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List of works by Christopher Newton-Cheh

50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study

scientific article

52 Genetic Loci Influencing Myocardial Mass

scientific article

A Comprehensive Evaluation of the Genetic Architecture of Sudden Cardiac Arrest

A Systematic Evaluation of the QTc Interval and Antidepressants in Youth: An Electronic Health Record Study

scientific article published on July 2015

A blood pressure genetic risk score is a significant predictor of incident cardiovascular events in 32,669 individuals

scientific article published on 18 March 2013

A common NOS1AP genetic polymorphism is associated with increased cardiovascular mortality in users of dihydropyridine calcium channel blockers

scientific article

A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization

scientific article

A common missense variant in the neuregulin 1 gene is associated with both schizophrenia and sudden cardiac death

scientific article published on 21 March 2013

A common variant at 9p21 is associated with sudden and arrhythmic cardiac death

scientific article

A common variant in the β2-adrenergic receptor and risk of sudden cardiac death

scientific article published on 6 January 2011

A common variant near the KCNJ2 gene is associated with T-peak to T-end interval

scientific article published on 15 February 2012

A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern

scientific article

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017

article

Acute Metabolic Influences on the Natriuretic Peptide System in Humans

scientific article published on February 2016

An enhancer polymorphism at the cardiomyocyte intercalated disc protein NOS1AP locus is a major regulator of the QT interval

scientific article

Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics

scientific article

Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes

scientific article

Assessment of conventional cardiovascular risk factors and multiple biomarkers for the prediction of incident heart failure and atrial fibrillation

scientific article

Association Analysis of FOXO3 Longevity Variants With Blood Pressure and Essential Hypertension

scientific article

Association of NOS1AP genetic variants with QT interval duration in families from the Diabetes Heart Study

scientific article

Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure

scientific article published on 15 February 2009

Association of genetic variation in the natriuretic peptide system with cardiovascular outcomes

scientific article published on 27 January 2011

Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals

scientific article

Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring

scientific article published on 23 June 2008

Atrial natriuretic peptide is negatively regulated by microRNA-425.

scientific article published on 15 July 2013

Blood pressure and human genetic variation in the general population

scientific article

Blood pressure loci identified with a gene-centric array

scientific article

Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts

scientific article

Calcium channel blockers, NOS1AP, and heart-rate-corrected QT prolongation

scientific article

Candidate gene association resource (CARe): design, methods, and proof of concept

scientific article

Cardiac natriuretic peptides, obesity, and insulin resistance: evidence from two community-based studies

scientific article

Cardiac transplantation followed by dose-intensive melphalan and autologous stem-cell transplantation for light chain amyloidosis and heart failure

scientific article

Cardiovascular Pharmacogenomics: Current Status and Future Directions—Report of a National Heart, Lung, and Blood Institute Working Group ⬇️

scientific article published on April 24, 2012

Case records of the Massachusetts General Hospital. Case 11-2011. A 47-year-old man with systemic lupus erythematosus and heart failure

scientific article published on April 2011

Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sample

scientific article published on 12 February 2007

Clinical correlates and heritability of QT interval duration in blacks: the Jackson Heart Study.

scientific article published on 27 May 2009

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease

scientific article published on 2 March 2016

Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium

scientific article

Common Genetic Variation at the Endothelial Nitric Oxide Synthase Locus and Relations to Brachial Artery Vasodilator Function in the Community

Common Genetic Variation in KCNH2 Is Associated With QT Interval Duration

scientific article published on 20 August 2007

Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study

scientific article

Common genetic variants associated with sudden cardiac death: the FinSCDgen study

scientific article

Common genetic variants, QT interval, and sudden cardiac death in a Finnish population-based study

scientific article

Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling

scientific article published on 03 September 2013

Common genetic variation near the connexin-43 gene is associated with resting heart rate in African Americans: a genome-wide association study of 13,372 participants.

scientific article

Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies

scientific article

Common variants at ten loci influence QT interval duration in the QTGEN Study

scientific article published on 22 March 2009

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

scientific article

Common variants in KCNN3 are associated with lone atrial fibrillation

scientific article

Common variants in cardiac ion channel genes are associated with sudden cardiac death

scientific article

Common variation in the NOS1AP gene is associated with reduced glucose-lowering effect and with increased mortality in users of sulfonylurea

scientific article published in July 2008

Conserved noncoding sequences are selectively constrained and not mutation cold spots

article by Jared A Drake et al published 25 December 2005 in Nature Genetics

Contribution of Clinical Correlates and 13 C-Reactive Protein Gene Polymorphisms to Interindividual Variability in Serum C-Reactive Protein Level

article

Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

scientific article published in September 2017

Cross-sectional relations of multiple biomarkers from distinct biological pathways to brachial artery endothelial function

scientific article published on 13 February 2006

Development and application of a longitudinal electrocardiogram repository: the Framingham Heart Study

scientific article

Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study

scientific article

Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures

scientific article (publication date: 10 May 2016)

Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure

scientific article

Distribution and correlates of midregional proadrenomedullin in the general population.

scientific article published on 18 June 2009

Early repolarization pattern in competitive athletes: clinical correlates and the effects of exercise training

scientific article

Effect of phosphodiesterase inhibition on insulin resistance in obese individuals

scientific article

Effect of weight loss after weight loss surgery on plasma N-terminal pro-B-type natriuretic peptide levels ⬇️

scientific article published on November 15, 2010

Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations

scientific article

Effects of subacute dietary salt intake and acute volume expansion on diastolic function in young normotensive individuals.

scientific article

Effects of transdermal testosterone on natriuretic peptide levels in women: a randomized placebo-controlled pilot study ⬇️

scientific article published on December 2, 2011

Electrocardiographic assessment for therapeutic proteins—scientific discussion ⬇️

scientific article published on October 1, 2010

Erratum: Corrigendum: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

scholarly article published in Nature Genetics

Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

scientific article published in July 2017

Evaluation of ventricular arrhythmias in early clinical pharmacology trials and potential consequences for later development

scientific article published on May 2010

Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans

scientific article

Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness

scientific article published in 2007

Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes

scientific article

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci

scientific article published on 20 February 2014

Gene-environment interaction between SCN5A-1103Y and hypokalemia influences QT interval prolongation in African Americans: the Jackson Heart Study

scientific article published on 22 October 2013

Genetic Predisposition to Higher Blood Pressure Increases Coronary Artery Disease Risk ⬇️

scientific article published on March 11, 2013

Genetic Reduction in Left Ventricular Protein Kinase C-α and Adverse Ventricular Remodeling in Human Subjects

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Genetic association studies of complex traits: design and analysis issues

scientific article

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

scientific article

Genetic basis of blood pressure and hypertension

scientific article published on 21 May 2012

Genetic determinants of QT interval variation and sudden cardiac death

scientific article published on 30 April 2007

Genetic determinants of sudden cardiac death

scientific article published on October 2008

Genetic polymorphisms confer risk of atrial fibrillation in patients with heart failure: a population-based study

scientific article published on 6 November 2012

Genetic polymorphisms for estimating risk of atrial fibrillation in the general population: a prospective study

scientific article published on May 2012

Genetic variants and blood pressure in a population-based cohort: the Cardiovascular Risk in Young Finns study

scientific article published on 24 October 2011

Genetic variants related to height and risk of atrial fibrillation: the cardiovascular health study

scientific article

Genetic variation in NOS1AP is associated with sudden cardiac death: evidence from the Rotterdam Study

scientific article published on 30 July 2009

Genome-wide analysis yields new loci associating with aortic valve stenosis

scientific article published on 7 March 2018

Genome-wide association analysis identifies multiple loci related to resting heart rate

scientific article

Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study

scientific article published in 2007

Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae

scientific article

Genome-wide association studies of late-onset cardiovascular disease

scientific article

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

scientific article

Genome-wide association study in humans

scientific article published on January 2009

Genome-wide association study of PR interval

scientific article

Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension

scientific article

Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study

scientific article

Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae

scientific article published on 15 February 2009

Heritability of Atrial Fibrillation

scientific article published in December 2017

Heritability of Risk for Sudden Cardiac Arrest in ESRD.

scientific article

Heritability, Linkage, and Genetic Associations of Exercise Treadmill Test Responses

article

High prevalence of four long QT syndrome founder mutations in the Finnish population

scientific article

High-Dose versus Low-Dose Vitamin D Supplementation and Arterial Stiffness among Individuals with Prehypertension and Vitamin D Deficiency.

scientific article

Human genetics, natriuretic peptides and hypertension.

scientific article published in August 2011

Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals

scientific article

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

scientific article published on 14 April 2013

Impact of ancestry and common genetic variants on QT interval in African Americans

scientific article

Increased burden of cardiovascular disease in carriers of APOL1 genetic variants

scientific article published on 30 December 2013

Increased power of mixed models facilitates association mapping of 10 loci for metabolic traits in an isolated population

scientific article

Influence of sex and hormone status on circulating natriuretic peptides

scientific article

Intracranial aneurysm risk locus 5q23.2 is associated with elevated systolic blood pressure

scientific article

Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation

scientific article published on 13 January 2009

Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project

scientific article published on 16 August 2011

Loci influencing blood pressure identified using a cardiovascular gene-centric array

scientific article published on 8 January 2013

Loci influencing blood pressure identified using a cardiovascular gene-centric array

scientific article

Long-term outcomes in individuals with prolonged PR interval or first-degree atrioventricular block

scientific article published on June 2009

Low plasma level of atrial natriuretic peptide predicts development of diabetes: the prospective Malmo Diet and Cancer study

scientific article published on 23 November 2011

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

scientific article published on 12 September 2016

MicroRNA miR-425 is a negative regulator of atrial natriuretic peptide.

