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List of works by Markku Laakso

35th Annual Meeting of the European Association for the Study of Diabetes

article

35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999

article

40 EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004 ⬇️

article

A 100-kDa urinary protein is associated with insulin resistance in offspring of type 2 diabetic patients

scientific article published on 8 July 2005

A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression

scientific article published in April 2018

A Follow‐Up Study of Age‐Associated Memory Impairment: Neuropsychological Predictors of Dementia ⬇️

scientific article published on September 1, 1995

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

scientific article published on 10 May 2017

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

scientific article

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

scientific article published on 24 March 2017

A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study

scientific article published on 15 November 2017

A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

scientific article

A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism

scientific article published in May 2018

A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus

scientific article

A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study

scientific article published on 26 November 2007

A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell

scientific article published on 16 January 2014

A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis

scientific article

A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes

scientific article published on January 2011

A deletion in the alpha2B-adrenergic receptor gene and autonomic nervous function in central obesity

scientific article published in August 2003

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

scientific article published on 13 May 2012

A genome-wide association search for type 2 diabetes genes in African Americans

scientific article published on 4 January 2012

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

scientific article published on June 2016

A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors

scientific article published on 31 August 2017

A major gene effect on fasting insulin and insulin sensitivity in familial combined hyperlipidemia

scientific article published in October 2001

A mouse model of human hyperinsulinism produced by the E1506K mutation in the sulphonylurea receptor SUR1.

scientific article published on 31 July 2013

A nationwide study on parathyroid carcinoma

scientific article published on 31 March 2017

A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.

scientific article

A novel mutation, Ser143Pro, in the lamin A/C gene is common in finnish patients with familial dilated cardiomyopathy

scientific article

A novel surrogate index for hepatic insulin resistance

scientific article published on 25 November 2010

A post-mortem study of noradrenergic, serotonergic and GABAergic neurons in Alzheimer's disease

scientific article published in March 1988

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

scientific article published on 23 November 2016

APOE-epsilon4 is associated with weight loss in women with AD: a population-based study

scientific article published in March 2001

Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial

scientific article

Acarbose for the prevention of Type 2 diabetes, hypertension and cardiovascular disease in subjects with impaired glucose tolerance: facts and interpretations concerning the critical analysis of the STOP-NIDDM Trial data

scientific article

Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial

scientific article

Acoustic-reflex responses in patients with insulin-dependent diabetes mellitus

scientific article

Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis

scientific article published on 3 December 2009

Acute detachment of hexokinase II from mitochondria modestly increases oxygen consumption of the intact mouse heart

scientific article published on 21 April 2017

Acute insulin response tests for the differential diagnosis of congenital hyperinsulinism

scientific article published in October 2002

Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose

scientific article published on 09 September 2009

Additive effects of the mutations in the beta3-adrenergic receptor and uncoupling protein-1 genes on weight loss and weight maintenance in Finnish women

scientific article published in December 1998

Adenovirus-Mediated Gene Transfer to Lower Limb Artery of Patients with Chronic Critical Leg Ischemia ⬇️

scientific article published on July 1, 1998

Adiponectin gene haplotype is associated with preeclampsia

scientific article published in January 2006

Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes

scientific article

Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss

scientific article published on 7 November 2013

Adipose tissue TCF7L2 splicing is regulated by weight loss and associates with glucose and fatty acid metabolism

scientific article

Adverse effects of obesity on lipid and lipoprotein levels in insulin-dependent and non-insulin-dependent diabetes

scientific article published on 01 February 1990

Age of onset and type of diabetes

scientific article published in March 1985

Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis

scientific article published in September 2004

Aldose reductase gene polymorphisms and peripheral nerve function in patients with type 2 diabetes

scientific article

Aldose reductase gene polymorphisms and susceptibility to microvascular complications in Type 2 diabetes

scientific article

Alpha-synuclein pathology is highly dependent on the case selection

scientific article published in August 2001

Amino acid substitutions in hexokinase II among patients with NIDDM.

scientific article published on March 1995

An SNP in the adiponectin gene is associated with decreased serum adiponectin levels and risk for impaired glucose tolerance

scientific article published in May 2005

An association between a subset of Finnish late-onset Alzheimer's disease and alpha2-macroglobulin

scientific article

Analysis of protein-coding genetic variation in 60,706 humans

scientific article (publication date: 17 August 2016)

Antihypertensive drugs as predictors of type 2 diabetes among subjects with impaired glucose tolerance

scientific article published in December 2000

Antiplatelet therapy is effective in the prevention of stroke or death in women: subgroup analysis of the European Stroke Prevention Study (ESPS)

scientific article published on 01 October 1991

Antiplatelet treatment in elderly people with transient ischaemic attacks or ischaemic strokes

scientific article published on January 1995

Apolipoprotein E gene promoter (-219G/T) polymorphism is associated with premature coronary heart disease

scientific article published on 25 July 2001

Apolipoprotein E4 Phenotype Is Not an Important Risk Factor for Coronary Heart Disease or Stroke in Elderly Subjects ⬇️

scientific article published on September 1, 1995

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

scientific article (publication date: November 2010)

Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion

scientific article published on 20 January 2015

Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population

scientific article published on 21 September 2006

Association between Chlamydia pneumoniae antibodies and intimal calcification in femoral arteries of nondiabetic patients

scientific article published on March 2002

Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention Study

scientific article

Association between features of the insulin resistance syndrome and alzheimer's disease independently of apolipoprotein e4 phenotype: cross sectional population based study ⬇️

scientific article published on October 25, 1997

Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.

scientific article published on 05 June 2009

Association of C-reactive protein, interleukin-1 receptor antagonist and adiponectin with the metabolic syndrome

scientific article

Association of Chlamydia pneumoniae and acute coronary heart disease events in non-insulin dependent diabetic and non-diabetic subjects in Finland

scientific article published on May 1996

Association of Common Genetic Variation in The FOXO1 Gene with β-Cell Dysfunction, Impaired Glucose Tolerance, And Type 2 Diabetes

scientific article published in February 2009

Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels

Association of adiponectin level and variants in the adiponectin gene with glucose metabolism, energy expenditure, and cytokines in offspring of type 2 diabetic patients

scientific article published on 26 April 2005

Association of angiotensin converting enzyme and plasminogen activator inhibitor-1 promoter gene polymorphisms with features of the insulin resistance syndrome in patients with premature coronary heart disease

scientific article

Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes

scientific article published on 13 January 2009

Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes.

scientific article

Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men.

scientific article published on 12 December 2010

Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men.

scientific article published on 04 April 2013

Association of leucine 7 to proline 7 polymorphism in the preproneuropeptide Y with serum lipids in patients with coronary heart disease

scientific article published in March 2002

Association of metabolic syndrome with Alzheimer disease: a population-based study

scientific article published in September 2006

Association of obesity and distribution of obesity with glucose tolerance and cardiovascular risk factors in the elderly

scientific article published on 01 September 1992

Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes ⬇️

scientific article published on July 29, 2013

Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study

scientific article published on 25 May 2006

Association of serum lipids and lipoproteins with plasma C-peptide concentration in non-insulin-dependent diabetic and non-diabetic subjects

scientific article published on 01 September 1987

Association of the Leu72Met polymorphism of the ghrelin gene with the risk of Type 2 diabetes in subjects with impaired glucose tolerance in the Finnish Diabetes Prevention Study

scientific article published in June 2006

Association of the PRO12ALA polymorphism of the PPAR-gamma2 gene with oxidized low-density lipoprotein and cardiolipin autoantibodies in nondiabetic and type 2 diabetic subjects

scientific article published in February 2003

Association of the Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study

scientific article published in August 2002

Associations between two single nucleotide polymorphisms in the adiponectin gene and polycystic ovary syndrome

scientific article published in September 2005

Associations of blood pressure with carotid intima-media thickness in elderly Finns with diabetes mellitus or impaired glucose tolerance ⬇️

scientific article published on October 1, 2003

Associations of multiple lipoprotein and apolipoprotein measures with worsening of glycemia and incident type 2 diabetes in 6607 non-diabetic Finnish men.

scientific article published on 23 March 2015

Astrogliosis and the ApoE genotype. an immunohistochemical study of postmortem human brain tissue

scientific article

Asymptomatic atherosclerosis and insulin resistance

scientific article published in July 1991

Asymptomatic hyperglycemia and atherosclerotic vascular disease in the elderly

scientific article published on 01 August 1992

Asymptomatic hyperglycemia and cardiovascular risk factors in the elderly

scientific article published on 01 June 1991

Atherosclerosis and cardiovascular risk reduction with PPAR agonists

scientific article published on October 2007

Atherosclerotic Vascular Disease and Its Risk Factors in Non-Insulin-Dependent Diabetic and Nondiabetic Subjects in Finland ⬇️

scientific article published on 01 June 1988

Atherosclerotic vascular disease in middle-aged, insulin-treated, diabetic patients. Association with endogenous insulin secretion capacity

scientific article published on 01 May 1988

Auditory brainstem latencies in type I (insulin-dependent) diabetic patients

scientific article published in November 1993

Author Correction: Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS

scientific article published in Nature Communications

Author Correction: Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition

article

Autoantibodies against oxidized LDL are associated with severe chest pain attacks in patients with coronary heart disease

scientific article

Autonomic nervous function and its relationship to cardiac performance in middle-aged diabetic patients without clinically evident cardiovascular disease ⬇️

scientific article published on 01 July 1992

Autosomal dominant diabetes arising from a Wolfram syndrome 1 mutation

scientific article published on 31 July 2013

Baroreflex sensitivity in essential and secondary hypertension

scientific article published in December 2002

Blood pressure and atherosclerotic plaques in carotid, aortic and femoral arteries in elderly Finns with diabetes mellitus or impaired glucose tolerance

scientific article published in January 2005

Both fasting and glucose-stimulated proinsulin levels predict hyperglycemia and incident type 2 diabetes: a population-based study of 9,396 Finnish men

