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List of works by Annabelle Varrot

A LecA ligand identified from a galactoside-conjugate array inhibits host cell invasion by Pseudomonas aeruginosa

scientific article

A Lectin from Platypodium elegans with Unusual Specificity and Affinity for Asymmetric Complex N-Glycans

scientific article

A Soluble Fucose-Specific Lectin from Aspergillus fumigatus Conidia - Structure, Specificity and Possible Role in Fungal Pathogenicity

scientific article

A TNF-like trimeric lectin domain from Burkholderia cenocepacia with specificity for fucosylated human histo-blood group antigens

scientific article

A recombinant fungal lectin for labeling truncated glycans on human cancer cells

scientific article published on 4 June 2015

Algal lectin binding to core (α1-6) fucosylated N-glycans: structural basis for specificity and production of recombinant protein

scientific article published on 08 January 2015

An Unusual Mechanism of Glycoside Hydrolysis Involving Redox and Elimination Steps by a Family 4 β-Glycosidase fromThermotoga maritima

article

Anti-biofilm Agents against Pseudomonas aeruginosa: A Structure-Activity Relationship Study of C-Glycosidic LecB Inhibitors

scientific article published on 11 October 2019

Architecture and Evolution of Blade Assembly in β-propeller Lectins

scientific article published on 07 March 2019

Aromatic thioglycoside inhibitors against the virulence factor LecA from Pseudomonas aeruginosa

scientific article

Atomic resolution structure of endoglucanase Cel5A in complex with methyl 4,4II,4III,4IV-tetrathio-α-cellopentoside highlights the alternative binding modes targeted by substrate mimics

BC2L-C N-Terminal Lectin Domain Complexed with Histo Blood Group Oligosaccharides Provides New Structural Information

scientific article published on 07 January 2020

Bacteria love our sugars: Interaction between soluble lectins and human fucosylated glycans, structures, thermodynamics and design of competing glycocompounds

article by Aymeric Audfray et al published May 2013 in Comptes Rendus Chimie

Biochemical and structural characterization of the novel sialic acid-binding site of Escherichia coli heat-labile enterotoxin LT-IIb

scientific article

Biochemical and structural studies of target lectin SapL1 from the emerging opportunistic microfungus Scedosporium apiospermum

scientific article published on 09 August 2021

Biophysical characterization and structural determination of the potent cytotoxic Psathyrella asperospora lectin

scientific article published on 7 February 2017

Carbohydrate binding specificities and crystal structure of the cholera toxin-like B-subunit from Citrobacter freundii

scientific article

Characterization of a high-affinity sialic acid-specific CBM40 from Clostridium perfringens and engineering of a divalent form

scientific article

Characterization of novel lectins from Burkholderia pseudomallei and Chromobacterium violaceum with seven-bladed β-propeller fold

scientific article published on 18 November 2019

Characterization of the ganglioside recognition profile of Escherichia coli heat-labile enterotoxin LT-IIc

scientific article published on 01 April 2022

Cinnamide Derivatives of d-Mannose as Inhibitors of the Bacterial Virulence Factor LecB from Pseudomonas aeruginosa

scientific article

Contact-Killing Polyelectrolyte Microcapsules Based on Chitosan Derivatives

Covalent Lectin Inhibition and Application in Bacterial Biofilm Imaging

scientific article published on 28 September 2017

Covalent Lectin Inhibition and Application in Bacterial Biofilm Imaging

Crystal Structures of Fungal Tectonin in Complex with O-Methylated Glycans Suggest Key Role in Innate Immune Defense

scientific article published in February 2018

Crystal structure of the catalytic core domain of the family 6 cellobiohydrolase II, Cel6A, from Humicola insolens, at 1.92 Å resolution

scientific article published in 1999

Crystallization and preliminary X-ray analysis of the 6-phospho-α-glucosidase from Bacillus subtilis

article

Deciphering the Glycan Preference of Bacterial Lectins by Glycan Array and Molecular Docking with Validation by Microcalorimetry and Crystallography

scientific article

Dimerization of the fungal defense lectin CCL2 is essential for its toxicity against nematodes.