scientific article published on 29 August 2013

MicroRNA-425 and microRNA-155 cooperatively regulate atrial natriuretic peptide expression and cGMP production

scientific article published on 26 April 2018

Multiple biomarkers and the risk of incident hypertension

scientific article published on 22 January 2007

Multiple biomarkers for the prediction of first major cardiovascular events and death

scientific article

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

scientific article

Novel MicroRNA Regulators of Atrial Natriuretic Peptide Production

scientific article published on 16 May 2016

Novel and conventional biomarkers for prediction of incident cardiovascular events in the community

scientific article

Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts

scientific article

Novel loci associated with increased risk of sudden cardiac death in the context of coronary artery disease

scientific article

On the interpretation of genetic association studies

scientific article published on 01 August 2004

On the significance of linkage studies of complex traits

scientific article published on July 2004

Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium

scientific article

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

scientific article (publication date: 11 August 2012)

Plasma copeptin and the risk of diabetes mellitus

scientific article published on 03 May 2010

Plasma renin and risk of cardiovascular disease and mortality: the Framingham Heart Study

scientific article published on 25 September 2007

Polymorphisms associated with cholesterol and risk of cardiovascular events

scientific article

Predictive value of electrocardiographic T-wave morphology parameters and T-wave peak to T-wave end interval for sudden cardiac death in the general population

scientific article published on 23 July 2013

Prevalence of arrhythmia-associated gene mutations and risk of sudden cardiac death in the Finnish population

scientific article published on 08 May 2013

Psychotropic drugs associated with corrected QT interval prolongation

scientific article published in February 2009

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scholarly article published in Nature Genetics

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

erratum

QT interval and long-term mortality risk in the Framingham Heart Study

scientific article

QT interval is a heritable quantitative trait with evidence of linkage to chromosome 3 in a genome-wide linkage analysis: The Framingham Heart Study

scientific article published on March 2005

Rare Exome Sequence Variants in CLCN6 Reduce Blood Pressure Levels and Hypertension Risk

scientific article published on 11 December 2015

Rare independent mutations in renal salt handling genes contribute to blood pressure variation

scientific article

Relation of QRS width in healthy persons to risk of future permanent pacemaker implantation

scientific article

Relation of visceral adiposity to circulating natriuretic peptides in ambulatory individuals

scientific article

Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection

scientific article

Relationship of common candidate gene variants to electrocardiographic T-wave peak to T-wave end interval and T-wave morphology parameters

scientific article

Resequencing and clinical associations of the 9p21.3 region: a comprehensive investigation in the Framingham heart study

scientific article published on 11 January 2013

Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association

scientific article published in November 2018

Response to Letter Regarding Article, “Cross-Sectional Relations of Multiple Biomarkers From Distinct Biological Pathways to Brachial Artery Endothelial Function”

Risk profiles for aortic dissection and ruptured or surgically treated aneurysms: a prospective cohort study

scientific article

Sequencing of SCN5A identifies rare and common variants associated with cardiac conduction: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

scientific article

Sex differences and genetic associations with myocardial infarction

scientific article published in June 2004

Should Identifying a Titin Truncating Variant Change the Management of Patients With Dilated Cardiomyopathy?

scientific article published in October 2017

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

scientific article

The Expressed Genome in Cardiovascular Diseases and Stroke: Refinement, Diagnosis, and Prediction: A Scientific Statement From the American Heart Association

scientific article

The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports

scientific article

The early repolarization pattern in the general population: clinical correlates and heritability

scientific article

The electrocardiographic early repolarization pattern in athletes: normal variant or sudden death risk factor?

scientific article published on May 2012

The genetic component of bicuspid aortic valve and aortic dilation. An exome-wide association study.

scientific article published on 25 November 2016

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016

The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits

scientific article

Therapeutic hypothermia for cardiac arrest: real-world utilization trends and hospital mortality

scientific article

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

scientific article published on 12 September 2016

Validation of Polygenic Scores for QT Interval in Clinical Populations

scientific article published in October 2017

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry ⬇️

scientific article published on 13 July 2009

Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery

scientific article

Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart study

scientific article published on 2 April 2007

Vitamin D Supplementation Modulates T Cell-Mediated Immunity in Humans: Results from a Randomized Control Trial

scientific article published on 14 December 2015

Vitamin D therapy in individuals with prehypertension or hypertension: the DAYLIGHT trial

scientific article published on 30 October 2014

Weight loss, saline loading, and the natriuretic peptide system

scientific article

What can genetic studies of left ventricular mass tell us?

scientific article published on December 2011

What can human genetics teach us about the causes of cardiovascular disease?

scientific article published in June 2010

What have genome-wide association studies taught us about cGMP and blood pressure regulation?

scientific article published on 29 August 2013

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