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List of works by Leslie Orgel

A Method for the 32P Labeling of Peptides or Peptide Nucleic Acid Oligomers ⬇️

scientific article published on July 1, 1998

A Nonenzymatic RNA Polymerase Model ⬇️

scientific article published on February 18, 1983

A Reversible Photochromic Polymer

scientific article published in Nature

A comparison of RNA with DNA in template-directed synthesis

A convenient synthesis of a novel nucleoside analogue: 4-(alpha-diformyl-methyl)-1-(beta-D-ribofuranosyl)-2-pyrimidinone

scientific article published on May 2000

A highly enantio-selective hexitol nucleic acid template for nonenzymatic oligoguanylate synthesis.

scientific article

A simple procedure for constructing 5'-amino-terminated oligodeoxynucleotides in aqueous solution

scientific article

ADAPTATION TO WIDE-SPREAD DISTURBANCE OF ENZYME FUNCTION

scientific article published on 01 July 1964

Acceleration of the template-directed reactions of nucleoside 5′-phosphorimidazolides by acylation ⬇️

scientific article published on 01 April 1991

Amino acid activation with adenosine 5′-phosphorimidazolide ⬇️

scientific article published on May 12, 1978

Aminomalononitrile and 4-Amino-5-cyanoimidazole in Hydrogen Cyanide Polymerization and Adenine Synthesis1 ⬇️

scientific article published on 01 November 1965

An Unusual Photochemical Rearrangement in the Synthesis of Adenine from Hydrogen Cyanide1

scientific article published in 1966

An efficient, sequence-specific method for crosslinking complementary oligonucleotides using binuclear platinum complexes

scientific article published on December 1991

Analysis of high molecular weight material from the polymerization of adenosine cyclic 2', 3'-phosphate

scientific article published in January 1974

Anticipating an RNA world. Some past speculations on the origin of life: where are they today? ⬇️

scientific article published on January 1, 1993

Are you serious, Dr Mitchell?

scientific article published on November 1999

Binding of hairpin and dumbbell DNA to transcription factors ⬇️

scientific article published on December 25, 1991

Biochemical Evolution

journal article; published in Nature on 1971-12-01

Bis-cyclopentadienyl Iron: a Molecular Sandwich

scientific article published in Nature

Blunt-end and single-strand ligations by Escherichia coli ligase: influence on an in vitro amplication scheme

scientific article published on 01 April 1990

Catalysis of accurate poly(C)-directed synthesis of 3'-5'-linked oligoguanylates by Zn2+

scientific article published on 01 December 1980

Catalysis of the oligomerization of O-phospho-serine, aspartic acid, or glutamic acid by cationic micelles

scientific article published on 01 February 1996

Catalysts for the polymerization of adenosine cyclic 2',3'-phosphate on a poly (U) template

scientific article published on 01 July 1971

Catalysts for the self-polymerization of adenosine cyclic 2', 3'-phosphate

scientific article

Co-Ordination Chemistry

article published in 1959

Co-Ordination Chemistry

Co-chairman's remarks: genome organization and evolution

scientific article published on 01 December 1993

Condensation of activated diguanylates on a poly(C) template ⬇️

scientific article published on 01 January 1981

Crosslinking transcription factors to their recognition sequences with PtII complexes

scientific article

Cyanoacetylene in prebiotic synthesis

scientific article published on 01 November 1966

Cyclization of nucleotide analogues as an obstacle to polymerization

scientific article published in December 1988

Did template-directed nucleation precede molecular replication?

scientific article published in January 1986

Directed panspermia

scientific article (publication date: July 1973)

Disulfide-linked oligonucleotide phosphorothioates: novel analogues of nucleic acids

scientific article published on 01 January 1991

Efficient catalysis of polycytidylic acid-directed oligoguanylate formation by Pb2+ ⬇️

scientific article published on 01 October 1980

Efficient oligomerization of negatively-charged beta-amino acids at -20 degrees C.

scientific article published in May 1997

Efficient transfer of information from hexitol nucleic acids to RNA during nonenzymatic oligomerization.

scientific article published in January 1999

Electronic properties of transition-metal oxides—I

Enantiomeric cross-inhibition in the synthesis of oligonucleotides on a nonchiral template

scientific article

Enzymatic synthesis of polymers containing nicotinamide mononucleotide

scientific article (publication date: 25 September 1995)

Evolution of the Genetic Apparatus: A Review

scientific article

Evolution of the genetic apparatus

scientific article (publication date: December 1968)

Formation of P1, P2-dinucleoside 5′-pyrophosphates under potentially prebiological conditions ⬇️

scientific article published on May 12, 1978

Formation of oligonucleotide-PNA-chimeras by template-directed ligation

scientific article published on 01 January 1998

Formation of the imidazolides of dinucleotides under potentially prebiotic conditions

scientific article published on June 20, 1978

Further studies of urea-catalyzed phosphorylation reactions ⬇️

scientific article published on 01 January 1973

Gene-duplication and the origin of proteins with novel functions

scientific article published on August 22, 1977

Hayflick-NIH Settlement

scientific article published in Science

Heteropolynucleotides as templates for non-enzymatic polymerizations

scientific article published on 01 December 1978

In vitro integration of human immunodeficiency virus type 1 cDNA into targets containing protein-induced bends

scientific article

In vitro selection of optimal DNA substrates for T4 RNA ligase

scientific article

In vitro selection of optimal DNA substrates for ligation by a water-soluble carbodiimide

scientific article published on 01 June 1994

Induction of mutations in bacteriophage T4 with divalent manganese ⬇️

scientific article published on 01 December 1965

Information transfer from DNA to peptide nucleic acids by template- directed syntheses ⬇️

scientific article published on December 1, 1997

Information transfer from peptide nucleic acids to RNA by template- directed syntheses ⬇️

scientific article published on December 1, 1997

Inhibition of DNA synthesis by cross-linking the template to platinum-thiol derivatives of complementary oligodeoxynucleotides

scientific article

International transfers

journal article; published in Nature, 1976-04

Ion Compression and the Colour of Ruby

scientific article published in Nature

Ligation of oligonucleotides to nucleic acids or proteins via disulfide bonds

scientific article

Localized Electrons in Body-Centred Cubic Metals

scientific article published in Nature

Mechanism of enzyme inhibition by phosphate esters

scientific article published on 01 September 1959

Model for Origin of Monosaccharides: Synthesis of Sugars in Potentially Prebiotic Conditions ⬇️

scientific article published in Nature

Molecular replication

scientific article

N, N'-carbonyldiimidazole-induced diketopiperazine formation in aqueous solution in the presence of adenosine-5'-monophosphate

scientific article published on 01 December 1976

N,N'-carbonyldiimidazole-induced peptide formation in aqueous solution

scientific article published on May 20, 1976

Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C, U) templates

scientific article published on 01 June 1984

Non-enzymic oligonucleotide synthesis on a polycytidylate template

scientific article published on 01 March 1969

Non-enzymic template-directed synthesis on RNA random copolymers. Poly(C, G) templates

scientific article published on 01 April 1986

Nonenzymatic oligomerization reactions on templates containing inosinic acid or diaminopurine nucleotide residues

Nonenzymatic sequence-specific cleavage of single-stranded DNA.

scientific article published on February 1985

Nonenzymatic synthesis of RNA and DNA oligomers on hexitol nucleic acid templates: the importance of the A structure

scientific article published in March 1999

Nonenzymatic template-directed reactions on altritol oligomers, preorganized analogues of oligonucleotides

scientific article published on January 2000

Nonenzymatic template-directed synthesis on hairpin oligonucleotides. 2. Templates containing cytidine and guanosine residues

scientific article published in January 1992

Nonenzymatic template-directed synthesis on hairpin oligonucleotides. 3. Incorporation of adenosine and uridine residues

scientific article published in October 1992

Nonenzymatic template-directed synthesis on oligodeoxycytidylate sequences in hairpin oligonucleotides

scientific article published in January 1992

Nucleic acid duplexes incorporating a dissociable covalent base pair

scientific article published on December 1999

Nucleic acids. Adding to the genetic alphabet

scientific article published in Nature

Nucleoside Synthesis under Potentially Prebiotic Conditions ⬇️

scientific article published in Nature

ORIGIN OF LIFE: Enhanced: A Simpler Nucleic Acid

scientific article published in Science

Oligomerization of (guanosine 5'-phosphor)-2-methylimidazolide on poly(C). An RNA polymerase model

scientific article published on 01 November 1982

Oligomerization of 3'-amino-3'deoxyguanosine-5'phosphorimidazolidate on a d(CpCpCpCpC) template

scientific article

Oligomerization of L-gamma-carboxyglutamic acid

scientific article published on 01 March 1999

Oligomerization of activated D- and L-guanosine mononucleotides on templates containing D- and L-deoxycytidylate residues

scientific article published on November 1998

Oligomerization of deoxyguanosine 5'-phosphoro-2-methylimidazolide on a polycytidylate template

scientific article published on 01 December 1999

Oligomerization of negatively-charged amino acids by carbonyldiimidazole

scientific article

Oligonucleotide synthesis catalyzed by the zinc(2+) ion ⬇️

scientific article published on June 11, 1975

Oligonucleotides as probes for studying polymerization reactions in dilute aqueous solution

Oligonucleotides as probes for studying polymerization reactions in dilute aqueous solution: II. Polycondensations

scientific article published on 01 February 1995

On the possible role of crystals in the origins of life. VII. The adsorption and polymerization of phosphoramidates by montmorillonite clay.

scientific article published in January 1974

Optimization of the efficiency of cross-linking PtII oligonucleotide phosphorothioate complexes to complementary oligonucleotides

scientific article published in September 1990

Origin and ancestor: separate environments

scientific article published in February 1999

Origin of life. A simpler nucleic acid

scientific article (publication date: 17 November 2000)

Oxidative acylation using thioacids ⬇️

scientific article published on September 4, 1997

PCR with detachable primers

scientific article

Peptide-formation on cysteine-containing peptide scaffolds

scientific article published on 01 October 1999

Phosphorylation of glyceric acid in aqueous solution using trimetaphosphate

scientific article

Poly(U)-directed peptide-bond formation from the 2'(3')-glycyl esters of adenosine derivatives

scientific article published on September 1980

Polycytidylate and poly(7-deazaguanylate): a pair of complementary templates

scientific article published on 01 March 1994

Polymerization of a monomeric guanosine derivative in a hydrogen- bonded aggregate

scientific article published in October 1989

Polymerization of amino acids containing nucleotide bases

scientific article

Polymerization of beta-amino acids in aqueous solution

scientific article published on 01 February 1998

Polymerization of nucleotide analogues I: reaction of nucleoside 5'-phosphorimidazolides with 2'-amino-2'-deoxyuridine

scientific article published on May 26, 1976

Polymerization of the cyclic pyrophosphates of nucleosides and their analogues

scientific article published in January 1990

Polymerization on the rocks: beta-amino acids and arginine

scientific article published on 01 June 1998

Polymerization on the rocks: negatively-charged alpha-amino acids

scientific article published on 01 June 1998

Polymerization on the rocks: theoretical introduction

scientific article published on 01 June 1998

Polyphosphate and trimetaphosphate formation under potentially prebiotic conditions

scientific article

Polyphosphorylation and non-enzymatic template-directed ligation of oligonucleotides

scientific article published on 01 February 2000

Postsynthesis functionalization of oligonucleotides

scientific article published on 01 January 1994

Prebiotic Activation Processes

scientific article published in Nature

Prebiotic peptide-formation in the solid state. I. Reactions of benzoate ion and glycine with adenosine 5'-phosphorimidazolide

scientific article (publication date: 9 June 1975)

Prebiotic peptide-formation in the solid state. II. Reaction of glycine with adenosine 5'-triphosphate and P1,P2-diadenosine-pyrophosphate

scientific article published on November 4, 1975

Prebiotic peptide-formation in the solid state. III. Condensation reactions of glycine in solid state mixtures containing inorganic polyphosphates

scientific article (publication date: 4 November 1975)

Prebiotic synthesis of propiolaldehyde and nicotinamide

scientific article published on 01 September 1970

Preparation of ligation intermediates and related polynucleotide pyrophosphates ⬇️

scientific article published on May 15, 1984

Presentation of ligands on hydroxylapatite

scientific article published in March 1997

Pyrophosphate formation as the most efficient condensation reaction of activated nucleotides ⬇️

scientific article published on 01 February 1991

Reaction on alternating GC oligonucleotide templates

scientific article

Reactions of adenosine 5'phosphorimidazolide with adenosine analogs on a polyuridylic acid template

scientific article published on 01 June 1977

Reactions of polyfunctional amino acids with N,N'-carbonyldiimidazole in aqueous solution--oligopeptide formation

scientific article published on March 28, 1977

Replacement of the 3'-CH group by nitrogen in the carbocyclic analogue of thymidine

scientific article (publication date: August 1989)

Selection in vitro ⬇️

scientific article published on September 21, 1979

Self-condensation of activated dinucleotides on polynucleotide templates with alternating sequences ⬇️

scientific article published on 01 December 1979

Self-organizing biochemical cycles

scientific article

Selfish DNA

scientific article published in Nature

Selfish DNA: the ultimate parasite

scientific article

Separation of "uncharged" oligodeoxynucleotide analogs by anion-exchange chromatography at high pH.

scientific article published in March 1996

Sequence dependent N-terminal rearrangement and degradation of peptide nucleic acid (PNA) in aqueous solution

scientific article

Single-strand regions of poly(G) act as templates for oligo(C) synthesis

scientific article published on 01 March 1994

Some acyclic analogues of nucleotides and their template-directed reactions

scientific article published in January 1989

Some applications of wave-mechanics to valency problems

doctoral thesis

Specificity of template-directed synthesis with adenine nucleosides

scientific article published on 01 January 1970

Stereochemistry of Cupric Compounds

scientific article published in Nature

Structure and Spectra of [(Phenanthroline)2Fe(CNMe)2]2+ and [(Phenanthroline)2Fe(CN)2H2]2+

scientific article published in Nature

Structure of the Trinuclear Basic Acetates

scientific article published in Nature

Studies in Prebiotic Synthesis. I. Aminomalononitrile and 4-Amino-5-cyanoimidazole1,2 ⬇️

scientific article published on 01 August 1966

Studies in prebiotic synthesis. 3. Synthesis of pyrimidines from cyanoacetylene and cyanate

scientific article published on 01 May 1968

Studies in prebiotic synthesis. IV. Conversion of 4-aminoimidazole-5-carbonitrile derivatives to purines

scientific article published on 01 November 1968

Studies in prebiotic synthesis. V. Synthesis and photoanomerization of pyrimidine nucleosides

scientific article published on 01 February 1970

Studies in prebiotic synthesis: VII. Solid-state synthesis of purine nucleosides

scientific article published on 01 January 1972

Studies of oligoadenylate formation on a poly(U) template ⬇️

scientific article published on March 15, 1979

Suppression of and complementation among mutants of the regulatory gene of the lactose operon of Escherichia coli ⬇️

scientific article published on 01 November 1965

Synthesis of 5'-deoxy-5'-nucleosideacetic acid derivatives

scientific article published on 01 January 1990

Synthesis of an amplifiable reporter RNA for bioassays

scientific article

Synthesis of long prebiotic oligomers on mineral surfaces

scientific article published in May 1996

Synthesis of oligoguanylates on oligocytidylate templates ⬇️

scientific article published on 01 January 1981

THE THEORY OF INTER-ALLELIC COMPLEMENTATION

scientific article published on 01 January 1964

Temperature-dependence of the template-directed synthesis of oligoguanylates

scientific article published on 01 January 1984

Template catalysis of acetyl transfer reactions ⬇️

scientific article published on January 28, 1971

Template switching between PNA and RNA oligonucleotides

scientific article

Template-directed extension of a guanosine 5'-phosphate covalently attached to an oligodeoxycytidylate template

scientific article published in December 1991

Template-directed oligomerization of 3-isoadenosine 5'-phosphate

scientific article published on 01 January 1988

Template-directed oligomerization of 5'-deoxy-5'-nucleosideacetic acid derivatives

scientific article published on 01 January 1990

Template-directed oligonucleotide ligation on hydroxylapatite

scientific article published in June 1986

Template-directed polynucleotide synthesis on mineral surfaces

scientific article published on 01 January 1984

Template-directed reactions of aminonucleosides ⬇️

scientific article published on August 5, 1977

Template-directed synthesis and selective adsorption of oligoadenylates on hydroxyapatite

scientific article published on 01 August 1980

Template-directed synthesis of oligoadenylates catalyzed by Pb2+ ions ⬇️

scientific article published on October 1, 1979

Template-directed synthesis of oligoguanylates in the presence of metal ions

scientific article published on 01 December 1980

Template-directed synthesis on oligodeoxycytidylate and polydeoxycytidylate templates

scientific article published on 01 January 1985

Template-directed synthesis on short oligoribocytidylates

scientific article published on 01 January 1986

Template-directed synthesis on the oligonucleotide d(C7-G-C7)

scientific article published on 01 March 1986

Template-directed synthesis on the pentanucleotide CpCpGpCpC ⬇️

scientific article published on September 25, 1984

Template-directed synthesis with 2-aminoadenosine

scientific article published on January 1984

Template-directed synthesis with adenosine-5'-phosphorimidazolide

scientific article

The Chemical Basis of Mutation ⬇️

scientific article

The Origin of Life on the Earth

scientific article published on October 1, 1994

The action of a water-soluble carbodiimide on adenosine-5'-polyphosphates

scientific article

The catalysis of nucleotide polymerization by compounds of divalent lead ⬇️

scientific article published on April 12, 1979

The crystal structure of ferrocene

scientific article (publication date: 10 April 1956)

The cyclization of arabinosyladenine-5'-phosphorimidazolide

scientific article published on 01 January 1991

The effect of Mg2+ and Ca2+ on urea-catalyzed phosphorylation reactions

scientific article published on 01 November 1973

The effect of poly(C) on the formation of peptide bonds from the 2′(3′)-glycyl ester of a guanosine nucleotide ⬇️

scientific article published on 01 January 1981

The formation of dipeptides from amino acids and the 2′(3′)-glycyl ester of an adenylate ⬇️

scientific article published on October 1, 1979

The formation of peptides from glycine thioesters ⬇️

scientific article published on October 1, 1979

The formation of peptides from the 2′(3′)-glycyl ester of a nucleotide ⬇️

scientific article (publication date: 2 August 1978)

The limits of template-directed synthesis with nucleoside-5'-phosphoro(2-methyl)imidazolides

scientific article published on 01 December 1993

The maintenance of the accuracy of protein synthesis and its relevance to ageing ⬇️

scientific article

The origin of life--a review of facts and speculations

scientific article

The origin of life--how long did it take?

scientific article

The origin of polynucleotide-directed protein synthesis

scientific article published on December 1989

The origins of life--a status report

scientific article

The search for organic substances and inorganic volatile compounds in the surface of Mars

scientific article published in September 1977

The specificity of peptide chain extension by N-carboxyanhydrides

scientific article

The stability of different forms of double-stranded decoy DNA in serum and nuclear extracts ⬇️

scientific article published on November 11, 1992

The template properties of some oligodeoxynucleotides containing cytidine and guanosine

scientific article published on January 1986

The template properties of tetranucleoside triphosphoramidates having cytosine-guanosine residues

scientific article published in October 1989

The use of gel electrophoresis to study the reactions of activated amino acids with oligonucleotides

scientific article published on 01 January 1994

Triple helices formed by polyuridylic acid with some adenosine derivatives ⬇️

scientific article published on July 11, 1975

Triple helices formed by polyuridylic acid with some amino deoxyadenosine derivatives ⬇️

scientific article (publication date: 23 June 1976)

Unexpected substrate specificity of T4 DNA ligase revealed by in vitro selection

scientific article

Unnatural selection in chemical systems

scientific article

Urea-Inorganic Phosphate Mixtures as Prebiotic Phosphorylating Agents ⬇️

scientific article published on February 5, 1971

Which 3-ribofuranosyl-substituted purine 5′-phosphates undergo template-directed oligomerization? ⬇️

scientific article published on 01 June 1991

β structures of alternating polypeptides and their possible prebiotic significance ⬇️

scientific article published on July 31, 1975

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