scientific article

Direct experimental observation of the hydrogen-bonding network of a glycosidase along its reaction coordinate revealed by atomic resolution analyses of endoglucanase Cel5A

scientific article (publication date: March 2003)

Direct experimental observation of the hydrogen-bonding network of a glycosidase along its reaction coordinate revealed by atomic resolution analyses of endoglucanase Cel5A

Direct observation of the protonation state of an imino sugar glycosidase inhibitor upon binding

scientific article

Discoidin I from Dictyostelium discoideum and Interactions with Oligosaccharides: Specificity, Affinity, Crystal Structures, and Comparison with Discoidin II

scientific article

Discovery of two classes of potent glycomimetic inhibitors of Pseudomonas aeruginosa LecB with distinct binding modes

scientific article

Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting beta-glucosidases

scientific article (publication date: 21 April 2003)

Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting β-glucosidasesElectronic supplementary information (ESI) available: details of data and structure quality for complex of cel6A with 1. See ht

Effect of Noncanonical Amino Acids on Protein-Carbohydrate Interactions: Structure, Dynamics, and Carbohydrate Affinity of a Lectin Engineered with Fluorinated Tryptophan Analogs

scientific article published on 12 June 2018

Elucidating the glycan-binding specificity and structure of <i>Cucumis melo</i> agglutinin, a new R-type lectin

scientific article published in 2024

Exploiting sp2 -Hybridisation in the Development of Potent 1,5-α-l-Arabinanase Inhibitors

scientific article published on 7 March 2017

Expression, Purification, and Applications of the Recombinant Lectin PVL from Psathyrella velutina Specific for Terminal N-Acetyl-Glucosamine

scientific article published on 01 January 2020

Expression, Purification, and Functional Characterization of Tectonin 2 from Laccaria bicolor: A Six-Bladed Beta-Propeller Lectin Specific for O-Methylated Glycans

scientific article published on 01 January 2020

Fucose-binding Lectin from Opportunistic Pathogen Burkholderia ambifaria Binds to Both Plant and Human Oligosaccharidic Epitopes

scientific article

Fungal lectins: structure, function and potential applications

scientific article published on 03 August 2013

Genomic Rearrangements and Functional Diversification of lecA and lecB Lectin-Coding Regions Impacting the Efficacy of Glycomimetics Directed against Pseudomonas aeruginosa

scientific article published on 31 May 2016

Glycomimetic, orally bioavailable LecB inhibitors block biofilm formation of Pseudomonas aeruginosa.

scientific article published on 22 December 2017

Glycosylated asterisks are among the most potent low valency inducers of Concanavalin A aggregation

scientific article

High Affinity Interaction between a Bivalve C-type Lectin and a Biantennary Complex-type N-Glycan Revealed by Crystallography and Microcalorimetry

scientific article

Histo-blood group antigens as mediators of infections

scientific article

Human Bronchial Epithelial Cells Inhibit Aspergillus fumigatus Germination of Extracellular Conidia via FleA Recognition

scientific article published in Scientific Reports

Induction of rare conformation of oligosaccharide by binding to calcium-dependent bacterial lectin: X-ray crystallography and modelling study

scientific article published on 18 May 2019

Insights into ligand-induced conformational change in Cel5A from Bacillus agaradhaerens revealed by a catalytically active crystal form

scientific article

Lateral Protonation of a Glycosidase Inhibitor. Structure of theBacillusagaradhaerensCel5A in Complex with a Cellobiose-Derived Imidazole at 0.97 Å Resolution

scientific article published in 1999

LecA (PA-IL): A Galactose-Binding Lectin from Pseudomonas aeruginosa

scientific article published on 01 January 2020

LecB, a High Affinity Soluble Fucose-Binding Lectin from Pseudomonas aeruginosa

scientific article published on 01 January 2020

Lectin Binding and its Structural Basis

Mapping the conformational itinerary of beta-glycosidases by X-ray crystallography

scientific article

Membrane deformation by neolectins with engineered glycolipid binding sites

scientific article

Microbial recognition of human cell surface glycoconjugates

scientific article

Mixed-linkage cellooligosaccharides: a new class of glycoside hydrolase inhibitors

