List of works - Eric Gouaux

A competitive inhibitor traps LeuT in an open-to-out conformation

scientific article

Antidepressant binding site in a bacterial homologue of neurotransmitter transporters

scientific article

Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX

scientific article

Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter

scientific article

Crystal structure and association behaviour of the GluR2 amino-terminal domain

scientific article

Crystal structure of the ATP-gated P2X(4) ion channel in the closed state

scientific article

Glycine receptor mechanism elucidated by electron cryo-microscopy

scientific article

How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters

scientific article

Insights into transport mechanism from LeuT engineered to transport tryptophan ⬇️

scientific article published on September 27, 2011

Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualate

scientific article

Mechanism of glutamate receptor desensitization

scientific article

Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core

scientific article

Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores

scientific article

Molecular mechanism of ATP binding and ion channel activation in P2X receptors ⬇️

scientific article published on May 10, 2012

NMDA receptor structures reveal subunit arrangement and pore architecture

scientific article

Neurotransmitter and psychostimulant recognition by the dopamine transporter

scientific article

Pore architecture and ion sites in acid-sensing ion channels and P2X receptors

scientific article published on 30 July 2009

Principles of activation and permeation in an anion-selective Cys-loop receptor ⬇️

scientific article published on May 15, 2011

Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal

scientific article (publication date: 13 May 2003)

Structural basis for action by diverse antidepressants on biogenic amine transporters

scientific article

Structural basis for modulation and agonist specificity of HCN pacemaker channels

scientific article

Structural plasticity and dynamic selectivity of acid-sensing ion channel-spider toxin complexes ⬇️

scientific article published on July 29, 2012

Structure and Mechanism of a Na+-Independent Amino Acid Transporter

scientific article

Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH

scientific article

Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context ⬇️

scientific article published on January 15, 2012

Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue ⬇️

scientific article published on July 27, 2012

Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity

scientific article (publication date: 27 February 2003)

Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes ⬇️

scientific article published on May 2, 2003

X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel

scientific article

X-ray structure of dopamine transporter elucidates antidepressant mechanism

scientific article

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

scientific article

X-ray structures define human P2X3 receptor gating cycle and antagonist action

scientific article

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states ⬇️

scientific article published on January 9, 2012

List of works by Eric Gouaux

A competitive inhibitor traps LeuT in an open-to-out conformation

Antidepressant binding site in a bacterial homologue of neurotransmitter transporters

Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX

Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter

Crystal structure and association behaviour of the GluR2 amino-terminal domain

Crystal structure of the ATP-gated P2X(4) ion channel in the closed state

Glycine receptor mechanism elucidated by electron cryo-microscopy

How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters

Insights into transport mechanism from LeuT engineered to transport tryptophan ⬇️

Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualate

Mechanism of glutamate receptor desensitization

Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core

Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores

Molecular mechanism of ATP binding and ion channel activation in P2X receptors ⬇️

NMDA receptor structures reveal subunit arrangement and pore architecture

Neurotransmitter and psychostimulant recognition by the dopamine transporter

Pore architecture and ion sites in acid-sensing ion channels and P2X receptors

Principles of activation and permeation in an anion-selective Cys-loop receptor ⬇️

Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal

Structural basis for action by diverse antidepressants on biogenic amine transporters

Structural basis for modulation and agonist specificity of HCN pacemaker channels

Structural plasticity and dynamic selectivity of acid-sensing ion channel-spider toxin complexes ⬇️

Structure and Mechanism of a Na+-Independent Amino Acid Transporter

Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH

Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context ⬇️

Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue ⬇️

Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity

Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes ⬇️

X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel

X-ray structure of dopamine transporter elucidates antidepressant mechanism

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

X-ray structures define human P2X3 receptor gating cycle and antagonist action

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states ⬇️