Search filters

List of works by Christian Gieger

'Omics' biomarkers associated with chronic low back pain: protocol of a retrospective longitudinal study.

scientific article published on 19 October 2016

1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

scientific article

16p11.2 600 kb Duplications confer risk for typical and atypical Rolandic epilepsy

scientific article published on 16 June 2014

4th Pediatric Allergy and Asthma Meeting (PAAM)

scientific article (publication date: November 2016)

52 Genetic Loci Influencing Myocardial Mass

scientific article

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

scientific article

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

scientific article published on 24 March 2017

A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population ⬇️

scientific article published on 8 October 2015

A catalog of genetic loci associated with kidney function from analyses of a million individuals

scientific article published on 31 May 2019

A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization

scientific article

A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease

scientific article

A genome-wide association search for type 2 diabetes genes in African Americans

scientific article published on 4 January 2012

A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3

scientific article

A genome-wide association study identifies three loci associated with mean platelet volume

scientific article published on 24 December 2008

A genome-wide association study of metabolic traits in human urine

scientific article

A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study

scientific article published on 9 November 2011

A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis

scientific article published on 10 April 2015

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

scientific article

A genome-wide perspective of genetic variation in human metabolism

scientific article

A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol

scientific article

A genomewide association study of smoking relapse in four European population-based samples

scientific article published on 01 August 2013

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

scientific article published on 10 April 2019

A multimetric approach to analysis of genome-wide association by single markers and composite likelihood

scholarly article

A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1

scientific article

A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function

scientific article published on 12 February 2009

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

scientific article published on 23 November 2016

A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke

scientific article

A systematic evaluation of short tandem repeats in lipid candidate genes: riding on the SNP-wave

scientific article

A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis

scientific article

Adiposity as a cause of cardiovascular disease: a Mendelian randomization study

scientific article

Age- and sex-specific causal effects of adiposity on cardiovascular risk factors

scientific article published on 23 February 2015

Alterations in Lipid and Inositol Metabolisms in Two Dopaminergic Disorders

scientific article published on 25 January 2016

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

scientific article published on 31 May 2017

An atlas of genetic influences on human blood metabolites

scientific article

An evaluation of the genetic-matched pair study design using genome-wide SNP data from the European population

scientific article

An integrated epigenetic and transcriptomic analysis reveals distinct tissue-specific patterns of DNA methylation associated with atopic dermatitis

scientific article published on 13 February 2014

An omics investigation into chronic widespread musculoskeletal pain reveals epiandrosterone sulfate as a potential biomarker

scientific article published on 22 April 2015

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

scientific article published on 29 September 2013

Analysis of repeated leukocyte DNA methylation assessments reveals persistent epigenetic alterations after an incident myocardial infarction

Analyzing illumina gene expression microarray data from different tissues: methodological aspects of data analysis in the metaxpress consortium

scientific article

Anxiety Associated Increased CpG Methylation In The Promoter of Asb1: A Translational Approach Evidenced By Epidemiological And Clinical Studies And A Murine Model

scientific article published on 25 May 2017

Association analysis between the prostaglandin E synthase 2 R298H polymorphism and body mass index in 8079 participants of the KORA study cohort

scientific article

Association between DNA Methylation in Whole Blood and Measures of Glucose Metabolism: KORA F4 Study

scientific article

Association between functional FABP2 promoter haplotypes and body mass index: analyses of 8072 participants of the KORA cohort study

scientific article published in June 2009

Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder

scientific article published on 11 April 2012

Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells

scientific article published on 20 April 2015

Association of Methylation Signals With Incident Coronary Heart Disease in an Epigenome-Wide Assessment of Circulating Tumor Necrosis Factor α.

scientific article

Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction

scientific article published in March 2010

Association of acyl-CoA-binding protein (ACBP) single nucleotide polymorphisms and type 2 diabetes in two German study populations

scientific article

Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants

scientific article

Association of adiposity genetic variants with menarche timing in 92,105 women of European descent

scientific article published on 04 April 2013

Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults

Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts

scientific article published on April 2009

Association of prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism with type 2 diabetes in two German study populations

scientific article

Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans

scientific article

Associations between thyroid hormones and serum metabolite profiles in an euthyroid population

scientific article

Associations of autozygosity with a broad range of human phenotypes

scientific article published on 31 October 2019

Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes

scientific article published on 4 August 2015

Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

scientific article published on 01 September 2018

Author Correction: Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease

scientific article published in Nature Communications

Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles

scientific article (publication date: 9 December 2013)