scientific article

Molecular Basis of Arabinobio-hydrolase Activity in Phytopathogenic Fungi: CRYSTAL STRUCTURE AND CATALYTIC MECHANISM OF FUSARIUM GRAMINEARUM GH93 EXO- -L-ARABINANASE

scientific article

Monitoring lectin interactions with carbohydrates

scientific article published on January 2014

Multivalent Glycomimetics with Affinity and Selectivity toward Fucose-Binding Receptors from Emerging Pathogens

scientific article

Mycobacterium tuberculosis strains possess functional cellulases

scientific journal article

NAD+ and metal-ion dependent hydrolysis by family 4 glycosidases: structural insight into specificity for phospho-beta-D-glucosides

scientific article

Non-Carbohydrate Glycomimetics as Inhibitors of Calcium(II)-binding Lectins

scientific article published on 13 December 2020

Novel catalytic mechanism of glycoside hydrolysis based on the structure of an NAD+/Mn2+ -dependent phospho-alpha-glucosidase from Bacillus subtilis

scientific article published in September 2004

O-Alkylated heavy atom carbohydrate probes for protein X-ray crystallography: Studies towards the synthesis of methyl 2-O-methyl-L-selenofucopyranoside

scientific article published on 22 December 2016

Recognition of Complex Core-Fucosylated N-Glycans by a Mini Lectin

Recognition of Complex Core-Fucosylated N-Glycans by a Mini Lectin

scientific article published on 18 July 2018

Recombinant Lectin from Tepary Bean (Phaseolus acutifolius) with Specific Recognition for Cancer-Associated Glycans: Production, Structural Characterization, and Target Identification

scientific article published on 23 April 2020

Recombinant fungal lectin as a new tool to investigate O-GlcNAcylation processes

scientific article published on 18 October 2016

Reduction of lectin valency drastically changes glycolipid dynamics in membranes but not surface avidity

scientific article

Role of Water Molecules in Structure and Energetics of Pseudomonas aeruginosa Lectin I Interacting with Disaccharides

scientific article

Secondary sugar binding site identified for LecA lectin from Pseudomonas aeruginosa

scientific article

Snapshots along an enzymatic reaction coordinate: analysis of a retaining beta-glycoside hydrolase

scientific article

Structural basis for ligand binding and processivity in cellobiohydrolase Cel6A from Humicola insolens

scientific article

Structural basis for mannose recognition by a lectin from opportunistic bacteria Burkholderia cenocepacia

scientific article

Structural basis of the affinity for oligomannosides and analogs displayed by BC2L-A, a Burkholderia cenocepacia soluble lectin

scientific article

Structural basis of the preferential binding for globo-series glycosphingolipids displayed by Pseudomonas aeruginosa lectin I

scientific article

Structural changes of the active site tunnel of Humicola insolens cellobiohydrolase, Cel6A, upon oligosaccharide binding

scientific article

Structural insights into Aspergillus fumigatus lectin specificity: AFL binding sites are functionally non-equivalent

scientific article

Structure and RNA recognition by the snRNA and snoRNA transport factor PHAX

scientific article

Structure and engineering of tandem repeat lectins

scientific article published on 13 December 2019

Structure and function of Humicola insolens family 6 cellulases: structure of the endoglucanase, Cel6B, at 1.6 Å resolution

scientific article published in 2000

Structure determination of Discoidin II from Dictyostelium discoideum and carbohydrate binding properties of the lectin domain

scientific article

Structure of the Humicola insolens cellobiohydrolase Cel6A D416A mutant in complex with a non-hydrolysable substrate analogue, methyl cellobiosyl-4-thio-beta-cellobioside, at 1.9 A

scientific article

Structure of the specificity domain of the Dorsal homologue Gambif1 bound to DNA

scientific article

Structure of theHumicola insolenscellobiohydrolase Cel6A D416A mutant in complex with a non-hydrolysable substrate analogue, methyl cellobiosyl-4-thio-β-cellobioside, at 1.9 Å

The Hidden Conformation of Lewis x, a Human Histo-Blood Group Antigen, Is a Determinant for Recognition by Pathogen Lectins

scientific article

The virulence factor LecB varies in clinical isolates: consequences for ligand binding and drug discovery

α-L-Arabinofuranosylated pyrrolidines as arabinanase inhibitors

scientific article

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