article published on 01 April 1998

Isolated limb perfusion in the management of locally advanced extremity soft tissue sarcoma

scientific article published in April 2003

Isolated limb perfusion of an irradiated foot with tumor necrosis factor, interferon, and melphalan

scientific article published on 01 June 1996

Isolated limb perfusion prolongs the limb recurrence-free interval after several episodes of excisional surgery for locoregional recurrent melanoma

scientific article published on 12 April 2004

Isolated limb perfusion with TNF-alpha and melphalan for distal parts of the limb in soft tissue sarcoma patients

scientific article

Isolated limb perfusion with TNF-alpha and melphalan in locally advanced soft tissue sarcomas of the extremities.

scientific article

Isolated limb perfusion with high-dose tumor necrosis factor-alpha in combination with interferon-gamma and melphalan for nonresectable extremity soft tissue sarcomas: a multicenter trial

scientific article published on October 1996

Isolated limb perfusion with melphalan and TNF-alpha in the treatment of extremity sarcoma

scientific article

Isolated limb perfusion with tumor necrosis factor and melphalan prevents amputation in patients with multiple sarcomas in arm or leg.

scientific article

Isolated limb perfusion with tumour necrosis factor-alpha and melphalan with or without interferon-gamma for the treatment of in-transit melanoma metastases: a multicentre randomized phase II study.

scientific article published on October 1999

KEYNOTE-716: Phase III study of adjuvant pembrolizumab versus placebo in resected high-risk stage II melanoma

scientific article published on 24 December 2019

LDH correlation with survival in advanced melanoma from two large, randomised trials (Oblimersen GM301 and EORTC 18951).

scientific article published on 4 May 2009

Laboratory models of regional chemotherapy

scientific article

Lack of cell-cycle specific effects of tumor necrosis factor-alpha on tumor cells in vitro: implications for combination tumor therapy with doxorubicin

scientific article published in January 2002

Leukocyte adherence inhibition, natural killer cell activity, gamma-interferon production capacity and phytohemagglutinin response in patients treated with recombinant leukocyte A interferon

scientific article published on 01 January 1985

Liver and tumour tissue concentrations of TNF-alpha in cancer patients treated with TNF-alpha and melphalan by isolated liver perfusion

scientific article

Local treatment for recurrent colorectal hepatic metastases after partial hepatectomy

scientific article

Long term follow up of the EORTC 18952 trial of adjuvant therapy in resected stage IIB-III cutaneous melanoma patients comparing intermediate doses of interferon-alpha-2b (IFN) with observation: Ulceration of primary is key determinant for IFN-sensi

scientific article published on 17 January 2016

Long-term protective effect of mature DC-LAMP+ dendritic cell accumulation in sentinel lymph nodes containing micrometastatic melanoma

scientific article (publication date: July 2007)

Long-term results of the "liver first" approach in patients with locally advanced rectal cancer and synchronous liver metastases

scientific article

Long-term results of the randomized phase III trial EORTC 18991 of adjuvant therapy with pegylated interferon alfa-2b versus observation in resected stage III melanoma

scientific article published on 24 September 2012

Long-term results of tumor necrosis factor alpha- and melphalan-based isolated limb perfusion in locally advanced extremity soft tissue sarcomas

scientific article

Longer Follow-Up Confirms Recurrence-Free Survival Benefit of Adjuvant Pembrolizumab in High-Risk Stage III Melanoma: Updated Results From the EORTC 1325-MG/KEYNOTE-054 Trial

scientific article published on 18 September 2020

Low-dose tumor necrosis factor-alpha augments antitumor activity of stealth liposomal doxorubicin (DOXIL) in soft tissue sarcoma-bearing rats

scientific article published in September 2000

Lymph node ratio as a prognostic factor in melanoma: results from European Organization for Research and Treatment of Cancer 18871, 18952, and 18991 studies

scientific article published on 01 June 2018

Lymphokine-activated killer cell and interleukin-2 inhibitors: their role in adoptive immunotherapy

scientific article published on 01 July 1987

MR angiography of tumor-related vasculature: from the clinic to the micro-environment

scientific article

Management of Immune-Related Adverse Events Affecting Outcome in Patients Treated With Checkpoint Inhibitors-Reply

scientific article published on 18 June 2020

Management of Melanoma Patients: Benefit of Intense Follow-Up Schedule Is Not Demonstrated

scientific article published on 01 October 2003

Management of immune checkpoint blockade dysimmune toxicities: a collaborative position paper

scientific article

Management of melanoma: a European perspective

scientific article

Management of pegylated interferon alpha toxicity in adjuvant therapy of melanoma

scientific article published on 14 June 2012

Management of psychiatric adverse events with immunotherapy with interferon-alfa

scientific article

Manipulation of the tumour-associated vasculature to improve tumour therapy

scientific article

Mastectomy by Inverted Drip Incision and Immediate Reconstruction: Data From 510 Cases ⬇️

scientific article published on May 1, 2003

Meeting report: consensus from the first and second Global Workshops in Melanoma November 19-20, 2008

Melanoma and immunotherapy

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Melanoma and immunotherapy bridge 2015 : Naples, Italy. 1-5 December 2015

scientific article

Melanoma burden by melanoma stage: Assessment through a disease transition model

scientific article published on 13 December 2015

Melanoma in 2011: a new paradigm tumor for drug development

scientific article published on 10 January 2012

Melanoma patients with positive sentinel nodes who did not undergo completion lymphadenectomy: a multi-institutional study

scientific article published on 12 April 2006

Melanoma staging: Evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual

scientific article published on 13 October 2017

Melanoma--the pieces of the puzzle finally start coming together! Preface

scientific article published on 3 April 2011

Melanoma: MSLT-1--SNB is a biomarker, not a therapeutic intervention

scientific article published on 08 April 2014

Melanoma: smart therapeutic strategies in immuno-oncology.

scientific article published on 4 March 2014

Melanomas prevent endothelial cell death under restrictive culture conditions by signaling through AKT and p38 MAPK/ ERK-1/2 cascades

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Metastatic melanoma to the liver: a contemporary and comprehensive review of surgical, systemic, and regional therapeutic options

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Metastatic melanoma: New paradigms of treatment and new toxicities

scientific article

Mild hyperthermia triggered doxorubicin release from optimized stealth thermosensitive liposomes improves intratumoral drug delivery and efficacy

scientific article published on 21 March 2013

Modulation of multidrug resistance with dexniguldipine hydrochloride (B8509-035) in the CC531 rat colon carcinoma model

scientific article published on 01 January 1996

Molecular characterization and patient outcome of melanoma nodal metastases and an unknown primary site.

scientific article

Monitoring of anti-vaccine CD4 T cell frequencies in melanoma patients vaccinated with a MAGE-3 protein.

scientific article published on February 2005

Multidrug resistance in rat colon carcinoma cell lines CC531, CC531mdr+ and CC531rev

scientific article published on November 1993

Multimarker reverse transcriptase-polymerase chain reaction assay in lymphatic drainage and sentinel node tumor burden

scientific article

Multimodality approach to the sentinel node: an algorithm for the use of presentinel lymph node biopsy ultrasound (after lymphoscintigraphy) in conjunction with presentinel lymph node biopsy fine needle aspiration cytology.

scientific article

Multiplex bead-based measurement of humoral immune responses against tumor-associated antigens in stage II melanoma patients of the EORTC18961 trial.

scientific article published on 12 February 2018

Multivariate analysis of prognostic factors among 2,313 patients with stage III melanoma: comparison of nodal micrometastases versus macrometastases

scientific article

NK cells modulate MHC class I expression on tumor cells and their susceptibility to lysis

scientific article published on 01 November 2000

NKp30 isoforms and NKp30 ligands are predictive biomarkers of response to imatinib mesylate in metastatic GIST patients

scientific article published on 25 April 2016

Neoadjuvant systemic therapy in melanoma: recommendations of the International Neoadjuvant Melanoma Consortium

scientific article published on 01 July 2019

Neoadjuvant therapy in melanoma: the next step?

