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List of works by Philippe Chavrier

A NUMB-EFA6B-ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility

scientific article published on 30 July 2018

A WASp-VASP complex regulates actin polymerization at the plasma membrane.

scientific article

A conserved C-terminal domain of EFA6-family ARF6-guanine nucleotide exchange factors induces lengthening of microvilli-like membrane protrusions.

scientific article published in July 2002

A dominant-negative mutant of the Rab5 GTPase enhances T cell signaling by interfering with TCR down-modulation in transgenic mice

scientific article published on 01 December 1997

A new pipeline for pathophysiological analysis of the mammary gland based on organoid transplantation and organ clearing

scientific article published on 28 May 2020

A role for mammalian diaphanous-related formins in complement receptor (CR3)-mediated phagocytosis in macrophages

scientific article published on November 2005

ADP ribosylation factor 6 is activated and controls membrane delivery during phagocytosis in macrophages

scientific article

AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin

scientific article published on January 2016

AP-1 and ARF1 control endosomal dynamics at sites of FcR mediated phagocytosis

scientific article

ARF proteins: roles in membrane traffic and beyond

scientific article (publication date: May 2006)

ARF1-mediated actin polymerization produces movement of artificial vesicles

scientific article

ARF6 Interacts with JIP4 to control a motor switch mechanism regulating endosome traffic in cytokinesis.

scientific article published in February 2009

ARF6 controls post-endocytic recycling through its downstream exocyst complex effector

scientific article

ARF6 promotes the formation of Rac1 and WAVE-dependent ventral F-actin rosettes in breast cancer cells in response to epidermal growth factor

scientific article

ARF6, PI3-kinase and host cell actin cytoskeleton in Toxoplasma gondii cell invasion.

scientific article

ARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion

scientific article

ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function ⬇️

scientific article published on August 18, 1998

ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion.

scientific article published on 16 August 2012

Abscission accomplished by PtdIns(3)P.

scientific article published in April 2010

Actin dynamics during phagocytosis ⬇️

scientific article published on December 1, 2001

An array of microfabricated pillars to study cell migration

scientific article published in August 2005

An immunologist's look at the Rho and Rab GTP-binding proteins.

scientific article

Cdc42 localization and cell polarity depend on membrane traffic ⬇️

scientific article

Cell polarity during motile processes: keeping on track with the exocyst complex.

scientific article published on February 2011

Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells.

scientific article published on 30 January 2017

Cellular and Molecular Mechanisms of MT1-MMP-Dependent Cancer Cell Invasion

scientific article

Characterization of a Lysozyme-Major Histocompatibility Complex Class II Molecule-loading Compartment as a Specialized Recycling Endosome in Murine B Lymphocytes

scientific article published in Journal of Biological Chemistry

Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins

scientific article

Control of MT1-MMP transport by atypical PKC during breast-cancer progression

scientific article

Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function

scientific article published on 31 July 2018

Correction: Exo70 Subunit of the Exocyst Complex Is Involved in Adhesion-Dependent Trafficking of Caveolin-1.

scientific article published on 23 August 2013

Cytokinesis arrest and redistribution of actin-cytoskeleton regulatory components in cells expressing the Rho GTPase CDC42Hs.

scientific article published on February 1996

Decoupling of activation and effector binding underlies ARF6 priming of fast endocytic recycling

scientific article published on 01 April 2011

Different endocytic compartments are involved in the tight association of class II molecules with processed hen egg lysozyme and ribonuclease A in B cells

scientific article published on 01 June 1995

Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity

scientific article

Early endosome membrane dynamics characterized by flow cytometry.

scientific article published on September 1997

Endocytic traffic in animal cell cytokinesis.

scientific article published on 28 May 2008

Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia

scientific article

Exo70 subunit of the exocyst complex is involved in adhesion-dependent trafficking of caveolin-1

scientific article (publication date: 2012)

Fc receptor-mediated phagocytosis requires CDC42 and Rac1 ⬇️

scientific article published on November 2, 1998

Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics

scientific article (publication date: April 2005)

HDAC6 is required for invadopodia activity and invasion by breast tumor cells ⬇️

scientific article published on October 23, 2010

Human syntaxin 3 is localized apically in human intestinal cells ⬇️

scientific article published on September 1, 1997

Impaired PRC2 activity promotes transcriptional instability and favors breast tumorigenesis

scientific article

Implication of metastasis suppressor NM23-H1 in maintaining adherens junctions and limiting the invasive potential of human cancer cells.

scientific article published on 14 September 2010

Inducible membrane recruitment of small GTP-binding proteins by rapamycin-based system in living cells

scientific article published on 01 January 2000

Inducible recruitment of Cdc42 or WASP to a cell-surface receptor triggers actin polymerization and filopodium formation

scientific article published on 01 April 1999

Isoprenylation of rab proteins on structurally distinct cysteine motifs.

scientific article published in August 1992

LIMK Regulates Tumor-Cell Invasion and Matrix Degradation Through Tyrosine Phosphorylation of MT1-MMP.

scientific article published on 27 April 2016

LIN7A is a major determinant of cell-polarity defects in breast carcinomas

scientific article published on 17 February 2016

LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration.

scientific article published on 22 June 2018

MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion

scientific article published on 25 October 2019

MT1-MMP targeting to endolysosomes is mediated by upregulation of flotillins

scientific article published on 05 September 2018

MT1-MMP-dependent invasion is regulated by TI-VAMP/VAMP7.

scientific article

Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia.

scientific article published on September 2009

May the force be with you: Myosin-X in phagocytosis.

scientific article published in July 2002

Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling

scientific article

Molecular cloning of YPT1/SEC4-related cDNAs from an epithelial cell line

scientific article

Nucleus-Invadopodia Duo During Cancer Invasion

scientific article published on 17 December 2018

Phagocytosis of immunoglobulin-coated emulsion droplets

scientific article published on 20 February 2015

Protein interaction mapping: a Drosophila case study

scientific article published on 14 February 2005

RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs

scientific article published on 02 June 2016

Reconstituted killer cell inhibitory receptors for major histocompatibility complex class I molecules control mast cell activation induced via immunoreceptor tyrosine-based activation motifs.

scientific article published on April 1997

Regulated delivery of molecular cargo to invasive tumour-derived microvesicles ⬇️

scientific article

Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse.

scientific article

Selective Rac1 inhibition in dendritic cells diminishes apoptotic cell uptake and cross-presentation in vivo

scientific article published on 21 September 2004

Selective control of membrane ruffling and actin plaque assembly by the Rho GTPases Rac1 and CDC42 in FcepsilonRI-activated rat basophilic leukemia (RBL-2H3) cells

scientific article published on 01 September 1997

Signaling and membrane dynamics during phagocytosis: many roads lead to the phagos(R)ome

scientific article published in August 2004

Social networking in tumor cell communities is associated with increased aggressiveness

scientific article published on 21 January 2016

Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes

scientific article

TI-VAMP/VAMP7 is required for optimal phagocytosis of opsonised particles in macrophages

scientific article

The N-terminal domain of a rab protein is involved in membrane-membrane recognition and/or fusion.

scientific article

The O-chain of Brucella abortus lipopolysaccharide induces SDS-resistant MHC class II molecules in mouse B cells.

scientific article published in September 1994

The advantage of channeling nucleotides for very processive functions

scientific article

The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA.

scientific article published on 9 June 2008

The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4

scientific article

Toward a structural understanding of arf family:effector specificity.

scientific article published on December 2010

Triple association of CDC25-, Dbl- and Sec7-related domains in mammalian guanine-nucleotide-exchange factors

scientific article published on 01 December 1998

Tyrosine phosphorylation of the Wiskott-Aldrich syndrome protein by Lyn and Btk is regulated by CDC42

scientific article published on 01 September 1998

V-ATPase: a potential pH sensor

scientific article published on 01 February 2006

[ARHGAP10, a novel RhoGAP at the cross-road between ARF1 and Cdc42 pathways, regulates Arp2/3 complex and actin dynamics on Golgi membranes]

scientific article published on 01 August 2005

[When microtubules meet clathrin-coated pits]

scientific article published on 24 February 2014

aPKCi triggers basal extrusion of luminal mammary epithelial cells by tuning contractility and vinculin localization at cell junctions

scientific article published on 07 November 2019

p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer.

scientific article

αTAT1 catalyses microtubule acetylation at clathrin-coated pits

scientific article

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