scientific article

Cardiac adrenergic activity is associated with left ventricular hypertrophy in genetically homogeneous subjects with hypertrophic cardiomyopathy

scientific article published in April 2003

Cardiac adrenergic innervation is affected in asymptomatic subjects with very early stage of coronary artery disease

scientific article published in January 2002

Cardiovascular disease risk factors as predictors of type 2 (non-insulin-dependent) diabetes mellitus in elderly subjects

scientific article published in June 1993

Cardiovascular risk factors associated with insulin resistance cluster in families with early-onset coronary heart disease

scientific article

Cardiovascular risk factors clustering with endogenous hyperinsulinaemia predict death from coronary heart disease in patients with Type II diabetes

scientific article published in February 2000

Carriers of an Inactivating β-Cell ATP-Sensitive K+ Channel Mutation Have Normal Glucose Tolerance and Insulin Sensitivity and Appropriate Insulin Secretion ⬇️

scientific article published on January 1, 2002

Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty

scientific article published in January 2000

Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects

scientific article published on 2 December 2009

Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men

scientific article published on 17 February 2009

Changes in the prevalence and incidence of diabetes mellitus in Finnish adults, 1970-1987.

scientific article published in May 1991

Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population

scientific article published on 9 January 2003

Chlorpropamide-alcohol flushing and coronary heart disease in non-insulin dependent diabetics

scientific article

Cholinergic deficit in Alzheimer's disease: A study based on CSF and autopsy data ⬇️

scientific article published on February 1, 1988

Chromium supplementation in impaired glucose tolerance of elderly: effects on blood glucose, plasma insulin, C-peptide and lipid levels

scientific article published on 01 July 1992

Cine MR imaging of myocardial contractile impairment in patients with hypertrophic cardiomyopathy attributable to Asp175Asn mutation in the alpha-tropomyosin gene

scientific article published on 12 July 2005

Circulating RNAs as predictive markers for the progression of type 2 diabetes

Circulating metabolite predictors of glycemia in middle-aged men and women

scientific article

Clinical characteristics in the discrimination between patients with low or high C-peptide level among middle-aged insulin-treated diabetics

scientific article published in February 1987

Clinical, Genetic, and Biochemical Characteristics of Early-Onset Diabetes in the Finnish Population

scientific article

Codon 54 polymorphism of the human intestinal fatty acid binding protein 2 gene is associated with dyslipidemias but not with insulin resistance in patients with familial combined hyperlipidemia

scientific article published in June 1997

Cognitive Function in an Elderly Population With Persistent Impaired Glucose Tolerance ⬇️

scientific article published on March 1, 1998

Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q

scientific article

Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response

scientific article published on 20 May 2009

Common polymorphisms (single-nucleotide polymorphisms SNP+45 and SNP+276) of the adiponectin gene regulate serum adiponectin concentrations and blood pressure in young Finnish men.

scientific article published on 26 October 2005

Common polymorphisms in the PPARgamma2 and IRS-1 genes and their interaction influence serum adiponectin concentration in young Finnish men.

scientific article published on 25 January 2005

Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes. The Finnish Diabetes Prevention Study

scientific article

Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial

scientific article published on 8 December 2004

Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects

scientific article published on 14 August 2009

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

scientific article

Common variants associated with plasma triglycerides and risk for coronary artery disease

scientific article

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways ⬇️

scientific article

Common variants at 30 loci contribute to polygenic dyslipidemia

scientific article

Common variants in beta2- and beta3-adrenergic receptor genes and uncoupling protein 1 as predictors of the risk for type 2 diabetes and body weight changes. The Finnish Diabetes Prevention Study

scientific article published in October 2004

Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study

scientific article published on 30 October 2017

Congenital hyperinsulinism

scientific article published in January 2005

Conjugated bile acids associate with altered rates of glucose and lipid oxidation after Roux-en-Y gastric bypass

scientific article published on September 2012

Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice

scientific article published on June 2012

Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

scientific article published on 23 August 2017

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

Corrigendum: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

scholarly article published in Nature Genetics

Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance

scientific article

Decreased muscarinic receptor binding in cerebral cortex and hippocampus in Alzheimer's disease

scientific article

Decreased plasma C-reactive protein levels in 4 allele carriers

Decreased plasma β-amyloid in the Alzheimer's disease APP A673T variant carriers

scientific article published on 26 May 2017

Defects in insulin secretion and insulin action in non-insulin-dependent diabetes mellitus are inherited. Metabolic studies on offspring of diabetic probands ⬇️

scientific article published on January 1, 1998

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Demonstration of disturbed free fatty acid metabolism of myocardium in patients with non-insulin-dependent diabetes mellitus as measured with iodine-123-heptadecanoic acid

scientific article published on 01 January 1991

Desmosterol in human nonalcoholic steatohepatitis

scientific article published on 29 July 2013

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans

scientific article

Detection of Novel Gene Variants Associated with Congenital Hypothyroidism in a Finnish Patient Cohort

scientific article published on 02 July 2016

Determination of C-peptide in the choice of treatment for diabetics

scientific article published on 01 January 1983

Diabetes Secondary to Treatment with Statins

scientific article published on February 2017

Diabetes and atherosclerosis: an epidemiologic view

scientific article

Diabetes mellitus and brain atrophy: a computed tomography study in an elderly population

scientific article published on November 1, 1992

Dietary fat in relation to erythrocyte fatty acid composition in men

scientific article published on 24 August 2013

Dietary fat predicts coronary heart disease events in subjects with type 2 diabetes

scientific article published on March 2003

Dietary polyunsaturated fatty acids and the Pro12Ala polymorphisms of PPARG regulate serum lipids through divergent pathways: a randomized crossover clinical trial

scientific article published on 7 October 2015

Different regulation of free fatty acid levels and glucose oxidation by the Trp64Arg polymorphism of the beta3-adrenergic receptor gene and the promoter variant (A-3826G) of the uncoupling protein 1 gene in familial combined hyperlipidemia

scientific article published in November 1998

Differential Associations of Inflammatory Markers With Insulin Sensitivity and Secretion: The Prospective METSIM Study

scientific article published on September 2017

Directional dominance on stature and cognition in diverse human populations

scientific article published in July 2015

Discovery and refinement of loci associated with lipid levels

scientific article

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium

scientific article

Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis

scientific article published on 28 April 2011

Distinct metabolic and vascular effects of dietary triglycerides and cholesterol in atherosclerotic and diabetic mouse models

scientific article

Distribution and medical impact of loss-of-function variants in the Finnish founder population

scientific article

Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1.

scientific article published on October 2000

Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance

scientific article published in February 2008

Dyslipidemia and Hyperglycemia Predict Coronary Heart Disease Events in Middle-Aged Patients With NIDDM ⬇️

scientific article published on August 1, 1997

ERPs reveal deficits in automatic cerebral stimulus processing in patients with NIDDM.

scientific article

Early abnormalities in coronary heart disease risk factors in relatives of subjects with non-insulin-dependent diabetes

scientific article published on 01 June 1992

Early familial dilated cardiomyopathy: identification with determination of disease state parameter from cine MR image data

scientific article

Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial

scientific article published on May 2009

Effect of genotype on success of lifestyle intervention in subjects at risk for type 2 diabetes

scientific article published on 13 December 2006

Effect of nateglinide on the incidence of diabetes and cardiovascular events

scientific article published on 14 March 2010

Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial

scientific article

Effect of the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor (PPAR) gamma2 gene on the expression of PPARgamma target genes in adipose tissue of massively obese subjects

scientific article published in April 2003

Effect of the Pro12Ala polymorphism of the PPAR-gamma2 gene on long-term weight change in Finnish non-diabetic subjects

scientific article

Effect of the interleukin-6 (-174) g/c promoter polymorphism on adiponectin and insulin sensitivity

scientific article published in May 2005

Effect of valsartan on the incidence of diabetes and cardiovascular events

scientific article

Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men.

scientific article published on 18 March 2011

Effects of a very-low-calorie diet on metabolic control and cardiovascular risk factors in the treatment of obese non-insulin-dependent diabetics

scientific article published in May 1990

Effects of bezafibrate on insulin sensitivity and glucose tolerance in subjects with combined hyperlipidemia

scientific article published on December 1, 1992

Effects of epinephrine on insulin-mediated glucose uptake in whole body and leg muscle in humans: role of blood flow

scientific article published on 01 August 1992

Effects of euglycaemic and hypoglycaemic hyperinsulinaemia on sympathetic and parasympathetic regulation of haemodynamics in healthy subjects

scientific article published in September 2003

Effects of hypocaloric diet and insulin therapy on metabolic control and mechanisms of hyperglycemia in obese non-insulin-dependent diabetic subjects

scientific article published on November 1988

Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial

scientific article published on 26 November 2005

Effects of losartan on insulin sensitivity in hypertensive subjects

scientific article published on 01 September 1996

Efficient estimation and applications of cross-validated genetic predictions

Electrocardiographic alterations during hyperinsulinemic hypoglycemia in healthy subjects.

scientific article published on April 2008

Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes

scientific article

Elevated plasma homocysteine level is an independent predictor of coronary heart disease events in patients with type 2 diabetes mellitus

scientific article published in January 2004

Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism

scientific article

Eosinophilic fasciitis

scientific article published on 01 January 1987

Epidemiological evidence for the association of hyperglycaemia and atherosclerotic vascular disease in non-insulin-dependent diabetes mellitus

scientific article

Epigenetic regulation of glucose-stimulated osteopontin (OPN) expression in diabetic kidney

scientific article published on 21 November 2015

Epigenetic regulation of the thioredoxin-interacting protein (TXNIP) gene by hyperglycemia in kidney

scientific article published on February 2016

Epigenome-wide association in adipose tissue from the METSIM cohort

scientific article published on 16 March 2018

Epigenome-wide association in adipose tissue from the METSIM cohort.

scientific article published in July 2018

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

scientific article

Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article published in November 2011

Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article published in May 2010

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 23 January 2018

Essential hypertension and cognitive function. The role of hyperinsulinemia

scientific article

Essential hypertension and insulin resistance in non-insulin-dependent diabetes

scientific article published on 01 December 1989

European Stroke Prevention Study (ESPS): antithrombotic therapy is also effective in the elderly

scientific article published on 01 February 1993

European stroke prevention study: effectiveness of antiplatelet therapy in diabetic patients in secondary prevention of stroke

scientific article published on 01 June 1992

Evaluation of Heart Size and Pulmonary Vasculature

Evaluation of heart size and pulmonary vasculature. Conventional chest roentgenography and image intensifier photofluorography compared

scientific article published on May 1, 1991

Evidence for physiological coupling of insulin-mediated glucose metabolism and limb blood flow

scientific article published in December 2000

Evidence of how rs7575840 influences apolipoprotein B-containing lipid particles

scientific article

Exercise during military training improves cardiovascular risk factors in young men ⬇️

scientific article published on February 24, 2011

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

scientific article

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

article by Jason Flannick et al published 22 May 2019 in Nature

Exome-wide association study of plasma lipids in >300,000 individuals

scientific article published on 30 October 2017

Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis

scientific article

Factors associated with fasting and postglucagon plasma C-peptide levels in middle-aged insulin-treated diabetic patients

scientific article published in February 1989

Familial aggregation of non-insulin dependent diabetes and coronary heart disease are accompanied by different effects on serum lipids, lipoproteins and apolipoproteins

scientific article published in January 1991

Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).

scientific article published on 29 February 2004

Family history of coronary heart disease is a stronger predictor of coronary heart disease morbidity and mortality than family history of non-insulin dependent diabetes mellitus

scientific article published on June 1996

Family-specific aggregation of lipid GWAS variants confers the susceptibility to familial hypercholesterolemia in a large Austrian family

scientific article published on 22 July 2017

Fasting and OGTT-derived measures of insulin resistance as compared with the euglycemic-hyperinsulinemic clamp in nondiabetic Finnish offspring of type 2 diabetic individuals

scientific article published on 11 November 2014

Fasting, postprandial and postprandial plus glucagon-stimulated plasma C-peptide levels in non-insulin-dependent diabetics and in control subjects.

scientific article published in January 1987

Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity

scientific article

Femoral atherosclerosis in middle-aged subjects: association with cardiovascular risk factors and insulin resistance

scientific article published in October 1996

Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability

scientific article

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Finnish Diabetes Risk Score Is Associated with Impaired Insulin Secretion and Insulin Sensitivity, Drug-Treated Hypertension and Cardiovascular Disease: A Follow-Up Study of the METSIM Cohort

scientific article

First-pass MR imaging in the assessment of perfusion impairment in patients with hypertrophic cardiomyopathy and the Asp175Asn mutation of the alpha-tropomyosin gene

scientific article

Fragile-X: neuropsychological test performance, CGG triplet repeat lengths, and hippocampal volumes

scientific article published on July 1997

Frontal dysfunction blocks the therapeutic effect of THA on attention in Alzheimer's disease

scientific article published in May 1997

Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia

scientific article published in Scientific Reports

Functional consequences of naturally occurring variants of human hexokinase II ⬇️

scientific article published on October 1, 1998

G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia

scientific article

Galanin preproprotein is associated with elevated plasma triglycerides

scientific article

Gastrointestinal symptoms in middle-aged diabetic patients

scientific article published on 01 May 1993

Gender difference in the impact of type 2 diabetes on coronary heart disease risk

scientific article published in December 2004

Gender differences in C-reactive protein, interleukin-1 receptor antagonist and adiponectin levels in the metabolic syndrome: a population-based study

scientific article published on 23 April 2008

Gender differences relating to metabolic syndrome and proinflammation in Finnish subjects with elevated blood pressure ⬇️

scientific article published on 20 August 2009

Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease.

scientific article

Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes

scientific article

Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry

scientific article

Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits

scientific article

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Genetic basis and outcome in a nationwide study of Finnish patients with hypertrophic cardiomyopathy

Genetic evidence of assortative mating in humans

article

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

scientific article published on 18 November 2009

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

scientific article

Genetic influences contributing to LDL particle size in familial combined hyperlipidaemia

scientific article published in September 2002

Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits

scientific article published on 04 April 2013

Genetic risk scores in the prediction of plasma glucose, impaired insulin secretion, insulin resistance and incident type 2 diabetes in the METSIM study

scientific article published in June 2017

Genetic screening for the risk of type 2 diabetes: worthless or valuable?

scientific article

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetic study between SIRT1, PPARD, PGC-1alpha genes and Alzheimer's disease

scientific article published on 30 April 2008

Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes

scientific article published on February 2013

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

scientific article published on 6 October 2011

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

scientific journal article

Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: The Finnish Diabetes Prevention Study

scientific article published in October 2005

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

scientific article published on 26 June 2011

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Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

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Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci

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Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

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Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

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Genome-wide association study identifies eight loci associated with blood pressure

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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

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Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.

