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List of works by Steven C. Almo

1-methylthio-D-xylulose 5-phosphate methylsulfurylase: a novel route to 1-deoxy-D-xylulose 5-phosphate in Rhodospirillum rubrum

scientific article published on 8 October 2012

1.8 Å structure of murine GITR ligand dimer expressed inDrosophila melanogasterS2 cells

scientific article

1H, 13C, 15N NMR sequence-specific resonance assignments for human apo-Mts1 (S100A4)

scientific article published on 01 April 2001

2.8-A-resolution crystal structure of an active-site mutant of aspartate aminotransferase from Escherichia coli

scientific article

8-THP-DHI analogs as potent Type I dual TIE-2/VEGF-R2 receptor tyrosine kinase inhibitors

scientific article published on 13 April 2010

A Binary Arginine Methylation Switch on Histone H3 Arginine 2 Regulates Its Interaction with WDR5

scientific article published on 31 March 2020

A CapG gain-of-function mutant reveals critical structural and functional determinants for actin filament severing

scientific article

A General Strategy for the Discovery of Metabolic Pathways: d-Threitol, l-Threitol, and Erythritol Utilization in Mycobacterium smegmatis

scientific article

A High-Affinity Adenosine Kinase from Anopheles gambiae

scientific article

A Picomolar Transition State Analogue Inhibitor of MTAN as a Specific Antibiotic for Helicobacter pylori

scientific article

A Small Protein Associated with Fungal Energy Metabolism Affects the Virulence of Cryptococcus neoformans in Mammals

scientific article published on September 2016

A Unique cis-3-Hydroxy-l-proline Dehydratase in the Enolase Superfamily

article

A high-affinity interaction with ADP-actin monomers underlies the mechanism and in vivo function of Srv2/cyclase-associated protein.

scientific article published on 08 September 2004

A metabolic pathway for bile acid dehydroxylation by the gut microbiome

scientific article published on 17 June 2020

A naturally occurring antiviral ribonucleotide encoded by the human genome

scientific article published in Nature

A naturally occurring mutation K220T in the pleiotropic activator PrfA of Listeria monocytogenes results in a loss of virulence due to decreasing DNA-binding affinity

scientific article published on 01 April 2007

A novel bifunctional transcriptional regulator of riboflavin metabolism in Archaea

scientific article

A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT

scientific article

A switch from parallel to antiparallel strand orientation in a coiled-coil X-ray structure via two core hydrophobic mutations

scientific article

ATP-binding Cassette (ABC) Transport System Solute-binding Protein-guided Identification of Novel d-Altritol and Galactitol Catabolic Pathways in Agrobacterium tumefaciens C58.

scientific article

Acid-Induced Equilibrium Folding Intermediate of Human Platelet Profilin†

scientific article published in 2007

Active site and remote contributions to catalysis in methylthioadenosine nucleosidases.

scientific article

An HSV-2 single-cycle candidate vaccine deleted in glycoprotein D, ΔgD-2, protects male mice from lethal skin challenge with clinical isolates of HSV-1 and HSV-2.

scientific article published on 5 December 2017

An essential bifunctional enzyme in Mycobacterium tuberculosis for itaconate dissimilation and leucine catabolism

scientific article published on 18 July 2019

Analysis of the Structure and Function of FOX-4 Cephamycinase.

scientific article

Annotating Enzymes of Uncertain Function: The Deacylation of d -Amino Acids by Members of the Amidohydrolase Superfamily ,

scientific article

Anopheles gambiae purine nucleoside phosphorylase: catalysis, structure, and inhibition

scientific article

Anti-CTLA-4 therapy requires an Fc domain for efficacy.

scientific article published on 26 March 2018

Antibodies against immunodominant antigens of Mycobacterium tuberculosis in subjects with suspected tuberculosis in the United States compared by HIV status

scientific article

Aptamer-targeted antigen delivery

scientific article

Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function

scientific article

Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars

scientific article published on 11 July 2016

Assignment of pterin deaminase activity to an enzyme of unknown function guided by homology modeling and docking

scientific article published on 2 January 2013

At the periphery of the amidohydrolase superfamily: Bh0493 from Bacillus halodurans catalyzes the isomerization of D-galacturonate to D-tagaturonate

scientific article published on 3 January 2008

Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase

scientific article

Atomic structure of the nuclear pore complex targeting domain of a nup116 homologue from the yeast, Candida glabrata

scientific article

Author Correction: A naturally occurring antiviral ribonucleotide encoded by the human genome

scientific article published on 16 June 2020

B7-1 and B7-2: similar costimulatory ligands with different biochemical, oligomeric and signaling properties

scientific article

Better and faster: improvements and optimization for mammalian recombinant protein production

scientific article

Biochemical and Structural Characterization of the Human TL1A Ectodomain ,

scientific article

Biochemical characterization of two haloalkane dehalogenases: DccA from Caulobacter crescentus and DsaA from Saccharomonospora azurea

scientific article published on 2 February 2016

Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes

scientific article published on January 2015

COHbC and COHbS crystallize in the R2 quaternary state at neutral pH in the presence of PEG 4000

scientific article published on 20 April 2005

CUE-101, a Novel E7-pHLA-IL2-Fc Fusion Protein, Enhances Tumor Antigen-Specific T-Cell Activation for the Treatment of HPV16-Driven Malignancies

scientific article published on 21 January 2020

Calf spleen purine nucleoside phosphorylase complexed with substrates and substrate analogues

scientific article

Can the propensity of protein crystallization be increased by using systematic screening with metals?

scientific article published on 23 June 2017

Cas5d processes pre-crRNA and is a member of a larger family of CRISPR RNA endonucleases

scientific article

Catalytic site conformations in human PNP by 19F-NMR and crystallography

scientific article

Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis

scientific article published on 17 June 2020

Closed site complexes of adenine phosphoribosyltransferase from Giardia lamblia reveal a mechanism of ribosyl migration

scientific article

Co-stimulate or Co-inhibit Regulatory T Cells, Which Side to Go?

scientific article

Cofilin (ADF) affects lateral contacts in F-actin

scientific article published in March 2004

Comparison of Alicyclobacillus acidocaldarius o-Succinylbenzoate Synthase to Its Promiscuous N-Succinylamino Acid Racemase/ o-Succinylbenzoate Synthase Relatives

scientific article published on 30 May 2018

Comparison of experimental and computational functional group mapping of an RNase A structure: implications for computer-aided drug design

scientific article published on 01 September 1996

Compensatory mechanisms allow undersized anchor-deficient class I MHC ligands to mediate pathogenic autoreactive T cell responses

scientific article

Computation-Facilitated Assignment of the Function in the Enolase Superfamily: A Regiochemically Distinct Galactarate Dehydratase from Oceanobacillus iheyensis ,

scientific article

Computational Redesign of PD-1 Interface for PD-L1 Ligand Selectivity

scientific article published on 28 March 2019

Computational, Structural, and Kinetic Evidence That Vibrio vulnificus FrsA Is Not a Cofactor-Independent Pyruvate Decarboxylase

scientific article

Computational-guided discovery and characterization of a sesquiterpene synthase from Streptomyces clavuligerus

scientific article published on 21 April 2015

Conformational Changes in Orotidine 5′-Monophosphate Decarboxylase: A Structure-Based Explanation for How the 5′-Phosphate Group Activates the Enzyme

scientific article

Conformational Changes in Orotidine 5′-Monophosphate Decarboxylase: “Remote” Residues That Stabilize the Active Conformation

scientific article

Considerations for combined immune checkpoint modulation and radiation treatment

scientific article

Correction to "A General Strategy for the Discovery of Metabolic Pathways: D-Threitol, L-Threitol, and Erythritol Utilization in Mycobacterium smegmatis".

scientific article published on 15 March 2016

Correction: Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity.

scientific article

Covalent docking predicts substrates for haloalkanoate dehalogenase superfamily phosphatases

scientific journal article

Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3.

scientific article published in November 2016

Crystal Structure of the Marburg Virus GP2 Core Domain in Its Postfusion Conformation

scientific article

Crystal packing induces a conformational change in profilin-I from Acanthamoeba castellanii

scientific article

Crystal structure of Clostridium acetobutylicum Aspartate kinase (CaAK): An important allosteric enzyme for amino acids production.

scientific article published in September 2014

Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor

scientific article

Crystal structure of human Karyopherin β2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2

scientific article

Crystal structure of the Yersinia protein-tyrosine phosphatase YopH complexed with a specific small molecule inhibitor

scientific article

Crystal structure of the actin binding domain of the cyclase-associated protein

scientific article

Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2

scientific article

Crystal structure of the receptor-binding domain of human B7-2: Insights into organization and signaling

scientific article (publication date: 4 March 2003)

Crystal structures of Giardia lamblia guanine phosphoribosyltransferase at 1.75 A(,)

scientific article

Crystallization and preliminary X-ray analysis of human platelet profilin complexed with an oligo proline peptide

scientific article published on 01 January 1998

Crystallization and preliminary X-ray analysis of the complex between human CTLA-4 and B7-2

