List of works - Christopher Southan

A genomic perspective on human proteases

scientific article

A genomic perspective on human proteases as drug targets

scientific article

A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development. IUPHAR Review 29

scientific article published on 01 May 2020

A tale of two drug targets: the evolutionary history of BACE1 and BACE2

scientific article (publication date: 2013)

ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

scientific article

Accessing Expert-Curated Pharmacological Data in the IUPHAR/BPS Guide to PHARMACOLOGY

scholarly article by Joanna L. Sharman et al published March 2018 in Current Protocols in Bioinformatics

Amino acid sequence of beta-galactoside-binding bovine heart lectin. Member of a novel class of vertebrate proteins

scientific article

An open-access tool for designing drug control into engineered proteins

Analysis of in vitro bioactivity data extracted from drug discovery literature and patents: Ranking 1654 human protein targets by assayed compounds and molecular scaffolds

scientific article (publication date: 13 May 2011)

Analytical and micropreparative capillary electrophoresis of the peptides from calcitonin

article

Assessing the protease and protease inhibitor content of the human genome.

scientific article published in September 2000

BACE2 as a new diabetes target: a patent review (2010 – 2012) ⬇️

scientific article published on March 18, 2013

Bovine dopamine beta-hydroxylase, primary structure determined by cDNA cloning and amino acid sequencing.

scientific article published on July 1990

COVALENT STRUCTURE OF FIBRINOGEN

scientific article published on 01 June 1983

Caveat usor: assessing differences between major chemistry databases

scientific article published on 16 February 2018

Challenges and recommendations for obtaining chemical structures of industry-provided repurposing candidates ⬇️

scientific article published on November 15, 2012

Challenges of Connecting Chemistry to Pharmacology: Perspectives from Curating the IUPHAR/BPS Guide to PHARMACOLOGY

scientific article published on 01 July 2018

Challenges of Connecting Chemistry to Pharmacology: Perspectives from Curating the IUPHAR/BPS Guide to PHARMACOLOGY

scholarly article published 2018

Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response

scientific article

Characterization of peptides cleaved by plasmin from the C-terminal polymerization domain of human fibrinogen

scientific article published in October 1985

Comparing the Chemical Structure and Protein Content of ChEMBL, DrugBank, Human Metabolome Database and the Therapeutic Target Database

scientific article published on 11 December 2013

Complementarity between public and commercial databases: new opportunities in medicinal chemistry informatics

scientific article published on January 2007

Delayed release of an abnormal fibrinopeptide A from fibrinogen Manchester: effect of the Aα 16 Arg → His substitution upon fibrin monomer polymerization and the immunological crossreactivity of the peptide

scientific article published on 01 April 1983

Desperately seeking curated D-A-R-C-P

conference poster

Direct analysis of plasma fibrinogen-derived fibrinopeptides by high-performance liquid chromatography

scientific article published on 01 July 1986

Direct analysis of plasma fibrinogen-derived fibrinopeptides by high-performance liquid chromatography: investigation of nine congenital fibrinogen abnormalities

scientific article published in April 1987

Disposable Microbore High-Pressure Liquid Chromatography Columns for Protein and Peptide Separations

scientific article published in 1999

Déjà vu: Stimulating open drug discovery for SARS-CoV-2

scientific article published on 19 April 2020

Endothelin

scientific article

Expanding opportunities for mining bioactive chemistry from patents

scientific article

Exploiting new genome data and Internet resources for the phylogenetic analysis of proteases, substrates and inhibitors

scientific article

Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor

scientific article

Extracting and connecting chemical structures from text sources using chemicalize.org

scientific article (publication date: 23 April 2013)

Fibrinogen Manchester. Detection of a heterozygous phenotype in the intraplatelet pool

scientific article published on August 1985

Fibrinogen Manchester: identification of an abnormal fibrinopeptide A with a C-terminal arginine→histidine substitution

scientific article published on 01 May 1983

Finding small molecules for the 'next Ebola'

scientific article

Finding, Delineating and Analysing Genes

Genetically abnormal fibrinogens--strategies for structure elucidation, including fibrinopeptide analysis.

scientific article published on January 1984

Glutathione transferases in the tapeworm Moniezia expansa

scientific article published on September 1989

Has the yo-yo stopped? An assessment of human protein-coding gene number

scientific article published on June 2004

Hydrolases (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Hydrolases (version 2019.5) in the IUPHAR/BPS Guide to Pharmacology Database

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

scientific article (publication date: December 1999)

Identification, genomic organization, and mRNA expression of LACTB, encoding a serine beta-lactamase-like protein with an amino-terminal transmembrane domain

scientific article

Illustrating and homology modeling the proteins of the Zika virus

scientific article

InChI in the wild: an assessment of InChIKey searching in Google ⬇️

scientific article (publication date: 11 February 2013)

Inactivation of dopamine beta-hydroxylase by beta-ethynyltyramine: kinetic characterization and covalent modification of an active site peptide

scientific article

Inactivation of dopamine beta-hydroxylase by p-cresol: isolation and characterization of covalently modified active site peptides

scientific article published on December 1988

Is systems pharmacology ready to impact upon therapy development? A study on the cholesterol biosynthesis pathway

scientific article published on 14 September 2017

Last rolls of the yoyo: Assessing the human canonical protein count

scientific article

MPSA short communications

article by Eugene M. Barnes et al published July 1994 in The Protein Journal

Making every SAR point count: the development of Chemistry Connect for the large-scale integration of structure and bioactivity data

scientific article

Mapping between databases of compounds and protein targets

scientific article published on January 2012

Minimum information about a bioactive entity (MIABE).

scientific article

New drugs and emerging therapeutic targets in the endothelin signaling pathway and prospects for personalized precision medicine

scientific article published on 01 June 2018

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

scientific article published on 14 September 2016

Opening up connectivity between documents, structures and bioactivity

scientific article published on 02 April 2020

Parallel worlds of public and commercial bioactive chemistry data

scientific article

Proteases: Evolution

Proteomic approaches to central nervous system disorders.

scientific article

Purification to apparent homogeneity and partial amino acid sequence of rat liver O6-alkylguanine-DNA-alkyltransferase

scientific article published in January 1990

Purification, properties, sequencing, and cloning of a lipoprotein-associated, serine-dependent phospholipase involved in the oxidative modification of low-density lipoproteins

scientific article

Quantitative assessment of the expanding complementarity between public and commercial databases of bioactive compounds

scientific article (publication date: 6 July 2009)

Rat ATP citrate-lyase. Molecular cloning and sequence analysis of a full-length cDNA and mRNA abundance as a function of diet, organ, and age

scientific journal article

Retrieving GPCR data from public databases

scientific article

SARConnect: A Tool to Interrogate the Connectivity Between Proteins, Chemical Structures and Activity Data

scientific article

Separation by capillary electrophoresis followed by dynamic elution

scientific article published on 01 July 1991

Sequence similarity between dopamine beta-hydroxylase and peptide alpha-amidating enzyme: evidence for a conserved catalytic domain

scientific article

Shouldn't enantiomeric purity be included in the 'minimum information about a bioactive entity? Response from the MIABE group

Splice variants: a homology modeling approach

scientific article published in February 2004