List of works - Joan B. Broderick

Activation of HydA(DeltaEFG) requires a preformed [4Fe-4S] cluster.

scientific article published in July 2009

Active-Site Controlled, Jahn-Teller Enabled Regioselectivity in Reductive S-C Bond Cleavage of <i>S</i>-Adenosylmethionine in Radical SAM Enzymes

scientific article published on 29 December 2020

Adenosylmethionine-dependent iron-sulfur enzymes: versatile clusters in a radical new role

scientific article

An anchoring role for FeS clusters: chelation of the amino acid moiety of S-adenosylmethionine to the unique iron site of the [4Fe-4S] cluster of pyruvate formate-lyase activating enzyme

scientific article published in September 2002

An efficient deprotection of N-trimethylsilylethoxymethyl (SEM) groups from dinucleosides and dinucleotides

scientific article

Assembling iron-sulfur clusters in the cytosol

scientific article published on 01 May 2007

Biochemical and kinetic characterization of radical S-adenosyl-L-methionine enzyme HydG.

scientific article published on 20 November 2013

Biochemistry: A radically different enzyme

scientific article published in June 2010

Bioinorganic chemistry

scientific article published on 01 April 2003

Biosynthesis of complex iron-sulfur enzymes

scientific article published on 08 March 2011

Characterization of an active spore photoproduct lyase, a DNA repair enzyme in the radical S-adenosylmethionine superfamily

scientific article

Characterization of the Preprocessed Copper Site Equilibrium in Amine Oxidase and Assignment of the Reactive Copper Site in Topaquinone Biogenesis.

scientific article

Chemoselective deprotection of triethylsilyl ethers

scientific article

Combined Mössbauer spectroscopic, multi-edge X-ray absorption spectroscopic, and density functional theoretical study of the radical SAM enzyme spore photoproduct lyase

scientific article

Control of radical chemistry in the AdoMet radical enzymes

scientific article published on February 2009

Coordination of adenosylmethionine to a unique iron site of the [4Fe-4S] of pyruvate formate-lyase activating enzyme: a Mössbauer spectroscopic study

scientific article published in February 2002

Direct H atom abstraction from spore photoproduct C-6 initiates DNA repair in the reaction catalyzed by spore photoproduct lyase: evidence for a reversibly generated adenosyl radical intermediate

scientific article published in March 2002

EPR and FTIR analysis of the mechanism of H2 activation by [FeFe]-hydrogenase HydA1 from Chlamydomonas reinhardtii

scientific article published on 24 April 2013

Electron Spin Relaxation and Biochemical Characterization of the Hydrogenase Maturase HydF: Insights into [2Fe-2S] and [4Fe-4S] Cluster Communication and Hydrogenase Activation

scientific article

Electron-nuclear double resonance spectroscopic evidence that S-adenosylmethionine binds in contact with the catalytically active [4Fe-4S](+) cluster of pyruvate formate-lyase activating enzyme

scientific article published in March 2002

Emerging paradigms for complex iron-sulfur cofactor assembly and insertion

scientific article published on 05 April 2012

Emerging themes in radical SAM chemistry

scientific article

Escherichia coli LipA is a lipoyl synthase: in vitro biosynthesis of lipoylated pyruvate dehydrogenase complex from octanoyl-acyl carrier protein

scientific article

Evidence for retention of biological activity of a non-heme iron enzyme adsorbed on a silver colloid: A surface-enhanced resonance Raman scattering study

article

Flavodoxin cofactor binding induces structural changes that are required for protein-protein interactions with NADP(+) oxidoreductase and pyruvate formate-lyase activating enzyme

scientific article

Frontiers in enzymatic C–H-bond activation

scientific article published on 01 February 2009

Genome sequence of Desulfitobacterium hafniense DCB-2, a Gram-positive anaerobe capable of dehalogenation and metal reduction ⬇️

scientific article published on February 8, 2012

Glycyl radical activating enzymes: structure, mechanism, and substrate interactions

scientific article

H-cluster assembly during maturation of the [FeFe]-hydrogenase

scientific article published on 28 June 2014

HydF as a scaffold protein in [FeFe] hydrogenase H-cluster biosynthesis.

