List of works - Zdzislaw Wawrzak

"Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target

scientific article published on December 2005

2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H

scientific article published on April 2006

A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid

scientific article published on 01 March 2020

A convergent coordination chemistry-based approach to dissymmetric macrocyclic cofacial porphyrin complexes

scientific article published on 14 August 2007

A requirement for an active proton delivery network supports a Compound I mediated C-C bond cleavage in CYP51 catalysis

scientific article published on 03 June 2020

Antitrypanosomal Lead Discovery: Identification of a Ligand-Efficient Inhibitor of Trypanosoma cruzi CYP51 and Parasite Growth

scientific article

Basis of Miscoding of the DNA Adduct N2,3-Ethenoguanine by Human Y-family DNA Polymerases

scientific article

Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51

scientific article published in Journal of Biological Chemistry

Biochemical and Structural Analyses of Two Cryptic Esterases in Bacteroides intestinalis and their Synergistic Activities with Cognate Xylanases.

scientific article

Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi

scientific article published on 7 December 2015

Complexes of Trypanosoma cruzi Sterol 14 -Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITY

scientific article

Concerning P450 evolution: Structural Analyses Support Bacterial Origin of Sterol 14α-Demethylases

scientific article published on 08 October 2020

Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants ⬇️

scientific article published on May 17, 2011

Covalent incorporation of selenium into oligonucleotides for X-ray crystal structure determination via MAD: proof of principle. Multiwavelength anomalous dispersion

scientific article

Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity

scientific article published on May 2017

Crystal structure of a B-form DNA duplex containing (L)-alpha-threofuranosyl (3'-->2') nucleosides: a four-carbon sugar is easily accommodated into the backbone of DNA

scientific article

Crystal structure of a luteoviral RNA pseudoknot and model for a minimal ribosomal frameshifting motif

scientific article published on August 2005

Crystal structure of nonphosphorylated receiver domain of the stress response regulator RcsB from Escherichia coli

scientific article

Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles

scientific article

Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections

scientific article

Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity

scientific article published on March 2004

Crystal structures of putative phosphoglycerate kinases from B. anthracis and C. jejuni

scientific article

Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance

scientific article

Crystallization and preliminary crystallographic analysis of endonuclease VIII in its uncomplexed form

scientific article

Cytochrome c nitrite reductase from the bacterium Geobacter lovleyi represents a new NrfA subclass

scientific article published on 09 June 2020

High-resolution structures of scytalone dehydratase-inhibitor complexes crystallized at physiological pH

scientific article published in June 1999

Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design

scientific article published on 16 June 2016

Inherent steroid 17α,20-lyase activity in defunct cytochrome P450 17A enzymes.

scientific article published on 6 December 2017

Kinetic and structural mechanisms of (5'S)-8,5'-cyclo-2'-deoxyguanosine-induced dna replication stalling

scientific article

Mechanism of inhibition of 3 alpha, 20 beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor

scientific article

Molecular Dissection of Xyloglucan Recognition in a Prominent Human Gut Symbiont

scientific article

Novel carbohydrate binding modules in the surface anchored α-amylase of Eubacterium rectale provide a molecular rationale for the range of starches used by this organism in the human gut.

scientific article

Recognition of O6 -benzyl-2′-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction ⬇️

scientific article published on June 8, 2013

Retraction: Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus

scientific article published on 6 February 2017

Selenium-assisted nucleic acid crystallography: use of phosphoroselenoates for MAD phasing of a DNA structure

scientific article

Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallogr

scientific article published on 25 June 2018

Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition

scientific article

Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin.

scientific article published on February 2016

Structural Insights into Inhibition of Sterol 14 -Demethylase in the Human Pathogen Trypanosoma cruzi

scientific article

Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis

scientific article published on 3 March 2017

Structural and biochemical characterization of 20β-hydroxysteroid dehydrogenase from Bifidobacterium adolescentis strain L2-32

scientific article published on 17 June 2019

Structural and kinetic basis of steroid 17α,20-lyase activity in teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2.

scientific article

Structural basis of Toxoplasma gondii Perforin-Like Protein 1 membrane interaction and activity during egress

Structural basis of Toxoplasma gondii perforin-like protein 1 membrane interaction and activity during egress

scientific article published on 04 December 2018

Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Δ7-24, 25-dihydrolanosterol ⬇️

scientific article published on November 30, 2011

Structure and DNA binding of alkylation response protein AidB

scientific article

Structure and activity of the NAD(P)+-dependent succinate semialdehyde dehydrogenase YneI from Salmonella typhimurium

scientific article

Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus

retracted scientific article

Structure of galactarate dehydratase, a new fold in an enolase involved in bacterial fitness after antibiotic treatment

scientific article published on 17 December 2019

Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway

scientific article

Structure of the two-subsite beta-d-xylosidase from Selenomonas ruminantium in complex with 1,3-bis[tris(hydroxymethyl)methylamino]propane

scientific article

Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs

scientific article

Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantum

scientific article

Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis.

scientific article published on 9 April 2018

Supramolecular allosteric cofacial porphyrin complexes

scientific article published on December 2006

The structure of a doripenem-bound OXA-51 class D β-lactamase variant with enhanced carbapenemase activity

scientific article

Three-dimensional structure of homodimeric cholesterol esterase-ligand complex at 1.4 A resolution

scientific article

Type III effector NleH2 from Escherichia coli O157:H7 str. Sakai features an atypical protein kinase domain

scientific article

VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis

scientific article

Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors

scientific article published on 11 November 2019

Why does TNA cross-pair more strongly with RNA than with DNA? an answer from X-ray analysis

scientific article

X-ray Crystal Structure of Divalent Metal-Activated β-xylosidase, RS223BX

scientific article published on 23 July 2015

List of works by Zdzislaw Wawrzak

"Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target

2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H

A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid

A convergent coordination chemistry-based approach to dissymmetric macrocyclic cofacial porphyrin complexes

A requirement for an active proton delivery network supports a Compound I mediated C-C bond cleavage in CYP51 catalysis

Antitrypanosomal Lead Discovery: Identification of a Ligand-Efficient Inhibitor of Trypanosoma cruzi CYP51 and Parasite Growth

Basis of Miscoding of the DNA Adduct N2,3-Ethenoguanine by Human Y-family DNA Polymerases

Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51

Biochemical and Structural Analyses of Two Cryptic Esterases in Bacteroides intestinalis and their Synergistic Activities with Cognate Xylanases.

Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi

Complexes of Trypanosoma cruzi Sterol 14 -Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITY

Concerning P450 evolution: Structural Analyses Support Bacterial Origin of Sterol 14α-Demethylases

Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants ⬇️

Covalent incorporation of selenium into oligonucleotides for X-ray crystal structure determination via MAD: proof of principle. Multiwavelength anomalous dispersion

Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity

Crystal structure of a B-form DNA duplex containing (L)-alpha-threofuranosyl (3'-->2') nucleosides: a four-carbon sugar is easily accommodated into the backbone of DNA

Crystal structure of a luteoviral RNA pseudoknot and model for a minimal ribosomal frameshifting motif

Crystal structure of nonphosphorylated receiver domain of the stress response regulator RcsB from Escherichia coli

Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles

Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections

Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity

Crystal structures of putative phosphoglycerate kinases from B. anthracis and C. jejuni

Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance

Crystallization and preliminary crystallographic analysis of endonuclease VIII in its uncomplexed form

Cytochrome c nitrite reductase from the bacterium Geobacter lovleyi represents a new NrfA subclass

High-resolution structures of scytalone dehydratase-inhibitor complexes crystallized at physiological pH

Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design

Inherent steroid 17α,20-lyase activity in defunct cytochrome P450 17A enzymes.

Kinetic and structural mechanisms of (5'S)-8,5'-cyclo-2'-deoxyguanosine-induced dna replication stalling

Mechanism of inhibition of 3 alpha, 20 beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor

Molecular Dissection of Xyloglucan Recognition in a Prominent Human Gut Symbiont

Novel carbohydrate binding modules in the surface anchored α-amylase of Eubacterium rectale provide a molecular rationale for the range of starches used by this organism in the human gut.

Recognition of O6 -benzyl-2′-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction ⬇️

Retraction: Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus

Selenium-assisted nucleic acid crystallography: use of phosphoroselenoates for MAD phasing of a DNA structure

Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallogr

Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition

Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin.

Structural Insights into Inhibition of Sterol 14 -Demethylase in the Human Pathogen Trypanosoma cruzi

Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis

Structural and biochemical characterization of 20β-hydroxysteroid dehydrogenase from Bifidobacterium adolescentis strain L2-32

Structural and kinetic basis of steroid 17α,20-lyase activity in teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2.

Structural basis of Toxoplasma gondii Perforin-Like Protein 1 membrane interaction and activity during egress

Structural basis of Toxoplasma gondii perforin-like protein 1 membrane interaction and activity during egress

Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Δ7-24, 25-dihydrolanosterol ⬇️

Structure and DNA binding of alkylation response protein AidB

Structure and activity of the NAD(P)+-dependent succinate semialdehyde dehydrogenase YneI from Salmonella typhimurium

Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus

Structure of galactarate dehydratase, a new fold in an enolase involved in bacterial fitness after antibiotic treatment

Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway

Structure of the two-subsite beta-d-xylosidase from Selenomonas ruminantium in complex with 1,3-bis[tris(hydroxymethyl)methylamino]propane

Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs

Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantum

Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis.

Supramolecular allosteric cofacial porphyrin complexes

The structure of a doripenem-bound OXA-51 class D β-lactamase variant with enhanced carbapenemase activity

Three-dimensional structure of homodimeric cholesterol esterase-ligand complex at 1.4 A resolution

Type III effector NleH2 from Escherichia coli O157:H7 str. Sakai features an atypical protein kinase domain

VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis

Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors

Why does TNA cross-pair more strongly with RNA than with DNA? an answer from X-ray analysis

X-ray Crystal Structure of Divalent Metal-Activated β-xylosidase, RS223BX