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List of works by Carol Prives

A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint

scientific article published in June 2009

A role for caspase 2 and PIDD in the process of p53-mediated apoptosis

scholarly article

APC/CCdc20targets E2F1 for degradation in prometaphase ⬇️

scientific article published on October 26, 2010

Accurate and sensitive quantification of protein-DNA binding affinity.

scientific article published on 2 April 2018

Anything but simple: a phosphorylation-driven toggle within Brd4 triggers gene-specific transcriptional activation.

scientific article published in March 2013

Cancer: Mutant p53 and chromatin regulation

scientific article

Caspase 2 is both required for p53-mediated apoptosis and downregulated by p53 in a p21-dependent manner

scientific article

Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation

scientific article published on 16 October 2002

Chromatin dysregulation by mutant p53

scientific article published on 23 February 2016

Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry

scientific article published on 9 August 2013

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

article

Cyclin G recruits PP2A to dephosphorylate Mdm2

scientific journal article

Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73.

scientific article published on 3 April 2003

DECOD: fast and accurate discriminative DNA motif finding

scientific article

DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation ⬇️

scientific article

Deconstructing nucleotide binding activity of the Mdm2 RING domain ⬇️

scientific article published on July 29, 2010

Deconstruction of p53 functions and regulation

scientific article published on 01 November 2002

Decreased p21 levels are required for efficient restart of DNA synthesis after S phase block

scientific article published on 3 November 2003

Discovering Transcription Factor Noncoding RNA Targets Using ChIP-Seq Analysis

scientific article published on 01 January 2020

Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay.

scientific article published on 28 July 2011

Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein

scientific article

Dissimilar DNA binding by p53 in normal and tumor-derived cells

article

Distinct expression profiles of p63 variants during urothelial development and bladder cancer progression

scientific article

Does control of mutant p53 by Mdm2 complicate cancer therapy?

scientific article published on May 2008

Dysfunction of the MDM2/p53 axis is linked to premature aging

scientific article published on 28 August 2017

Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 protein

scientific article published on October 2002

Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription.

scientific article published on 19 April 2006

Gain-of-function mutant p53: history and speculation

scientific article published on 01 July 2019

Inhibition of TFII-I-dependent cell cycle regulation by p53.

scientific article

Lysine-independent turnover of cyclin G1 can be stabilized by B'alpha subunits of protein phosphatase 2A.

scientific article

Lysines in the tetramerization domain of p53 selectively modulate G1 arrest

scientific article published on 21 May 2016

MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling

scientific article published on 20 February 2020

MOZ increases p53 acetylation and premature senescence through its complex formation with PML ⬇️

scientific article published on February 19, 2013

Mdm2 and MdmX as Regulators of Gene Expression ⬇️

scientific article published on March 1, 2012

Mdm2 and PCAF increase Chk2 ubiquitination and degradation independently of their intrinsic E3 ligase activities

scientific article

MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress

scientific article published on 30 January 2012

Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells

scientific article

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

scientific article

Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling

scientific article published on April 2014

Mutant p53 gain of function: the NF-Y connection

scientific article

Mutant p53 succumbs to starvation ⬇️

scientific article published on February 19, 2013

Mutant p53: one name, many proteins

scientific article

Mutational analysis of the p53 core domain L1 loop

scientific article

Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress

scientific article

Noncoding RNAs: The Missing “Linc” in p53-Mediated Repression ⬇️

scientific article published on August 6, 2010

Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes

scientific article published on 24 October 2012

Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization

scientific article published on October 2003

P53 and aging: A fresh look at an old paradigm

scientific article published on July 2010

P53 and prognosis: new insights and further complexity

scientific article

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

scientific article

Quantitative Analysis of the DNA Methylation Sensitivity of Transcription Factor Complexes

scientific article published on June 2017

Questioning the role of checkpoint kinase 2 in the p53 DNA damage response

scientific article published on 24 March 2003

RETRACTED: p73alpha regulation by Chk1 in response to DNA damage

retracted article

Regulation of p53 activity through lysine methylation

scientific article

Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11 ⬇️

scientific article published on July 31, 2011

Relevance of the p53-MDM2 axis to aging

scientific article published in December 2017

Replication of damaged DNA in vitro is blocked by p53.

scientific article published on July 2003

Repression of p63 and induction of EMT by mutant Ras in mammary epithelial cells

scientific article published on 28 September 2016

Retraction for Gonzalez et al., “p73α Regulation by Chk1 in Response to DNA Damage”.

scientific article published on 28 August 2017

Ribosomal Proteins RPL37, RPS15 and RPS20 Regulate the Mdm2-p53-MdmX Network ⬇️

scientific article published on July 16, 2013

Ribosomal protein L37 and the p53 network ⬇️

scientific article published on 01 November 2010

Ribosomal protein S7 is both a regulator and a substrate of MDM2

scientific article

STXBP4 Drives Tumor Growth and Is Associated with Poor Prognosis through PDGF Receptor Signaling in Lung Squamous Cell Carcinoma

scientific article published on 13 January 2017

STXBP4 regulates APC/C-mediated p63 turnover and drives squamous cell carcinogenesis

scientific article published on 07 May 2018

Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456.

scientific article published on 21 August 2007

Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation

scientific article

Susceptibility of p53 unstructured N terminus to 20 S proteasomal degradation programs the stress response.

scientific article published on 17 July 2009

TAp63 prevents premature aging by promoting adult stem cell maintenance

scientific article

Targeting mutant p53 through the mevalonate pathway.

scientific article

The C terminus of p53 binds the N-terminal domain of MDM2.

scientific article published on 18 July 2010

The C9ORF72 Gene, Implicated in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia, Encodes a Protein That Functions in Control of Endothelin and Glutamate Signaling

scientific article published on 29 October 2018

The Chk2 protein kinase

scientific article published in August 2004

The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity

scientific article published on 14 December 2006

The Roles of MDM2 and MDMX in Cancer.

scientific article published on 17 March 2016

The S phase checkpoint: when the crowd meets at the fork

scientific article

The Tail That Wags the Dog: How the Disordered C-Terminal Domain Controls the Transcriptional Activities of the p53 Tumor-Suppressor Protein.

scientific article published on 23 September 2016

The continuing saga of p53--more sleepless nights ahead

scientific article published on 01 September 2005

The linchpin? Pin1 meets p73.

scientific article published on June 2004

The p21 and PCNA partnership: a new twist for an old plot

scientific article published on 21 December 2008

The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain

scientific article published on 01 March 2015

The p53-HAT connection: PCAF rules? ⬇️

scientific article published on August 14, 2012

The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells ⬇️

scientific article published on January 3, 2002

Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53.

scientific article published on 11 November 2016

Transcriptional regulation by p53.

scientific article published on 28 April 2010

UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability ⬇️

scientific article published on May 30, 2013

Unfolding the roles of resveratrol in p53 regulation

Unleashing the power of p53: lessons from mice and men.

scientific article

Wild-type and cancer-related p53 proteins are preferentially degraded by MDM2 as dimers rather than tetramers.

scientific article published on 16 March 2018

hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes

scientific article

p21 can be a barrier to ferroptosis independent of p53

scientific article published on 24 September 2020

p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation.

scientific article published on 9 September 2008

p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression

scientific article published on 20 December 2018

p53 and Metabolism: The GAMT Connection

scientific article published in November 2009

p53 and p73 display common and distinct requirements for sequence specific binding to DNA

scientific article published on 14 December 2006

p53 binding to nucleosomes within the p21 promoter in vivo leads to nucleosome loss and transcriptional activation ⬇️

scientific article published on May 23, 2011

p53 in the cytoplasm: a question of overkill?

scientific article published in February 2004

p53 is localized to a sub-nucleolar compartment after proteasomal inhibition in an energy-dependent manner

scientific article published on 25 November 2008

p53 leans on its siblings

scientific article

p53 linear diffusion along DNA requires its C terminus

scientific article published in November 2004

p53, DNA damage, and NAD+ homeostasis

scientific article published on 8 May 2014

p53-Dependent induction of PVT1 and miR-1204.

scientific article published on 22 November 2011

p53-Dependent p21 mRNA elongation is impaired when DNA replication is stalled.

scientific article published on 11 December 2006

p53: master of life, death, and the epigenome

scientific article

p73 Expression in human normal and tumor tissues: loss of p73alpha expression is associated with tumor progression in bladder cancer.

scientific article published on November 2003

p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2.

scientific article

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