scientific article

Hydrogenase cluster biosynthesis: organometallic chemistry nature's way

article

Identification and characterization of a novel member of the radical AdoMet enzyme superfamily and implications for the biosynthesis of the Hmd hydrogenase active site cofactor.

scientific article

In vitro activation of [FeFe] hydrogenase: new insights into hydrogenase maturation.

scientific article published on 20 March 2007

Inactivation of E. coli pyruvate formate-lyase: role of AdhE and small molecules

scientific article published on 12 January 2007

Insights into [FeFe]-hydrogenase structure, mechanism, and maturation

scientific article published on August 2011

Iron-Sulfur Cluster States of the Hydrogenase Maturase HydF.

scientific article published on 30 August 2017

Iron-sulfur cluster coordination in the [FeFe]-hydrogenase H cluster biosynthetic factor HydF

scientific journal article

Mechanism of Radical Initiation in the Radical S-Adenosyl-l-methionine Superfamily

article

Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme

scientific article published on 2 August 2017

Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis

scientific article published on 06 July 2018

Photoinduced Electron Transfer in a Radical SAM Enzyme Generates an S-Adenosylmethionine Derived Methyl Radical

scientific article published on 26 September 2019

Pyruvate formate-lyase activating enzyme: elucidation of a novel mechanism for glycyl radical formation

scientific article

Pyruvate formate-lyase and its activation by pyruvate formate-lyase activating enzyme

scientific article published on 12 December 2013

Pyruvate formate-lyase, evidence for an open conformation favored in the presence of its activating enzyme

scientific article

Radical AdoMet enzymes in complex metal cluster biosynthesis

scientific article published on 14 January 2012

Radical S-adenosyl-L-methionine chemistry in the synthesis of hydrogenase and nitrogenase metal cofactors

scientific article

Radical S-adenosylmethionine enzymes

scientific article published on 29 January 2014

Radical S-adenosylmethionine maquette chemistry: Cx3Cx2C peptide coordinated redox active [4Fe-4S] clusters

scientific article published on 05 September 2019

Radical SAM enzymes in methylation and methylthiolation

scientific article

Reversible H atom abstraction catalyzed by the radical S-adenosylmethionine enzyme HydG.

scientific article

S K-edge XAS and DFT calculations on SAM dependent pyruvate formate-lyase activating enzyme: nature of interaction between the Fe4S4 cluster and SAM and its role in reactivity

scientific article published on 28 October 2011

Solution phase dynamics of the DNA repair enzyme spore photoproduct lyase as probed by H/D exchange

scientific article

Special issue on iron-sulfur proteins: Structure, function, biogenesis and diseases

scientific article

Spectroscopic approaches to elucidating novel iron-sulfur chemistry in the "radical-Sam" protein superfamily

scientific article published in February 2005

Spore photoproduct lyase catalyzes specific repair of the 5R but not the 5S spore photoproduct

scientific article published on February 2009

Stepwise [FeFe]-hydrogenase H-cluster assembly revealed in the structure of HydA(DeltaEFG)

scientific article

Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme

scientific article

Structural studies of the interaction of S-adenosylmethionine with the [4Fe-4S] clusters in biotin synthase and pyruvate formate-lyase activating enzyme

scientific article published on July 2003

Synthesis of the 2Fe subcluster of the [FeFe]-hydrogenase H cluster on the HydF scaffold

scientific article

The Elusive 5'-Deoxyadenosyl Radical: Captured and Characterized by Electron Paramagnetic Resonance and Electron Nuclear Double Resonance Spectroscopies

scientific article published on 22 July 2019

The antiviral protein viperin is a radical SAM enzyme

scientific article

The iron-sulfur cluster of pyruvate formate-lyase activating enzyme in whole cells: cluster interconversion and a valence-localized [4Fe-4S]2+ state

scientific article

Viperin: a radical response to viral infection

scientific article

Why Nature Uses Radical SAM Enzymes so Widely: Electron Nuclear Double Resonance Studies of Lysine 2,3-Aminomutase Show the 5'-dAdo• "Free Radical" Is Never Free

scientific article

[FeFe]- and [NiFe]-hydrogenase diversity, mechanism, and maturation.