Automatic scoring and quality assessment using accuracy bounds for FP-TDI SNP genotyping data

scientific article

Biobanken

Biological, clinical and population relevance of 95 loci for blood lipids

scientific article

Biomarkers for type 2 diabetes and impaired fasting glucose using a nontargeted metabolomics approach

scientific article (publication date: December 2013)

Blood cis-eQTL analysis fails to identify novel association signals among sub-threshold candidates from genome-wide association studies in restless legs syndrome

scientific article

Body fat free mass is associated with the serum metabolite profile in a population-based study

scientific article

Burden analysis of rare microdeletions suggests a strong impact of neurodevelopmental genes in genetic generalised epilepsies

scientific article

CONAN: copy number variation analysis software for genome-wide association studies

scientific article

Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies

scientific article published on 20 September 2018

Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies

scholarly article published 11 February 2018

Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D: a cross-sectional analysis in population-based data

scientific article

Characterization of whole-genome autosomal differences of DNA methylation between men and women

scientific article

Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci

scientific journal article

Common genetic variants associate with serum phosphorus concentration

scientific article

Common variants associated with plasma triglycerides and risk for coronary artery disease

scientific article

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways ⬇️

scientific article

Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis

scientific journal article

Common variants at ten loci modulate the QT interval duration in the QTSCD Study

scientific article

Common variants in P2RY11 are associated with narcolepsy

scientific article

Common variants near MC4R are associated with fat mass, weight and risk of obesity

scientific article

Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection.

scientific article

Comparative analysis of plasma metabolomics response to metabolic challenge tests in healthy subjects and influence of the FTO obesity risk allele

article

Connecting genetic risk to disease end points through the human blood plasma proteome

scientific article published on 27 February 2017

Correction: Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study

scientific article published on 14 September 2017

Correction: Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution.

scientific article published on 27 July 2009

Correction: Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1

Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

scientific article published on 23 August 2017

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

Correlation between genetic and geographic structure in Europe

scientific article

Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

scientific article published on 26 May 2017

Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

scientific article published on November 2016

Corrigendum: Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

scientific article published on 30 March 2015

Corrigendum: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

scholarly article published in Nature Genetics

DNA methylation and body-mass index: a genome-wide analysis

scientific article

DNA methylation of lipid-related genes affects blood lipid levels

scientific article published on 12 January 2015

DNA methylation-based measures of biological age: meta-analysis predicting time to death

scientific article

DNA mismatch repair gene MSH6 implicated in determining age at natural menopause

scientific article published on 19 December 2013

DYT16 revisited: exome sequencing identifies PRKRA mutations in a European dystonia family

scientific article published on 20 August 2014

Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation.

scientific article published on 8 January 2018

DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning

scientific article published on 03 February 2020

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups

scientific article published on 11 September 2015

Diagnostic and Prognostic Metabolites Identified for Joint Symptoms in the KORA Population

scientific article

Diastrophic dysplasia sulfate transporter (SLC26A2) is expressed in the adrenal cortex and regulates aldosterone secretion

scientific article published on 3 March 2014

Dilution of candidates: the case of iron-related genes in restless legs syndrome

scientific article published on 29 August 2012

Directional dominance on stature and cognition in diverse human populations

scientific article published in July 2015

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

scientific article

Discovery and fine mapping of serum protein loci through transethnic meta-analysis

scientific article

Discovery and refinement of loci associated with lipid levels

scientific article

Discovery of sexual dimorphisms in metabolic and genetic biomarkers

scientific article

Disentangling the genetics of lean mass

article

ERRATUM: Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

article by Matthew B. Lanktree et al published June 2012 in American Journal of Human Genetics

Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study

scientific article

Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes

scientific article published on 5 August 2015

Effects of statins on the immunoglobulin G glycome

scientific article published on 02 March 2017

Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies

scientific article published on 14 October 2011

Epigenetic Signatures at AQP3 and SOCS3 Engage in Low-Grade Inflammation across Different Tissues

scientific article

Epigenetics meets metabolomics: an epigenome-wide association study with blood serum metabolic traits

scientific article published on 06 September 2013

Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study

scientific article

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

scientific article published on 21 December 2016

Erratum: Common variants in P2RY11 are associated with narcolepsy

scholarly article published in Nature Genetics

Erratum: Connecting genetic risk to disease end points through the human blood plasma proteome

scientific article published on 11 April 2017

Erratum: Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses

article

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

scientific article

Erratum: Narcolepsy is strongly associated with the T-cell receptor alpha locus

scholarly article published in Nature Genetics

Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article published in May 2010

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 23 January 2018

European lactase persistence genotype shows evidence of association with increase in body mass index

scientific article

Evaluation of gene-obesity interaction effects on cholesterol levels: a genetic predisposition score on HDL-cholesterol is modified by obesity

scientific article published on 21 September 2012

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

article by Jason Flannick et al published 22 May 2019 in Nature

Exome-wide association study of plasma lipids in >300,000 individuals

scientific article published on 30 October 2017

Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci

scientific article

Extensive alterations of the whole-blood transcriptome are associated with body mass index: results of an mRNA profiling study involving two large population-based cohorts

scientific article published on 15 October 2015

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

scientific article published on 08 October 2018

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

scientific article published on 21 June 2013

Gender-specific pathway differences in the human serum metabolome

scientific article

Gene set of nuclear-encoded mitochondrial regulators is enriched for common inherited variation in obesity

scientific article

Gene-PUFA interactions and obesity risk

scientific article published on 18 May 2011

Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia

scientific article

Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations

scientific article published on 17 December 2013

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci

scientific article published on 20 February 2014

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

scientific article published on 05 May 2020

Genetic Geostatistical Framework for Spatial Analysis of Fine-Scale Genetic Heterogeneity in Modern Populations: Results from the KORA Study

scientific article published on 16 July 2015

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scientific article published on 17 September 2018

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Genetic architecture of circulating lipid levels

scientific article

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

scientific article

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

scientific article

Genetic associations with lipoprotein subfractions provide information on their biological nature

scientific article

Genetic determinants of circulating interleukin-1 receptor antagonist levels and their association with glycemic traits

scientific article

Genetic evidence for PLASMINOGEN as a shared genetic risk factor of coronary artery disease and periodontitis

scientific article published on 2 December 2014

Genetic evidence of assortative mating in humans

article

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

scientific article

Genetic predictors of fibrin D-dimer levels in healthy adults

scientific article

Genetic regulation of serum phytosterol levels and risk of coronary artery disease

scientific article

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

scientific article published on 18 April 2016

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

scientific article published on 6 October 2011

Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis

scientific article published on 7 December 2012

Genetic variants in the leukemia-associated Rho guanine nucleotide exchange factor (ARHGEF12) gene are not associated with T2DM and related parameters in Caucasians (KORA study).

scientific article published in September 2007

Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk

scientific article

Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease

scientific article published on 8 July 2009

Genetic variation in metabolic phenotypes: study designs and applications ⬇️

scientific article published on 03 October 2012

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

scientific article published on 26 June 2011

Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes

scientific article published on 30 October 2017

Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum

scientific article

Genetics of human metabolism: an update

scientific article

Genome wide meta-analysis highlights the role of genetic variation in RARRES2 in the regulation of circulating serum chemerin

scientific article

Genome wide meta-analysis identifies novel determinants of circulating serum progranulin

scientific article published on 27 November 2017

Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2

scientific article

Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality

scientific article published on 9 September 2015

Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

scientific article published on 27 February 2020

Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture

scientific article

Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.

scientific article published on 3 December 2015

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

scientific article published in Nature Communications

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

scientific article

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

scientific article published on 6 February 2017

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

scientific article published in February 2013

Genome-wide association analysis identifies multiple loci related to resting heart rate

scientific article

Genome-wide association analysis identifies six new loci associated with forced vital capacity

scientific article

Genome-wide association analysis identifies three psoriasis susceptibility loci

scientific journal article

Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4

scientific journal article

Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

scientific journal article

Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32.

