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List of works by John Cambier

A Precision B Cell-Targeted Therapeutic Approach to Autoimmunity Caused by Phosphatidylinositol 3-Kinase Pathway Dysregulation

scientific article published on 10 May 2019

A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels

scientific article

A dose-dependent role for EBF1 in repressing non-B-cell-specific genes.

scientific article

A human CD4 monoclonal antibody for the treatment of T-cell lymphoma combines inhibition of T-cell signaling by a dual mechanism with potent Fc-dependent effector activity

scientific article published in October 2007

A rapid method for the purification of immunoglobulin M (IgM) from the sera of certain mammalian species

scientific article published on 01 January 1974

Acquired hematopoietic stem cell defects determine B-cell repertoire changes associated with aging.

scholarly article

Activation and anergy in bone marrow B cells of a novel immunoglobulin transgenic mouse that is both hapten specific and autoreactive.

scientific article

Aging and immune function. Summary of a workshop held at Trudeau Institute, Saranac Lake, NY

scientific article published on 01 June 2005

Anti-CD79 antibody induces B cell anergy that protects against autoimmunity.

scientific article published on 17 January 2014

Anti-immunoglobulin M activates nuclear calcium/calmodulin-dependent protein kinase II in human B lymphocytes.

scientific article

Antigens varying in affinity for the B cell receptor induce differential B lymphocyte responses.

scientific article

Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production

scientific article published in December 2014

Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways.

scientific article published on 24 April 2013

Autonomous SHIP-dependent FcgammaR signaling in pre-B cells leads to inhibition of cell migration and induction of cell death.

scientific article published in March 2004

B Cell-Intrinsic STING Signaling Triggers Cell Activation, Synergizes with B Cell Receptor Signals, and Promotes Antibody Responses

article

B cell antigen receptor signaling 101.

scientific article published in July 2004

B cell antigen receptor signaling: roles in cell development and disease.

scientific article

B cell development: signal transduction by antigen receptors and their surrogates.

scientific article

B cell expression of the SH2-containing inositol 5-phosphatase (SHIP-1) is required to establish anergy to high affinity, proteinacious autoantigens

scientific article

B cell maintenance and function in aging

scientific article published on 04 May 2012

B cell receptor signaling in human systemic lupus erythematosus.

scientific article published on September 2006

B cells and type 1 diabetes ...in mice and men.

scientific article

B cells talk to their progenitors

scientific article published on 01 March 2011

B lymphocyte activation during cognate interactions with CD4+ T lymphocytes: molecular dynamics and immunologic consequences.

scientific article published on December 2003

B lymphocyte antigen receptor signaling: initiation, amplification, and regulation

scientific article

Bacterial superantigens induce V beta-specific T cell receptor internalization

scientific article published on 01 July 1996

Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking

scientific article published in Nature

CD72-mediated B cell activation involves recruitment of CD19 and activation of phosphatidylinositol 3-kinase

scientific article published on 01 October 1998

COPD is associated with production of autoantibodies to a broad spectrum of self-antigens, correlative with disease phenotype.

scientific article published on March 2013

Capturing antigen receptor components

scientific article published on 01 February 1991

Cellular reactive oxygen species inhibit MPYS induction of IFNβ

scientific article

Change you can B(cell)eive in: recent progress confirms a critical role for B cells in type 1 diabetes

scientific article published in August 2009

Co-receptor and accessory regulation of B-cell antigen receptor signal transduction.

scientific article published on December 1997

Contamination of DNase Preparations Confounds Analysis of the Role of DNA in Alum-Adjuvanted Vaccines

scientific article published on 29 June 2016

Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome

scientific article published on 06 September 2013

Cytoplasmic protein tyrosine phosphatases SHP-1 and SHP-2: regulators of B cell signal transduction.

scientific article

Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection.

scientific article published in January 1998

Differential STIM1 expression in T and B cell subsets suggests a role in determining antigen receptor signal amplitude

scientific article

Differential binding activity of ARH1/TAM motifs

scientific article published on 01 January 1995

Distinct signal thresholds for the unique antigen receptor-linked gene expression programs in mature and immature B cells.

scientific article

Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells

scientific article

Establishing anergy as a bona fide in vivo mechanism of B cell tolerance.

scientific article published on November 2009

Evaluation of methods for the isolation of plasma membranes displaying guanosine 5'-triphosphate-dependence for the regulation of adenylate cyclase activity: potential application to the study of other guanosine 5'-triphosphate-dependent transductio

scientific article published on 01 November 1988

Fc gamma RIIB as a potential molecular target for intravenous gamma globulin therapy.

scientific article

Fc gammaRIIB1 inhibition of BCR-mediated phosphoinositide hydrolysis and Ca2+ mobilization is integrated by CD19 dephosphorylation

scientific article published on 01 July 1997

FcgammaRIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation.

scientific article published on 12 September 2008

General parity between trio and pairwise breeding of laboratory mice in static caging

scientific article published on November 2014

Hyper-Ia antigen expression on B cells from B6-lpr/lpr mice correlates with manifestations of the autoimmune state

scientific article published on 01 January 1985

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

scientific article

Identification of anergic B cells within a wild-type repertoire.

scientific article

Imbalanced PTEN and PI3K Signaling Impairs Class Switch Recombination.

scientific article

Immune senescence. Editorial overview

scientific article published on 23 July 2011

Immunosenescence: a problem of lymphopoiesis, homeostasis, microenvironment, and signaling

scientific article

Impaired B cell function during viral infections due to PTEN-mediated inhibition of the PI3K pathway.

scientific article published on 24 March 2017

Inhibitory receptors abound?

scientific article (publication date: 10 June 1997)

Integrated immunology in Colorado.

scientific article published in March 2013

Interleukin-4 overcomes the negative influence of cyclic AMP accumulation on antigen receptor stimulated B lymphocytes

scientific article published on 01 October 1998

Introduction: multifaceted roles of lipids and their catabolites in immune cell signaling.

scientific article

Involvement of CD4 D3-D4 membrane proximal extracellular domain for the inhibitory effect of oxidative stress on activation-induced CD4 down-regulation and its possible role for T cell activation.

scientific article published on May 2003

Ligation of human CD4 interferes with antigen-induced activation of primary T cells

scientific article published on 01 June 2002

MHC class II structural requirements for the association with Igalpha/beta, and signaling of calcium mobilization and cell death

scientific article published on 26 December 2007

MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP.

scientific article

Maintenance of B cell anergy requires constant antigen receptor occupancy and signaling

scientific article published on 02 October 2005

Manipulation of B cell antigen receptor tyrosine phosphorylation using aluminum fluoride and sodium orthovanadate.

scientific article published on November 1995

Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4.

scientific article published on 31 August 2003

Modulation of MHC class II signal transduction by CD19

scientific article published on 01 January 2007

Modulation of in vitro murine B-lymphocyte response by curcumin

scientific article

Negative regulation of FcϵRI signaling by FcγRII costimulation in human blood basophils

scientific article published on 01 August 2000

Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling.

scientific article

Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells

scientific article published on 15 May 2013

Positive regulation of interleukin-4-mediated proliferation by the SH2-containing inositol-5'-phosphatase

scientific article published on September 2000

Promotion of B cell immune responses via an alum-induced myeloid cell population

scientific article published in June 2004

Qualitative Regulation of B Cell Antigen Receptor Signaling by CD19: Selective Requirement for PI3-Kinase Activation, Inositol-1,4,5-Trisphosphate Production and Ca2+ Mobilization ⬇️

scientific article published on December 1, 1997

Regulation of BCR signal transduction in B-1 cells requires the expression of the Src family kinase Lck.

scientific article published on September 2004

Regulation of hematopoietic cell function by inhibitory immunoglobulin G receptors and their inositol lipid phosphatase effectors.

scientific article

Retention of anergy and inhibition of antibody responses during acute γ herpesvirus 68 infection

scientific article

Role of B lymphocytes in the pathogenesis of type 1 diabetes.

scientific article published on January 2014

Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling

scientific article

SMIP-016 in action: CD37 as a death receptor

scientific article

STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration.

scientific article

Seeing the way to B-cell growth

scientific article published on 01 February 1986

Selective in vivo recruitment of the phosphatidylinositol phosphatase SHIP by phosphorylated FcγRIIB during negative regulation of IgE-dependent mouse mast cell activation

article

Signal transduction by T- and B-cell antigen receptors: converging structures and concepts

scientific article published on June 1, 1992

Silencing of autoreactive B cells by anergy: a fresh perspective.

scientific article

Sorting of B lymphoblasts based upon cell diameter provides cell populations enriched in different stages of cell cycle

scientific article published on 01 September 1983

Structural compartmentalization of MHC class II signaling function.

scientific article

T-cell development and transmembrane signaling: changing biological responses through an unchanging receptor ⬇️

scientific article published on February 1, 1991

TCR-induced transmembrane signaling by peptide/MHC class II via associated Ig-alpha/beta dimers.

scientific article

Targeting DDR2 enhances tumor response to anti-PD-1 immunotherapy

article

The B-cell antigen receptor complex: structure and signal transduction

scientific article published on 01 September 1994

The SHIP phosphatase becomes associated with Fc gammaRIIB1 and is tyrosine phosphorylated during 'negative' signaling

scientific article published on 01 December 1996

The biochemical basis of transmembrane signalling by B lymphocyte surface immunoglobulin

scientific article

The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.

scientific article published on 3 January 2018

The conundrum of inhibitory signaling by ITAM-containing immunoreceptors: potential molecular mechanisms.

scientific article

The inositol 5-phosphatase SHIP-1 and adaptors Dok-1 and 2 play central roles in CD4-mediated inhibitory signaling.

scientific article published on 24 February 2012

The major histocompatibility complex-restricted antigen receptor on T cells: Distribution on thymus and peripheral T cells

article

The thymus has two functionally distinct populations of immature alpha beta + T cells: one population is deleted by ligation of alpha beta TCR.

scientific article

Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap

scientific article

Unique features of SHIP, SHP-1 and SHP-2 binding to FcgammaRIIb revealed by surface plasmon resonance analysis

scientific article published on 01 May 1999

αβ TCR⁺ T cells, but not B cells, promote autoimmune keratitis in b10 mice lacking γδ T cells

scientific article published on 25 January 2012

γδ T cells affect IL-4 production and B-cell tolerance

scientific article

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