scientific article published on 17 January 2018

Neuropsychiatric side effects of interferon-alfa therapy

scientific article published in February 2003

Neurotoxic and neuroprotective metabolites of kynurenine in patients with renal cell carcinoma treated with interferon-alpha: course and relationship with psychiatric status

scientific article

New developments in melanoma: utility of ultrasound imaging (initial staging, follow-up and pre-SLNB).

scientific article

New developments in sentinel node staging in melanoma: controversies and alternatives

scientific article

New drugs in melanoma: it's a whole new world

scientific article published on 27 July 2011

Nitric oxide production and monoamine oxidase activity in cancer patients during interferon-alpha therapy

scientific article published on 26 October 2008

Nomograms to predict recurrence and survival in stage IIIB and IIIC melanoma after therapeutic lymphadenectomy

scientific article published on 6 March 2014

Novel immune checkpoint blocker approved for the treatment of advanced melanoma

scientific article

Novel monoclonal antibodies against membrane structures that are preferentially expressed on IL-2-activated rat NK cells

scientific article published on 01 February 1998

On the release and half-life of S100B protein in the peripheral blood of melanoma patients

scientific article published on 01 November 2001

One hundred consecutive isolated limb perfusions with TNF-alpha and melphalan in melanoma patients with multiple in-transit metastases

scientific article

Optimizing the outcome of surgery in patients with rectal cancer and synchronous liver metastases

scientific article

Outcome after therapeutic lymph node dissection in patients with unknown primary melanoma site

scientific article

Outcome and prognostic factor analysis of 217 consecutive isolated limb perfusions with tumor necrosis factor-alpha and melphalan for limb-threatening soft tissue sarcoma

scientific article

Outcome of microscopic incomplete resection (R1) of colorectal liver metastases in the era of neoadjuvant chemotherapy

scientific article

PD-Loma: a cancer entity with a shared sensitivity to the PD-1/PD-L1 pathway blockade

scientific article published on 09 November 2018

Patient- and treatment-related factors associated with acute regional toxicity after isolated perfusion for melanoma of the extremities

scientific article published on 01 June 1994

Pegylated interferon-alpha2b treatment in melanoma patients: influence on amino acids, 5-hydroxyindolacetic acid and pteridine plasma concentrations

scientific article

Pegylated liposomal tumor necrosis factor-alpha results in reduced toxicity and synergistic antitumor activity after systemic administration in combination with liposomal doxorubicin (Doxil) in soft tissue sarcoma-bearing rats

scientific article published in January 2002

Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial

scientific article

Pharmacokinetics, Tissue Distribution and Therapeutic Effect of Cationic Thermosensitive Liposomal Doxorubicin Upon Mild Hyperthermia

scientific article

Phase 1/2 study of subcutaneous and intradermal immunization with a recombinant MAGE-3 protein in patients with detectable metastatic melanoma

scientific article

Phase I clinical trial combining imatinib mesylate and IL-2 in refractory cancer patients: IL-2 interferes with the pharmacokinetics of imatinib mesylate

scientific article published on February 2013

Phase I clinical trial combining imatinib mesylate and IL-2: HLA-DR(+) NK cell levels correlate with disease outcome

scientific article published on February 2013

Phase III trial comparing adjuvant treatment with pegylated interferon Alfa-2b versus observation: prognostic significance of autoantibodies--EORTC 18991.

scientific article

Plasma membrane targeting by short chain sphingolipids inserted in liposomes improves anti-tumor activity of mitoxantrone in an orthotopic breast carcinoma xenograft model

scientific article published on 14 May 2015

Platelet MAO activity during treatment with pegylated interferon-alfa in melanoma patients

scientific article

Polymorphisms in the CD28/CTLA4/ICOS genes: role in malignant melanoma susceptibility and prognosis?

scientific article

Post-surgery adjuvant therapy with intermediate doses of interferon alfa 2b versus observation in patients with stage IIb/III melanoma (EORTC 18952): randomised controlled trial

scientific article

Potent immunomodulatory effects of the trifunctional antibody catumaxomab

scientific article published on 4 June 2013

Potential cost-effectiveness of US-guided FNAC in melanoma patients as a primary procedure and in follow-up

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Pre-SN Ultrasound-FNAC can be Sensitive for Lymph Node Metastases in Melanoma Patients if Performed with the Use of the Berlin Criteria

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Precision cancer medicine: the future is now, only better

scientific article

Predictive gene signature in MAGE-A3 antigen-specific cancer immunotherapy

scientific article published on 28 May 2013

Predictors of responses to immune checkpoint blockade in advanced melanoma

scientific article published on 19 September 2017

Pregnancy and melanoma: a European-wide survey to assess current management and a critical literature overview.

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Preoperative radiotherapy improves outcome in recurrent rectal cancer

scientific article

Prerequisites for effective isolated limb perfusion using tumour necrosis factor alpha and melphalan in rats

scientific article published in April 1999

Pretreatment levels of peripheral neutrophils and leukocytes as independent predictors of overall survival in patients with American Joint Committee on Cancer Stage IV Melanoma: results of the EORTC 18951 Biochemotherapy Trial

scientific article published on 01 April 2007

Prognosis in patients with sentinel node-positive melanoma is accurately defined by the combined Rotterdam tumor load and Dewar topography criteria

scientific article

Prognosis of Patients With Stage III Melanoma According to American Joint Committee on Cancer Version 8: A Reassessment on the Basis of 3 Independent Stage III Melanoma Cohorts

scientific article published on 12 June 2020

Prognosis of primary mucosal penile melanoma: a series of 19 Dutch patients and 47 patients from the literature

scientific article

Prognostic and predictive value of AJCC-8 staging in the phase III EORTC1325/KEYNOTE-054 trial of pembrolizumab vs placebo in resected high-risk stage III melanoma

scientific article published on 11 June 2019

Prognostic and predictive value of YKL-40 in stage IIB-III melanoma

scientific article

Prognostic factors after cervical lymph node dissection for cutaneous melanoma metastases

scientific article

Prognostic impact of the expression of NCR1 and NCR3 NK cell receptors and PD-L1 on advanced non-small cell lung cancer

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Prognostic significance of mitotic rate in localized primary cutaneous melanoma: an analysis of patients in the multi-institutional American Joint Committee on Cancer melanoma staging database

scientific article

Prognostic value of patient-reported outcomes from international randomised clinical trials on cancer: a systematic review

scientific article published on 01 December 2019

Prolonged Survival in Stage III Melanoma with Ipilimumab Adjuvant Therapy

scientific article

Prolonged continuous hepatic artery infusion with interleukin-2 in unresectable liver metastases of colorectal cancer: a phase IA-B study

scientific article published on March 1996

Prophylactic isolated limb perfusion for localized, high-risk limb melanoma: results of a multicenter randomized phase III trial. European Organization for Research and Treatment of Cancer Malignant Melanoma Cooperative Group Protocol 18832, the Wor

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Putting Europe in the driving seat

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Quantitative detection of circulating tumor cells in cutaneous and ocular melanoma and quality assessment by real-time reverse transcriptase-polymerase chain reaction

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Radiotherapy for soft tissue sarcomas after isolated limb perfusion and surgical resection: essential for local control in all patients?

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Randomized adjuvant therapy trials in melanoma: surgical and systemic

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Randomized dose-escalation study evaluating peginterferon alfa-2a in patients with metastatic malignant melanoma

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Randomized trials in melanoma: an update

scientific article

Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma

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Re-evaluating the role of dacarbazine in metastatic melanoma: what have we learned in 30 years?

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Reaching first base in the treatment of metastatic melanoma

scientific article published on 11 September 2006

Reactive oxygen species and melanoma: an explanation for gender differences in survival?

scientific article published on 10 March 2010

Recruitment of inflammatory cells to a tumor deposit potentiates the immunotherapeutic effects of interleukin-2

scientific article published on 01 January 1986

Redefining the role of interferon in the treatment of malignant diseases

scientific article

Reducing the need for sentinel node procedures by ultrasound examination of regional lymph nodes

scientific article published on 26 January 2005

Regional administration of natural killer cells in a rat hepatic metastasis model results in better tumor infiltration and anti-tumor response than systemic administration

scientific article

Regional administration of recombinant tumour necrosis factor-alpha in cancer, with special reference to melanoma

scientific article published on 01 March 1998

Regional application of cytokines: experience with various clinical protocols

scientific article published on 01 September 1992

Regression of Advanced Ovarian Carcinoma by Intraperitoneal Treatment With Autologous TLymphocytes Retargeted by a Bispecific Monoclonal Antibody ⬇️

scientific article published on October 4, 1995

Regulation of CD4(+)NKG2D(+) Th1 cells in patients with metastatic melanoma treated with sorafenib: role of IL-15Rα and NKG2D triggering

scientific article published on 6 November 2013

Regulation of iron metabolism in the acute-phase response: interferon gamma and tumour necrosis factor alpha induce hypoferraemia, ferritin production and a decrease in circulating transferrin receptors in cancer patients

scientific article published on 01 July 1998

Reirradiation, surgery and IORT for recurrent rectal cancer in previously irradiated patients

scientific article

Relapse-Free Survival as a Surrogate for Overall Survival in the Evaluation of Stage II-III Melanoma Adjuvant Therapy.

scientific article published in January 2018

Relation between limb toxicity and treatment outcomes after isolated limb perfusion for recurrent melanoma

scientific article published on 01 May 1999

Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel-Lindau Gene Mutation Status

scientific article published on 17 December 2015

Repeated isolated limb perfusion in melanoma patients with recurrent in-transit metastases

scientific article published on 23 June 2015

Reply to 'Challenging PD-L1 expressing cytotoxic T cells as a predictor for response to immunotherapy in melanoma'

scientific article published in Nature Communications

Report from the society for biological therapy and vascular biology faculty of the NCI workshop on angiogenesis monitoring

scientific article published in March 2004

Response to: Comment on 'Diagnosis and treatment of basal cell carcinoma: European consensus-based interdisciplinary guidelines'

scientific article published on 22 September 2020

Results of a double perfusion schedule with melphalan in patients with melanoma of the lower limb

scientific article published on 01 January 1993

Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma

scientific article

Results of interleukin-2-based treatment in advanced melanoma: a case record-based analysis of 631 patients.

scientific article published in September 1998

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

scientific article

Risk stratification of sentinel node-positive melanoma patients defines surgical management and adjuvant therapy treatment considerations.

scientific article published on 13 April 2018

Role of ultrasound in the assessment of the sentinel node of melanoma patients

scientific article published on 01 December 2010

Rotterdam Criteria for sentinel node (SN) tumor burden and the accuracy of ultrasound (US)-guided fine-needle aspiration cytology (FNAC): can US-guided FNAC replace SN staging in patients with melanoma?

scientific article published on 8 September 2009

SLNB in melanoma-DFS a true and cost-effective benefit?

scientific article published on 14 October 2014

Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study

scientific article

Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination

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Salvage abdominoperineal resection and perineal wound healing in local recurrent or persistent anal cancer

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Secondary Tumors Arising in Patients Undergoing BRAF Inhibitor Therapy Exhibit Increased BRAF-CRAF Heterodimerization

scientific article published on 29 January 2016

Selection of immunostimulant AS15 for active immunization with MAGE-A3 protein: results of a randomized phase II study of the European Organisation for Research and Treatment of Cancer Melanoma Group in Metastatic Melanoma

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Sentinel lymph-node false positivity in melanoma

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Sentinel node tumor burden according to the Rotterdam criteria is the most important prognostic factor for survival in melanoma patients: a multicenter study in 388 patients with positive sentinel nodes

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Serum amino acids, biopterin and neopterin during long-term immunotherapy with interferon-alpha in high-risk melanoma patients

scientific article published in July 2003

Serum concentrations of pegylated interferon alpha-2b in patients with resected stage III melanoma receiving adjuvant pegylated interferon alpha-2b in a randomized phase III trial (EORTC 18991).

scientific article

Sex differences in melanoma survival are not related to mitotic rate of the primary tumor

scientific article published on 19 November 2014

Sex is an independent prognostic indicator for survival and relapse/progression-free survival in metastasized stage III to IV melanoma: a pooled analysis of five European organisation for research and treatment of cancer randomized controlled trials

scientific article published on 20 May 2013

Short-chain glycoceramides promote intracellular mitoxantrone delivery from novel nanoliposomes into breast cancer cells

scientific article published on 16 October 2014

Side effects and toxicities of targeted therapies in stage IV melanoma

scientific article published on January 2015

Site-specific antitumour effects of 2 pyrimidinone compounds in rats

scientific article

Skin tumors induced by sorafenib; paradoxic RAS-RAF pathway activation and oncogenic mutations of HRAS, TP53, and TGFBR1

scientific article published on 17 November 2011

Soluble factors produced by macrophages/monocytes inhibit lymphokine-activated killer activity in rat splenocyte cultures

scientific article published on 01 January 1994

Stromal influences on breast cancer cell growth ⬇️

scientific article published on January 1, 1992

Superior outcome of women with stage I/II cutaneous melanoma: pooled analysis of four European Organisation for Research and Treatment of Cancer phase III trials

scientific article published on 30 April 2012

Support systems to guide clinical decision-making in precision oncology: The Cancer Core Europe Molecular Tumor Board Portal

scientific article published on 01 July 2020

Surgical management of melanoma: an EORTC Melanoma Group survey

scientific article

Surrogate endpoints for overall survival in metastatic melanoma: a meta-analysis of randomised controlled trials

scientific article published on 31 January 2014

Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade

scientific article published on 03 September 2019

Synergistic antitumor activity of cyclophosphamide and ABPP in the treatment of established and advanced tumors in murine tumor models

scientific article published on 01 January 1987

Synergistic antitumor activity of histamine plus melphalan in isolated limb perfusion: preclinical studies

scientific article

Synergistic antitumor effects of histamine plus melphalan in isolated hepatic perfusion for liver metastases

scientific article

Synergistic antitumor response of interleukin 2 with melphalan in isolated limb perfusion in soft tissue sarcoma-bearing rats

scientific article

Synergistic antitumour effect of recombinant human tumour necrosis factor alpha with melphalan in isolated limb perfusion in the rat

scientific article published on 01 April 1996

Systemic leakage during isolated limb perfusion for melanoma

scientific article published on 01 September 1993

TNF and manipulation of the tumor cell-stromal interface: "ways to make chemotherapy effective".

scientific article

TNF is here to stay--revisited

scientific article published on 01 March 2001

TNF registered in Europe: does TNF get a second chance?

scientific article published on 01 July 2000

TNF-alpha has no direct in vivo metabolic effect on human muscle

scientific article published on 01 April 1997

TNF-alpha in cancer treatment: molecular insights, antitumor effects, and clinical utility

scientific article

TNF-based isolated limb perfusion: a decade of experience with antivascular therapy in the management of locally advanced extremity soft tissue sarcomas.

scientific article

Targeted and heat-triggered doxorubicin delivery to tumors by dual targeted cationic thermosensitive liposomes

scientific article published on 29 August 2014

Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy

scientific article published on 10 April 2016

Technology insight: Utility of TNF-alpha-based isolated limb perfusion to avoid amputation of irresectable tumors of the extremities

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The "liver-first approach" for patients with locally advanced rectal cancer and synchronous liver metastases

scientific article

The 2017 complete overhaul of adjuvant therapies for high-risk melanoma and its consequences for staging and management of melanoma patients

scientific article

The AJCC staging proposal for cutaneous melanoma: comments by the EORTC Melanoma Group

scientific article published on 01 January 2001

The EORTC melanoma group translational research program on prognostic factors and ultrastaging in association with the adjuvant therapy trials in stage II and stage III melanoma. European Organization for Research and Treatment of Cancer

scientific article published on 01 October 2001

The EORTC-DeCOG nomogram adequately predicts outcomes of patients with sentinel node-positive melanoma without the need for completion lymph node dissection

scientific article published on 23 May 2020

The European Academy of Cancer Sciences

The Great Debate at "Melanoma Bridge", Naples, December 7th, 2019

scientific article published on 16 April 2020

The PD-1/PD-L1-Checkpoint Restrains T cell Immunity in Tumor-Draining Lymph Nodes

scientific article published on 15 September 2020

The Rotterdam criteria for sentinel node tumor load: the simplest prognostic factor?

scientific article published on 17 November 2008

The biology behind prognostic factors of cutaneous melanoma

scientific article published on May 2010

The challenge to bring personalized cancer medicine from clinical trials into routine clinical practice: the case of the Institut Gustave Roussy ⬇️

scientific article published on 16 March 2012

The development and purification of a bispecific antibody for lymphokine-activated killer cell targeting against the rat colon carcinoma CC531.

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The development of novel mouse monoclonal antibodies against the CC531 rat colon adenocarcinoma

scientific article published on 01 January 2000

The development of optimal pathological assessment of sentinel lymph nodes for melanoma.

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The great debate at "Melanoma Bridge 2018", Naples, December 1st, 2018.

scientific article published on 10 May 2019

The impact of the immunotherapy revolution on lymph nodal surgery

scientific article published on 11 October 2019

The infiltration of experimentally induced lung metastases of colon carcinoma CC531 by adoptively transferred interleukin-2-activated natural killer cells in Wag rats

scientific article published on 01 February 1994

The need for a network to establish and validate predictive biomarkers in cancer immunotherapy

scientific article published on 3 November 2017

The new era of adjuvant therapies for melanoma

scientific article published on 01 September 2018

The palliative value of tumor necrosis factor alpha-based isolated limb perfusion in patients with metastatic sarcoma and melanoma

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The prognostic significance of sentinel node tumour burden in melanoma patients: an international, multicenter study of 1539 sentinel node-positive melanoma patients

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The requirements for successful immunotherapy of intraperitoneal cancer using interleukin-2 and lymphokine-activated killer cells

scientific article published on 01 October 1987

The risk of in-transit melanoma metastasis depends on tumor biology and not the surgical approach to regional lymph nodes

scientific article published on 01 July 2005

The role of MHC class I expression in rat NK cell-mediated lysis of syngeneic tumor cells and virus-infected cells.

scientific article published on August 1996

The role of isolated limb perfusion for melanoma confined to the extremities

scientific article published in April 2003

The use of neo-adjuvant chemotherapy in patients with resectable colorectal liver metastases: Clinical risk score as possible discriminator.

scientific article published on 2 May 2015

The value of preoperative ultrasound (after lymphoscintigraphy) in conjunction with pre-sentinel lymph node biopsy fine-needle aspiration outweighs the usage of ultrasound alone in conjunction with lymphoscintigraphy: the need for an algorithm.

scientific article published in August 2010

The αVβ3/αVβ5 integrin inhibitor cilengitide augments tumor response to melphalan isolated limb perfusion in a sarcoma model

scientific article published on 05 December 2012

Therapeutic cancer vaccine development: will it ride the wave of new immunomodulatory agents?

scientific article published on 01 September 2011

Therapeutic vaccines in solid tumours: can they be harmful?

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Tissue inhibitor of metalloproteinase-3 (TIMP3) expression decreases during melanoma progression and inhibits melanoma cell migration

scientific article published on 11 August 2016

Tobacco: deadly in any form or disguise

scientific article published in The Lancet

Towards a Cancer Mission in Horizon Europe

scientific article published on 01 November 2019

Towards a cancer mission in Horizon Europe: recommendations

scientific article published on 01 August 2020

Toxicity and antitumor activity of interferon gamma alone and in combinations with TNFalpha and melphalan in isolated limb perfusion in the BN175 sarcoma tumor model in rats.

scientific article published on January 1999

Transcriptional response to hypoxic stress in melanoma and prognostic potential of GBE1 and BNIP3.

