List of works - Kaspars Tars

3H-1,2-benzoxathiepine 2,2-dioxides: a new class of isoform-selective carbonic anhydrase inhibitors.

scientific article published in December 2017

5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: solution and X-ray crystallographic studies

scientific article

5-Substituted-benzylsulfanyl-thiophene-2-sulfonamides with effective carbonic anhydrase inhibitory activity: Solution and crystallographic investigations.

scientific article

Alternative mutations of a positively selected residue elicit gain or loss of functionalities in enzyme evolution

scientific article

Assembly of mixed rod-like and spherical particles from group I and II RNA bacteriophage coat proteins.

scientific article

Asymmetric cryo-EM reconstruction of phage MS2 reveals genome structure in situ

scientific article

CntA oxygenase substrate profile comparison and oxygen dependency of TMA production in Providencia rettgeri

scientific article published on 7 November 2017

Complete genome sequence of the Enterobacter cancerogenus bacteriophage Enc34

scientific article published on October 2012

Crystal Structure of the Maturation Protein from Bacteriophage Qβ.

scientific article published on 19 January 2017

Crystal packing of a bacteriophage MS2 coat protein mutant corresponds to octahedral particles

scientific article

Crystal structure of Plasmodium falciparum proplasmepsin IV: the plasticity of proplasmepsins.

scientific article published on 9 August 2016

Crystal structure of human gamma-butyrobetaine hydroxylase

scientific article

Crystal structure of the bacteriophage Qβ coat protein in complex with the RNA operator of the replicase gene

scientific article

Crystal structure of the infectious phenotype-associated outer surface protein BBA66 from the Lyme disease agent Borrelia burgdorferi

scientific article

Crystal structure of the read-through domain from bacteriophage Qβ A1 protein

scientific article

Crystal structures of the Erp protein family members ErpP and ErpC from Borrelia burgdorferi reveal the reason for different affinities for complement regulator factor H

scientific article

Different binding modes of free and carrier-protein-coupled nicotine in a human monoclonal antibody

scientific article

Efficient Expression and Crystallization System of Cancer-Associated Carbonic Anhydrase Isoform IX

scientific article

Eliminating Factor H-Binding Activity of Borrelia burgdorferi CspZ Combined with Virus-Like Particle Conjugation Enhances Its Efficacy as a Lyme Disease Vaccine

scientific article published on 8 February 2018

Expression and purification of active, stabilized trimethyllysine hydroxylase.

scientific article

Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV

scientific article

Genome structure of caulobacter phage phiCb5.

scientific article published on 16 February 2011

Highly efficient production of phosphorylated hepatitis B core particles in yeast Pichia pastoris

article

Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-Nε-trimethyllysine.

scientific article published on 14 December 2016

Investigating the structural basis of purine specificity in the structures of MS2 coat protein RNA translational operator hairpins

scientific article

Is protein deuteration beneficial for proton detected solid-state NMR at and above 100 kHz magic-angle spinning?

scientific article published on 25 July 2017

Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria.

scientific article published on 2 March 2016

Modulating catalytic activity by unnatural amino acid residues in a GSH-binding loop of GST P1-1

scientific article

Molecular basis for regulation of Src by the docking protein p130Cas

scientific article

N-Acylbenzenesulfonamide Dihydro-1,3,4-oxadiazole Hybrids: Seeking Selectivity toward Carbonic Anhydrase Isoforms.

scientific article

N-Substituted and ring opened saccharin derivatives selectively inhibit transmembrane, tumor-associated carbonic anhydrases IX and XII.

scientific article published on 7 April 2017

NMR Spectroscopic Assignment of Backbone and Side-Chain Protons in Fully Protonated Proteins: Microcrystals, Sedimented Assemblies, and Amyloid Fibrils

scientific article published on 16 November 2016

New anticancer drug candidates sulfonamides as selective hCA IX or hCA XII inhibitors

scientific article published on 16 January 2018

Out-and-back 13C-13C scalar transfers in protein resonance assignment by proton-detected solid-state NMR under ultra-fast MAS.

scientific article published on 29 June 2013

PRR1 coat protein binding to its RNA translational operator

scientific article

Plasmepsin Inhibitory Activity and Structure-Guided Optimization of a Potent Hydroxyethylamine-Based Antimalarial Hit

scientific article

Production and characterization of novel ssRNA bacteriophage virus-like particles from metagenomic sequencing data

scientific article published on 13 May 2019

Production and purification of chimeric HBc virus-like particles carrying influenza virus LAH domain as vaccine candidates ⬇️

scientific article published on 10 November 2017

QSAR of multiple mutated antibodies

scientific article

Rapid proton-detected NMR assignment for proteins with fast magic angle spinning

scientific article

Sample preparation induced artifacts in cryo-electron tomographs

scientific article

Structural Analysis of a Glutathione Transferase A1-1 Mutant Tailored for High Catalytic Efficiency with Toxic Alkenals

scientific article

Structural Basis for DNA Recognition of a Single-stranded DNA-binding Protein from Enterobacter Phage Enc34.

