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List of works by Shahriar Mobashery

715. Bulgecin A lowers Imipenem MICs in Clinical MDR Acinetobacter baumannii (ACB) Strains

A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis

scientific article

A Structural Dissection of the Active Site of the Lytic Transglycosylase MltE from Escherichia coli

scholarly article by David A Dik et al published 26 September 2018 in Biochemistry

A Type VI secretion system delivers a cell-wall amidase to target bacterial competitors

scientific article published on 12 April 2020

A chemical biological strategy to facilitate diabetic wound healing.

scientific article published on 26 September 2013

A computational evaluation of the mechanism of penicillin-binding protein-catalyzed cross-linking of the bacterial cell wall

scientific article

A convenient synthesis of a selective gelatinase inhibitor as an antimetastatic agent

scientific article

A dynamic structure for the acyl-enzyme species of the antibiotic aztreonam with the Citrobacter freundii beta-lactamase revealed by infrared spectroscopy and molecular dynamics simulations

scientific article published in February 2003

A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia.

scientific article published in July 2005

A mechanism-based inhibitor targeting the DD-transpeptidase activity of bacterial penicillin-binding proteins.

scientific article

A novel beta-lactamase activity from a penicillin-binding protein of Treponema pallidum and why syphilis is still treatable with penicillin.

scientific article

A positive positive to negative

scientific article published on 01 October 2018

A potent gelatinase inhibitor with anti-tumor-invasive activity and its metabolic disposition

scientific article published on February 2009

A practical synthesis of nitrocefin

scientific article published in January 2005

AAC(3)-XI, a new aminoglycoside 3-N-acetyltransferase from Corynebacterium striatum

scientific article

Ab initio QM/MM study of class A beta-lactamase acylation: dual participation of Glu166 and Lys73 in a concerted base promotion of Ser70.

scientific article published in November 2005

Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy

scientific article

Activation by Allostery in Cell-Wall Remodeling by a Modular Membrane-Bound Lytic Transglycosylase from Pseudomonas aeruginosa

scientific article

Activation for catalysis of penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus by bacterial cell wall

scientific article published in February 2005

Activation of BlaR1 protein of methicillin-resistant Staphylococcus aureus, its proteolytic processing, and recovery from induction of resistance.

scientific article published on 6 September 2011

Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases

scientific article

Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other Gram-Positive Bacteria

scholarly article by Sara Ceballos et al published August 2018 in Antimicrobial Agents and Chemotherapy

Allostery, Recognition of Nascent Peptidoglycan, and Cross-linking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae

scientific article published on 22 January 2018

Amidase Activity of AmiC Controls Cell Separation and Stem Peptide Release and Is Enhanced by NlpD in Neisseria gonorrhoeae

scientific article published on 16 March 2016

Aminoglycoside 2''-phosphotransferase type IIIa from Enterococcus.

scientific article

Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site

scientific article

Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance

scientific article (publication date: December 2000)

An Amino Acid Position at Crossroads of Evolution of Protein Function: ANTIBIOTIC SENSOR DOMAIN OF BlaR1 PROTEIN FROM STAPHYLOCOCCUS AUREUS VERSUS CLASS D  -LACTAMASES

scientific article

An Antibiotic-Resistance Enzyme from a Deep-Sea Bacterium

scientific article

Antibiotics as physiological stress inducers and bacterial response to the challenge

scientific article published on 09 October 2012

Antimetastatic activity of a novel mechanism-based gelatinase inhibitor

scientific article

Bacterial AmpD at the crossroads of peptidoglycan recycling and manifestation of antibiotic resistance

scientific article published on July 2009

Bacterial cell-wall recycling.

scientific article

Bacterial resistance to beta-lactam antibiotics: compelling opportunism, compelling opportunity

scientific article

Binding of the gene repressor BlaI to the bla operon in methicillin-resistant Staphylococcus aureus.