scientific article

[FeFe]-hydrogenase cyanide ligands derived from S-adenosylmethionine-dependent cleavage of tyrosine.

scientific article published in February 2010

[FeFe]-hydrogenase maturation.

scientific article

[FeFe]-hydrogenase maturation: HydG-catalyzed synthesis of carbon monoxide.

scientific article published in July 2010

[FeFe]-hydrogenase maturation: insights into the role HydE plays in dithiomethylamine biosynthesis

scientific article published on 2 March 2015

[FeFe]-hydrogenase oxygen inactivation is initiated at the H cluster 2Fe subcluster

scientific article

List of works by Joan B. Broderick

Activation of HydA(DeltaEFG) requires a preformed [4Fe-4S] cluster.

Active-Site Controlled, Jahn-Teller Enabled Regioselectivity in Reductive S-C Bond Cleavage of <i>S</i>-Adenosylmethionine in Radical SAM Enzymes

Adenosylmethionine-dependent iron-sulfur enzymes: versatile clusters in a radical new role

An anchoring role for FeS clusters: chelation of the amino acid moiety of S-adenosylmethionine to the unique iron site of the [4Fe-4S] cluster of pyruvate formate-lyase activating enzyme

An efficient deprotection of N-trimethylsilylethoxymethyl (SEM) groups from dinucleosides and dinucleotides

Assembling iron-sulfur clusters in the cytosol

Biochemical and kinetic characterization of radical S-adenosyl-L-methionine enzyme HydG.

Biochemistry: A radically different enzyme

Bioinorganic chemistry

Biosynthesis of complex iron-sulfur enzymes

Characterization of an active spore photoproduct lyase, a DNA repair enzyme in the radical S-adenosylmethionine superfamily

Characterization of the Preprocessed Copper Site Equilibrium in Amine Oxidase and Assignment of the Reactive Copper Site in Topaquinone Biogenesis.

Chemoselective deprotection of triethylsilyl ethers

Combined Mössbauer spectroscopic, multi-edge X-ray absorption spectroscopic, and density functional theoretical study of the radical SAM enzyme spore photoproduct lyase

Control of radical chemistry in the AdoMet radical enzymes

Coordination of adenosylmethionine to a unique iron site of the [4Fe-4S] of pyruvate formate-lyase activating enzyme: a Mössbauer spectroscopic study

Direct H atom abstraction from spore photoproduct C-6 initiates DNA repair in the reaction catalyzed by spore photoproduct lyase: evidence for a reversibly generated adenosyl radical intermediate

EPR and FTIR analysis of the mechanism of H2 activation by [FeFe]-hydrogenase HydA1 from Chlamydomonas reinhardtii

Electron Spin Relaxation and Biochemical Characterization of the Hydrogenase Maturase HydF: Insights into [2Fe-2S] and [4Fe-4S] Cluster Communication and Hydrogenase Activation

Electron-nuclear double resonance spectroscopic evidence that S-adenosylmethionine binds in contact with the catalytically active [4Fe-4S](+) cluster of pyruvate formate-lyase activating enzyme

Emerging paradigms for complex iron-sulfur cofactor assembly and insertion

Emerging themes in radical SAM chemistry

Escherichia coli LipA is a lipoyl synthase: in vitro biosynthesis of lipoylated pyruvate dehydrogenase complex from octanoyl-acyl carrier protein

Evidence for retention of biological activity of a non-heme iron enzyme adsorbed on a silver colloid: A surface-enhanced resonance Raman scattering study

Flavodoxin cofactor binding induces structural changes that are required for protein-protein interactions with NADP(+) oxidoreductase and pyruvate formate-lyase activating enzyme

Frontiers in enzymatic C–H-bond activation

Genome sequence of Desulfitobacterium hafniense DCB-2, a Gram-positive anaerobe capable of dehalogenation and metal reduction ⬇️

Glycyl radical activating enzymes: structure, mechanism, and substrate interactions

H-cluster assembly during maturation of the [FeFe]-hydrogenase

HydF as a scaffold protein in [FeFe] hydrogenase H-cluster biosynthesis.