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Glycated hemoglobin levels are mostly dependent on nonglycemic parameters in 9398 Finnish men without diabetes

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Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men

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Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: full text: The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD)

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Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offspring of patients with type 2 diabetes

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Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance

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Heterozygous RFX6 protein truncating variants cause Maturity-Onset Diabetes of the Young (MODY) with reduced penetrance

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Hexokinase II partial knockout impairs exercise-stimulated glucose uptake in oxidative muscles of mice

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Hexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes

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High amount of visceral fat mass is associated with multiple metabolic changes in offspring of type 2 diabetic patients

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High circulating levels of RBP4 and mRNA levels of aP2, PGC-1alpha and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naïve type 2 diabetic subjects

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High fasting plasma insulin is an indicator of coronary heart disease in non-insulin-dependent diabetic patients and nondiabetic subjects

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High plasma insulin level associated with coronary heart disease in the elderly

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High serum levels of advanced glycation end products predict increased coronary heart disease mortality in nondiabetic women but not in nondiabetic men: a population-based 18-year follow-up study

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High-density lipoprotein-cholesterol and not HbA1c was directly related to cardiovascular outcome in PROactive ⬇️

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High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status

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Human hexokinase II: sequence and homology to other hexokinases

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Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men

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Hyperinsulinemia predicts multiple atherogenic changes in lipoproteins in elderly subjects

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Hyperproinsulinemia is not a characteristic feature in the offspring of patients with different phenotypes of type II diabetes

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Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene

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Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study

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Imaging diagnostics in early dementia

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Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity

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Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance

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Impaired free fatty acid suppression during hyperinsulinemia is a characteristic finding in familial combined hyperlipidemia, but insulin resistance is observed only in hypertriglyceridemic patients.

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Impaired left ventricular systolic function during exercise in middle-aged insulin-dependent and noninsulin-dependent diabetic subjects without clinically evident cardiovascular disease

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Improvement of metabolic control does not normalize auditory brainstem latencies in subjects with insulin-dependent diabetes mellitus ⬇️

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Increased serum levels of advanced glycation endproducts predict total, cardiovascular and coronary mortality in women with type 2 diabetes: a population-based 18 year follow-up study

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K121Q PC‐1 Gene Polymorphism Is Not Associated with Insulin Resistance in a Spanish Population ⬇️

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Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans

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Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

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Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

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Markers of tissue-specific insulin resistance predict the worsening of hyperglycemia, incident type 2 diabetes and cardiovascular disease

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Metabolic defects in persistent impaired glucose tolerance are related to the family history of non—insulin-dependent diabetes mellitus ⬇️

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Mice with targeted disruption of spermidine/spermine N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging

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Molecular Characterization of the Lipid Genome-Wide Association Study Signal on Chromosome 18q11.2 Implicates HNF4A-Mediated Regulation of the TMEM241 Gene

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Mortality from Coronary Heart Disease in Subjects with Type 2 Diabetes and in Nondiabetic Subjects with and without Prior Myocardial Infarction ⬇️

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Mouse hexokinase II gene: structure, cDNA, promoter analysis, and expression pattern

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Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

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Myocardial late gadolinium enhancement is associated with raised serum amino-terminal propeptide of type III collagen concentrations in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha tropomyosin gene: m

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New variants in the glycogen synthase gene (Gln71His, Met416Val) in patients with NIDDM from eastern Finland.

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Non-cholesterol sterol levels predict hyperglycemia and conversion to type 2 diabetes in Finnish men

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Oxidised LDL and progression of atherosclerosis

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PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease

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Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

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Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

erratum

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

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Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

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Risk factors predicting lower extremity amputations in patients with NIDDM.

scientific article published in June 1996

Role of osteopontin and its regulation in pancreatic islet

scientific article published on 24 November 2017

SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity

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SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome

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SNPs in PPARG associate with type 2 diabetes and interact with physical activity

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SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function

scientific article published on 5 December 2016

Safety and Feasibility of Catheter-Based Local Intracoronary Vascular Endothelial Growth Factor Gene Transfer in the Prevention of Postangioplasty and In-Stent Restenosis and in the Treatment of Chronic Myocardial Ischemia ⬇️

scientific article published on May 12, 2003

Screening for Down syndrome in the fetus using maternal blood samples

scientific article published on 01 January 1990

Second European Stroke Prevention Study: antiplatelet therapy is effective regardless of age. ESPS2 Working Group

scientific article

Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial

scientific article (publication date: 8 October 2005)

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 19 December 2017

Serine/threonine protein kinase 25 (STK25): a novel negative regulator of lipid and glucose metabolism in rodent and human skeletal muscle ⬇️

scientific article published on March 4, 2012

Serum homocysteine, creatinine, and glucose as predictors of the severity and extent of coronary artery disease in asymptomatic members of high-risk families

scientific article published in July 2002

Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans.

scientific article

Serum lipids and lipoproteins in middle-aged non-insulin-dependent diabetics

scientific article published on 01 September 1985

Serum lipids, lipoproteins, and apolipoproteins and the excessive occurrence of coronary heart disease in non-insulin-dependent diabetic patients

scientific article published on 01 October 1989

Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects

scientific article published in October 1995

Serum zinc level and coronary heart disease events in patients with type 2 diabetes

scientific article published in March 2007

Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation

scientific article

Severity of hippocampal atrophy correlates with the prolongation of MRI T2 relaxation time in temporal lobe epilepsy but not in Alzheimer's disease

scientific article published in June 1996

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

scientific article

Short Adult Stature Predicts Impaired β-Cell Function, Insulin Resistance, Glycemia, and Type 2 Diabetes in Finnish Men.

scientific article

Similarity of the impact of type 1 and type 2 diabetes on cardiovascular mortality in middle-aged subjects

scientific article

Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells

scientific article published on 11 November 2015

Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake

scientific article published in December 2005

Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial

scientific article published in July 2006

Single nucleotide polymorphisms of the HNF4alpha gene are associated with the conversion to type 2 diabetes mellitus: the STOP-NIDDM trial

scientific article published on 13 July 2006

Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans

scientific article

Single nucleotide polymorphisms of the melanocortin-3 receptor gene are associated with substrate oxidation and first-phase insulin secretion in offspring of type 2 diabetic subjects

scientific article published on 27 December 2006

Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance

scientific article

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

scientific article

Smoking is independently associated with high plasma insulin levels in nondiabetic men.

scientific article published in November 1996

Somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with Parkinson's disease and its relation to dementia

scientific article

Sotalol, prolonged Q-T interval, and ventricular tachyarrhythmias

scientific article published on 01 December 1981

Stability of age-associated memory impairment during a longitudinal population-based study

scientific article published in January 1997

Status of the DELPHI vertex detector: Alignment methods and geometrical resolution

Stopping insulin treatment in middle-aged diabetic patients with high postglucagon plasma C-peptide. Effect on glycaemic control, serum lipids and lipoproteins

scientific article published in January 1988

Structure and costs of health care of diabetic patients in Finland

scientific article published in May 1996

Structure of the human hexokinase II gene

scientific article published on November 1994

Subjective memory complaints and personality traits in normal elderly subjects

scientific article published on January 1994

Subtle hyperproinsulinaemia characterises the defective insulin secretory capacity in offspring of glutamic acid decarboxylase antibody-positive patients with latent autoimmune diabetes mellitus in adults

scientific article published in August 2005

Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on basal metabolic rate in obese Finns

scientific article published in March 1998

Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans

article

THA disrupts mismatch negativity in Alzheimer disease

scientific article published in September 1997

Tetrahydroaminoacridine improves the recency effect in Alzheimer's disease

scientific article published in March 1998

The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels

scientific article published on 10 August 2009

The Adipocyte-Expressed Forkhead Transcription Factor Foxc2 Regulates Metabolism Through Altered Mitochondrial Function ⬇️

scientific article published on February 1, 2011

The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity

scientific article published in February 2003

The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects

scientific article

The D299G/T399I Toll-like receptor 4 variant associates with body and liver fat: results from the TULIP and METSIM Studies

scientific article

The European Stroke Prevention Study (ESPS): results by arterial distribution

scientific article published on 01 June 1991

The European Stroke Prevention Study: Results according to sex ⬇️

scientific article published on 01 August 1991

The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study

scientific article

The G-250A substitution in the promoter region of the hepatic lipase gene is associated with the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial

scientific article published in February 2005

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

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The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia

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The Leu7Pro polymorphism of the neuropeptide Y gene regulates free fatty acid metabolism

scientific article published in May 2003

The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases

scientific article published on 24 January 2017

The Metabolome in Finnish Carriers of the MYBPC3-Q1061X Mutation for Hypertrophic Cardiomyopathy

scientific article published on 12 August 2015

The Pro12A1a substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with dyslipidemia

scientific article published in August 2000

The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface

scientific article

The Pro12Ala polymorphism of the PPAR gamma 2 gene influences sex hormone-binding globulin level and its relationship to the development of the metabolic syndrome in young Finnish men.

scientific article

The Pro12Ala polymorphism of the PPAR gamma 2 gene regulates weight from birth to adulthood

scientific article published in February 2004

The Pro12Ala polymorphism of the PPARgamma2 gene is associated with hepatic glucose uptake during hyperinsulinemia in subjects with type 2 diabetes mellitus

scientific article published in April 2009

The Relation of Proinsulin, Insulin, and Proinsulin-to-Insulin Ratio to Insulin Sensitivity and Acute Insulin Response in Normoglycemic Subjects ⬇️

scientific article published on December 1, 1997

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

scientific article published in June 2017

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue.

scientific article

The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain

scientific article

The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis.

scientific article

The association of apolipoprotein E polymorphism with memory: a population based study ⬇️

scientific article published on May 26, 1995

The association of the K121Q polymorphism of the plasma cell glycoprotein-1 gene with type 2 diabetes and hypertension depends on size at birth

scientific article

The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge

scientific article (publication date: 2011)

The cancer-associated FGFR4-G388R polymorphism enhances pancreatic insulin secretion and modifies the risk of diabetes

retracted scientific article published on June 2013

The cardiac beta-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in the Finnish population

scientific article published in November 1998

The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study

scientific article published on 7 March 2008

The common polymorphisms (single nucleotide polymorphism [SNP] +45 and SNP +276) of the adiponectin gene predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial

scientific article published in March 2005

The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight: the Finnish Diabetes Prevention Study

scientific article published on 29 January 2009

The effect of standard chow and reduced hexokinase II on growth, cardiac and skeletal muscle hexokinase and low-flow cardiac ischaemia-reperfusion injury.

scientific article

The effect of the -308A allele of the TNF-alpha gene on insulin action is dependent on obesity

scientific article

The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-gamma2 gene on skeletal muscle glucose uptake depends on obesity: a positron emission tomography study

scientific article published on 26 April 2005

The effects of the Pro12Ala polymorphism of the PPARgamma-2 gene on lipid metabolism interact with body size at birth

scientific article published in October 2003

The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth

scientific article published in July 2002

The effects of weight loss on insulin sensitivity, skeletal muscle composition and capillary density in obese non-diabetic subjects

scientific article published on 01 February 1996

The genetic and metabolic determinants of cardiovascular complications in type 2 diabetes: recent insights from animal models and clinical investigations

scientific article published on October 2013

The genetic architecture of type 2 diabetes

scientific article (publication date: 11 July 2016)

The genetic regulatory signature of type 2 diabetes in human skeletal muscle

scientific article published on 29 June 2016

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016

The hormone sensitive lipase gene in familial combined hyperlipidemia and insulin resistance

scientific article published in April 2001

The human hexokinase II gene promoter: functional characterization and detection of variants among patients with NIDDM ⬇️

scientific article published on December 1, 1997

The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology

scientific article (publication date: 26 April 2017)

The interuncal distance in Alzheimer disease and age-associated memory impairment.

scientific article

The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns

scientific article published on 15 February 2007

The metabolic syndrome predicts incident congestive heart failure: a 20-year follow-up study of elderly Finns

scientific article published on 10 November 2009

The metabolic syndrome predicts incident stroke: a 14-year follow-up study in elderly people in Finland

scientific article published on 6 March 2008

The metabolism of plant sterols is disturbed in postmenopausal women with coronary artery disease

scientific article published in March 2009

The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish Diabetes Prevention Study

scientific article published in April 2010

Thoracoabdominal calcifications predict cardiovascular disease mortality in type 2 diabetic and nondiabetic subjects: 18-year follow-up study

scientific article

Trans-ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus

scientific article

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

scientific article published on 12 September 2016

Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained

scientific article

Trauma, renal vein thrombosis and subsequent nephrotic syndrome

scientific article published on 01 June 1982

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

scientific article

Two founder mutations in the alpha-tropomyosin and the cardiac myosin-binding protein C genes are common causes of hypertrophic cardiomyopathy in the Finnish population

scientific article published on 2 April 2012

Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland

scientific article

Two novel mutations in the beta-myosin heavy chain gene associated with dilated cardiomyopathy

scientific article published in December 2004

Type-2 diabetes and cognitive function in a non-demented population.

scientific article

Underlying genetic models of inheritance in established type 2 diabetes associations

scientific article published on 14 July 2009

Update on Current Care Guideline. Diabetes

scientific article published on January 2016

Update on Type 2 Diabetes as a Cardiovascular Disease Risk Equivalent ⬇️

scientific article published on February 1, 2013

Variable effects of statins on glucose homeostasis parameters and their diabetogenic role. Reply to Kostapanos MS, Agouridis AP and Elisaf MS [letter].

scientific article

Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies

scientific article

Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study

scientific article

Variants in MTNR1B influence fasting glucose levels

scientific article

Variants in the Human Intestinal Fatty Acid Binding Protein 2 Gene in Obese Subjects ⬇️

scientific article published on August 1, 1997

Variants in the hepatocyte nuclear factor-1alpha and -4alpha genes in Finnish and Chinese subjects with late-onset type 2 diabetes

scientific article published in October 2000

Variants of the fatty acid-binding protein 2 gene are not associated with coronary heart disease in nondiabetic subjects and in patients with NIDDM.

scientific article published in May 1998

Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion

article

Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study

scientific article

Verbal fluency activates the left medial temporal lobe: a functional magnetic resonance imaging study

scientific article published in April 2000

Visfatin is an adipokine, but it is not regulated by thiazolidinediones

scientific article published on 4 January 2006

WISP2 regulates preadipocyte commitment and PPARγ activation by BMP4.

scientific article published on 28 January 2013

WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels

scientific article published on August 2008

[Chlorpropamide and the alcohol flush reaction and coronary artery disease in adult diabetics]

scientific article published on 01 January 1984

[Prolonged QT(U) interval: association with disease and use of drugs]

scientific article published on 01 January 1986

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