scientific article

Catalytic Cycle of Glycoside Hydrolase BglX from Pseudomonas aeruginosa and Its Implications for Biofilm Formation

scientific article published on 07 January 2020

Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa.

scientific article

Catalytic mechanism of penicillin-binding protein 5 of Escherichia coli

scientific article published on 09 August 2007

Catalytic spectrum of the penicillin-binding protein 4 of Pseudomonas aeruginosa, a nexus for the induction of β-lactam antibiotic resistance

scientific journal article

Cell surface association of matrix metalloproteinase-9 (gelatinase B).

scientific article

Cell-Wall Recycling of the Gram-Negative Bacteria and the Nexus to Antibiotic Resistance

scientific article published on 30 May 2018

Cell-Wall Remodeling by the Zinc-Protease AmpDh3 from Pseudomonas aeruginosa

scientific article

Characterization of the Dimerization Interface of Membrane Type 4 (MT4)-Matrix Metalloproteinase ⬇️

scientific article published on August 2, 2011

Characterization of the beta-lactam antibiotic sensor domain of the MecR1 signal sensor/transducer protein from methicillin-resistant Staphylococcus aureus.

scientific article published on 6 June 2007

Characterization of the bifunctional aminoglycoside-modifying enzyme ANT(3'')-Ii/AAC(6')-IId from Serratia marcescens

scientific article published in July 2006

Cinnamonitrile Adjuvants Restore Susceptibility to β-Lactams against Methicillin-Resistant Staphylococcus aureus

scientific article published on 01 July 2019

Cleavage at the stem region releases an active ectodomain of the membrane type 1 matrix metalloproteinase

scientific article

Co-opting the cell wall in fighting methicillin-resistant Staphylococcus aureus: potent inhibition of PBP 2a by two anti-MRSA beta-lactam antibiotics

scientific article

Complex pattern of membrane type 1 matrix metalloproteinase shedding. Regulation by autocatalytic cells surface inactivation of active enzyme

scientific article

Complications from dual roles of sodium hydride as a base and as a reducing agent

scientific article published on March 2009

Computational investigation of irreversible inactivation of the zinc-dependent protease carboxypeptidase A

scientific article published on 01 March 2005

Conformational Dynamics in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus, Allosteric Communication Network and Enablement of Catalysis.

scientific article published on 18 January 2017

Conformational analyses of thiirane-based gelatinase inhibitors

scientific article published on 5 December 2007

Conformational transition in the aminoacyl t-RNA site of the bacterial ribosome both in the presence and absence of an aminoglycoside antibiotic

scientific article published on 01 May 2007

Constructing and deconstructing the bacterial cell wall

scientific article published on 20 November 2019

Corrigendum: Muropeptides in Pseudomonas aeruginosa and their Role as Elicitors of β-Lactam-Antibiotic Resistance.

scientific article published in October 2016

Critical involvement of a carbamylated lysine in catalytic function of class D  -lactamases

scientific article

Crystal Structures of Bacterial Peptidoglycan Amidase AmpD and an Unprecedented Activation Mechanism

scientific article

Crystal Structures of Penicillin-Binding Protein 6 from Escherichia coli

scientific article

Crystal structure of CbpF, a bifunctional choline-binding protein and autolysis regulator from Streptococcus pneumoniae

scientific article

Crystal structure of CbpF, a bifunctional choline-binding protein and autolysis regulator from Streptococcus pneumoniae

scientific article published on 13 March 2009

Crystallization and preliminary X-ray diffraction analysis of the lytic transglycosylase MltE from Escherichia coli ⬇️

scientific article published on December 24, 2010

Cytoplasmic-membrane anchoring of a class A beta-lactamase and its capacity in manifesting antibiotic resistance

scientific article published on 14 May 2007

DFT studies of the ring-opening mechanism of SB-3CT, a potent inhibitor of matrix metalloproteinase 2.