scientific article

Genome-wide association analysis of high-density lipoprotein cholesterol in the population-based KORA study sheds new light on intergenic regions

scientific article published on October 2008

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

scholarly article by Johannes Waage et al published August 2018 in Nature Genetics

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

scientific article

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

scientific article published in June 2009

Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

scientific article

Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels

scientific article

Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium

scientific article

Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).

scientific article

Genome-wide association study identifies 48 common genetic variants associated with handedness

scientific article published on 28 September 2020

Genome-wide association study identifies 74 loci associated with educational attainment

scientific article published on 11 May 2016

Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23

scholarly article by Jeanette Erdmann et al published 18 November 2010 in European Heart Journal

Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2

scientific article

Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk ⬇️

scientific article

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

scientific article published on 16 October 2011

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

scientific article

Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1

scientific journal article

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

scientific article

Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A.

scientific article

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

scientific article published on 17 January 2018

Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine

scientific article published on 21 September 2014

Genome-wide association study of PR interval

scientific article

Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions

scientific article

Genome-wide association study reveals genetic risk underlying Parkinson's disease

scientific article

Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts

scientific article (publication date: 2012)

Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms

scientific article

Genome-wide exploration identifies sex-specific genetic effects of alleles upstreamNPYto increase the risk of severe periodontitis in men

scientific article published on 11 November 2014

Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease

scientific article published in Nature Communications

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

scientific journal article

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

scientific article

Genome-wide meta-analysis of common variant differences between men and women

scientific article published on 27 July 2012

Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci

scientific article

Genome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL

scientific journal article

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

scientific article published on February 2016

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

scientific article published on 27 April 2017

Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations

scientific article published on 20 March 2009

Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus

scientific article

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.

scientific article published on 23 March 2016

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

scientific article

Genomewide association analysis of coronary artery disease

scientific article

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

scientific article published on 23 September 2016

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

scientific article published on 24 April 2017

Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research

scientific article

Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with progressive atherosclerosis and incident cardiovascular disease

scientific article

Heritability of young- and old-onset ischaemic stroke.

scientific article

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

scientific article

How to link call rate and p-values for Hardy-Weinberg equilibrium as measures of genome-wide SNP data quality

scientific article

Human gene expression sensitivity according to large scale meta-analysis

scientific article

Human metabolic individuality in biomedical and pharmaceutical research

scientific article (publication date: 31 August 2011)

Human serum metabolic profiles are age dependent

scientific article

Hundreds of variants clustered in genomic loci and biological pathways affect human height

scientific article

IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies

scientific article

Identification and MS-assisted interpretation of genetically influenced NMR signals in human plasma

scientific article published on 15 February 2013

Identification of Immune-Relevant Factors Conferring Sarcoidosis Genetic Risk

scientific article

Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease

scientific article

Identification of seven loci affecting mean telomere length and their association with disease

scientific article published on April 2013

Identification of ten loci associated with height highlights new biological pathways in human growth

scientific article

IgG glycosylation and DNA methylation are interconnected with smoking

scientific article

ImmunoChip study implicates antigen presentation to T cells in narcolepsy

scientific article

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

scientific article published on 12 September 2017

Impact of common regulatory single-nucleotide variants on gene expression profiles in whole blood

scientific article

Increased amino acids levels and the risk of developing of hypertriglyceridemia in a 7-year follow-up

scientific article published on 09 January 2014

Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function

scientific article published on 8 September 2012

Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma

scientific article

Interrogating causal pathways linking genetic variants, small molecule metabolites, and circulating lipids

scientific article

JC polyomavirus infection is strongly controlled by human leucocyte antigen class II variants

scientific article

Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index

scientific article

KORA-gen--resource for population genetics, controls and a broad spectrum of disease phenotypes

scientific article

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

scientific article

Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci.

scientific article

Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair

scientific article published in December 2015

Large-scale TUBB4A mutational screening in isolated dystonia and controls

scientific article published on 20 August 2015

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

scientific article

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

scientific article

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

scientific article

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

scientific article published in November 2015

Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study

scientific article published in 2008

Loci influencing blood pressure identified using a cardiovascular gene-centric array

scientific article published on 8 January 2013

Loci influencing blood pressure identified using a cardiovascular gene-centric array.

