List of works - Alexei Savchenko

A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair

scientific article

A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats

scientific article

A pathogen type III effector with a novel E3 ubiquitin ligase architecture

scientific article

A small molecule discrimination map of the antibiotic resistance kinome

scientific article

ADP-dependent 6-Phosphofructokinase from Pyrococcus horikoshii OT3: STRUCTURE DETERMINATION AND BIOCHEMICAL CHARACTERIZATION OF PH1645

scientific article

An extremely SAD case: structure of a putative redox-enzyme maturation protein from Archaeoglobus fulgidus at 3.4 A resolution

scientific article

Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643

scientific article

Biochemical and Structural Studies of Conserved Maf Proteins Revealed Nucleotide Pyrophosphatases with a Preference for Modified Nucleotides

scientific article

Biochemical and Structural Studies of Uncharacterized Protein PA0743 from Pseudomonas aeruginosa Revealed NAD+-dependent L-Serine Dehydrogenase

scientific article

Complete Genome Sequence of Citrobacter rodentium Strain DBS100

scientific article published on 13 June 2019

Conserved protein YecM fromEscherichia coli shows structural homology to metal-binding isomerases and oxygenases

scientific article (publication date: May 2003)

Crystal Structure of Thermotoga maritima 0065, a Member of the IclR Transcriptional Factor Family

scientific article

Crystal Structure of an Integron Gene Cassette-Associated Protein from Vibrio cholerae Identifies a Cationic Drug-Binding Module

scientific article

Crystal complexes of a predicted S-adenosylmethionine-dependent methyltransferase reveal a typical AdoMet binding domain and a substrate recognition domain

scientific article

Crystal structure and molecular modeling study of N-carbamoylsarcosine amidase Ta0454 from Thermoplasma acidophilum

scientific article

Crystal structure of RNase T, an exoribonuclease involved in tRNA maturation and end turnover

scientific article

Crystal structure of a putative isochorismatase hydrolase from Oleispira antarctica

scientific article

Crystal structure of a putative transcriptional regulator SCO0520 from Streptomyces coelicolor A3(2) reveals an unusual dimer among TetR family proteins

scientific article

Crystal structure of secretory protein Hcp3 from Pseudomonas aeruginosa

scientific article

Crystal structures of MTH1187 and its yeast ortholog YBL001c

scientific article

Crystal structures of TM0549 and NE1324--two orthologs of E. coli AHAS isozyme III small regulatory subunit

scientific article

Crystal structures of putative phosphoglycerate kinases from B. anthracis and C. jejuni

scientific article

Data mining crystallization databases: knowledge-based approaches to optimize protein crystal screens

scientific article

Elucidation of the Molecular Basis for Arabinoxylan-Debranching Activity of a Thermostable Family GH62 -L-Arabinofuranosidase from Streptomyces thermoviolaceus

scientific article

Enzyme genomics: Application of general enzymatic screens to discover new enzymes.

scientific article

Function-biased choice of additives for optimization of protein crystallization - the case of the putative thioesterase PA5185 from Pseudomonas aeruginosa PAO1

scientific article

Functional and Structural Characterization of Four Glutaminases from Escherichia coli and Bacillus subtilis †

scientific article

Genome sequence and functional genomic analysis of the oil-degrading bacterium Oleispira antarctica

scientific article

Glyoxylate and pyruvate are antagonistic effectors of the Escherichia coli IclR transcriptional regulator

scientific article

High-throughput crystallization screening.

scientific article

In situ proteolysis for protein crystallization and structure determination

scientific article

Integrating Structure, Bioinformatics, and Enzymology to Discover Function: BioH, A NEW CARBOXYLESTERASE FROM ESCHERICHIA COLI

scientific article (publication date: 11 July 2003)

Methyltransferase That Modifies Guanine 966 of the 16 S rRNA: FUNCTIONAL IDENTIFICATION AND TERTIARY STRUCTURE

scientific article

Molecular basis of the antimutagenic activity of the house-cleaning inosine triphosphate pyrophosphatase RdgB from Escherichia coli

scientific article

Molecular mechanisms of vancomycin resistance

scientific article published on 23 January 2020

Multidrug-Resistant Pandemic (H1N1) 2009 Infection in Immunocompetent Child ⬇️

scientific article published on August 1, 2011

NMR and X-ray crystallography, complementary tools in structural proteomics of small proteins.