Crystallization and preliminary crystallographic analysis of the N-terminal actin binding domain of human fimbrin ⬇️

scientific article published on 01 July 1997

Cysteine 81 is critical for the interaction of S100A4 and myosin-IIA

scientific article

D-Ribulose 5-phosphate 3-epimerase: functional and structural relationships to members of the ribulose-phosphate binding (beta/alpha)8-barrel superfamily

scientific article

Danio rerio αE-catenin is a monomeric F-actin binding protein with distinct properties from Mus musculus αE-catenin

scientific article published on 20 June 2013

Deamination of 6-Aminodeoxyfutalosine in Menaquinone Biosynthesis by Distantly Related Enzymes

scientific article

Decoy Strategies: The Structure of TL1A:DcR3 Complex

scientific article

Determinants of the CmoB carboxymethyl transferase utilized for selective tRNA wobble modification

scientific article published on 8 April 2015

Development and Evaluation of an Optimal Human Single-Chain Variable Fragment-Derived BCMA-Targeted CAR T Cell Vector

scholarly article by Eric L Smith published in June 2018

Development, clinical translation, and utility of a COVID-19 antibody test with qualitative and quantitative readouts

scientific article published on 11 September 2020

Different cell surface oligomeric states of B7-1 and B7-2: implications for signaling

scientific article

Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin.

scientific article published on 23 January 2017

Discovery of a bacterial 5-methylcytosine deaminase

scientific article

Discovery of a dipeptide epimerase enzymatic function guided by homology modeling and virtual screening

scientific article

Discovery of a novel L-lyxonate degradation pathway in Pseudomonas aeruginosa PAO1.

scientific article

Discovery of a novel stereospecific β-hydroxyacyl-CoA lyase/thioesterase shared by three metabolic pathways in Mycobacterium tuberculosis

scholarly article published 15 May 2018

Discovery of an L-fucono-1,5-lactonase from cog3618 of the amidohydrolase superfamily

scientific article published on 20 December 2012

Discovery of function in the enolase superfamily: D-mannonate and d-gluconate dehydratases in the D-mannonate dehydratase subgroup

scientific journal article

Discovery of new enzymes and metabolic pathways by using structure and genome context

scientific article

Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens

scientific article published on 03 September 2019

Divergence of Structure and Function in the Haloacid Dehalogenase Enzyme Superfamily: Bacteroides thetaiotaomicron BT2127 Is an Inorganic Pyrophosphatase

scientific article

Divergent evolution in enolase superfamily: strategies for assigning functions

scientific article

Divergent evolution of ligand binding in the o-succinylbenzoate synthase family

scientific article published on 09 October 2013

Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β

scientific article

Durable antitumor responses to CD47 blockade require adaptive immune stimulation

scientific article published on 18 April 2016

Dynamic equilibrium of B7-1 dimers and monomers differentially affects immunological synapse formation and T cell activation in response to TCR/CD28 stimulation

scientific article

Engineering ESPT Pathways Based on Structural Analysis of LSSmKate Red Fluorescent Proteins with Large Stokes Shift

scientific article

Entropy-driven binding of picomolar transition state analogue inhibitors to human 5'-methylthioadenosine phosphorylase.

scientific article published on 7 November 2011

Essential functions and actin-binding surfaces of yeast cofilin revealed by systematic mutagenesis ⬇️

scientific article published on September 15, 1997

Evolution of Enzymatic Activities in the Enolase Superfamily: Stereochemically Distinct Mechanisms in Two Families of cis , cis -Muconate Lactonizing Enzymes † ‡

scientific article

Evolution of Enzymatic Activities in the Enolase Superfamily: l -Rhamnonate Dehydratase † ‡

scientific article

Evolution of GITRL immune function: Murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily

scientific article

Evolution of enzymatic activities in the enolase superfamily: D-Mannonate dehydratase from Novosphingobium aromaticivorans

scientific article

Evolution of enzymatic activities in the enolase superfamily: D-tartrate dehydratase from Bradyrhizobium japonicum

scientific journal article

Evolution of enzymatic activities in the enolase superfamily: L-fuconate dehydratase from Xanthomonas campestris

scientific journal article

Evolution of enzymatic activities in the enolase superfamily: L-talarate/galactarate dehydratase from Salmonella typhimurium LT2

scientific article

Evolution of enzymatic activities in the enolase superfamily: galactarate dehydratase III from Agrobacterium tumefaciens C58

scientific journal article

Evolved streptavidin mutants reveal key role of loop residue in high-affinity binding

scientific article

Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes.

scientific article

Expression, Clinical Significance, and Receptor Identification of the Newest B7 Family Member HHLA2 Protein

scientific article published on 30 December 2014

Expression, crystallization and preliminary X-ray analysis of ligand-free human glutathione S-transferase M2-2

scientific article

Expression, refolding, purification, molecular characterization, crystallization, and preliminary X-ray analysis of the receptor binding domain of human B7-2.

scientific article

Extended Stokes Shift in Fluorescent Proteins: Chromophore–Protein Interactions in a Near-Infrared TagRFP675 Variant

scientific article

Four generations of transition-state analogues for human purine nucleoside phosphorylase.

scientific article

Function discovery and structural characterization of a methylphosphonate esterase

scientific article published on 28 April 2015

Functional Annotation and Three-Dimensional Structure of Dr0930 from Deinococcus radiodurans , a Close Relative of Phosphotriesterase in the Amidohydrolase Superfamily † ‡

scientific article

Functional Classification of Immune Regulatory Proteins

scientific article

Functional Identification and Structure Determination of Two Novel Prolidases from cog1228 in the Amidohydrolase Superfamily,

scientific article

Functional Identification of Incorrectly Annotated Prolidases from the Amidohydrolase Superfamily of Enzymes † ‡

scientific article

Functional annotation and structural characterization of a novel lactonase hydrolyzing D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate

scientific article

Functional assignment of multiple catabolic pathways for D-apiose

scientific article published on 04 June 2018

Functional diversity of the phosphoglucomutase superfamily: structural implications

scientific article published on 01 September 1999

Functional synergy of actin filament cross-linking proteins

scientific article

GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease

scientific article

GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells

scientific article published on 01 March 2019

Gain of structure and IgE epitopes by eukaryotic expression of the major Timothy grass pollen allergen, Phl p 1.

scientific article

Galactaro δ-lactone isomerase: lactone isomerization by a member of the amidohydrolase superfamily

scientific article published on 24 January 2014

General principles of binding between cell surface receptors and multi-specific ligands: A computational study.

scientific article published on 10 October 2017

Genetically modified hematopoietic stem/progenitor cells that produce IL-10-secreting regulatory T cells

scientific article published on 25 January 2019

HVEM signaling promotes protective antibody-dependent cellular cytotoxicity (ADCC) vaccine responses to herpes simplex viruses

scientific article published on 01 August 2020

Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily

scientific article

How H13 histocompatibility peptides differing by a single methyl group and lacking conventional MHC binding anchor motifs determine self-nonself discrimination

scientific article

How actin crosslinking and bundling proteins cooperate to generate an enhanced cell mechanical response.

scientific article published on August 2005

Identification of Mycobacterial Ribosomal Proteins as Targets for CD4 T Cells That Enhance Protective Immunity in Tuberculosis

scholarly article published by Alessandro Sette in 2018

Identification of a novel tRNA wobble uridine modifying activity in the biosynthesis of 5-methoxyuridine.

scientific article

Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design

scientific article

Identification of functional residues on Caenorhabditis elegans actin-interacting protein 1 (UNC-78) for disassembly of actin depolymerizing factor/cofilin-bound actin filaments

scientific article

Identification of the in vivo function of the high-efficiency D-mannonate dehydratase in Caulobacter crescentus NA1000 from the enolase superfamily.

scientific article

Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients

scientific article published on 21 September 2020

In vivo detection of antigen-specific CD8+ T cells by immuno-positron emission tomography

scientific article published on 14 September 2020

In vivo importance of actin nucleotide exchange catalyzed by profilin

scientific article

Increased Heterologous Protein Expression in Drosophila S2 Cells for Massive Production of Immune Ligands/Receptors and Structural Analysis of Human HVEM

scientific article

Influence of a heptad repeat stutter on the pH-dependent conformational behavior of the central coiled-coil from influenza hemagglutinin HA2

scientific article

Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase

scientific article

Inhibition and Structure of Trichomonas vaginalis Purine Nucleoside Phosphorylase with Picomolar Transition State Analogues †

scientific article

Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile.

scientific article published on 29 April 2016

Integrative structure-function mapping of the nucleoporin Nup133 suggests a conserved mechanism for membrane anchoring of the nuclear pore complex

scientific article

Investigating the physiological roles of low-efficiency D-mannonate and D-gluconate dehydratases in the enolase superfamily: pathways for the catabolism of L-gulonate and L-idonate

scientific article

Investigating the role of a backbone to substrate hydrogen bond in OMP decarboxylase using a site-specific amide to ester substitution

scientific article

Ionic interactions in crystalline bovine pancreatic ribonuclease A

scientific article

Large-scale determination of sequence, structure, and function relationships in cytosolic glutathione transferases across the biosphere

scientific article

Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family

scientific article

Mapping the G-actin binding surface of cofilin using synchrotron protein footprinting

scientific article

Mapping the functional surface of domain 2 in the gelsolin superfamily

scientific article

Mapping the interaction of cofilin with subdomain 2 on actin

scientific article

Mechanism and Structure of γ-Resorcylate Decarboxylase.

scientific article published on 28 December 2017

Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization ,

scientific article

Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Importance of Residues in the Orotate Binding Site

scientific article

Mechanistic Basis for Functional Promiscuity in the TNF and TNF Receptor Superfamilies: Structure of the LIGHT:DcR3 Assembly

scientific article

Mechanistic dissection of the PD-L1:B7-1 co-inhibitory immune complex

scientific article published on 04 June 2020

Mechanistic diversity in the RuBisCO superfamily: the "enolase" in the methionine salvage pathway in Geobacillus kaustophilus

scientific article

Methylthioadenosine Deaminase in an Alternative Quorum Sensing Pathway in Pseudomonas aeruginosa

scientific article

Methylthioinosine Phosphorylase from Pseudomonas aeruginosa . Structure and Annotation of a Novel Enzyme in Quorum Sensing

scientific article

Micromechanics and ultrastructure of actin filament networks crosslinked by human fascin: a comparison with alpha-actinin.

scientific article published in July 2001

Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models

scientific article

Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex.

scientific article published on 2 February 2017

Molecular and structural analysis of a continuous birch profilin epitope defined by a monoclonal antibody

scientific article published in November 1996

Molecular recognition of human CD1b antigen complexes: evidence for a common pattern of interaction with alpha beta TCRs.

scientific article

Multiple-particle tracking measurements of heterogeneities in solutions of actin filaments and actin bundles

scientific article

NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family

scientific article

Narrow-Spectrum Antibiotic Targeting of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis

scientific article published on 05 July 2020

Nectin family of cell-adhesion molecules: structural and molecular aspects of function and specificity

scientific article

Neighboring Group Participation in the Transition State of Human Purine Nucleoside Phosphorylase †

scientific article

New York-Structural GenomiX Research Consortium (NYSGXRC): a large scale center for the protein structure initiative.

scientific article

Novel Metabolic Pathways and Regulons for Hexuronate Utilization in Proteobacteria

scientific article published on 20 December 2018

Novel water-mediated hydrogen bonds as the structural basis for the low oxygen affinity of the blood substitute candidate rHb(alpha 96Val-->Trp)

scientific article

Nucleoside hydrolase from Leishmania major. Cloning, expression, catalytic properties, transition state inhibitors, and the 2.5-å crystal structure

scientific article

Nucleotide- and activator-dependent structural and dynamic changes of arp2/3 complex monitored by hydrogen/deuterium exchange and mass spectrometry

scientific article published on 17 March 2009

Oligomerization of profilins from birch, man and yeast. Profilin, a ligand for itself?

Orange Fluorescent Proteins: Structural Studies of LSSmOrange, PSmOrange and PSmOrange2

scientific article

Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase

scientific article (publication date: 27 May 2003)

PD-L1 is an activation-independent marker of brown adipocytes

scientific article published on 21 September 2017

Panoramic view of a superfamily of phosphatases through substrate profiling

scientific article published on 6 April 2015

Periplasmic domains of Pseudomonas aeruginosa PilN and PilO form a stable heterodimeric complex

scientific article

Phased translation function revisited: structure solution of the cofilin-homology domain from yeast actin-binding protein 1 using six-dimensional searches

scientific article published on 24 February 2005

Phenothiazines inhibit S100A4 function by inducing protein oligomerization

scientific article

Photoactivation mechanism of PAmCherry based on crystal structures of the protein in the dark and fluorescent states

scientific article

Photoswitchable red fluorescent protein with a large Stokes shift

scientific article

Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A

scientific article

Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model

scientific article (publication date: 2011)

Polylysine induces an antiparallel actin dimer that nucleates filament assembly: crystal structure at 3.5-A resolution

scientific article

Prediction and assignment of function for a divergent N-succinyl amino acid racemase

scientific article

Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant proline betaine.

scientific article published on 11 February 2014

Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks

scientific journal article

Prediction of enzymatic pathways by integrative pathway mapping.

scientific article

Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily

scientific article

Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect

scientific article

Profilin binds proline-rich ligands in two distinct amide backbone orientations

scientific article

Profilin is required for optimal actin-dependent transcription of respiratory syncytial virus genome RNA.