Hydrogenase cluster biosynthesis: organometallic chemistry nature's way

Identification and characterization of a novel member of the radical AdoMet enzyme superfamily and implications for the biosynthesis of the Hmd hydrogenase active site cofactor.

In vitro activation of [FeFe] hydrogenase: new insights into hydrogenase maturation.

Inactivation of E. coli pyruvate formate-lyase: role of AdhE and small molecules

Insights into [FeFe]-hydrogenase structure, mechanism, and maturation

Iron-Sulfur Cluster States of the Hydrogenase Maturase HydF.

Iron-sulfur cluster coordination in the [FeFe]-hydrogenase H cluster biosynthetic factor HydF

Mechanism of Radical Initiation in the Radical S-Adenosyl-l-methionine Superfamily

Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme

Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis

Photoinduced Electron Transfer in a Radical SAM Enzyme Generates an S-Adenosylmethionine Derived Methyl Radical

Pyruvate formate-lyase activating enzyme: elucidation of a novel mechanism for glycyl radical formation

Pyruvate formate-lyase and its activation by pyruvate formate-lyase activating enzyme

Pyruvate formate-lyase, evidence for an open conformation favored in the presence of its activating enzyme

Radical AdoMet enzymes in complex metal cluster biosynthesis

Radical S-adenosyl-L-methionine chemistry in the synthesis of hydrogenase and nitrogenase metal cofactors

Radical S-adenosylmethionine enzymes

Radical S-adenosylmethionine maquette chemistry: Cx3Cx2C peptide coordinated redox active [4Fe-4S] clusters

Radical SAM enzymes in methylation and methylthiolation

Reversible H atom abstraction catalyzed by the radical S-adenosylmethionine enzyme HydG.

S K-edge XAS and DFT calculations on SAM dependent pyruvate formate-lyase activating enzyme: nature of interaction between the Fe4S4 cluster and SAM and its role in reactivity

Solution phase dynamics of the DNA repair enzyme spore photoproduct lyase as probed by H/D exchange

Special issue on iron-sulfur proteins: Structure, function, biogenesis and diseases

Spectroscopic approaches to elucidating novel iron-sulfur chemistry in the "radical-Sam" protein superfamily

Spore photoproduct lyase catalyzes specific repair of the 5R but not the 5S spore photoproduct

Stepwise [FeFe]-hydrogenase H-cluster assembly revealed in the structure of HydA(DeltaEFG)

Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme

Structural studies of the interaction of S-adenosylmethionine with the [4Fe-4S] clusters in biotin synthase and pyruvate formate-lyase activating enzyme

Synthesis of the 2Fe subcluster of the [FeFe]-hydrogenase H cluster on the HydF scaffold

The Elusive 5'-Deoxyadenosyl Radical: Captured and Characterized by Electron Paramagnetic Resonance and Electron Nuclear Double Resonance Spectroscopies

The antiviral protein viperin is a radical SAM enzyme

The iron-sulfur cluster of pyruvate formate-lyase activating enzyme in whole cells: cluster interconversion and a valence-localized [4Fe-4S]2+ state

Viperin: a radical response to viral infection

Why Nature Uses Radical SAM Enzymes so Widely: Electron Nuclear Double Resonance Studies of Lysine 2,3-Aminomutase Show the 5'-dAdo• "Free Radical" Is Never Free

[FeFe]- and [NiFe]-hydrogenase diversity, mechanism, and maturation.

[FeFe]-hydrogenase cyanide ligands derived from S-adenosylmethionine-dependent cleavage of tyrosine.

[FeFe]-hydrogenase maturation.

[FeFe]-hydrogenase maturation: HydG-catalyzed synthesis of carbon monoxide.

[FeFe]-hydrogenase maturation: insights into the role HydE plays in dithiomethylamine biosynthesis

[FeFe]-hydrogenase oxygen inactivation is initiated at the H cluster 2Fe subcluster