scientific article

NleG Type 3 effectors from enterohaemorrhagic Escherichia coli are U-Box E3 ubiquitin ligases

scientific article published in 2010

One-Pot Biocatalytic Transformation of Adipic Acid to 6-Aminocaproic Acid and 1,6-Hexamethylenediamine Using Carboxylic Acid Reductases and Transaminases

scientific article published on 07 January 2020

Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes.

scientific article

Polyphosphate-dependent synthesis of ATP and ADP by the family-2 polyphosphate kinases in bacteria

scientific article

PoxA, YjeK, and Elongation Factor P Coordinately Modulate Virulence and Drug Resistance in Salmonella enterica

scientific article

Protein production and purification

scientific article

Riboneogenesis in Yeast

scientific article

Structural Analysis of HopPmaL Reveals the Presence of a Second Adaptor Domain Common to the HopAB Family of Pseudomonas syringae Type III Effectors

scientific article

Structural Insight into the Mechanism of c-di-GMP Hydrolysis by EAL Domain Phosphodiesterases

scientific article

Structural analysis of a putative aminoglycoside N-acetyltransferase from Bacillus anthracis

scientific article

Structural and Biochemical Characterization of the Type II Fructose-1,6-bisphosphatase GlpX from Escherichia coli

scientific article

Structural and Functional Characterization of DUF1471 Domains of Salmonella Proteins SrfN, YdgH/SssB, and YahO

scientific article

Structural and Functional Survey of Environmental Aminoglycoside Acetyltransferases Reveals Novel Functionality of Resistance Enzymes.

scientific article

Structural and functional insight into the universal stress protein family

scientific article

Structural basis for the evolution of vancomycin resistance D,D-peptidases

scientific article

Structural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteria

scientific article

Structural characterization of Helicobacter pylori dethiobiotin synthetase reveals differences between family members

scientific article

Structural characterization of aminoglycoside 4'-O-adenylyltransferase ANT(4')-IIb from Pseudomonas aeruginosa

scientific article published on 29 January 2020

Structural characterization of the putative ABC-type 2 transporter from Thermotoga maritima MSB8.

scientific article

Structure and Activity of the Metal-independent Fructose-1,6-bisphosphatase YK23 from Saccharomyces cerevisiae

scientific article

Structure and Function of APH(4)-Ia, a Hygromycin B Resistance Enzyme

scientific article

Structure and Protein-Protein Interaction Studies on Chlamydia trachomatis Protein CT670 (YscO Homolog)

scientific article

Structure and activity of the NAD(P)+-dependent succinate semialdehyde dehydrogenase YneI from Salmonella typhimurium

scientific article

Structure and activity of the Pseudomonas aeruginosa hotdog-fold thioesterases PA5202 and PA2801

scientific article

Structure and activity of the Saccharomyces cerevisiae dUTP pyrophosphatase DUT1, an essential housekeeping enzyme

scientific article

Structure and activity of the cold-active and anion-activated carboxyl esterase OLEI01171 from the oil-degrading marine bacterium Oleispira antarctica

scientific article

Structure of Escherichia coli ribose-5-phosphate isomerase: a ubiquitous enzyme of the pentose phosphate pathway and the Calvin cycle

scientific article

Structure of a short-chain dehydrogenase/reductase from Bacillus anthracis

scientific article

Structure of the LdcB LD-Carboxypeptidase Reveals the Molecular Basis of Peptidoglycan Recognition

scientific article

Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases

scientific article

Structure of the full-length Serratia marcescens acetyltransferase AAC(3)-Ia in complex with coenzyme A

scientific article published on 30 January 2020

Structure-Based Mutational Studies of Substrate Inhibition of Betaine Aldehyde Dehydrogenase BetB from Staphylococcus aureus

scientific article

Structure-function analysis identifies highly sensitive strigolactone receptors in Striga

scientific article

Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance

scientific article

Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis.

scientific article published on 9 April 2018

The 2.2 A resolution structure of RpiB/AlsB from Escherichia coli illustrates a new approach to the ribose-5-phosphate isomerase reaction

scientific article

The HD domain of the Escherichia coli tRNA nucleotidyltransferase has 2',3'-cyclic phosphodiesterase, 2'-nucleotidase, and phosphatase activities

scientific article

The Legionella pneumophila effector Ceg4 is a phosphotyrosine phosphatase that attenuates activation of eukaryotic MAPK pathways.

scientific article published on 4 January 2018

The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism

scientific article

The X-ray crystal structure of PA1607 from Pseudomonas aureginosa at 1.9 A resolution--a putative transcription factor

scientific article

The crystal structure of pyrimidine/thiamin biosynthesis precursor-like domain-containing protein CAE31940 from proteobacterium Bordetella bronchiseptica RB50, and evolutionary insight into the NMT1/THI5 family

scientific article

The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor

scientific article

The crystal structure of the AF2331 protein from Archaeoglobus fulgidus DSM 4304 forms an unusual interdigitated dimer with a new type of alpha + beta fold.

scientific article

Thermotoga neapolitana adenylate kinase is highly active at 30 degrees C

scientific article

Toroidal Structure and DNA Cleavage by the CRISPR-Associated [4Fe-4S] Cluster Containing Cas4 Nuclease SSO0001 from Sulfolobus solfataricus

scientific article

Type III effector NleH2 from Escherichia coli O157:H7 str. Sakai features an atypical protein kinase domain

scientific article

X-ray crystal structure of CutA from Thermotoga maritima at 1.4 Å resolution

scientific article

List of works by Alexei Savchenko

A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair

A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats

A pathogen type III effector with a novel E3 ubiquitin ligase architecture

A small molecule discrimination map of the antibiotic resistance kinome

ADP-dependent 6-Phosphofructokinase from Pyrococcus horikoshii OT3: STRUCTURE DETERMINATION AND BIOCHEMICAL CHARACTERIZATION OF PH1645

An extremely SAD case: structure of a putative redox-enzyme maturation protein from Archaeoglobus fulgidus at 3.4 A resolution

Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643

Biochemical and Structural Studies of Conserved Maf Proteins Revealed Nucleotide Pyrophosphatases with a Preference for Modified Nucleotides

Biochemical and Structural Studies of Uncharacterized Protein PA0743 from Pseudomonas aeruginosa Revealed NAD+-dependent L-Serine Dehydrogenase

Complete Genome Sequence of Citrobacter rodentium Strain DBS100

Conserved protein YecM fromEscherichia coli shows structural homology to metal-binding isomerases and oxygenases

Crystal Structure of Thermotoga maritima 0065, a Member of the IclR Transcriptional Factor Family

Crystal Structure of an Integron Gene Cassette-Associated Protein from Vibrio cholerae Identifies a Cationic Drug-Binding Module

Crystal complexes of a predicted S-adenosylmethionine-dependent methyltransferase reveal a typical AdoMet binding domain and a substrate recognition domain

Crystal structure and molecular modeling study of N-carbamoylsarcosine amidase Ta0454 from Thermoplasma acidophilum

Crystal structure of RNase T, an exoribonuclease involved in tRNA maturation and end turnover

Crystal structure of a putative isochorismatase hydrolase from Oleispira antarctica

Crystal structure of a putative transcriptional regulator SCO0520 from Streptomyces coelicolor A3(2) reveals an unusual dimer among TetR family proteins

Crystal structure of secretory protein Hcp3 from Pseudomonas aeruginosa

Crystal structures of MTH1187 and its yeast ortholog YBL001c

Crystal structures of TM0549 and NE1324--two orthologs of E. coli AHAS isozyme III small regulatory subunit

Crystal structures of putative phosphoglycerate kinases from B. anthracis and C. jejuni

Data mining crystallization databases: knowledge-based approaches to optimize protein crystal screens

Elucidation of the Molecular Basis for Arabinoxylan-Debranching Activity of a Thermostable Family GH62 -L-Arabinofuranosidase from Streptomyces thermoviolaceus

Enzyme genomics: Application of general enzymatic screens to discover new enzymes.

Function-biased choice of additives for optimization of protein crystallization - the case of the putative thioesterase PA5185 from Pseudomonas aeruginosa PAO1

Functional and Structural Characterization of Four Glutaminases from Escherichia coli and Bacillus subtilis †

Genome sequence and functional genomic analysis of the oil-degrading bacterium Oleispira antarctica

Glyoxylate and pyruvate are antagonistic effectors of the Escherichia coli IclR transcriptional regulator

High-throughput crystallization screening.

In situ proteolysis for protein crystallization and structure determination

Integrating Structure, Bioinformatics, and Enzymology to Discover Function: BioH, A NEW CARBOXYLESTERASE FROM ESCHERICHIA COLI

Methyltransferase That Modifies Guanine 966 of the 16 S rRNA: FUNCTIONAL IDENTIFICATION AND TERTIARY STRUCTURE

Molecular basis of the antimutagenic activity of the house-cleaning inosine triphosphate pyrophosphatase RdgB from Escherichia coli

Molecular mechanisms of vancomycin resistance

Multidrug-Resistant Pandemic (H1N1) 2009 Infection in Immunocompetent Child ⬇️

NMR and X-ray crystallography, complementary tools in structural proteomics of small proteins.

NleG Type 3 effectors from enterohaemorrhagic Escherichia coli are U-Box E3 ubiquitin ligases

One-Pot Biocatalytic Transformation of Adipic Acid to 6-Aminocaproic Acid and 1,6-Hexamethylenediamine Using Carboxylic Acid Reductases and Transaminases

Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes.

Polyphosphate-dependent synthesis of ATP and ADP by the family-2 polyphosphate kinases in bacteria

PoxA, YjeK, and Elongation Factor P Coordinately Modulate Virulence and Drug Resistance in Salmonella enterica

Protein production and purification

Riboneogenesis in Yeast

Structural Analysis of HopPmaL Reveals the Presence of a Second Adaptor Domain Common to the HopAB Family of Pseudomonas syringae Type III Effectors

Structural Insight into the Mechanism of c-di-GMP Hydrolysis by EAL Domain Phosphodiesterases

Structural analysis of a putative aminoglycoside N-acetyltransferase from Bacillus anthracis

Structural and Biochemical Characterization of the Type II Fructose-1,6-bisphosphatase GlpX from Escherichia coli

Structural and Functional Characterization of DUF1471 Domains of Salmonella Proteins SrfN, YdgH/SssB, and YahO

Structural and Functional Survey of Environmental Aminoglycoside Acetyltransferases Reveals Novel Functionality of Resistance Enzymes.

Structural and functional insight into the universal stress protein family

Structural basis for the evolution of vancomycin resistance D,D-peptidases

Structural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteria

Structural characterization of Helicobacter pylori dethiobiotin synthetase reveals differences between family members

Structural characterization of aminoglycoside 4'-O-adenylyltransferase ANT(4')-IIb from Pseudomonas aeruginosa

Structural characterization of the putative ABC-type 2 transporter from Thermotoga maritima MSB8.

Structure and Activity of the Metal-independent Fructose-1,6-bisphosphatase YK23 from Saccharomyces cerevisiae

Structure and Function of APH(4)-Ia, a Hygromycin B Resistance Enzyme

Structure and Protein-Protein Interaction Studies on Chlamydia trachomatis Protein CT670 (YscO Homolog)

Structure and activity of the NAD(P)+-dependent succinate semialdehyde dehydrogenase YneI from Salmonella typhimurium

Structure and activity of the Pseudomonas aeruginosa hotdog-fold thioesterases PA5202 and PA2801

Structure and activity of the Saccharomyces cerevisiae dUTP pyrophosphatase DUT1, an essential housekeeping enzyme

Structure and activity of the cold-active and anion-activated carboxyl esterase OLEI01171 from the oil-degrading marine bacterium Oleispira antarctica

Structure of Escherichia coli ribose-5-phosphate isomerase: a ubiquitous enzyme of the pentose phosphate pathway and the Calvin cycle

Structure of a short-chain dehydrogenase/reductase from Bacillus anthracis

Structure of the LdcB LD-Carboxypeptidase Reveals the Molecular Basis of Peptidoglycan Recognition

Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases

Structure of the full-length Serratia marcescens acetyltransferase AAC(3)-Ia in complex with coenzyme A

Structure-Based Mutational Studies of Substrate Inhibition of Betaine Aldehyde Dehydrogenase BetB from Staphylococcus aureus

Structure-function analysis identifies highly sensitive strigolactone receptors in Striga

Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance

Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis.

The 2.2 A resolution structure of RpiB/AlsB from Escherichia coli illustrates a new approach to the ribose-5-phosphate isomerase reaction

The HD domain of the Escherichia coli tRNA nucleotidyltransferase has 2',3'-cyclic phosphodiesterase, 2'-nucleotidase, and phosphatase activities

The Legionella pneumophila effector Ceg4 is a phosphotyrosine phosphatase that attenuates activation of eukaryotic MAPK pathways.

The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism

The X-ray crystal structure of PA1607 from Pseudomonas aureginosa at 1.9 A resolution--a putative transcription factor

The crystal structure of pyrimidine/thiamin biosynthesis precursor-like domain-containing protein CAE31940 from proteobacterium Bordetella bronchiseptica RB50, and evolutionary insight into the NMT1/THI5 family

The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor