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List of works by Tom Brown, Sr.

2'-Alkynyl spin-labelling is a minimally perturbing tool for DNA structural analysis

scientific article published on 01 April 2020

5-Formylcytosine does not change the global structure of DNA.

scientific article published on 15 May 2017

A Hitchhiker’s Guide to Click-Chemistry with Nucleic Acids

scientific article published in 2021

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A

scientific article published on 05 August 2019

An artificial triazole backbone linkage provides a split-and-click strategy to bioactive chemically modified CRISPR sgRNA

scientific article published on 08 April 2019

An autonomous molecular assembler for programmable chemical synthesis

scientific article

Assembly of a biocompatible triazole-linked gene by one-pot click-DNA ligation

scientific article published on 11 September 2017

CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape

scientific article published on 23 October 2017

Consecutive 5'- and 3'-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response

scientific article published on 15 April 2020

DNA Structural Changes Induced by Intermolecular Triple Helix Formation

scientific article published on 15 January 2020

DNA-Coated Gold Nanoparticles for the Detection of mRNA in Live Hydra Vulgaris Animals

scientific article published on 11 December 2018

Design of thiazole orange oligonucleotide probes for detection of DNA and RNA by fluorescence and duplex melting

scientific article published on 03 June 2019

Dynamics of the 4D genome during in vivo lineage specification and differentiation

scientific article published on 01 June 2020

Electrophilic RNA for Peptidyl-RNA Synthesis and Site-Specific Cross-Linking with tRNA-Binding Enzymes.

scientific article published on 26 September 2016

Enzymatic incorporation and fluorescent labelling of cyclooctyne-modified deoxyuridine triphosphates in DNA.

scientific article published on 5 June 2014

Enzyme-free synthesis of cyclic single-stranded DNA constructs containing a single triazole, amide or phosphoramidate backbone linkage and their use as templates for rolling circle amplification and nanoflower formation

scientific article published on 24 August 2018

Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above

Gene assembly via one-pot chemical ligation of DNA promoted by DNA nanostructures.

scientific article published in May 2018

Graphene Oxide-Upconversion Nanoparticle Based Optical Sensors for Targeted Detection of mRNA Biomarkers Present in Alzheimer's Disease and Prostate Cancer

scientific article

Graphene Oxide–Upconversion Nanoparticle Based Portable Sensors for Assessing Nutritional Deficiencies in Crops

scientific article published on 06 June 2018

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale

scientific article published on 22 January 2021

Instrument-free quantitative gold nanoparticle-based liquid-phase colorimetric assays for use in resource-poor environments.

scientific article

Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition.

scientific article published on 29 November 2017

Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices

scientific article published on 08 April 2019

Lighting Up DNA with the Environment-Sensitive Bright Adenine Analogue qAN4

scientific article published on 01 February 2020

Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA.

scientific article

Molecular Requirements of High-Fidelity Replication-Competent DNA Backbones for Orthogonal Chemical Ligation

scientific article published on 18 January 2017

Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers

scientific article

NMR analyses on N-hydroxymethylated nucleobases - implications for formaldehyde toxicity and nucleic acid demethylases.

scientific article published in May 2018

Nanopore sequencing of single-cell transcriptomes with scCOLOR-seq

scientific article published on 01 July 2021

Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors

scientific article published on 01 September 2019

Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue

scientific article published on 01 March 2018

Radiolabeled Oligonucleotides Targeting the RNA Subunit of Telomerase Inhibit Telomerase and Induce DNA Damage in Telomerase-Positive Cancer Cells

scientific article published on 16 July 2019

Redox Capacitive Assaying of C-Reactive Protein at a Peptide Supported Aptamer Interface

scientific article published on 7 February 2018

Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries

scientific article published on 7 December 2017

Shining Light on CRISPR Gene Editing

scientific article published on 14 April 2020

Single tube gene synthesis by phosphoramidate chemical ligation

scientific article

Site-selective immobilization of functionalized DNA origami on nanopatterned Teflon AF

Spectroscopic and Hydrodynamic Characterisation of DNA-Linked Gold Nanoparticle Dimers in Solution using Two-Photon Photoluminescence

scientific article published on 21 February 2018

Stable end-sealed DNA as robust nano-rulers for single-molecule fluorescence

Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications

scientific article published on 01 May 2019

Synthesis, Affinity for Complementary RNA and DNA, and Enzymatic Stability of Triazole-Linked Locked Nucleic Acids (t-LNAs).

scientific article

Synthesis, oligonucleotide incorporation and fluorescence properties in DNA of a bicyclic thymine analogue

scientific article published in Scientific Reports

Toward Complete Sequence Flexibility of Nucleic Acid Base Analogue FRET.

scientific article published on 14 June 2017

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