List of works - Eric Gouaux

A competitive inhibitor traps LeuT in an open-to-out conformation

scientific article

Aminomethanesulfonic acid illuminates the boundary between full and partial agonists of the pentameric glycine receptor

scientific article published in 2022

Antidepressant binding site in a bacterial homologue of neurotransmitter transporters

scientific article

Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM

scientific article published on 11 April 2019

Autoimmune receptor encephalitis in mice induced by active immunization with conformationally stabilized holoreceptors

scientific article published on 01 July 2019

Chemical and structural investigation of the paroxetine-human serotonin transporter complex

scientific article published on 03 July 2020

Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX

scientific article

Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter

scientific article

Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABA receptor in complex with GABA

scientific article published on 25 July 2018

Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.

scientific article published on 23 February 2017

Crystal structure and association behaviour of the GluR2 amino-terminal domain

scientific article

Crystal structure of the ATP-gated P2X(4) ion channel in the closed state

scientific article

Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography

scientific article published in PLoS ONE

Expression and purification of a functional heteromeric GABAA receptor for structural studies

scientific article published on 20 July 2018

Glycine receptor mechanism elucidated by electron cryo-microscopy

scientific article

How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters

scientific article

Illumination of serotonin transporter mechanism and role of the allosteric site

scientific article published on 01 December 2021

Insights into transport mechanism from LeuT engineered to transport tryptophan ⬇️

scientific article published on September 27, 2011

Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualate

scientific article

Mechanism of glutamate receptor desensitization

scientific article

Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core

scientific article

Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores

scientific article

Molecular mechanism of ATP binding and ion channel activation in P2X receptors ⬇️

scientific article published on May 10, 2012

NMDA receptor structures reveal subunit arrangement and pore architecture

scientific article

Neurotransmitter and psychostimulant recognition by the dopamine transporter

scientific article

Pore architecture and ion sites in acid-sensing ion channels and P2X receptors

scientific article published on 30 July 2009

Principles of activation and permeation in an anion-selective Cys-loop receptor ⬇️

scientific article published on May 15, 2011

Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal

scientific article (publication date: 13 May 2003)

Structural basis for action by diverse antidepressants on biogenic amine transporters

scientific article

Structural basis for modulation and agonist specificity of HCN pacemaker channels

scientific article

Structural plasticity and dynamic selectivity of acid-sensing ion channel-spider toxin complexes ⬇️

scientific article published on July 29, 2012

Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3

scientific article published on 12 February 2019

Structure and Mechanism of a Na+-Independent Amino Acid Transporter

scientific article

Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH

scientific article

Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5

scientific article published on 02 August 2018

Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context ⬇️

scientific article published on January 15, 2012

Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue ⬇️

scientific article published on July 27, 2012

The His-Gly motif of acid-sensing ion channels resides in a reentrant 'loop' implicated in gating and ion selectivity

scientific article published on 04 June 2020

The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter

scientific article

Thermostabilization and purification of the human dopamine transporter (hDAT) in an inhibitor and allosteric ligand bound conformation

scientific article published on 02 July 2018

Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity

scientific article (publication date: 27 February 2003)

Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes ⬇️

scientific article published on May 2, 2003

X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel

scientific article

X-ray structure of dopamine transporter elucidates antidepressant mechanism

scientific article

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

scientific article

X-ray structures define human P2X3 receptor gating cycle and antagonist action

scientific article

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states ⬇️

scientific article published on January 9, 2012

List of works by Eric Gouaux

A competitive inhibitor traps LeuT in an open-to-out conformation

Aminomethanesulfonic acid illuminates the boundary between full and partial agonists of the pentameric glycine receptor

Antidepressant binding site in a bacterial homologue of neurotransmitter transporters

Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM

Autoimmune receptor encephalitis in mice induced by active immunization with conformationally stabilized holoreceptors

Chemical and structural investigation of the paroxetine-human serotonin transporter complex

Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX

Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter

Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABA receptor in complex with GABA

Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.

Crystal structure and association behaviour of the GluR2 amino-terminal domain

Crystal structure of the ATP-gated P2X(4) ion channel in the closed state

Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography

Expression and purification of a functional heteromeric GABAA receptor for structural studies

Glycine receptor mechanism elucidated by electron cryo-microscopy

How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters

Illumination of serotonin transporter mechanism and role of the allosteric site

Insights into transport mechanism from LeuT engineered to transport tryptophan ⬇️

Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualate

Mechanism of glutamate receptor desensitization

Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core

Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores

Molecular mechanism of ATP binding and ion channel activation in P2X receptors ⬇️

NMDA receptor structures reveal subunit arrangement and pore architecture

Neurotransmitter and psychostimulant recognition by the dopamine transporter

Pore architecture and ion sites in acid-sensing ion channels and P2X receptors

Principles of activation and permeation in an anion-selective Cys-loop receptor ⬇️

Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal

Structural basis for action by diverse antidepressants on biogenic amine transporters

Structural basis for modulation and agonist specificity of HCN pacemaker channels

Structural plasticity and dynamic selectivity of acid-sensing ion channel-spider toxin complexes ⬇️

Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3

Structure and Mechanism of a Na+-Independent Amino Acid Transporter

Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH

Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5

Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context ⬇️

Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue ⬇️

The His-Gly motif of acid-sensing ion channels resides in a reentrant 'loop' implicated in gating and ion selectivity

The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter

Thermostabilization and purification of the human dopamine transporter (hDAT) in an inhibitor and allosteric ligand bound conformation

Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity

Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes ⬇️

X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel

X-ray structure of dopamine transporter elucidates antidepressant mechanism

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

X-ray structures define human P2X3 receptor gating cycle and antagonist action

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states ⬇️