scientific article published on 30 October 2017

Transforming growth factor beta secretion from primary breast cancer fibroblasts ⬇️

scientific article published on April 28, 1995

Translational control of tumor immune escape via the eIF4F-STAT1-PD-L1 axis in melanoma

scientific article published on 29 October 2018

Translational research in clinical trials: the only way forward

scientific article published on 01 November 2001

Treatment algorithms in stage IV melanoma

scientific article published on January 2015

Treatment modifications in tumour necrosis factor-α (TNF)-based isolated limb perfusion in patients with advanced extremity soft tissue sarcomas.

scientific article published on 16 December 2014

Treatment of colon cancer in rats with rMuTNF and the interferon-inducer bropirimine

scientific article published on 01 January 1989

Trends in treatment for synchronous colorectal liver metastases: differences in outcome before and after 2000.

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Trial Watch

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Trial Watch-Small molecules targeting the immunological tumor microenvironment for cancer therapy

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Trial Watch: Adoptive cell transfer for anticancer immunotherapy

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Trial Watch: Adoptive cell transfer for anticancer immunotherapy

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Trial Watch: Adoptive cell transfer for oncological indications

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Trial Watch: Adoptive cell transfer immunotherapy

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Trial Watch: Anticancer radioimmunotherapy

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Trial Watch: Chemotherapy with immunogenic cell death inducers.

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Trial Watch: DNA vaccines for cancer therapy

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Trial Watch: Experimental Toll-like receptor agonists for cancer therapy

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Trial Watch: Immunogenic cell death inducers for anticancer chemotherapy

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Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications

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Trial Watch: Immunostimulation with Toll-like receptor agonists in cancer therapy

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Trial Watch: Immunostimulatory cytokines

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Trial Watch: Immunostimulatory monoclonal antibodies in cancer therapy

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Trial Watch: Immunotherapy plus radiation therapy for oncological indications

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Trial Watch: Peptide vaccines in cancer therapy

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Trial watch: Dendritic cell-based anticancer therapy

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Trial watch: IDO inhibitors in cancer therapy

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Trial watch: Peptide vaccines in cancer therapy

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Trial watch: Prognostic and predictive value of the immune infiltrate in cancer

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Trial watch: Tumor-targeting monoclonal antibodies for oncological indications

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Tumor necrosis factor alpha mediates homogeneous distribution of liposomes in murine melanoma that contributes to a better tumor response

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Tumor necrosis factor and isolated hepatic perfusion: from preclinical tumor models to clinical studies

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Tumor necrosis factor-alpha augmented tumor response in B16BL6 melanoma-bearing mice treated with stealth liposomal doxorubicin (Doxil) correlates with altered Doxil pharmacokinetics

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Tumor necrosis factor-based isolated limb perfusion for soft tissue sarcoma and melanoma: ten years of successful antivascular therapy

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Tumor necrosis factor-mediated interactions between inflammatory response and tumor vascular bed.

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Tumor plasticity interferes with anti-tumor immunity

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Tumor vascular therapy with TNF: critical review on animal models

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Ulceration and stage are predictive of interferon efficacy in melanoma: results of the phase III adjuvant trials EORTC 18952 and EORTC 18991.

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Ultrasound diagnosis of an atypical axillary lesion

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Ultrasound morphology criteria predict metastatic disease of the sentinel nodes in patients with melanoma

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Ultrasound of the sentinel node in melanoma patients: echo-free island is a discriminatory morphologic feature for node positivity.

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Ultrasound-guided fine needle aspiration cytology as an addendum to sentinel lymph node biopsy can perfect the staging strategy in melanoma patients

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Update on the role of ipilimumab in melanoma and first data on new combination therapies

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Update: current management issues in malignant melanoma.

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Upregulation of intratumoral HLA class I and peritumoral Mx1 in ulcerated melanomas

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Value of intraoperative radiotherapy in locally advanced rectal cancer

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When to perform surgery in stage IV melanoma patients?

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Who benefits most from adjuvant interferon treatment for melanoma?

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[Efficacy of the tumor necrosis factor-alpha (rTNF-alpha) associated with interferon-gamma and chemotherapy in extracorporeal circulation in the limb in inoperable malignant melanoma, soft tissue sarcoma and epidermoid carcinoma. A 4-year experience

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eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies

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