List of works - Domenico Tortorella

A bipartite trigger for dislocation directs the proteasomal degradation of an endoplasmic reticulum membrane glycoprotein

scientific article published on 17 December 2007

A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised

scientific article

A structural determinant of human cytomegalovirus US2 dictates the down-regulation of class I major histocompatibility molecules

scientific article published on 10 May 2006

An Influenza Virus Hemagglutinin-Based Vaccine Platform Enables the Generation of Epitope Specific Human Cytomegalovirus Antibodies

scientific article published on 14 June 2019

Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2

scientific article

CD46 facilitates entry and dissemination of human cytomegalovirus.

scientific article published on 20 June 2019

Cln6 mutants associated with neuronal ceroid lipofuscinosis are degraded in a proteasome-dependent manner

scientific article published on June 2009

Cotranslational endoplasmic reticulum assembly of FcepsilonRI controls the formation of functional IgE-binding receptors

scientific article

Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors

scientific article

Cytomegaloviruses use multiple mechanisms to elude the host immune response

scientific article published on June 1997

Development of a high-content screen for the identification of inhibitors directed against the early steps of the cytomegalovirus infectious cycle

scientific article

Development of a high-throughput assay to measure the neutralization capability of anti-cytomegalovirus antibodies

scientific article published on 6 February 2013

Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH

scientific article published on 25 April 2022

Dislocation of a type I membrane protein requires interactions between membrane-spanning segments within the lipid bilayer

scientific article

Dislocation of an endoplasmic reticulum membrane glycoprotein involves the formation of partially dislocated ubiquitinated polypeptides.

scientific article

Dislocation of ricin toxin A chains in human cells utilizes selective cellular factors

scientific article

Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential

scientific article

Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin

scientific article (publication date: April 2004)

Diverse immune evasion strategies by human cytomegalovirus

scientific article published on December 2012

Endoplasmic reticulum chaperones participate in human cytomegalovirus US2-mediated degradation of class I major histocompatibility complex molecules

scientific article published on May 2008

Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity

scientific article (publication date: 30 March 2017)

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits

scientific article published in September 2001

HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses

scientific article

Human cytomegalovirus US2 endoplasmic reticulum-lumenal domain dictates association with major histocompatibility complex class I in a locus-specific manner

scientific article

Human cytomegalovirus US28 facilitates cell-to-cell viral dissemination

scientific article published on 12 March 2014

Human cytomegalovirus US3 modulates destruction of MHC class I molecules

scientific article

Human cytomegalovirus gH stability and trafficking are regulated by ER-associated degradation and transmembrane architecture

scientific article published on 30 March 2016

Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells

scientific article published on May 2002

Human cytomegalovirus modulates monocyte-mediated innate immune responses during short-term experimental latency in vitro

scientific article

Human cytomegalovirus-encoded immune modulators partner to downregulate major histocompatibility complex class I molecules

scientific article

ISG15 deficiency and increased viral resistance in humans but not mice

scientific article

Immunochemical Analysis Shows All Three Domains of Diphtheria Toxin Penetrate across Model Membranes

scientific article published in Journal of Biological Chemistry

Immunochemical Analysis of the Structure of Diphtheria Toxin Shows All Three Domains Undergo Structural Changes at Low pH

scientific article published in Journal of Biological Chemistry

Membrane-specific, host-derived factors are required for US2- and US11-mediated degradation of major histocompatibility complex class I molecules

scientific article

Method for Efficient Pelleting of Small Unilamellar Model Membrane Vesicles

article

Neutralizing antibodies against previously encountered influenza virus strains increase over time: a longitudinal analysis.

scientific article

Novel class of potential therapeutics that target ricin retrograde translocation

scientific article

Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation

scientific article published on 12 December 2002

Quantifying absolute neutralization titers against SARS-CoV-2 by a standardized virus neutralization assay allows for cross-cohort comparisons of COVID-19 sera

scientific article published on 15 August 2020

Rescue of the 1947 Zika Virus Prototype Strain with a Cytomegalovirus Promoter-Driven cDNA Clone

scientific article (publication date: 28 September 2016)

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

scientific article

Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor

scientific article published on April 2001

Signal peptide peptidase is required for dislocation from the endoplasmic reticulum

scientific article (publication date: 15 June 2006)

TRAM1 is involved in disposal of ER membrane degradation substrates

scientific article

TRAM1 participates in human cytomegalovirus US2- and US11-mediated dislocation of an endoplasmic reticulum membrane glycoprotein

scientific article published on 02 January 2009

Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection

scientific article published on January 2016

Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection

article

The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice

scientific article

The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules

scientific article published on November 2002

Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11.