scientific article

Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis

scientific article

Prospecting for Unannotated Enzymes: Discovery of a 3′,5′-Nucleotide Bisphosphate Phosphatase within the Amidohydrolase Superfamily

scientific article

Protein production and purification

scientific article

Protein production from the structural genomics perspective: achievements and future needs.

scientific article

Publisher Correction: A naturally occurring antiviral ribonucleotide encoded by the human genome

scientific article published in Nature

Purification, characterization and crystallization of Acanthamoeba profilin expressed in Escherichia coli.

scientific article

Purification, characterization and crystallization of human platelet profilin expressed in Escherichia coli

scientific article published on 01 August 1994

Purification, crystallization and structural elucidation of D-galactaro-1,4-lactone cycloisomerase from Agrobacterium tumefaciens involved in pectin degradation

scientific article

Radiation-induced site-specific damage of mercury derivatives: phasing and implications

scientific article published on 16 August 2005

Recent advances in mammalian protein production

scientific article

Redesigning HVEM Interface for Selective Binding to LIGHT, BTLA, and CD160

scientific article published on 08 August 2020

Reducing allergenicity by altering allergen fold: a mosaic protein of Phl p 1 for allergy vaccination.

scientific article

Regulation of myosin-IIA assembly and Mts1 binding by heavy chain phosphorylation

scientific article published on 01 May 2005

Rescue of the Orphan Enzyme Isoguanine Deaminase

scientific article

S100A4 regulates macrophage chemotaxis

scientific article

Salmonella enterica MTAN at 1.36 Å Resolution: A Structure-Based Design of Tailored Transition State Analogs

scientific article

Sequence, structure, function, immunity: structural genomics of costimulation.

scientific article

Spatial arrangement of an RNA zipcode identifies mRNAs under post-transcriptional control

scientific article published on January 2012

Stilbene epoxidation and detoxification in a Photorhabdus luminescens-nematode symbiosis.

scientific article published on 28 February 2017

Structural Basis for Substrate Specificity in Phosphate Binding (β/α) 8 -Barrels: d -Allulose 6-Phosphate 3-Epimerase from Escherichia coli K-12 † ‡

scientific article

Structural Basis for the Divergence of Substrate Specificity and Biological Function within HAD Phosphatases in Lipopolysaccharide and Sialic Acid Biosynthesis

scientific article

Structural Basis of CD160:HVEM Recognition

scientific article published on 20 June 2019

Structural Characterization of Acylimine-Containing Blue and Red Chromophores in mTagBFP and TagRFP Fluorescent Proteins

scientific article

Structural Characterization of the Glycoprotein GP2 Core Domain from the CAS Virus, a Novel Arenavirus-Like Species

scientific article

Structural Determinants of the 5′-Methylthioinosine Specificity of Plasmodium Purine Nucleoside Phosphorylase

scientific article

Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides

scientific article published on 13 July 2017

Structural Reorganization of Proteins Revealed by Radiolysis and Mass Spectrometry: G-Actin Solution Structure Is Divalent Cation Dependent ⬇️

scientific article published on October 21, 2003

Structural Underpinnings of Nitrogen Regulation by the Prototypical Nitrogen-Responsive Transcriptional Factor NrpR ⬇️

scientific article published on November 10, 2010

Structural analysis of H2-Db class I molecules containing two different allelic forms of the type 1 diabetes susceptibility factor beta-2 microglobulin: implications for the mechanism underlying variations in antigen presentation

scientific article published on 17 October 2005

Structural analysis of adenine phosphoribosyltransferase from Saccharomyces cerevisiae

scientific article

Structural analysis of gelsolin using synchrotron protein footprinting.

scientific article

Structural and Mechanistic Characterization of l -Histidinol Phosphate Phosphatase from the Polymerase and Histidinol Phosphatase Family of Proteins

scientific article

Structural and Metabolic Specificity of Methylthiocoformycin for Malarial Adenosine Deaminases

scientific article

Structural and functional analysis of the costimulatory receptor programmed death-1.

scientific article published in March 2004

Structural and functional characterization of a single-chain peptide-MHC molecule that modulates both naive and activated CD8+ T cells

scientific article

Structural and functional dissection of the Abp1 ADFH actin-binding domain reveals versatile in vivo adapter functions

scientific article

Structural and functional studies indicating altered redox properties of hemoglobin E: implications for production of bioactive nitric oxide

scientific article

Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase

scientific article published on 01 May 2006

Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab

scientific article

Structural basis for co-stimulation by the human CTLA-4/B7-2 complex

scientific article

Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC

scientific article

Structural basis for tRNA methylthiolation by the radical SAM enzyme MiaB

scientific article published on 15 September 2021

Structural basis for the coevolution of a viral RNA–protein complex

scientific article

Structural basis of inducible costimulator ligand costimulatory function: determination of the cell surface oligomeric state and functional mapping of the receptor binding site of the protein.

scientific article

Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition

scientific article

Structural biology of cellular machines

scientific article

Structural determinants for the stereoselective hydrolysis of chiral substrates by phosphotriesterase

scientific article

Structural diversity within the mononuclear and binuclear active sites of N-acetyl-D-glucosamine-6-phosphate deacetylase

scientific article

Structural effects of cofilin on longitudinal contacts in F-actin

scientific article published in November 2002

Structural genomics of protein phosphatases

scientific article

Structural genomics: A pipeline for providing structures for the biologist

scientific article

Structural genomics: beyond the human genome project

scientific article

Structural mechanisms of costimulation

scientific article

Structural, mutational and biophysical studies reveal a canonical mode of molecular recognition between immune receptor TIGIT and nectin-2.

scientific article published on 12 December 2016

Structure and Catalytic Mechanism of LigI: Insight into the Amidohydrolase Enzymes of cog3618 and Lignin Degradation

scientific article

Structure and T cell inhibition properties of B7 family member, B7-H3.

scientific article published on 11 April 2013

Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion

scientific article

Structure and cancer immunotherapy of the B7 family member B7x

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Structure and dynamics of the actin filament

scientific article published on 01 March 2005

Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae

scientific article published on October 2006

Structure determination and characterization of Saccharomyces cerevisiae profilin

scientific article

Structure determination of turkey egg-white lysozyme using Laue diffraction data

scientific article published on April 1, 1992

Structure determination of yeast cofilin

scientific article

Structure of CD84 provides insight into SLAM family function

scientific article

Structure of Ca 2+ -Bound S100A4 and Its Interaction with Peptides Derived from Nonmuscle Myosin-IIA †

scientific article

Structure of Diethyl Phosphate Bound to the Binuclear Metal Center of Phosphotriesterase † ‡

scientific article

Structure of EVH1, a novel proline-rich ligand-binding module involved in cytoskeletal dynamics and neural function

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Structure of N-formimino-L-glutamate iminohydrolase from Pseudomonas aeruginosa

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Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion

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Structure of Salmonella typhimurium OMP Synthase in a Complete Substrate Complex

scientific article

Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470

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Structure of a putative BenF-like porin from Pseudomonas fluorescens Pf-5 at 2.6 Å resolution

scientific article

Structure of a single-chain H2A/H2B dimer

scientific article published on 28 April 2020

Structure of actin binding proteins: insights about function at atomic resolution

scientific article published on January 1994

Structure of an ABC transporter solute-binding protein specific for the amino sugars glucosamine and galactosamine.

scientific article published on 23 May 2016

Structure of murine CTLA-4 and its role in modulating T cell responsiveness

scientific article

Structure of mutant human carbonmonoxyhemoglobin C (betaE6K) at 2.0 A resolution

scientific article

Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity

scientific article

Structure of the S100A4/myosin-IIA complex

scientific article

Structure of the actin crosslinking core of fimbrin

scientific article

Structure of the amino-terminal domain of phage 434 repressor at 2.0 A resolution

scientific article

Structure of the profilin-poly-L-proline complex involved in morphogenesis and cytoskeletal regulation

scientific article

Structure, Dynamics, Evolution, and Function of a Major Scaffold Component in the Nuclear Pore Complex

scientific article

Structure, Mechanism, and Substrate Profile for Sco3058: The Closest Bacterial Homologue to Human Renal Dipeptidase,

scientific article

Structure, evolutionary conservation, and conformational dynamics of Homo sapiens fascin-1, an F-actin crosslinking protein

scientific article

Structure-based activity prediction for an enzyme of unknown function

scientific article

Structure-based function discovery of an enzyme for the hydrolysis of phosphorylated sugar lactones

scientific article

Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy

scientific article published on 06 February 2017

Structure-guided discovery of new deaminase enzymes

scientific journal article

Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function

scientific article

Structures of FOX-4 Cephamycinase in Complex with Transition-State Analog Inhibitors

scientific article published on 27 April 2020

Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces

scientific article

Structures of the L27 domain of Disc Large homolog 1 protein illustrate a self-assembly module.

scientific article published on 20 December 2017

Substrate Deconstruction and the Nonadditivity of Enzyme Recognition

scientific article

Substrate Distortion and the Catalytic Reaction Mechanism of 5-Carboxyvanillate Decarboxylase

scientific article published on 30 December 2015

Substrate Profile of the Phosphotriesterase Homology Protein from Escherichia coli

scientific article published on 16 October 2018

Synchrotron radiolysis and mass spectrometry: a new approach to research on the actin cytoskeleton.

scientific article

T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface

scientific article

Target selection and annotation for the structural genomics of the amidohydrolase and enolase superfamilies

scientific article published on 14 February 2009

Temperature-induced conformational changes in prosomatostatin-II: implications for processing

scientific article

Testing the sulfotransferase molecular pore hypothesis

scientific article published on 28 January 2013

The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor

scientific article

The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor

scientific article

The Enzyme Function Initiative

scientific article

The Hunt for 8-Oxoguanine Deaminase

scientific article

The Mechanism of the Reaction Catalyzed by Uronate Isomerase Illustrates How an Isomerase May Have Evolved from a Hydrolase within the Amidohydrolase Superfamily

scientific article

The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum

scholarly article

The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe-2S cluster

scientific article published on 16 July 2019

The biosynthesis of methanobactin.

scientific article

The gate that governs sulfotransferase selectivity

scientific article

The hidden treasure in your data: phasing with unexpected weak anomalous scatterers from routine data sets

scientific article

The immunoglobulin E-allergen interaction: a target for therapy of type I allergic diseases.

scientific article published in July 1998

The interchain disulfide linkage is not a prerequisite but enhances CD28 costimulatory function

scientific article

The modular structure of actin-regulatory proteins

scientific article published on February 1998

The molecular basis for allergen cross-reactivity: crystal structure and IgE-epitope mapping of birch pollen profilin

scientific article

The structural basis for the altered substrate specificity of the R292D active site mutant of aspartate aminotransferase from E. coli

scientific article

The structure of an actin-crosslinking domain from human fimbrin

scientific article

The structure of nonvertebrate actin: Implications for the ATP hydrolytic mechanism ⬇️

scientific article (publication date: 13 May 2003)

The usefulness of urine fluorescence for suspected antifreeze ingestion in children

scientific article published on 01 October 2005

Three-Dimensional Structure and Catalytic Mechanism of Cytosine Deaminase

scientific article

Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis

scientific article published in Nature

Tissue-expressed B7-H1 critically controls intestinal inflammation

scientific article published on 13 February 2014

Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing

scientific article

Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins

scientific article

Transition state model and mechanism of nucleophilic aromatic substitution reactions catalyzed by human glutathione S-transferase M1a-1a

scientific article published in March 2006

Transition state structure of purine nucleoside phosphorylase and principles of atomic motion in enzymatic catalysis

scientific article

Treatment of Severe COVID-19 with Convalescent Plasma in the Bronx, NYC

scientific article published on 04 December 2020

Trends in structural coverage of the protein universe and the impact of the Protein Structure Initiative.

scientific article

Trypanosomal nucleoside hydrolase. A novel mechanism from the structure with a transition-state inhibitor

scientific article

Tumor-expressed immune checkpoint B7x promotes cancer progression and antigen-specific CD8 T cell exhaustion and suppressive innate immune cells

scientific article published on 20 September 2017

Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin

scientific article

Understanding the Targeting Mechanisms of Multi-Specific Biologics in Immunotherapy with Multiscale Modeling

scientific article published on 20 November 2020

Viperin Reveals Its True Function

scientific article published on 30 June 2020

Visualizing Arp2/3 complex activation mediated by binding of ATP and WASp using structural mass spectrometry

scholarly article

Visualizing the Ca2+-dependent activation of gelsolin by using synchrotron footprinting

scientific article

X-ray Crystal Structure of Bovine 3 Glu-Osteocalcin

scientific article

X-ray Laue diffraction from crystals of xylose isomerase

scientific article published on January 1988

X-ray and EPR Characterization of the Auxiliary Fe-S Clusters in the Radical SAM Enzyme PqqE.

scientific article

X-ray crystal structures of birch pollen profilin and Phl p 2.

scientific article

X-ray crystallography over the past decade for novel drug discovery - where are we heading next?

scientific article

X-ray structure and mutational analysis of the atrazine Chlorohydrolase TrzN.

scientific article

X-ray structures of isoforms of the actin-binding protein profilin that differ in their affinity for phosphatidylinositol phosphates

scientific article

ZBP1 recognition of beta-actin zipcode induces RNA looping

scientific article

l -Enantiomers of Transition State Analogue Inhibitors Bound to Human Purine Nucleoside Phosphorylase

scientific article

l-Galactose metabolism in Bacteroides vulgatus from the human gut microbiota

scientific article

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