scientific article

Long term conservation of human metabolic phenotypes and link to heritability

scientific article

MEIS1 and BTBD9: genetic association with restless leg syndrome in end stage renal disease

scientific article

MTTP variants and body mass index, waist circumference and serum cholesterol level: Association analyses in 7582 participants of the KORA study cohort

scientific article published on 23 October 2008

Mapping the genetic architecture of gene regulation in whole blood

scientific article

Meta-Analysis of Genome-Wide Association Studies and Network Analysis-Based Integration with Gene Expression Data Identify New Suggestive Loci and Unravel a Wnt-Centric Network Associated with Dupuytren's Disease

scientific article

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

scientific article

Meta-analysis identifies seven susceptibility loci involved in the atopic march

scientific article

Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations

scientific article published in June 2009

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

scientific article

Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

scientific article published on 29 March 2016

Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations

scientific article

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

scientific article

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels

scientific article

Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error

scientific article

Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function

scientific article

Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting

scientific article (publication date: 11 November 2010)

Metabolic profiling reveals distinct variations linked to nicotine consumption in humans--first results from the KORA study

scientific article

Metabolite profiling reveals new insights into the regulation of serum urate in humans

scientific article published on 20 July 2013

Metabolites associate with kidney function decline and incident chronic kidney disease in the general population

scientific article

Metabolites of milk intake: a metabolomic approach in UK twins with findings replicated in two European cohorts.

scientific article published on 28 July 2016

Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate

scientific article published in June 2015

Metabolomic markers reveal novel pathways of ageing and early development in human populations

scientific article published on 08 July 2013

Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism

scientific article

Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

scientific article published on 12 August 2019

Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues

scientific article published on 12 September 2016

Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information

scientific article

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus

scientific article

Mitochondrial DNA variants in obesity

scientific article

Modulation of genetic associations with serum urate levels by body-mass-index in humans

scientific article

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

scientific article published on 19 October 2015

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

article

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

scientific article published in Nature Communications

Multi-omic signature of body weight change: results from a population-based cohort study

scientific article

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

scientific article (publication date: 17 September 2013)

Multiple loci are associated with white blood cell phenotypes

scientific article

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium

scientific article

Mutational screening of THAP1 in a German population with primary dystonia

scientific article

Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy

scientific article

NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality

scientific article published on 30 March 2017

Narcolepsy is strongly associated with the T-cell receptor alpha locus

scientific article

Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway

scientific article published on 14 November 2017

Network-based metabolite ratios for an improved functional characterization of genome-wide association study results

New gene functions in megakaryopoiesis and platelet formation

scientific article published on 30 November 2011

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

scientific article published on 25 February 2019

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

scholarly article published 12 June 2018

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ⬇️

scientific article published on February 2016

Niemann-Pick C disease gene mutations and age-related neurodegenerative disorders

scientific article (publication date: 2013)

Non-targeted metabolomics combined with genetic analyses identifies bile acid synthesis and phospholipid metabolism as being associated with incident type 2 diabetes

scientific article published on 12 July 2016

Nonadditive Effects of Genes in Human Metabolomics

scientific article published on 14 May 2015

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

scientific article

Novel SCARB2 mutation in action myoclonus-renal failure syndrome and evaluation of SCARB2 mutations in isolated AMRF features

scientific article

Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels

scientific article

Novel biomarkers for pre-diabetes identified by metabolomics

scientific article

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

scientific article published on 18 June 2018

Novel genetic associations with serum level metabolites identified by phenotype set enrichment analyses

scientific article

Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

scientific article

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation

scientific article published on 17 June 2016

Omics: Potential Role in Early-Phase Drug Development

article

On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies

scientific article

On the potential of models for location and scale for genome-wide DNA methylation data

scientific article

On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants

scientific article published on 24 January 2008

PSEA: Phenotype Set Enrichment Analysis--a new method for analysis of multiple phenotypes

scientific article

PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome

scientific article published on 27 July 2008

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

scientific article

Polymorphisms in the proteasomal subunit alpha4 are not associated with Parkinson's disease

scientific article published on 14 March 2008

Polymorphisms in the receptor for GDNF (RET) are not associated with Parkinson's disease in Southern Germany

scientific article

Population-genetic comparison of the Sorbian isolate population in Germany with the German KORA population using genome-wide SNP arrays

scientific article

Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: findings from 3,000 participants in the population-based KORA F4 study

scientific article

Prevalence of refractive error in Europe: the European Eye Epidemiology (E(3)) Consortium

scientific article

Psoriasis and cardiometabolic traits: modest association but distinct genetic architectures

scientific article

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scholarly article published in Nature Genetics

