List of works by Branimir Ivan Sikic

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

A Phase II trial of aprinocarsen, an antisense oligonucleotide inhibitor of protein kinase C alpha, administered as a 21-day infusion to patients with advanced ovarian carcinoma.

scientific article

A combined approach for purging multidrug-resistant leukemic cell lines in bone marrow using a monoclonal antibody and chemotherapy ⬇️

scientific article published on May 1, 1991

A first-in-human phase I study to evaluate the MEK1/2 inhibitor, cobimetinib, administered daily in patients with advanced solid tumors.

scientific article published on 16 July 2016

A method for detecting and correcting feature misidentification on expression microarrays

scientific article

A network model of a cooperative genetic landscape in brain tumors

scientific article

A phase I dose escalation and expansion study of the anticancer stem cell agent demcizumab (anti-DLL4) in patients with previously treated solid tumors.

scientific article

A phase I study of an agonist anti-CD27 human antibody (CDX-1127) in patients with advanced hematologic malignancies or solid tumors

scientific article published on 7 November 2013

A phase I study of an agonist anti-CD27 human antibody (CDX-1127) in patients with advanced hematologic malignancies or solid tumors.

scientific article

A phase I trial of aprinocarsen (ISIS 3521/LY900003), an antisense inhibitor of protein kinase C-alpha administered as a 24-hour weekly infusion schedule in patients with advanced cancer

scientific article

A phase I trial of continuous infusion of the multidrug resistance inhibitor zosuquidar with daunorubicin and cytarabine in acute myeloid leukemia.

scientific article

A phase I trial of doxorubicin, paclitaxel, and valspodar (PSC 833), a modulator of multidrug resistance

scientific article

A phase I trial of liposomal doxorubicin, paclitaxel and valspodar (PSC-833), an inhibitor of multidrug resistance

scientific article

A phase I trial of vandetanib combined with capecitabine, oxaliplatin and bevacizumab for the first-line treatment of metastatic colorectal cancer.

scientific article

A phase II study of gefitinib, 5-fluorouracil, leucovorin, and oxaliplatin in previously untreated patients with metastatic colorectal cancer

scientific article published on November 2008

A pilot phase II trial of valspodar modulation of multidrug resistance to paclitaxel in the treatment of metastatic carcinoma of the breast (E1195): a trial of the Eastern Cooperative Oncology Group.

scientific article published in November 2006

A safety, tolerability, and pharmacokinetic analysis of two phase I studies of multitargeted small molecule tyrosine kinase inhibitor XL647 with an intermittent and continuous dosing schedule in patients with advanced solid malignancies

scientific article published on 20 July 2018

Adsorption of antineoplastic drugs following large-volume ip administration to rats

scientific article published on 01 January 1982

Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance ⬇️

scientific article published on October 1, 1992

Amplification of whole tumor genomes and gene-by-gene mapping of genomic aberrations from limited sources of fresh-frozen and paraffin-embedded DNA.

scientific article

Assessment of purging with multidrug resistance (MDR) modulators and VP-16: results of long-term marrow culture

scientific article published on 01 September 1990

Association of DNA cross-linking with potentiation of the morpholino derivative of doxorubicin by human liver microsomes

scientific article published on 01 July 1989

Bleomycin, mitomycin, and cisplatin therapy for advanced squamous carcinoma of the uterine cervix: a phase II study of the Northern California Oncology Group

scientific article

CCAAT/enhancer-binding protein beta (nuclear factor for interleukin 6) transactivates the human MDR1 gene by interaction with an inverted CCAAT box in human cancer cells

scientific article (publication date: April 2004)

Cabazitaxel is more active than first-generation taxanes in ABCB1(+) cell lines due to its reduced affinity for P-glycoprotein.

scientific article published on 19 April 2018

Central nervous system toxicity and cerebrospinal fluid pharmacokinetics of intraventricularly administered bleomycin in beagles

scientific article published in August 1985

Characterization and immunoassay of human tumor-associated galactosyltransferase isoenzyme II

scientific article published on 01 September 1988

Characterization of covalent DNA binding of morpholino and cyanomorpholino derivatives of doxorubicin

scientific article published on October 21, 1992

Chromatin-Remodeling Complex SWI/SNF Controls Multidrug Resistance by Transcriptionally Regulating the Drug Efflux Pump ABCB1.

scientific article published on 8 August 2016

Cisplatin, doxorubicin, and cyclophosphamide chemotherapy for advanced endometrial carcinoma.

scientific article

Clinical Studies with Modulators of Multidrug Resistance ⬇️

scientific article published on April 1, 1995

Clinical reversal of multidrug resistance.

scientific article

Clinical trials of modulation of multidrug resistance. Pharmacokinetic and pharmacodynamic considerations

scientific article published on December 1993

Conservation of the class I beta-tubulin gene in human populations and lack of mutations in lung cancers and paclitaxel-resistant ovarian cancers.

scientific article published in January 2002

Cyclosporin A and cyclosporin SDZ PSC 833 enhance anti-CD5 ricin A-chain immunotoxins in human leukemic T cells

scientific article published on January 1994

DNA cross-linking and cytotoxicity of the alkylating cyanomorpholino derivative of doxorubicin in multidrug-resistant cells

scientific article published in October 1988

Decreased levels of baseline and drug-induced tubulin polymerisation are hallmarks of resistance to taxanes in ovarian cancer cells and are associated with epithelial-to-mesenchymal transition

scientific article

Decreased mutation rate for cellular resistance to doxorubicin and suppression of mdr1 gene activation by the cyclosporin PSC 833.

scientific article

Delivery of a normal infant following cisplatin, vinblastine, and bleomycin (PVB) chemotherapy for malignant teratoma of the ovary during pregnancy ⬇️

scientific article published on May 1, 1990

Development and characterization of a human sarcoma cell line, MES-SA, sensitive to multiple drugs.

scientific article published on October 1983

Differential expression of tubulin isotypes during the cell cycle

scientific article published in January 1996

Differential gene expression patterns and interaction networks in BCR-ABL-positive and -negative adult acute lymphoblastic leukemias.

scientific article published on 20 February 2007

Differential single- versus double-strand DNA breakage produced by doxorubicin and its morpholinyl analogues

scientific article

Dissociation of antitumor potency from anthracycline cardiotoxicity in a doxorubicin analog.

scientific article published in June 1985

Doxorubicin and the Alkylating Anthracycline 3'-Deamino-3'-(3-cyano-4-morpholinyl) doxorubicin: Comparative In Vitro Potency Against Leukemia and Bone Marrow Cells ⬇️

scientific article published on May 4, 1988

Drug resistance in clinical oncology and hematology. Introduction.

scientific article published in April 1995

Effect of different mathematical methods on etoposide area under the curve estimations and pharmacodynamic response predictions.

scientific article published in January 1996

Effect of high-dose cyclosporine on etoposide pharmacodynamics in a trial to reverse P-glycoprotein (MDR1 gene) mediated drug resistance

scientific article published on January 2000

Effect of whole-body hyperthermia on the disposition and metabolism of adriamycin in rabbits ⬇️

scientific article published on 01 May 1978

Effects of dietary ascorbic acid supplementation on hepatic drug-metabolizing enzymes in the guinea pig ⬇️

scientific article published on November 1, 1977

Effects of the methoxymorpholino derivative of doxorubicin and its bioactivated form versus doxorubicin on human leukemia and lymphoma cell lines and normal bone marrow.

scientific article

Enhancement of bleomycin activity against Lewis lung tumors in mice by local hyperthermia ⬇️

scientific article published on September 1, 1979

Enhancement of paclitaxel and carboplatin therapies by CCL2 blockade in ovarian cancers.

scientific article published on 18 April 2014

Enhancement of the clinical activity of melphalan by the hypoxic cell sensitizer misonidazole.

scientific article

Evidence of a role for functional heterogeneity in multidrug resistance transporters in clinical trials of P-glycoprotein modulation in acute myeloid leukemia

article

Expression and Silencing of the Microtubule-Associated Protein Tau in Breast Cancer Cells ⬇️

scientific article published on November 9, 2010

Expression of multidrug resistance gene mdr1 mRNA in a subset of normal bone marrow cells

scientific article published on June 1, 1992

First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers

scientific article published on 27 February 2019

Functional network analysis reveals extended gliomagenesis pathway maps and three novel MYC-interacting genes in human gliomas

scientific article published on October 2005

Gene expression patterns in ovarian carcinomas

scientific article

Gene expression profiles at diagnosis in de novo childhood AML patients identify FLT3 mutations with good clinical outcomes

scientific article

Gene expression profiling differentiates germ cell tumors from other cancers and defines subtype-specific signatures

scientific article

Genetic and epigenetic modeling of the origins of multidrug-resistant cells in a human sarcoma cell line

scientific article

Genomics of childhood leukemias: the virtue of complexity

scientific article published on 01 September 2008

Genomics-based hypothesis generation: a novel approach to unravelling drug resistance in brain tumours?

scientific article published on February 2004

Hepatic cytochrome P-450-dependent metabolism and enzymatic conjugation of foreign compounds in vitamin A-deficient rats

scientific article published on 01 January 1980

High-dose megestrol acetate therapy of ovarian carcinoma: a phase II study by the Northern California Oncology Group

scientific article published in December 1986

High-resolution genome-wide mapping of genetic alterations in human glial brain tumors

scientific article

Identification of ovarian cancer driver genes by using module network integration of multi-omics data

scientific article

Identification of ovarian cancer driver genes by using module network integration of multi-omics data

Improved therapeutic index of bleomycin when administered by continuous infusion in mice

scientific article published on December 1, 1978

In vitro drug metabolism in male and female athymic, nude mice

scientific article published in May 1978

In vitro selection and characterization of a bleomycin-resistant subline of B16 melanoma.

scientific article published in April 1986

Inhibition of lysosomal acid sphingomyelinase by agents which reverse multidrug resistance

scientific article published on April 1995

Integrated high-resolution genome-wide analysis of gene dosage and gene expression in human brain tumors

scientific article published on January 2007

Lack of correlation between cortisol-induced precocious maturation of the fetal rabbit lung and drug metabolism ⬇️

scientific article published on March 1, 1979

Late consolidative radiation therapy in the treatment of limited-stage small cell lung cancer

scientific article published in September 1991

Leukemic blast and natural killer cell P-glycoprotein function and inhibition in a clinical trial of zosuquidar infusion in acute myeloid leukemia

scientific article

Loss of cyclosporin and azidopine binding are associated with altered ATPase activity by a mutant P-glycoprotein with deleted phe(335).

scientific article

MDR 1 activation is the predominant resistance mechanism selected by vinblastine in MES-SA cells

scientific article published on October 2000

Mdr1 gene expression in childhood acute lymphoblastic leukemias and lymphomas: a critical evaluation by four techniques.

scientific article

Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport, and cell death

scientific article

Mechanisms of resistance to cabazitaxel.

scientific article published on 21 November 2014

Metabolic conversion of methoxymorpholinyl doxorubicin: from a DNA strand breaker to a DNA cross-linker

scientific article

Mitoxantrone, etoposide, and cyclosporine therapy in pediatric patients with recurrent or refractory acute myeloid leukemia

scientific article published on 01 May 2000

Mitoxantrone, etoposide, and cytarabine plus cyclosporine for patients with relapsed or refractory acute myeloid leukemia: an Eastern Cooperative Oncology Group pilot study.

scientific article

Mitoxantrone, etoposide, and cytarabine with or without valspodar in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome: a phase III trial (E2995)

scientific article

Modification of cisplatin toxicity with diethyldithiocarbamate

scientific article published in September 1990

Modulation and prevention of multidrug resistance by inhibitors of P-glycoprotein ⬇️

scientific article published on January 1, 1997

Modulation of etoposide (VP-16) cytotoxicity by verapamil or cyclosporine in multidrug-resistant human leukemic cell lines and normal bone marrow.

scientific article published in December 1990

Modulation of resistance to idarubicin by the cyclosporin PSC 833 (valspodar) in multidrug-resistant cells

scientific article published on May 2003

Molecular pathways: regulation and therapeutic implications of multidrug resistance

scientific article

Molecular targets in oncology: implications of the multidrug resistance gene.

scientific article published on March 1993

Monosomy of chromosome 10 associated with dysregulation of epidermal growth factor signaling in glioblastomas.

scientific article

Multidrug (pleiotropic) resistance in doxorubicin-selected variants of the human sarcoma cell line MES-SA.

scientific article published in September 1985

Multidrug resistance (mdr1) gene expression in adult acute leukemias: correlations with treatment outcome and in vitro drug sensitivity ⬇️

scientific article published on August 1, 1991

Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.

scientific article

Multifactorial mechanisms associated with broad cross-resistance of ovarian carcinoma cells selected by cyanomorpholino doxorubicin ⬇️

scientific article published on October 1, 1991

Mutation rates and mechanisms of resistance to etoposide determined from fluctuation analysis

scientific article published on August 1994

NFKBIA deletion in glioblastomas

scientific article published on 22 December 2010

Novel mechanism of resistance to paclitaxel (Taxol) in human K562 leukemia cells by combined selection with PSC 833.

scientific article published on January 1995

Paradoxical increase in DNA cross-linking in a human ovarian carcinoma cell line resistant to cyanomorpholino doxorubicin

scientific article published on July 1990

Pharmacokinetic interactions of cyclosporine with etoposide and mitoxantrone in children with acute myeloid leukemia

scientific article published in May 2002

Pharmacokinetics and protein binding of cis-dichlorodiammine platinum (II) administered as a one hour or as a twenty hour infusion ⬇️

scientific article published on 01 January 1980

Pharmacological considerations in the modulation of multidrug resistance

scientific article

Phase I and pharmacokinetic study of BMS-188797, a new taxane analog, administered on a weekly schedule in patients with advanced malignancies

scientific article published on November 2003

Phase I and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors

scientific article

Phase I study of an antisense oligonucleotide to protein kinase C-alpha (ISIS 3521/CGP 64128A) in patients with cancer

scientific article

Phase I study of gefitinib, oxaliplatin, 5-fluorouracil, and leucovorin (IFOX) in patients with advanced solid malignancies.

scientific article

Phase I study of valspodar (PSC-833) with mitoxantrone and etoposide in refractory and relapsed pediatric acute leukemia: a report from the Children's Oncology Group

scientific article

Phase I trial of doxorubicin with cyclosporine as a modulator of multidrug resistance.

scientific article

Phase I trial of etoposide with cyclosporine as a modulator of multidrug resistance ⬇️

scientific article published on October 1, 1992

Phase I trial of ixabepilone administered as three oral doses each separated by 6 hours every 3 weeks in patients with advanced solid tumors

scientific article published on 14 February 2012

Phase I trial of oblimersen (Genasense®) and gemcitabine in refractory and advanced malignancies

scientific article

Phase I trial of uracil-ftorafur, leucovorin, and etoposide: an active all-oral regimen for metastatic breast cancer

scientific article published in November 2003

Phase II study of gefitinib, fluorouracil, leucovorin, and oxaliplatin therapy in previously treated patients with metastatic colorectal cancer

scientific article published in August 2005

Preferential expression of a mutant allele of the amplified MDR1 (ABCB1) gene in drug-resistant variants of a human sarcoma

scientific article published on August 2002

Preliminary observations of intraperitoneal carboplatin pharmacokinetics during a phase I study of the Northern California Oncology Group

scientific article published in January 1986

Prevalence of multidrug resistance related to activation of the mdr1 gene in human sarcoma mutants derived by single-step doxorubicin selection.

scientific article published on September 1994

Purging multidrug resistant cells from bone marrow

scientific article published on January 1, 1992

Quantification of bleomycin pulmonary toxicity in mice by changes in lung hydroxyproline content and morphometric histopathology

scientific article published on March 1978

Randomized use of cyclosporin A (CsA) to modulate P-glycoprotein in children with AML in remission: Pediatric Oncology Group Study 9421.

scientific article

Rapid determination of PEGylated liposomal doxorubicin and its major metabolite in human plasma by ultraviolet-visible high-performance liquid chromatography.

scientific article published on November 2002

Re: genetic analysis of the beta-tubulin gene, TUBB, in non-small-cell lung cancer

scientific article published on 01 May 2002

Reannotation and Analysis of Clinical and Chemotherapy Outcomes in the Ovarian Data Set From The Cancer Genome Atlas

scientific article published on 01 December 2018

Regional activation of chromosomal arm 7q with and without gene amplification in taxane-selected human ovarian cancer cell lines

scientific article published on April 2006

Relative pulmonary toxicity and antitumor effects of two new bleomycin analogs, pepleomycin and tallysomycin A

scientific article published on 01 April 1980

Resistance mechanisms in human sarcoma mutants derived by single-step exposure to paclitaxel (Taxol).

scientific article published on March 1996

Reversal by cefoperazone of resistance to etoposide, doxorubicin, and vinblastine in multidrug resistant human sarcoma cells

scientific article published in December 1989

Reversal of multidrug resistance to cancer chemotherapy

scientific article

Role of cytochrome P-450 from the human CYP3A gene family in the potentiation of morpholino doxorubicin by human liver microsomes

scientific article published on 01 August 1992

Safety and Activity of Varlilumab, a Novel and First-in-Class Agonist Anti-CD27 Antibody, in Patients With Advanced Solid Tumors

scientific article

Safety and activity of varlilumab, a novel and first-in-class agonist anti-CD27 antibody, for hematologic malignancies

scientific article published on 01 May 2020

Second-look laparotomy in epithelial ovarian carcinoma: precise definition, sensitivity, and specificity of the operative procedure

scientific article published on February 1984

Sensitization of drug resistant human ovarian cancer cells to cyanomorpholino doxorubicin (MRA-CN) by modulation of glutathione metabolism.

scientific article published on January 1992

Single Gene Prognostic Biomarkers in Ovarian Cancer: A Meta-Analysis

scientific article

Spontaneous overexpression of the long form of the Bcl-X protein in a highly resistant P388 leukaemia

scientific article

Successful treatment of metastatic thymic carcinoma with cisplatin, vinblastine, bleomycin, and etoposide chemotherapy

scientific article published on November 1990

The distribution of 14C-imipramine in mice bearing lewis lung carcinoma ⬇️

scientific article published on November 19, 1979

The effects of ascorbic acid deficiency and repletion on pulmonary, renal, and hepatic drug metabolism in the guinea pig ⬇️

scientific article published on March 1, 1977

The effects of α-tocopherol on the toxicity, disposition, and metabolism of adriamycin in mice ⬇️

scientific article published on June 15, 1979

The miR-200 family differentially regulates sensitivity to paclitaxel and carboplatin in human ovarian carcinoma OVCAR-3 and MES-OV cells

scientific article published on 16 May 2015

The reversal of multidrug resistance.

scientific article published on January 1995

The use of probenecid as a chemoprotector against cisplatin nephrotoxicity ⬇️

scientific article published on March 15, 1991

Treatment of angioimmunoblastic T-cell lymphoma with cyclosporine

scientific article published on 01 June 1997

Treatment of poor prognosis AML patients using PSC833 (valspodar) plus mitoxantrone, etoposide, and cytarabine (PSC-MEC).

scientific article published on January 1999

Treatment of refractory and relapsed acute myelogenous leukemia with combination chemotherapy plus the multidrug resistance modulator PSC 833 (Valspodar).

scientific article

Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas

scientific article published on 19 December 2005

Use of etoposide in combination with cyclosporin for purging multidrug-resistant leukemic cells from bone marrow in a mouse model

scientific article published on October 1, 1992

Use of etoposide in combination with cyclosporine for purging multidrug resistant leukemic cells from bone marrow in a mouse model

scientific article published on January 1, 1992

Validation of a limited sampling model to determine etoposide area under the curve.

scientific article published in September 1997

Verapamil-mediated sensitization of doxorubicin-selected pleiotropic resistance in human sarcoma cells: selectivity for drugs which produce DNA scission.

scientific article

Volume-activated chloride current is not related to P-glycoprotein overexpression.

scientific article published on October 1994

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