List of works - James C Whisstock

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

scientific article (publication date: 7 September 2001)

MUSTANG: a multiple structural alignment algorithm

scientific article published in August 2006

Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function.

scientific article

An overview of the serpin superfamily

scientific article

AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP.

scientific article

A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity

scientific article

The structural basis for membrane binding and pore formation by lymphocyte perforin

scientific article

Prediction of protein function from protein sequence and structure

scientific article

Perforin and granzymes: function, dysfunction and human pathology

scientific article published on June 2015

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

scientific article published on 25 September 2005

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

scientific article

The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65.

scientific article

RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly

scientific article

A common fold mediates vertebrate defense and bacterial attack

scientific article

The MACPF/CDC family of pore-forming toxins

scientific article

Conservation within the myosin motor domain: implications for structure and function

article

PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites

scientific article

The major human and mouse granzymes are structurally and functionally divergent

scientific article

Functional insights from the distribution and role of homopeptide repeat-containing proteins

scientific article

GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop

scientific article

A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications

scientific article published on 02 October 2013

Glycoprotein Ib-IX-V.

scientific article

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

scientific article published in February 2013

Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis.

scientific article published on February 2004

Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems

scientific article

The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site

scientific article

Perforin: structure, function, and role in human immunopathology

scientific article

An atlas of serpin conformations.

scientific article published on February 1998

Molecular gymnastics: serpin structure, folding and misfolding

scientific article

The X-ray crystal structure of full-length human plasminogen

scientific article

Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer

scientific article

Cascleave: towards more accurate prediction of caspase substrate cleavage sites

scientific article published on 3 February 2010

Automatic generation of protein structure cartoons with Pro-origami

scientific article published on October 12, 2011

The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane

scientific article

SH3 domains in prokaryotes

scientific article

alpha 1-Antitrypsin Mmalton (Phe52-deleted) forms loop-sheet polymers in vivo. Evidence for the C sheet mechanism of polymerization

scientific article published in July 1995

Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase

scientific article

Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles ...

scientific article

Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions

scientific article

Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials

scientific article published on 30 September 2009

The molecular basis for perforin oligomerization and transmembrane pore assembly

scientific article

Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer

scholarly article

The 1.6 A crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis

scientific article

The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins

scientific article

PoPS: a computational tool for modeling and predicting protease specificity

scientific article published in June 2005

Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparin.

scientific article

Cleaved antitrypsin polymers at atomic resolution

scientific article

Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation

scientific article

Probing the unfolding pathway of alpha1-antitrypsin

scientific article published in April 1999

Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop

scientific article

List of works by James C Whisstock

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

MUSTANG: a multiple structural alignment algorithm

Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function.

An overview of the serpin superfamily

AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP.

A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity

The structural basis for membrane binding and pore formation by lymphocyte perforin

Prediction of protein function from protein sequence and structure

Perforin and granzymes: function, dysfunction and human pathology

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65.

RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly

A common fold mediates vertebrate defense and bacterial attack

The MACPF/CDC family of pore-forming toxins

Conservation within the myosin motor domain: implications for structure and function

PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites

The major human and mouse granzymes are structurally and functionally divergent

Functional insights from the distribution and role of homopeptide repeat-containing proteins

GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop

A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications

Glycoprotein Ib-IX-V.

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis.

Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems

The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site

Perforin: structure, function, and role in human immunopathology

An atlas of serpin conformations.

Molecular gymnastics: serpin structure, folding and misfolding

The X-ray crystal structure of full-length human plasminogen

Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer

Cascleave: towards more accurate prediction of caspase substrate cleavage sites

Automatic generation of protein structure cartoons with Pro-origami

The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane

SH3 domains in prokaryotes

alpha 1-Antitrypsin Mmalton (Phe52-deleted) forms loop-sheet polymers in vivo. Evidence for the C sheet mechanism of polymerization

Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase

Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles ...

Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions

Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials

The molecular basis for perforin oligomerization and transmembrane pore assembly

Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer

The 1.6 A crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis

The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins

PoPS: a computational tool for modeling and predicting protease specificity

Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparin.

Cleaved antitrypsin polymers at atomic resolution

Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation

Probing the unfolding pathway of alpha1-antitrypsin

Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop