List of works - Lara M. Mangravite

A community approach to mortality prediction in sepsis via gene expression analysis.

scientific article published on 15 February 2018

A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection

scientific article published in Nature Communications

A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection

A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT.

scientific article published on November 2012

A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research

scientific article published on 07 August 2018

A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease

scientific article published on 10 November 2020

A statin-dependent QTL for GATM expression is associated with statin-induced myopathy

scientific article (publication date: 17 October 2013)

An Open Toolkit for Tracking Open Science Partnership Implementation and Impact

An open toolkit for tracking open science partnership implementation and impact

scientific article published on 30 April 2019

An open toolkit for tracking open science partnership implementation and impact.

scientific article published on 4 December 2019

Author Correction: Molecular estimation of neurodegeneration pseudotime in older brains

scientific article published on 03 December 2020

Changes in atherogenic dyslipidemia induced by carbohydrate restriction in men are dependent on dietary protein source

scientific article published on 26 October 2011

Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate

scientific article

Combined influence of LDLR and HMGCR sequence variation on lipid-lowering response to simvastatin

scientific article

Correction: RHOA Is a Modulator of the Cholesterol-Lowering Effects of Statin

Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis

scientific article published on 23 August 2016

Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease

scientific article

Crowdsourcing biomedical research: leveraging communities as innovation engines

scientific article (publication date: 15 July 2016)

Crowdsourcing genetic prediction of clinical utility in the Rheumatoid Arthritis Responder Challenge

scientific article

Data Science Approaches for Effective Use of Mobile Device-Based Collection of Real-World Data

scientific article published on 09 February 2020

Democratizing Health Data for Translational Research

scientific article published in January 2018

Design of a virtual longitudinal observational study in Parkinson's disease (AT-HOME PD)

scientific article published on 22 December 2020

Detecting the impact of subject characteristics on machine learning-based diagnostic applications

scientific article published on 11 October 2019

Developing Predictive Molecular Maps of Human Disease through Community-based Modeling

Developing predictive molecular maps of human disease through community-based modeling

scientific article (publication date: 27 January 2012)

Differential Iron(II) Affinity of the Sites of the Diiron Cluster in Protein R2 of Escherichia coli Ribonucleotide Reductase: Tracking the Individual Sites through the O2 Activation Sequence

scientific article published in 1997

Effects of dietary saturated fat on LDL subclasses and apolipoprotein CIII in men

scientific article

Electron Injection through a Specific Pathway Determines the Outcome of Oxygen Activation at the Diiron Cluster in the F208Y Mutant ofEscherichia coliRibonucleotide Reductase Protein R2†

scientific article published on 01 January 1998

Engaging a community to enable disease-centric data sharing with the NF Data Portal

scientific article published on 13 December 2019

Erratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis

scientific article published on 10 October 2016

Erratum: Prediction of human population responses to toxic compounds by a collaborative competition

article

Evaluating the Utility of Smartphone-Based Sensor Assessments in Persons With Multiple Sclerosis in the Real-World Using an App (elevateMS): Observational, Prospective Pilot Digital Health Study

scientific article published on 27 October 2020

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1 ⬇️

scientific article published on April 28, 2003

Fatty acid desaturase regulation in adipose tissue by dietary composition is independent of weight loss and is correlated with the plasma triacylglycerol response

scientific article published in September 2007

Formative Evaluation of Participant Experience With Mobile eConsent in the App-Mediated Parkinson mPower Study: A Mixed Methods Study.

scientific article

Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations

scientific article

Functional dissection of Alzheimer's disease brain gene expression signatures in humans and mouse models

article

Gene expression elucidates functional impact of polygenic risk for schizophrenia

scientific article published on 26 September 2016

Genome-wide association of lipid-lowering response to statins in combined study populations

scientific article

HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism

scientific article published on 2 September 2013

Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases

scientific article

Identifying and ranking potential driver genes of Alzheimer's disease using multiview evidence aggregation

scientific article published on 01 July 2019

Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome

scientific article published on 08 January 2021

Indicators of retention in remote digital health studies: a cross-study evaluation of 100,000 participants

scientific article published on 17 February 2020

Informed Consent in Two Alzheimer's Disease Research Centers: Insights From Research Coordinators

scientific article published on 16 March 2020

Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs

scientific article

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

scientific article published on 12 October 2020

Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells

scientific article

Mangravite et al. reply

scientific article

Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models

scientific article published on 01 July 2020

Meta-analysis of the human brain transcriptome identifies heterogeneity across human AD coexpression modules robust to sample collection and methodological approach

Molecular estimation of neurodegeneration pseudotime in older brains

scientific article published on 13 November 2020

Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney

scientific article (publication date: 31 October 2003)

Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins

scientific article

PharmGKB update: III. Genetic variants of SLC22A1, solute carrier family 22 (organic cation transporter), member 1.

scientific article published in June 2004

PharmGKB very important pharmacogene: SLCO1B1.

scientific article published on March 2010

Pharmacogenomic discovery using cell-based models

scientific article

Pharmacogenomics of statin response

scientific article published on August 2007

Pharmacogenomics of statin response

scientific article published on 01 December 2008

Prediction of human population responses to toxic compounds by a collaborative competition

scientific article

RHOA is a modulator of the cholesterol-lowering effects of statin

scientific article

Research Highlights

Smartphone-Based VO2max Measurement With Heart Snapshot in Clinical and Real-world Settings With a Diverse Population: Validation Study

scientific article published on 4 June 2021

Sorting of rat SPNT in renal epithelium is independent of N-glycosylation

scientific article published on February 2003

Stratification of amyotrophic lateral sclerosis patients: a crowdsourcing approach

scientific article published in Scientific Reports

Stratification of amyotrophic lateral sclerosis patients: a crowdsourcing approach

Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer

scientific article

Targeted metabolomics and medication classification data from participants in the ADNI1 cohort

scientific article published on 17 October 2017

The AD Knowledge Portal: A Repository for Multi-Omic Data on Alzheimer's Disease and Aging

scientific article published on 01 December 2020

The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease

scientific article published on 11 September 2018

The PsychENCODE project

scientific article

The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics

scientific article

Transcriptome correlation analysis identifies two unique craniosynostosis subtypes associated with IRS1 activation.

scientific article published on 16 October 2012

Transmembrane protein 55B is a novel regulator of cellular cholesterol metabolism

scientific article published on 17 July 2014

Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters.

scientific article published on 13 March 2018

Variation in the 3-hydroxyl-3-methylglutaryl coenzyme a reductase gene is associated with racial differences in low-density lipoprotein cholesterol response to simvastatin treatment

scientific article published on 10 March 2008

List of works by Lara M. Mangravite

A community approach to mortality prediction in sepsis via gene expression analysis.

A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection

A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection

A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT.

A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research

A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease

A statin-dependent QTL for GATM expression is associated with statin-induced myopathy

An Open Toolkit for Tracking Open Science Partnership Implementation and Impact

An open toolkit for tracking open science partnership implementation and impact

An open toolkit for tracking open science partnership implementation and impact.

Author Correction: Molecular estimation of neurodegeneration pseudotime in older brains

Changes in atherogenic dyslipidemia induced by carbohydrate restriction in men are dependent on dietary protein source

Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate

Combined influence of LDLR and HMGCR sequence variation on lipid-lowering response to simvastatin

Correction: RHOA Is a Modulator of the Cholesterol-Lowering Effects of Statin

Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis

Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease

Crowdsourcing biomedical research: leveraging communities as innovation engines

Crowdsourcing genetic prediction of clinical utility in the Rheumatoid Arthritis Responder Challenge

Data Science Approaches for Effective Use of Mobile Device-Based Collection of Real-World Data

Democratizing Health Data for Translational Research

Design of a virtual longitudinal observational study in Parkinson's disease (AT-HOME PD)

Detecting the impact of subject characteristics on machine learning-based diagnostic applications

Developing Predictive Molecular Maps of Human Disease through Community-based Modeling

Developing Predictive Molecular Maps of Human Disease through Community-based Modeling

Developing predictive molecular maps of human disease through community-based modeling

Differential Iron(II) Affinity of the Sites of the Diiron Cluster in Protein R2 of Escherichia coli Ribonucleotide Reductase: Tracking the Individual Sites through the O2 Activation Sequence

Effects of dietary saturated fat on LDL subclasses and apolipoprotein CIII in men

Electron Injection through a Specific Pathway Determines the Outcome of Oxygen Activation at the Diiron Cluster in the F208Y Mutant ofEscherichia coliRibonucleotide Reductase Protein R2†

Engaging a community to enable disease-centric data sharing with the NF Data Portal

Erratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis

Erratum: Prediction of human population responses to toxic compounds by a collaborative competition

Evaluating the Utility of Smartphone-Based Sensor Assessments in Persons With Multiple Sclerosis in the Real-World Using an App (elevateMS): Observational, Prospective Pilot Digital Health Study

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1 ⬇️

Fatty acid desaturase regulation in adipose tissue by dietary composition is independent of weight loss and is correlated with the plasma triacylglycerol response

Formative Evaluation of Participant Experience With Mobile eConsent in the App-Mediated Parkinson mPower Study: A Mixed Methods Study.

Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations

Functional dissection of Alzheimer's disease brain gene expression signatures in humans and mouse models

Gene expression elucidates functional impact of polygenic risk for schizophrenia

Genome-wide association of lipid-lowering response to statins in combined study populations

HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism

Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases

Identifying and ranking potential driver genes of Alzheimer's disease using multiview evidence aggregation

Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome

Indicators of retention in remote digital health studies: a cross-study evaluation of 100,000 participants

Informed Consent in Two Alzheimer's Disease Research Centers: Insights From Research Coordinators

Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells

Mangravite et al. reply

Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models

Meta-analysis of the human brain transcriptome identifies heterogeneity across human AD coexpression modules robust to sample collection and methodological approach

Molecular estimation of neurodegeneration pseudotime in older brains

Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney

Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins

PharmGKB update: III. Genetic variants of SLC22A1, solute carrier family 22 (organic cation transporter), member 1.

PharmGKB very important pharmacogene: SLCO1B1.

Pharmacogenomic discovery using cell-based models

Pharmacogenomics of statin response

Pharmacogenomics of statin response

Prediction of human population responses to toxic compounds by a collaborative competition

RHOA is a modulator of the cholesterol-lowering effects of statin

Research Highlights

Smartphone-Based VO2max Measurement With Heart Snapshot in Clinical and Real-world Settings With a Diverse Population: Validation Study

Sorting of rat SPNT in renal epithelium is independent of N-glycosylation

Stratification of amyotrophic lateral sclerosis patients: a crowdsourcing approach

Stratification of amyotrophic lateral sclerosis patients: a crowdsourcing approach

Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer

Targeted metabolomics and medication classification data from participants in the ADNI1 cohort

The AD Knowledge Portal: A Repository for Multi-Omic Data on Alzheimer's Disease and Aging

The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease

The PsychENCODE project

The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics

Transcriptome correlation analysis identifies two unique craniosynostosis subtypes associated with IRS1 activation.

Transmembrane protein 55B is a novel regulator of cellular cholesterol metabolism

Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters.

Variation in the 3-hydroxyl-3-methylglutaryl coenzyme a reductase gene is associated with racial differences in low-density lipoprotein cholesterol response to simvastatin treatment