List of works - Kostas Tokatlidis

A cryptic matrix targeting signal of the yeast ADP/ATP carrier normally inserted by the TIM22 complex is recognized by the TIM23 machinery

scientific article published on January 2005

A disulfide relay system in mitochondria

scientific article

A novel intermembrane space-targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding

scientific article

An Intrinsically Disordered Domain Has a Dual Function Coupled to Compartment-Dependent Redox Control

scholarly article by Lucia Banci published in February 2013

An electron-transfer path through an extended disulfide relay system: the case of the redox protein ALR

scientific article

Analysis of the sorting signals directing NADH-cytochrome b5 reductase to two locations within yeast mitochondria.

scientific article published on July 1997

Anamorsin is a [2Fe-2S] cluster-containing substrate of the Mia40-dependent mitochondrial protein trapping machinery

scientific article

Assembly of Tim9 and Tim10 into a functional chaperone.

scientific article

Bacterial cellulases

scientific article published in February 1992

Biogenesis of mitochondrial inner membrane proteins

scientific article

Biogenesis of yeast Mia40 - uncoupling folding from import and atypical recognition features

scientific article

Common players in mitochondria biogenesis and neuronal protection against stress-induced apoptosis

scientific article published on 05 September 2013

Complementing structural information of modular proteins with small angle neutron scattering and contrast variation.

scientific article published on 13 February 2008

Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space.

scientific article

Conserved substrate binding by chaperones in the bacterial periplasm and the mitochondrial intermembrane space

scientific article

Directing proteins to mitochondria by fusion to mitochondrial targeting signals

scientific article published on 01 January 2000

Distinct Domains of Small Tims Involved in Subunit Interaction and Substrate Recognition

Erv1 mediates the Mia40-dependent protein import pathway and provides a functional link to the respiratory chain by shuttling electrons to cytochrome c.

scientific article published on 15 September 2005

Functional TIM10 chaperone assembly is redox-regulated in vivo.

scientific article published on 18 February 2004

Functional reconstitution of the import of the yeast ADP/ATP carrier mediated by the TIM10 complex

scientific article published in August 2001

High activity of inclusion bodies formed in Escherichia coli overproducing Clostridium thermocellum endoglucanase D.

scientific article published in April 1991

ICPBCZin: a red emitting ratiometric fluorescent indicator with nanomolar affinity for Zn2+ ions

scientific article published on 19 February 2008

Import of a major mitochondrial enzyme depends on synergy between two distinct helices of its presequence.

scientific article published on 15 July 2016

Import of mitochondrial carriers mediated by essential proteins of the intermembrane space

scientific article

Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis

scientific article published on 21 May 2015

Interaction of the duplicated segment carried by Clostridium thermocellum cellulases with cellulosome components

scientific article published on 01 October 1991

Introduction: Focus on mitochondria

scientific article

Involvement of separate domains of the cellulosomal protein S1 of Clostridium thermocellum in binding to cellulose and in anchoring of catalytic subunits to the cellulosome

scientific article published on 01 June 1992

Juxtaposition of the two distal CX3C motifs via intrachain disulfide bonding is essential for the folding of Tim10.

scientific article

Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA

scientific article

MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria

scientific article

Membrane protein import in yeast mitochondria

scientific article

MiR-195 regulates mitochondrial function by targeting mitofusin-2 in breast cancer cells.

scientific article published on 25 April 2019

Mitochondrial ATP-independent chaperones

scientific article published on September 2009

Mitochondrial Proteins Containing Coiled-Coil-Helix-Coiled-Coil-Helix (CHCH) Domains in Health and Disease

scientific article

Molecular Interactions of the Mitochondrial Tim12 Translocase Subunit

scientific article published on 01 January 2007

Molecular chaperone function of Mia40 triggers consecutive induced folding steps of the substrate in mitochondrial protein import

scientific article

Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR

scientific article

Mutation of Conserved Charged Residues in Mitochondrial TIM10 Subunits Precludes TIM10 Complex Assembly, but Does not Abolish Growth of Yeast Cells

article

Nascent chains: folding and chaperone interaction during elongation on ribosomes

scientific article

Orphan proteins of unknown function in the mitochondrial intermembrane space proteome: New pathways and metabolic cross-talk

scientific article

Oxidative folding in the mitochondrial intermembrane space: A regulated process important for cell physiology and disease ⬇️

scientific article

Oxidative folding of small Tims is mediated by site-specific docking onto Mia40 in the mitochondrial intermembrane space

scientific article published in 2007

Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane space

scientific article

Oxidative protein folding in the mitochondrial intermembrane space

scientific article published on October 2010

Properties conferred on Clostridium thermocellum endoglucanase CelC by grafting the duplicated segment of endoglucanase CelD.

scientific article

Shaping the import system of mitochondria.

scientific article published on 20 June 2018

Targeting and Maturation of Erv1/ALR in the Mitochondrial Intermembrane Space

The MIA pathway: a key regulator of mitochondrial oxidative protein folding and biogenesis.

scientific article

The N-terminal shuttle domain of Erv1 determines the affinity for Mia40 and mediates electron transfer to the catalytic Erv1 core in yeast mitochondria

scientific article published in November 2010

The biogenesis of mitochondrial intermembrane space proteins

scientific article published on 01 February 2020

The coiled coil-helix-coiled coil-helix proteins may be redox proteins

scientific article published on 02 April 2009

The dynamic dimerization of the yeast ADP/ATP carrier in the inner mitochondrial membrane is affected by conserved cysteine residues

scientific article

The essential function of Tim12 in vivo is ensured by the assembly interactions of its C-terminal domain

scientific article

The mitochondrial intermembrane space: a hub for oxidative folding linked to protein biogenesis

scientific article published on 03 October 2012

The mitochondrial processing peptidase behaves as a zinc-metallopeptidase

scientific article published in July 1998

The structural basis of the TIM10 chaperone assembly.

scientific article published on 18 February 2004

Tim9p, an essential partner subunit of Tim10p for the import of mitochondrial carrier proteins

scientific article

Translocation arrest of an intramitochondrial sorting signal next to Tim11 at the inner-membrane import site

scientific article published in Nature

Translocation of mitochondrial inner-membrane proteins: conformation matters.

scientific article

Trapping Oxidative Folding Intermediates During Translocation to the Intermembrane Space of Mitochondria: In Vivo and In Vitro Studies

article published in 2010

List of works by Kostas Tokatlidis

A cryptic matrix targeting signal of the yeast ADP/ATP carrier normally inserted by the TIM22 complex is recognized by the TIM23 machinery

A disulfide relay system in mitochondria

A novel intermembrane space-targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding

An Intrinsically Disordered Domain Has a Dual Function Coupled to Compartment-Dependent Redox Control

An electron-transfer path through an extended disulfide relay system: the case of the redox protein ALR

Analysis of the sorting signals directing NADH-cytochrome b5 reductase to two locations within yeast mitochondria.

Anamorsin is a [2Fe-2S] cluster-containing substrate of the Mia40-dependent mitochondrial protein trapping machinery

Assembly of Tim9 and Tim10 into a functional chaperone.

Bacterial cellulases

Biogenesis of mitochondrial inner membrane proteins

Biogenesis of yeast Mia40 - uncoupling folding from import and atypical recognition features

Common players in mitochondria biogenesis and neuronal protection against stress-induced apoptosis

Complementing structural information of modular proteins with small angle neutron scattering and contrast variation.

Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space.

Conserved substrate binding by chaperones in the bacterial periplasm and the mitochondrial intermembrane space

Directing proteins to mitochondria by fusion to mitochondrial targeting signals

Distinct Domains of Small Tims Involved in Subunit Interaction and Substrate Recognition

Erv1 mediates the Mia40-dependent protein import pathway and provides a functional link to the respiratory chain by shuttling electrons to cytochrome c.

Functional TIM10 chaperone assembly is redox-regulated in vivo.

Functional reconstitution of the import of the yeast ADP/ATP carrier mediated by the TIM10 complex

High activity of inclusion bodies formed in Escherichia coli overproducing Clostridium thermocellum endoglucanase D.

ICPBCZin: a red emitting ratiometric fluorescent indicator with nanomolar affinity for Zn2+ ions

Import of a major mitochondrial enzyme depends on synergy between two distinct helices of its presequence.

Import of mitochondrial carriers mediated by essential proteins of the intermembrane space

Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis

Interaction of the duplicated segment carried by Clostridium thermocellum cellulases with cellulosome components

Introduction: Focus on mitochondria

Involvement of separate domains of the cellulosomal protein S1 of Clostridium thermocellum in binding to cellulose and in anchoring of catalytic subunits to the cellulosome

Juxtaposition of the two distal CX3C motifs via intrachain disulfide bonding is essential for the folding of Tim10.

Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA

MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria

Membrane protein import in yeast mitochondria

MiR-195 regulates mitochondrial function by targeting mitofusin-2 in breast cancer cells.

Mitochondrial ATP-independent chaperones

Mitochondrial Proteins Containing Coiled-Coil-Helix-Coiled-Coil-Helix (CHCH) Domains in Health and Disease

Molecular Interactions of the Mitochondrial Tim12 Translocase Subunit

Molecular chaperone function of Mia40 triggers consecutive induced folding steps of the substrate in mitochondrial protein import

Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR

Mutation of Conserved Charged Residues in Mitochondrial TIM10 Subunits Precludes TIM10 Complex Assembly, but Does not Abolish Growth of Yeast Cells

Nascent chains: folding and chaperone interaction during elongation on ribosomes

Orphan proteins of unknown function in the mitochondrial intermembrane space proteome: New pathways and metabolic cross-talk

Oxidative folding in the mitochondrial intermembrane space: A regulated process important for cell physiology and disease ⬇️

Oxidative folding of small Tims is mediated by site-specific docking onto Mia40 in the mitochondrial intermembrane space

Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane space

Oxidative protein folding in the mitochondrial intermembrane space

Properties conferred on Clostridium thermocellum endoglucanase CelC by grafting the duplicated segment of endoglucanase CelD.

Shaping the import system of mitochondria.

Targeting and Maturation of Erv1/ALR in the Mitochondrial Intermembrane Space

The MIA pathway: a key regulator of mitochondrial oxidative protein folding and biogenesis.

The N-terminal shuttle domain of Erv1 determines the affinity for Mia40 and mediates electron transfer to the catalytic Erv1 core in yeast mitochondria

The biogenesis of mitochondrial intermembrane space proteins

The coiled coil-helix-coiled coil-helix proteins may be redox proteins

The dynamic dimerization of the yeast ADP/ATP carrier in the inner mitochondrial membrane is affected by conserved cysteine residues

The essential function of Tim12 in vivo is ensured by the assembly interactions of its C-terminal domain

The mitochondrial intermembrane space: a hub for oxidative folding linked to protein biogenesis

The mitochondrial processing peptidase behaves as a zinc-metallopeptidase

The structural basis of the TIM10 chaperone assembly.

Tim9p, an essential partner subunit of Tim10p for the import of mitochondrial carrier proteins

Translocation arrest of an intramitochondrial sorting signal next to Tim11 at the inner-membrane import site

Translocation of mitochondrial inner-membrane proteins: conformation matters.

Trapping Oxidative Folding Intermediates During Translocation to the Intermembrane Space of Mitochondria: In Vivo and In Vitro Studies