scientific article

Deciphering the Nature of Enzymatic Modifications of Bacterial Cell Walls

scientific article published on 7 June 2017

Design and characterization of a metalloproteinase inhibitor-tethered resin for the detection of active MMPs in biological samples

scientific article published on 01 April 2006

Design and synthesis of a structurally constrained aminoglycoside

scientific article published on 19 June 2007

Design of novel antibiotics that bind to the ribosomal acyltransfer site

scientific article published in April 2002

Design, synthesis, and characterization of potent, slow-binding inhibitors that are selective for gelatinases

scientific article published on 14 January 2002

Design, synthesis, and evaluation of a mechanism-based inhibitor for gelatinase A.

scientific article published in July 2005

Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling

scientific article

Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library.

scientific article published on 22 September 2017

Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity.

scientific article published on 21 February 2014

Discovery of a potent picolinamide antibacterial active against Clostridioides difficile

scientific article published on 07 August 2020

Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one

scientific article

Discrete steps in sensing of beta-lactam antibiotics by the BlaR1 protein of the methicillin-resistant Staphylococcus aureus bacterium

scholarly article

Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics

scientific article

Dissection of events in the resistance to β-lactam antibiotics mediated by the protein BlaR1 from Staphylococcus aureus.

scientific article published on 29 May 2012

Early Abrogation of Gelatinase Activity Extends the Time Window for tPA Thrombolysis after Embolic Focal Cerebral Ischemia in Mice.

scientific article

Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background

scientific article published on August 2008

Effect of synthetic matrix metalloproteinase inhibitors on lipopolysaccharide-induced blood-brain barrier opening in rodents: Differences in response based on strains and solvents

scientific article published on 20 December 2006

Elucidation of the molecular recognition of bacterial cell wall by modular pneumococcal phage endolysin CPL-1

scientific article

Elucidation of the structure of the membrane anchor of penicillin-binding protein 5 of Escherichia coli

scientific article

Enantiomers of a selective gelatinase inhibitor: (R)- and (S)-2-[(4-phenoxyphenyl)sulfonylmethyl]thiirane

scientific article published on 04 October 2014

Endless Resistance. Endless Antibiotics?

scientific article (publication date: 2016)

Endogenous matrix metalloproteinases 2 and 9 regulate activation of CD4+ and CD8+ T cells

scientific article

Enzymology of Bacterial Resistance

article

Exolytic and endolytic turnover of peptidoglycan by lytic transglycosylase Slt of Pseudomonas aeruginosa.

scientific article published on 9 April 2018

Exploitation of Conformational Dynamics in Imparting Selective Inhibition for Related Matrix Metalloproteinases

scientific article

Exploration of mild copper-mediated coupling of organotrifluoroborates in the synthesis of thiirane-based inhibitors of matrix metalloproteinases

scientific article

Exploration of the Structural Space in 4(3H)-Quinazolinone Antibacterials

scientific article published on 28 April 2020

Exploration of the structure-activity relationship of 1,2,4-oxadiazole antibiotics

scientific article

Exploring the functional space of thiiranes as gelatinase inhibitors using click chemistry

scientific article published on 27 February 2011

Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers

scientific article published on 19 July 2018

Extracellular proteases as targets for treatment of cancer metastases

scientific article published on 13 August 2004

Facile preparation of a highly functionalized tetrahydropyran by catalytic hydrogenation of an oxazoline

scientific article

Fluorescence Assessment of the AmpR-Signaling Network of Pseudomonas aeruginosa to Exposure to β-Lactam Antibiotics

scientific article published on 10 February 2020

Fluorinated aminoglycosides and their mechanistic implication for aminoglycoside 3'-phosphotransferases from Gram-negative bacteria

scientific article published in March 2004

From Genome to Proteome to Elucidation of Reactions for All Eleven Known Lytic Transglycosylases from Pseudomonas aeruginosa

scientific article published on 27 January 2017

Glycosylation at Asn211 regulates the activation state of the discoidin domain receptor 1 (DDR1).

scientific article published on 07 February 2014

High-Resolution Crystal Structure of MltE, an Outer Membrane-Anchored Endolytic Peptidoglycan Lytic Transglycosylase from Escherichia coli

scientific article

High-resolution X-ray structure of an acyl-enzyme species for the class D OXA-10 beta-lactamase

scientific article published in March 2002

Host-guest chemistry of the peptidoglycan

scientific article

How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function

scientific article

Hydrolysis of ATP by aminoglycoside 3'-phosphotransferases: an unexpected cost to bacteria for harboring an antibiotic resistance enzyme

scientific article

Hyperbaric oxygen therapy accelerates wound healing in diabetic mice by decreasing active matrix metalloproteinase-9

scientific article published on 03 December 2019

Identification and role of the homodimerization interface of the glycosylphosphatidylinositol-anchored membrane type 6 matrix metalloproteinase (MMP25)

scientific article published on 20 October 2008

Identification of Products of Inhibition of GES-2 β-Lactamase by Tazobactam by X-ray Crystallography and Spectrometry ⬇️

scientific article published on February 22, 2011

In Search of Selectivity in Inhibition of ADAM10

scientific article published on 11 June 2018

In Vitro and In Vivo Synergy of the Oxadiazole Class of Antibacterials with β-Lactams

scientific article published on 11 July 2016

Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia.

scientific article

Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor

scientific article published on 01 June 2006

Inhibitors for Bacterial Cell-Wall Recycling ⬇️

scientific article published on January 19, 2012

Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2.

scientific article published on June 2010

Insights into class D beta-lactamases are revealed by the crystal structure of the OXA10 enzyme from Pseudomonas aeruginosa

scientific article

Insights into pneumococcal fratricide from the crystal structures of the modular killing factor LytC

scientific article

Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site

scientific article published in February 2006

Investigation of signal transduction routes within the sensor/transducer protein BlaR1 of Staphylococcus aureus

scientific article published on 18 February 2015

Investigation of the mechanism of the cell wall DD-carboxypeptidase reaction of penicillin-binding protein 5 of Escherichia coli by quantum mechanics/molecular mechanics calculations.

scientific article published on 25 June 2008

Key side products due to reactivity of dimethylmaleoyl moiety as amine protective group

scientific article published on 25 August 2009

Kinetic mechanism of enterococcal aminoglycoside phosphotransferase 2"-Ib

scientific article published on 11 April 2007

Lysine N(zeta)-decarboxylation in the BlaR1 protein from Staphylococcus aureus at the root of its function as an antibiotic sensor

scientific article published on 08 March 2007

Lysine Nζ-Decarboxylation Switch and Activation of the β-Lactam Sensor Domain of BlaR1 Protein of Methicillin-resistant Staphylococcus aureus ⬇️

scientific article published on July 20, 2011

Lysine carboxylation in proteins: OXA-10 beta-lactamase

scientific article published in November 2005

Lytic transglycosylase MltB of Escherichia coli and its role in recycling of peptidoglycan strands of bacterial cell wall

scientific article

Lytic transglycosylases LtgA and LtgD perform distinct roles in remodeling, recycling and releasing peptidoglycan in Neisseria gonorrhoeae

scientific article published on 8 September 2016

Lytic transglycosylases: concinnity in concision of the bacterial cell wall

scientific article

MMP-9 inhibitors impair learning in spontaneously hypertensive rats

scientific article published in PLoS ONE

MT1-MMP shedding involves an ADAM and is independent of its localization in lipid rafts

scientific article published on 22 September 2006

Matrix metalloproteinase 2 (MMP2) inhibition: DFT and QM/MM studies of the deprotonation-initialized ring-opening reaction of the sulfoxide analogue of SB-3CT.

scientific article

Matrix metalloproteinase 2 inhibition: combined quantum mechanics and molecular mechanics studies of the inhibition mechanism of (4-phenoxyphenylsulfonyl)methylthiirane and its oxirane analogue.

scientific article

Mechanism of anchoring of OmpA protein to the cell wall peptidoglycan of the gram‐negative bacterial outer membrane ⬇️

scientific article published on September 30, 2011

Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly.

scientific article published on 7 March 2018

Mechanism-based profiling of MMPs.

scientific article published on January 2010

Mechanisms Complex biological processes and their central chemical events

scientific article published on 01 October 2003

Mechanistic basis for the action of new cephalosporin antibiotics effective against methicillin- and vancomycin-resistant Staphylococcus aureus

scientific article published on 3 February 2006

Mechanistic basis for the emergence of catalytic competence against carbapenem antibiotics by the GES family of beta-lactamases

scientific article published on 5 August 2009

Mechanistic characterization of the bifunctional aminoglycoside-modifying enzyme AAC(3)-Ib/AAC(6')-Ib' from Pseudomonas aeruginosa

scientific article published on 07 April 2007

Messenger Functions of the Bacterial Cell Wall-derived Muropeptides ⬇️

scientific article published on March 27, 2012

Metabolism of (4-phenoxyphenylsulfonyl) methylthiirane, a selective gelatinase inhibitor

scientific article published in March 2008

Metabolism of a highly selective gelatinase inhibitor generates active metabolite

scientific article published on 10 October 2007

Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge.

scientific article published on 26 May 2009

Molecular dynamics at the root of expansion of function in the M69L inhibitor-resistant TEM beta-lactamase from Escherichia coli

scientific article

Molecular structures and dynamics of the stepwise activation mechanism of a matrix metalloproteinase zymogen: challenging the cysteine switch dogma.

scientific article published on 12 October 2007

Muropeptide Binding and the X-ray Structure of the Effector Domain of the Transcriptional Regulator AmpR of Pseudomonas aeruginosa

scientific article published on 12 January 2017

Muropeptides in Pseudomonas aeruginosa and their Role as Elicitors of β-Lactam-Antibiotic Resistance

scientific article published on 25 April 2016

Mutational and structural analyses of the hinge region of membrane type 1-matrix metalloproteinase and enzyme processing

scientific article published on 18 May 2005

Mutational replacement of Leu-293 in the class C Enterobacter cloacae P99 beta-lactamase confers increased MIC of cefepime

scientific article published on June 2002

Mutations in mmpL and in the cell wall stress stimulon contribute to resistance to oxadiazole antibiotics in methicillin-resistant Staphylococcus aureus

scientific article

N-Glycosylation pattern of the zymogenic form of human matrix metalloproteinase-9.

scientific article

O-phenyl carbamate and phenyl urea thiiranes as selective matrix metalloproteinase-2 inhibitors that cross the blood-brain barrier

scientific article published on 08 October 2013

Orthologous and Paralogous AmpD Peptidoglycan Amidases from Gram-Negative Bacteria.

scientific article published on 21 June 2016

Penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.

scientific article

Peptidoglycan reshaping by a noncanonical peptidase for helical cell shape in Campylobacter jejuni

scientific article published on 23 January 2020

Pharmacological stabilization of intracranial aneurysms in mice: a feasibility study

scientific article

Phosphoryl transfer by aminoglycoside 3'-phosphotransferases and manifestation of antibiotic resistance

scientific article

Phosphorylation of BlaR1 in Manifestation of Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus and Its Abrogation by Small Molecules

scientific article published on 24 August 2015

Potent mechanism-based inhibitors for matrix metalloproteinases

scientific article published on 26 July 2005

Potentiation of the activity of β-lactam antibiotics by farnesol and its derivatives

scientific article published on 31 January 2018

Pronounced diversity in electronic and chemical properties between the catalytic zinc sites of tumor necrosis factor-alpha-converting enzyme and matrix metalloproteinases despite their high structural similarity

scientific article

Prospects of therapies targeting resistant bacteria-New challenges 20 years post emergence of vancomycin-resistant enterococcus

scientific article published on 22 October 2007

Prostate cancer-associated membrane type 1-matrix metalloproteinase: a pivotal role in bone response and intraosseous tumor growth.

scientific article published in June 2007

Protonation states of active-site lysines of penicillin-binding protein 6 from Escherichia coli and the mechanistic implications.

scientific article published on 6 February 2014

QM/MM Studies of the Matrix Metalloproteinase 2 (MMP2) Inhibition Mechanism of (S)-SB-3CT and its Oxirane Analogue ⬇️

scientific article published on November 9, 2010

Quest for selectivity in inhibition of matrix metalloproteinases

scientific article published in January 2004

Reaction Products and the X-ray Structure of AmpDh2, a Virulence Determinant of Pseudomonas aeruginosa

scientific article

Reactions of all Escherichia coli lytic transglycosylases with bacterial cell wall.

scientific article

Reactions of the three AmpD enzymes of Pseudomonas aeruginosa

scientific journal article

Recent advances in MMP inhibitor design

scientific article

Recognition of peptidoglycan and β-lactam antibiotics by the extracellular domain of the Ser/Thr protein kinase StkP from Streptococcus pneumoniae

scientific article

Regioselective Control of the SNAr Amination of 5-Substituted-2,4-Dichloropyrimidines Using Tertiary Amine Nucleophiles

scientific article published on 17 July 2015

Regiospecific syntheses of 6alpha-(1R-Hydroxyoctyl)penicillanic acid and 6beta-(1R-hydroxyoctyl)penicillanic acid as mechanistic probes of class D beta-lactamases

scientific article published on June 2009

Regulation of the expression of the β-lactam antibiotic-resistance determinants in methicillin-resistant Staphylococcus aureus (MRSA).

scientific article published on 03 March 2014

Resistance to beta-lactam antibiotics and its mediation by the sensor domain of the transmembrane BlaR signaling pathway in Staphylococcus aureus

scientific article published on 18 February 2003

Resistance to the third-generation cephalosporin ceftazidime by a deacylation-deficient mutant of the TEM β-lactamase by the uncommon covalent-trapping mechanism

scientific article published on 29 June 2011

Restoration of susceptibility of methicillin-resistant Staphylococcus aureus to beta-lactam antibiotics by acidic pH: role of penicillin-binding protein PBP 2a.

scientific article published on 12 March 2008

Revealing cell-surface intramolecular interactions in the BlaR1 protein of methicillin-resistant Staphylococcus aureus by NMR spectroscopy

scientific article

Roles of matrix metalloproteinases in flow-induced outward vascular remodeling

scientific article published on 10 June 2009

Selective Inhibition of MMP-2 Does Not Alter Neurological Recovery after Spinal Cord Injury.

scientific article published on 23 August 2016

Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier

scientific article

Selective inhibition of matrix metalloproteinase-9 attenuates secondary damage resulting from severe traumatic brain injury

scientific article (publication date: 2013)

Selective water-soluble gelatinase inhibitor prodrugs.

scientific article

Shared functional attributes between the mecA gene product of Staphylococcus sciuri and penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.

scientific article published on 13 June 2007

Shedding of discoidin domain receptor 1 by membrane-type matrix metalloproteinases

scientific article published on 21 March 2013

Short Alkylated Peptoid Mimics of Antimicrobial Lipopeptides ⬇️

scientific article published on October 18, 2010

Side reaction of significance in preparation of peptide- or peptidomimetic-based hydroxamate enzyme inhibitors

scientific article published on 01 March 2006

Slt, MltD, and MltG of Pseudomonas aeruginosa as Targets of Bulgecin A in Potentiation of β-Lactam Antibiotics

scientific article published on 18 January 2019

Source of phosphate in the enzymic reaction as a point of distinction among aminoglycoside 2''-phosphotransferases.

scientific article published on 21 January 2009

Strategy in inhibition of cathepsin B, a target in tumor invasion and metastasis

scientific article published in August 2004

Structural Analysis of the Role of Pseudomonas aeruginosa Penicillin-Binding Protein 5 in  -Lactam Resistance

scientific article

Structural Basis for Carbapenemase Activity of the OXA-23 β-Lactamase from Acinetobacter baumannii

scientific article

Structural Basis for Progression toward the Carbapenemase Activity in the GES Family of β-Lactamases ⬇️

scientific article published on November 16, 2012

Structural Basis of the Heterodimer Formation between Cell Shape-Determining Proteins Csd1 and Csd2 from Helicobacter pylori

scientific article

Structural and Functional Insights into Peptidoglycan Access for the Lytic Amidase LytA of Streptococcus pneumoniae

scientific article

Structural aspects for evolution of beta-lactamases from penicillin-binding proteins

scientific article

Structural basis for potent slow binding inhibition of human matrix metalloproteinase-2 (MMP-2).

scientific article published on 4 April 2003

Structural basis for the recognition of muramyltripeptide by Helicobacter pylori Csd4, a D,L-carboxypeptidase controlling the helical cell shape

scientific article

Structural basis of denuded glycan recognition by SPOR domains in bacterial cell division

scientific article published on 05 December 2019

Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase

scientific article

Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins

scientific article

Structure and Cell Wall Cleavage by Modular Lytic Transglycosylase MltC of Escherichia coli

scientific article

Structure of Csd3 from Helicobacter pylori, a cell shape-determining metallopeptidase

scientific article

Structure-Activity Relationship for Thiirane-Based Gelatinase Inhibitors

scientific article

Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials

scientific article published on 18 April 2016

Structure-Activity Relationship for the Oxadiazole Class of Antibacterials

scientific article published on 03 October 2019

Structure-activity relationship for the oxadiazole class of antibiotics.

scientific article published on 30 January 2015

Structure-activity relationship of the cinnamamide family of antibiotic potentiators for methicillin-resistant Staphylococcus aureus (MRSA)

scientific article published on 30 October 2018

Substrate recognition and catalysis by LytB, a pneumococcal peptidoglycan hydrolase involved in virulence

scientific article

Sulfonate-containing thiiranes as selective gelatinase inhibitors

scientific article

Sulfonylation-induced N- to O-acetyl migration in 2-acetamidoethanol derivatives

scientific article

Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials

scientific article published on 20 December 2019

Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA.

scientific article

Synthesis and NMR characterization of (Z,Z,Z,Z,E,E,ω)-heptaprenol

scientific article

Synthesis and evaluation of 1,2,4-triazolo[1,5-a]pyrimidines as antibacterial agents against Enterococcus faecium

scientific article

Synthesis and shift-reagent-assisted full NMR assignment of bacterial (Z8,E2,ω)-undecaprenol.

scientific article published on 15 November 2017

Synthesis of a fragment of bacterial cell wall

scientific article published in March 2004

Synthesis of an inhibitor-tethered resin for detection of active matrix metalloproteinases involved in disease

scientific article published on 01 August 2006

Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors

scientific article published on 01 September 2005

Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl)ethyl)thiiranes as potent gelatinase and MT1-MMP inhibitors

scientific article

Synthetic peptidoglycan motifs for germination of bacterial spores

scientific article

Synthetic peptidoglycan substrates for penicillin-binding protein 5 of Gram-negative bacteria

scientific article published in February 2004

Tackling antibiotic resistance

scientific article

Testosterone-induced matrix metalloproteinase activation is a checkpoint for neuronal addition to the adult songbird brain

scientific article published in January 2008

The Allosteric Site for the Nascent Cell Wall in Penicillin-Binding Protein 2a: An Achilles' Heel of Methicillin-Resistant Staphylococcus aureus

scientific article

The Cell Shape-determining Csd6 Protein from Helicobacter pylori Constitutes a New Family of L,D-Carboxypeptidase.

scientific article

The First Structural and Mechanistic Insights for Class D β-Lactamases: Evidence for a Novel Catalytic Process for Turnover of β-Lactam Antibiotics

article

The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity

scientific article published on 6 April 2016

The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus

scientific article published on 25 April 2019

The Tipper-Strominger Hypothesis and Triggering of Allostery in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus (MRSA).

scientific article

The X-Ray Structure of Carboxypeptidase A Inhibited by a Thiirane Mechanism-Based Inhibitor

scientific article

The basis for resistance to beta-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus

scientific article

The bifunctional enzymes of antibiotic resistance

scientific article published on 15 July 2009

The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography

scientific article (publication date: 26 March 2003)

The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity

scientific article published on 7 June 2016

The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth

scientific article

The future of the β-lactams.

scientific article published on 29 September 2010

The importance of a critical protonation state and the fate of the catalytic steps in class A beta-lactamases and penicillin-binding proteins

scientific article

The oxadiazole antibacterials

scientific article published on 27 May 2016

The sentinel role of peptidoglycan recycling in the β-lactam resistance of the Gram-negative Enterobacteriaceae and Pseudomonas aeruginosa.

scientific article

Thermodynamics of interactions of vancomycin and synthetic surrogates of bacterial cell wall

scientific article published on June 2006

Three decades of the class A beta-lactamase acyl-enzyme.

scientific article published on October 2009

Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials

scientific article published on 12 December 2015

Three-dimensional structure of the bacterial cell wall peptidoglycan

scholarly article

Total Syntheses of Bulgecins A, B, and C and Their Bactericidal Potentiation of the β-Lactam Antibiotics.

scientific article

Total synthesis of N-acetylglucosamine-1,6-anhydro-N-acetylmuramylpentapeptide and evaluation of its turnover by AmpD from Escherichia coli

scientific article published on April 2009

Transferase Versus Hydrolase: The Role of Conformational Flexibility in Reaction Specificity.

scientific article published on 5 January 2017

Turnover Chemistry and Structural Characterization of the Cj0843c Lytic Transglycosylase of <i>Campylobacter jejuni</i>

scientific article published on 22 March 2021

Turnover of Bacterial Cell Wall by SltB3, a Multidomain Lytic Transglycosylase of Pseudomonas aeruginosa

scientific article

Turnover of Bacterial Cell Wall by SltB3, a Multidomain Lytic Transglycosylase of Pseudomonas aeruginosa

scientific article published on 06 September 2016

Use of silver carbonate in the Wittig reaction

scientific article published on 26 November 2013

Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing

scientific article published on 27 September 2018

Versatility of aminoglycosides and prospects for their future

scientific article

Water-Soluble MMP-9 Inhibitor Reduces Lesion Volume after Severe Traumatic Brain Injury

scientific article published on 4 August 2015

Whole-Genome Shotgun Sequencing of Two β-Proteobacterial Species in Search of the Bulgecin Biosynthetic Cluster.

scientific article published on 22 September 2017

Why clinically used tazobactam and sulbactam are poor inhibitors of OXA-10 beta-lactamase: Raman crystallographic evidence

scientific article

X-ray Structure of Catenated Lytic Transglycosylase SltB1.

scientific article published on 13 November 2017

X-ray crystal structure of the acylated beta-lactam sensor domain of BlaR1 from Staphylococcus aureus and the mechanism of receptor activation for signal transduction

scientific article published in November 2004

X-ray structure of the Asn276Asp variant of the Escherichia coli TEM-1 beta-lactamase: direct observation of electrostatic modulation in resistance to inactivation by clavulanic acid

scientific article

β-Lactam Resistance Mechanisms: Gram-Positive Bacteria and Mycobacterium tuberculosis

scientific article published on 18 April 2016

β-Lactams against the Fortress of the Gram-Positive <i>Staphylococcus aureus</i> Bacterium

scientific article published on 29 December 2020

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