scientific article published on 14 November 2017

Structural and functional analysis of BB0689 from Borrelia burgdorferi, a member of the bacterial CAP superfamily

scientific article

Structural basis for featuring of steroid isomerase activity in alpha class glutathione transferases

scientific article

Structural basis of RNA binding discrimination between bacteriophages Qbeta and MS2.

scientific article published in March 2006

Structural basis of the suppressed catalytic activity of wild-type human glutathione transferase T1-1 compared to its W234R mutant

scientific article

Structural characterization of CspZ, a complement regulator factor H and FHL-1 binding protein from Borrelia burgdorferi

scientific article

Structural characterization of the Borrelia burgdorferi outer surface protein BBA73 implicates dimerization as a functional mechanism

scientific article

Structure and Function of CutC Choline Lyase from Human Microbiota Bacterium Klebsiella pneumoniae

scientific article published on 17 July 2015

Structure and stability of icosahedral particles of a covalent coat protein dimer of bacteriophage MS2

scientific article

Structure of AP205 Coat Protein Reveals Circular Permutation in ssRNA Bacteriophages

scientific article

Structure of an outer surface lipoprotein BBA64 from the Lyme disease agent Borrelia burgdorferi which is critical to ensure infection after a tick bite

scientific article

Structure of fully protonated proteins by proton-detected magic-angle spinning NMR

scientific article

Structure of phage fr capsids with a deletion in the FG loop: implications for viral assembly

scientific article

Structure-based redesign of GST A2-2 for enhanced catalytic efficiency with azathioprine

scientific article

Structures of plasmepsin II from Plasmodium falciparum in complex with two hydroxyethylamine-based inhibitors

scientific article published on 27 November 2015

Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases

scientific article

Targeting carnitine biosynthesis: discovery of new inhibitors against γ-butyrobetaine hydroxylase

scientific article

The Three-Dimensional Structure of Bacteriophage PP7 from Pseudomonas aeruginosa at 3.7-Å Resolution

scientific article published on 01 July 2000

The True Story and Advantages of RNA Phage Capsids as Nanotools

scientific article published on 10 November 2016

The capsid of the small RNA phage PRR1 is stabilized by metal ions

scientific article

The crystal structure of bacteriophage GA and a comparison of bacteriophages belonging to the major groups of Escherichia coli leviviruses ⬇️

scientific article published on September 5, 1997

The structure of bacteriophage phiCb5 reveals a role of the RNA genome and metal ions in particle stability and assembly

scientific article

The three-dimensional structure of cocksfoot mottle virus at 2.7 A resolution

scientific article (publication date: 5 June 2003)

The three-dimensional structure of ryegrass mottle virus at 2.9 A resolution

scientific article

Three-dimensional structure of 22 uncultured ssRNA bacteriophages: Flexibility of the coat protein fold and variations in particle shapes

scientific article published on 02 September 2020

X-ray crystallography-promoted drug design of carbonic anhydrase inhibitors

scientific article

Yeast-expressed bacteriophage-like particles for the packaging of nanomaterials.

scientific article published on February 2014

List of works by Kaspars Tars

3H-1,2-benzoxathiepine 2,2-dioxides: a new class of isoform-selective carbonic anhydrase inhibitors.

5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: solution and X-ray crystallographic studies

5-Substituted-benzylsulfanyl-thiophene-2-sulfonamides with effective carbonic anhydrase inhibitory activity: Solution and crystallographic investigations.

Alternative mutations of a positively selected residue elicit gain or loss of functionalities in enzyme evolution

Assembly of mixed rod-like and spherical particles from group I and II RNA bacteriophage coat proteins.

Asymmetric cryo-EM reconstruction of phage MS2 reveals genome structure in situ

CntA oxygenase substrate profile comparison and oxygen dependency of TMA production in Providencia rettgeri

Complete genome sequence of the Enterobacter cancerogenus bacteriophage Enc34

Crystal Structure of the Maturation Protein from Bacteriophage Qβ.

Crystal packing of a bacteriophage MS2 coat protein mutant corresponds to octahedral particles

Crystal structure of Plasmodium falciparum proplasmepsin IV: the plasticity of proplasmepsins.

Crystal structure of human gamma-butyrobetaine hydroxylase

Crystal structure of the bacteriophage Qβ coat protein in complex with the RNA operator of the replicase gene

Crystal structure of the infectious phenotype-associated outer surface protein BBA66 from the Lyme disease agent Borrelia burgdorferi

Crystal structure of the read-through domain from bacteriophage Qβ A1 protein

Crystal structures of the Erp protein family members ErpP and ErpC from Borrelia burgdorferi reveal the reason for different affinities for complement regulator factor H

Different binding modes of free and carrier-protein-coupled nicotine in a human monoclonal antibody

Efficient Expression and Crystallization System of Cancer-Associated Carbonic Anhydrase Isoform IX

Eliminating Factor H-Binding Activity of Borrelia burgdorferi CspZ Combined with Virus-Like Particle Conjugation Enhances Its Efficacy as a Lyme Disease Vaccine

Expression and purification of active, stabilized trimethyllysine hydroxylase.

Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV

Genome structure of caulobacter phage phiCb5.

Highly efficient production of phosphorylated hepatitis B core particles in yeast Pichia pastoris

Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-Nε-trimethyllysine.

Investigating the structural basis of purine specificity in the structures of MS2 coat protein RNA translational operator hairpins

Is protein deuteration beneficial for proton detected solid-state NMR at and above 100 kHz magic-angle spinning?

Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria.

Modulating catalytic activity by unnatural amino acid residues in a GSH-binding loop of GST P1-1

Molecular basis for regulation of Src by the docking protein p130Cas

N-Acylbenzenesulfonamide Dihydro-1,3,4-oxadiazole Hybrids: Seeking Selectivity toward Carbonic Anhydrase Isoforms.

N-Substituted and ring opened saccharin derivatives selectively inhibit transmembrane, tumor-associated carbonic anhydrases IX and XII.

NMR Spectroscopic Assignment of Backbone and Side-Chain Protons in Fully Protonated Proteins: Microcrystals, Sedimented Assemblies, and Amyloid Fibrils

New anticancer drug candidates sulfonamides as selective hCA IX or hCA XII inhibitors

Out-and-back 13C-13C scalar transfers in protein resonance assignment by proton-detected solid-state NMR under ultra-fast MAS.

PRR1 coat protein binding to its RNA translational operator

Plasmepsin Inhibitory Activity and Structure-Guided Optimization of a Potent Hydroxyethylamine-Based Antimalarial Hit

Production and characterization of novel ssRNA bacteriophage virus-like particles from metagenomic sequencing data

Production and purification of chimeric HBc virus-like particles carrying influenza virus LAH domain as vaccine candidates ⬇️

QSAR of multiple mutated antibodies

Rapid proton-detected NMR assignment for proteins with fast magic angle spinning

Sample preparation induced artifacts in cryo-electron tomographs

Structural Analysis of a Glutathione Transferase A1-1 Mutant Tailored for High Catalytic Efficiency with Toxic Alkenals

Structural Basis for DNA Recognition of a Single-stranded DNA-binding Protein from Enterobacter Phage Enc34.

Structural and functional analysis of BB0689 from Borrelia burgdorferi, a member of the bacterial CAP superfamily

Structural basis for featuring of steroid isomerase activity in alpha class glutathione transferases

Structural basis of RNA binding discrimination between bacteriophages Qbeta and MS2.

Structural basis of the suppressed catalytic activity of wild-type human glutathione transferase T1-1 compared to its W234R mutant

Structural characterization of CspZ, a complement regulator factor H and FHL-1 binding protein from Borrelia burgdorferi

Structural characterization of the Borrelia burgdorferi outer surface protein BBA73 implicates dimerization as a functional mechanism

Structure and Function of CutC Choline Lyase from Human Microbiota Bacterium Klebsiella pneumoniae

Structure and stability of icosahedral particles of a covalent coat protein dimer of bacteriophage MS2

Structure of AP205 Coat Protein Reveals Circular Permutation in ssRNA Bacteriophages

Structure of an outer surface lipoprotein BBA64 from the Lyme disease agent Borrelia burgdorferi which is critical to ensure infection after a tick bite

Structure of fully protonated proteins by proton-detected magic-angle spinning NMR

Structure of phage fr capsids with a deletion in the FG loop: implications for viral assembly

Structure-based redesign of GST A2-2 for enhanced catalytic efficiency with azathioprine

Structures of plasmepsin II from Plasmodium falciparum in complex with two hydroxyethylamine-based inhibitors

Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases

Targeting carnitine biosynthesis: discovery of new inhibitors against γ-butyrobetaine hydroxylase

The Three-Dimensional Structure of Bacteriophage PP7 from Pseudomonas aeruginosa at 3.7-Å Resolution

The True Story and Advantages of RNA Phage Capsids as Nanotools

The capsid of the small RNA phage PRR1 is stabilized by metal ions

The crystal structure of bacteriophage GA and a comparison of bacteriophages belonging to the major groups of Escherichia coli leviviruses ⬇️

The structure of bacteriophage phiCb5 reveals a role of the RNA genome and metal ions in particle stability and assembly

The three-dimensional structure of cocksfoot mottle virus at 2.7 A resolution

The three-dimensional structure of ryegrass mottle virus at 2.9 A resolution

Three-dimensional structure of 22 uncultured ssRNA bacteriophages: Flexibility of the coat protein fold and variations in particle shapes

X-ray crystallography-promoted drug design of carbonic anhydrase inhibitors

Yeast-expressed bacteriophage-like particles for the packaging of nanomaterials.