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

erratum

Publisher Correction: Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway

scientific article published on 13 February 2018

RL-SKAT: An Exact and Efficient Score Test for Heritability and Set Tests.

scientific article published on 12 October 2017

Rare sequence variants in ANO3 and GNAL in a primary torsion dystonia series and controls.

scientific article

Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4

scientific article published on 16 November 2021

Rare variants in LRRK1 and Parkinson's disease

scientific article

Rare variants in PLXNA4 and Parkinson's disease

scientific article

Rare variants in β-Amyloid precursor protein (APP) and Parkinson's disease

scientific article

Recessive mutations in the α3 (VI) collagen gene COL6A3 cause early-onset isolated dystonia

scientific article published on 21 May 2015

Replication of restless legs syndrome loci in three European populations

scientific article published on 10 March 2009

Replication study of multiple sclerosis (MS) susceptibility alleles and correlation of DNA-variants with disease features in a cohort of Austrian MS patients

Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon

scientific journal article

Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance

scientific article published on 30 September 2010

Risk variants for atrial fibrillation on chromosome 4q25 associate with ischemic stroke

scientific article published in October 2008

SLC23A1polymorphism rs6596473 in the vitamin C transporter SVCT1 is associated with aggressive periodontitis

SLC2A9 influences uric acid concentrations with pronounced sex-specific effects

scientific article

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 19 December 2017

Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior

scientific article

Serum metabolite concentrations and decreased GFR in the general population

scientific article published on 30 March 2012

Seven new loci associated with age-related macular degeneration

scientific article

Seventy-five genetic loci influencing the human red blood cell

scientific article published on 5 December 2012

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

scientific article

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

scientific article

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

scientific article

Statistical Methods in Genetic and Molecular Epidemiology and Their Application in Studies with Metabolic Phenotypes

scholarly article published 2012

Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases

scientific article

Systematic TOR1A non-c.907_909delGAG variant analysis in isolated dystonia and controls

scientific article published on 25 July 2016

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

scientific article published on 02 October 2019

Targeted resequencing and systematic in vivo functional testing identifies rare variants in MEIS1 as significant contributors to restless legs syndrome

scientific article

Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array

scientific article

Telomere length in circulating leukocytes is associated with lung function and disease.

scientific article published on 5 December 2013

The Human Blood Metabolome-Transcriptome Interface

scientific article published on 18 June 2015

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

The Pharmacogenetic Footprint of ACE Inhibition: A Population-Based Metabolomics Study

scientific article

The common non-synonymous variant G38S of the KCNE1-(minK)-gene is not associated to QT interval in Central European Caucasians: results from the KORA study

article

The genetic architecture of type 2 diabetes

scientific article (publication date: 11 July 2016)

The impact of low-frequency and rare variants on lipid levels

scientific article published on 11 May 2015

The molecular genetic architecture of self-employment

scientific article

The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis

scientific article (publication date: 2013)

The role ofSCARB2as susceptibility factor in Parkinson's disease

scholarly article by Franziska Hopfner et al published 13 February 2013 in Movement Disorders

The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits

scientific article

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

scientific article

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

scientific journal article

Tobacco smoking leads to extensive genome-wide changes in DNA methylation

scientific article

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

scientific article

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

scientific article

Validation of standard operating procedures in a multicenter retrospective study to identify -omics biomarkers for chronic low back pain

scientific article

Variant screening of the coding regions of MEIS1 in patients with restless legs syndrome

Variants in eukaryotic translation initiation factor 4G1 in sporadic Parkinson's disease

scientific article published on 16 June 2012

Variants inRUNX3Contribute to Susceptibility to Psoriatic Arthritis, Exhibiting Further Common Ground With Ankylosing Spondylitis

article

Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies

scientific article published on 2 July 2008

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants

scholarly article

pulver: an R package for parallel ultra-rapid p-value computation for linear regression interaction terms

scientific article published on 29 September 2017

Paulina is supported by:

About Paulina

Help