scientific article

US2, a Human Cytomegalovirus-encoded Type I Membrane Protein, Contains a Non-cleavable Amino-terminal Signal Peptide

scientific article published in Journal of Biological Chemistry

Ubiquitinylation of the cytosolic domain of a type I membrane protein is not required to initiate its dislocation from the endoplasmic reticulum

scientific article published on 27 June 2003

Viral immunoevasive strategies and trophoblast class I major histocompatibility complex antigens

scientific article

Viral subversion of the immune system

scientific article

Virion Glycoprotein-Mediated Immune Evasion by Human Cytomegalovirus: a Sticky Virus Makes a Slick Getaway

scientific article

Virus subversion of immunity: a structural perspective

scientific article

Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein

scientific article published on March 2002

List of works by Domenico Tortorella

A bipartite trigger for dislocation directs the proteasomal degradation of an endoplasmic reticulum membrane glycoprotein

A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised

A structural determinant of human cytomegalovirus US2 dictates the down-regulation of class I major histocompatibility molecules

An Influenza Virus Hemagglutinin-Based Vaccine Platform Enables the Generation of Epitope Specific Human Cytomegalovirus Antibodies

Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2

CD46 facilitates entry and dissemination of human cytomegalovirus.

Cln6 mutants associated with neuronal ceroid lipofuscinosis are degraded in a proteasome-dependent manner

Cotranslational endoplasmic reticulum assembly of FcepsilonRI controls the formation of functional IgE-binding receptors

Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors

Cytomegaloviruses use multiple mechanisms to elude the host immune response

Development of a high-content screen for the identification of inhibitors directed against the early steps of the cytomegalovirus infectious cycle

Development of a high-throughput assay to measure the neutralization capability of anti-cytomegalovirus antibodies

Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH

Dislocation of a type I membrane protein requires interactions between membrane-spanning segments within the lipid bilayer

Dislocation of an endoplasmic reticulum membrane glycoprotein involves the formation of partially dislocated ubiquitinated polypeptides.

Dislocation of ricin toxin A chains in human cells utilizes selective cellular factors

Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential

Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin

Diverse immune evasion strategies by human cytomegalovirus

Endoplasmic reticulum chaperones participate in human cytomegalovirus US2-mediated degradation of class I major histocompatibility complex molecules

Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits

HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses

Human cytomegalovirus US2 endoplasmic reticulum-lumenal domain dictates association with major histocompatibility complex class I in a locus-specific manner

Human cytomegalovirus US28 facilitates cell-to-cell viral dissemination

Human cytomegalovirus US3 modulates destruction of MHC class I molecules

Human cytomegalovirus gH stability and trafficking are regulated by ER-associated degradation and transmembrane architecture

Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells

Human cytomegalovirus modulates monocyte-mediated innate immune responses during short-term experimental latency in vitro

Human cytomegalovirus-encoded immune modulators partner to downregulate major histocompatibility complex class I molecules

ISG15 deficiency and increased viral resistance in humans but not mice

Immunochemical Analysis Shows All Three Domains of Diphtheria Toxin Penetrate across Model Membranes

Immunochemical Analysis of the Structure of Diphtheria Toxin Shows All Three Domains Undergo Structural Changes at Low pH

Membrane-specific, host-derived factors are required for US2- and US11-mediated degradation of major histocompatibility complex class I molecules

Method for Efficient Pelleting of Small Unilamellar Model Membrane Vesicles

Neutralizing antibodies against previously encountered influenza virus strains increase over time: a longitudinal analysis.

Novel class of potential therapeutics that target ricin retrograde translocation

Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation

Quantifying absolute neutralization titers against SARS-CoV-2 by a standardized virus neutralization assay allows for cross-cohort comparisons of COVID-19 sera

Rescue of the 1947 Zika Virus Prototype Strain with a Cytomegalovirus Promoter-Driven cDNA Clone

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor

Signal peptide peptidase is required for dislocation from the endoplasmic reticulum

TRAM1 is involved in disposal of ER membrane degradation substrates

TRAM1 participates in human cytomegalovirus US2- and US11-mediated dislocation of an endoplasmic reticulum membrane glycoprotein

Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection

Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection

The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice

The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules

Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11.

US2, a Human Cytomegalovirus-encoded Type I Membrane Protein, Contains a Non-cleavable Amino-terminal Signal Peptide

Ubiquitinylation of the cytosolic domain of a type I membrane protein is not required to initiate its dislocation from the endoplasmic reticulum

Viral immunoevasive strategies and trophoblast class I major histocompatibility complex antigens

Viral subversion of the immune system

Virion Glycoprotein-Mediated Immune Evasion by Human Cytomegalovirus: a Sticky Virus Makes a Slick Getaway

Virus subversion of immunity: a structural perspective

Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein