List of works - Wulf Blankenfeldt

A functional interplay between intein and extein sequences in protein splicing compensates for the essential block B histidine.

scientific article published on 3 October 2018

A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1

scientific article

Adenylylation: renaissance of a forgotten post-translational modification ⬇️

scientific article published on January 20, 2011

AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus xanthus.

scientific article published on 16 May 2017

AibA/AibB induziert eine intramolekulare Decarboxylierung in der De-novo-Biosynthese von Isovalerat aus Myxococcus xanthus

Analysis of the eukaryotic prenylome by isoprenoid affinity tagging

scientific article

Atomic resolution structure of EhpR: phenazine resistance in Enterobacter agglomerans Eh1087 follows principles of bleomycin/mitomycin C resistance in other bacteria

scientific article

Aus zwei mach eins: die Biosynthese der Phenazine

Biophysical Analysis of the Interaction of Rab6a GTPase with Its Effector Domains

scientific article published in Journal of Biological Chemistry

Biosynthese der Phenazine

Biosynthesis and Regulation of Phenazine Compounds inPseudomonas spp

article

Biosynthesis of Violacein, Structure and Function of l-Tryptophan Oxidase VioA from Chromobacterium violaceum.

scientific article

Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity.

scientific article

Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration.

scientific article

CYP154C5 Regioselectivity in Steroid Hydroxylation Explored by Substrate Modifications and Protein Engineering

scientific article published on 04 November 2020

Crystal Structure of Dihydro-Heme d1 Dehydrogenase NirN from Pseudomonas aeruginosa Reveals Amino Acid Residues Essential for Catalysis

scientific article published on 04 June 2019

Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus

scientific article

Crystal Structures of R-Type Bacteriocin Sheath and Tube Proteins CD1363 and CD1364 From in the Pre-assembled State

scientific article published on 03 August 2018

Crystal structure of AibC, a reductase involved in alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus.

scientific article published on 29 July 2016

Crystal structure of NirF: Insights into its role in heme d1 biosynthesis

scientific article published on 07 April 2020

Crystal structure of PhzG from Pseudomonas fluorescens 2-79 in complex with a second FMN in the substrate binding site

Crystal structure of bacterial cytotoxic necrotizing factor CNF<sub>Y</sub> reveals molecular building blocks for intoxication ⬇️

scientific article published on 07 January 2021

Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis

scientific article published on 23 September 2019

Crystal structure of trypanosoma cruzi tyrosine aminotransferase: Substrate specificity is influenced by cofactor binding mode

scientific article

Crystal structures and protein engineering of three different penicillin G acylases from Gram-positive bacteria with different thermostability

scientific article published on 21 June 2019

Crystal structures of chloroperoxidase with its bound substrates and complexed with formate, acetate, and nitrate

scientific article published on 20 June 2006

Crystal structures of human cardiac beta-myosin II S2-Delta provide insight into the functional role of the S2 subfragment.

scholarly article

Crystallization and preliminary X-ray analysis of the ergothioneine-biosynthetic methyltransferase EgtD.

scientific article

Crystallization and preliminary X-ray analysis of tyrosine aminotransferase from Trypanosoma cruzi epimastigotes

scientific article published on 01 January 1998

Crystallization and preliminary crystal structure analysis of the ligand-binding domain of PqsR (MvfR), the Pseudomonas quinolone signal (PQS) responsive quorum-sensing transcription factor of Pseudomonas aeruginosa

scientific article published on 30 August 2012

Crystallographic proof for an extended hydrogen-bonding network in small prolyl isomerases

scientific article

Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors

scientific article

Destructive twisting of neutral metalloproteases: the catalysis mechanism of the Dispase autolysis-inducing protein from Streptomyces mobaraensis DSM 40487

scientific article published on 17 September 2018

Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex

scientific article

Development of selective, potent RabGGTase inhibitors

scientific article

Directed evolution of Mycobacterium tuberculosis β-lactamase reveals gatekeeper residue that regulates antibiotic resistance and catalytic efficiency

scientific article

Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds

scientific article

Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo

scientific article published on 01 November 2018

Diversity and evolution of the phenazine biosynthesis pathway

scientific article published on 11 December 2009

Ergothioneine biosynthetic methyltransferase EgtD reveals the structural basis of aromatic amino acid betaine biosynthesis

scientific article

Expression, purification and crystal structure determination of a ferredoxin reductase from the actinobacterium Thermobifida fusca

scientific article published on 28 July 2020

Flexible Fragment Growing Boosts Potency of Quorum-Sensing Inhibitors against Pseudomonas aeruginosa Virulence

scientific article published on 28 November 2019

Formation of the pyruvoyl-dependent proline reductase Prd from Clostridioides difficile requires the maturation enzyme PrdH

scientific article published on 25 June 2024

High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA

scientific article

High-resolution structures of RmlC from Streptococcus suis in complex with substrate analogs locate the active site of this class of enzyme

scientific article

Inhibition and Regulation of the Ergothioneine Biosynthetic Methyltransferase EgtD.

scientific article published on 16 April 2018

Insights into ssDNA recognition by the OB fold from a structural and thermodynamic study of Sulfolobus SSB protein

scientific article (publication date: 2 June 2003)

Insights into the Cnx1E catalyzed MPT-AMP hydrolysis

scientific article published on 01 January 2020

Insights into the Dual Activity of a Bifunctional Dehydratase-Cyclase Domain.

scientific article

Large‐scale production, purification and refolding of the full‐length cellular prion protein from Syrian golden hamster in Escherichia coli using the glutathione S‐transferase‐fusion system ⬇️

scientific article published on January 15, 1998

Ligand Binding Induces an Ammonia Channel in 2-Amino-2-desoxyisochorismate (ADIC) Synthase PhzE

scientific article

Mechanisms and Specificity of Phenazine Biosynthesis Protein PhzF.

scientific article

Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef

scientific article

NAD(H)-mediated tetramerization controls the activity of phospholipase PlaB

scientific article published on 8 June 2021

Noncompaction of the ventricular myocardium is associated with a de novo mutation in the beta-myosin heavy chain gene

scientific article

Novel correlations between the genotype and the phenotype of hypertrophic and dilated cardiomyopathy: results from the German Competence Network Heart Failure

scientific article published on 12 July 2011

Of two make one: the biosynthesis of phenazines.

scientific article published on September 2009

Organization and Function of the Rab Prenylation and Recycling Machinery

Overexpression, purification and crystallization of PhzA, the first enzyme of the phenazine biosynthesis pathway of Pseudomonas fluorescens 2-79.

scientific article

Overexpression, purification, crystallization and data collection of a single-stranded DNA-binding protein from Sulfolobus solfataricus.

scientific article

Phenazine compounds in fluorescent Pseudomonas spp. biosynthesis and regulation

scientific article

PhzA/B catalyzes the formation of the tricycle in phenazine biosynthesis

scientific article

Position 123 of halohydrin dehalogenase HheG plays an important role in stability, activity, and enantioselectivity

scientific article published on 25 March 2019

Protein-Templated Hit Identification via an Ugi Four-Component Reaction

scientific article published on 19 May 2020

Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase

scientific article

Purification and crystallization of human Cu/Zn superoxide dismutase recombinantly produced in the protozoanLeishmania tarentolae

scientific article

RabGDI displacement by DrrA from Legionella is a consequence of its guanine nucleotide exchange activity

scientific article

Recent developments in the isolation, biological function, biosynthesis, and synthesis of phenazine natural products

scientific article published on 5 January 2017

Recent insights into the diversity, frequency and ecological roles of phenazines in fluorescent Pseudomonas spp.

scientific article published on 13 August 2012

Recombinant tyrosine aminotransferase from Trypanosoma cruzi: structural characterization and site directed mutagenesis of a broad substrate specificity enzyme

scientific article published in April 2001

Revisiting the planarity of nucleic acid bases: Pyramidilization at glycosidic nitrogen in purine bases is modulated by orientation of glycosidic torsion.

scientific article published on November 2009

RhoG and Cdc42 can contribute to Rac-dependent lamellipodia formation through WAVE regulatory complex-binding

scientific article published on 26 August 2019

Sequential additions of nucleophiles to tricarbonyl(η4-cycloheptadienyl)iron tetrafluoroborate

article

Structural basis for the relaxed substrate selectivity of Leishmania mexicana broad specificity aminotransferase

scientific article

Structural insights into antigen recognition of an anti-β-(1,6)-β-(1,3)-D-glucan antibody

scientific article published in Scientific Reports

Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus

scientific article

Structure and dynamics of a stabilized coiled-coil domain in the P-TEFb regulator Hexim1

scientific article

Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens

scientific article

Structure elucidation and preliminary assessment of hydrolase activity of PqsE, the Pseudomonas quinolone signal (PQS) response protein

scientific article

Structure of heme d1-free cd1 nitrite reductase NirS

scientific article published on 29 May 2020

Structure of the Ergothioneine-Biosynthesis Amidohydrolase EgtC

scientific article

Structure of the corrinoid:coenzyme M methyltransferase MtaA from Methanosarcina mazei

scientific article

Structure of the sulfoxide synthase EgtB from the ergothioneine biosynthetic pathway

scientific article

Structure-guided development of selective RabGGTase inhibitors

scientific article

Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation

scientific article

Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution

scientific article

Structures of the N-terminal domain of PqsA in complex with anthraniloyl- and 6-fluoroanthraniloyl-AMP: substrate activation in Pseudomonas Quinolone Signal (PQS) biosynthesis

scientific article

The AibR-isovaleryl coenzyme A regulator and its DNA binding site - a model for the regulation of alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus.

scientific article published on 9 December 2016

The Alkylquinolone Repertoire of Pseudomonas aeruginosa is linked to Structural Flexibility of the FabH-like PQS Biosynthesis Enzyme PqsBC.

scientific article

The Biosynthesis of Phenazines

article

The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b

scientific article

The Structure of LiuC, a 3-Hydroxy-3-Methylglutaconyl CoA Dehydratase Involved in Isovaleryl-CoA Biosynthesis in Myxococcus xanthus, Reveals Insights into Specificity and Catalysis

scientific article

The active site of an enzyme can host both enantiomers of a racemic ligand simultaneously

scientific article

The crystal structure of the heme d1 biosynthesis-associated small c-type cytochrome NirC reveals mixed oligomeric states in crystallo

scientific article published on 25 March 2020

The functional principle of eukaryotic molybdenum insertases

scientific article published on 24 May 2018

The hypothetical periplasmic protein PA1624 from Pseudomonas aeruginosa folds into a unique two-domain structure

scientific article published on 30 November 2020

The purification, crystallization and preliminary structural characterization of FAD-dependent monooxygenase PhzS, a phenazine-modifying enzyme from Pseudomonas aeruginosa

scientific journal article

The purification, crystallization and preliminary structural characterization of PhzF, a key enzyme in the phenazine-biosynthesis pathway from Pseudomonas fluorescens 2-79.

scientific article

The purification, crystallization and preliminary structural characterization of PhzM, a phenazine-modifying methyltransferase from Pseudomonas aeruginosa.

scientific article published on 11 August 2006

The purification, crystallization and preliminary structural characterization of glucose-1-phosphate thymidylyltransferase (RmlA), the first enzyme of the dTDP-L-rhamnose synthesis pathway from Pseudomonas aeruginosa

article

The purification, crystallization and preliminary structural characterization of human MAWDBP, a member of the phenazine biosynthesis-like protein family

scientific article published on 31 May 2006

The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (RmlA)

scientific article

The structural biology of phenazine biosynthesis

scientific article

The structure of 3-methylaspartase from Clostridium tetanomorphum functions via the common enolase chemical step

scientific article

The versatile Legionella effector protein DrrA.

scientific article published on January 2011

Three novel mutations in the ACTA2 gene in German patients with thoracic aortic aneurysms and dissections

scientific article

Total Biosynthesis of the Pyrrolo[4,2]benzodiazepine Scaffold Tomaymycin on an In Vitro Reconstituted NRPS System

scientific article published on 24 August 2017

Trapped intermediates in crystals of the FMN-dependent oxidase PhzG provide insight into the final steps of phenazine biosynthesis

scientific article

Variation on a Theme of SDR

article

Variation on a theme of SDR. dTDP-6-deoxy-L- lyxo-4-hexulose reductase (RmlD) shows a new Mg2+-dependent dimerization mode

scientific article

pyoverdine maturation enzyme PvdP has a noncanonical domain architecture and affords insight into a new subclass of tyrosinases

scientific article published in Journal of Biological Chemistry

List of works by Wulf Blankenfeldt

A functional interplay between intein and extein sequences in protein splicing compensates for the essential block B histidine.

A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1

Adenylylation: renaissance of a forgotten post-translational modification ⬇️

AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus xanthus.

AibA/AibB induziert eine intramolekulare Decarboxylierung in der De-novo-Biosynthese von Isovalerat aus Myxococcus xanthus

Analysis of the eukaryotic prenylome by isoprenoid affinity tagging

Atomic resolution structure of EhpR: phenazine resistance in Enterobacter agglomerans Eh1087 follows principles of bleomycin/mitomycin C resistance in other bacteria

Aus zwei mach eins: die Biosynthese der Phenazine

Biophysical Analysis of the Interaction of Rab6a GTPase with Its Effector Domains

Biosynthese der Phenazine

Biosynthesis and Regulation of Phenazine Compounds inPseudomonas spp

Biosynthesis of Violacein, Structure and Function of l-Tryptophan Oxidase VioA from Chromobacterium violaceum.

Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity.

Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration.

CYP154C5 Regioselectivity in Steroid Hydroxylation Explored by Substrate Modifications and Protein Engineering

Crystal Structure of Dihydro-Heme d1 Dehydrogenase NirN from Pseudomonas aeruginosa Reveals Amino Acid Residues Essential for Catalysis

Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus

Crystal Structures of R-Type Bacteriocin Sheath and Tube Proteins CD1363 and CD1364 From in the Pre-assembled State

Crystal structure of AibC, a reductase involved in alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus.

Crystal structure of NirF: Insights into its role in heme d1 biosynthesis

Crystal structure of PhzG from Pseudomonas fluorescens 2-79 in complex with a second FMN in the substrate binding site

Crystal structure of bacterial cytotoxic necrotizing factor CNF<sub>Y</sub> reveals molecular building blocks for intoxication ⬇️

Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis

Crystal structure of trypanosoma cruzi tyrosine aminotransferase: Substrate specificity is influenced by cofactor binding mode

Crystal structures and protein engineering of three different penicillin G acylases from Gram-positive bacteria with different thermostability

Crystal structures of chloroperoxidase with its bound substrates and complexed with formate, acetate, and nitrate

Crystal structures of human cardiac beta-myosin II S2-Delta provide insight into the functional role of the S2 subfragment.

Crystallization and preliminary X-ray analysis of the ergothioneine-biosynthetic methyltransferase EgtD.

Crystallization and preliminary X-ray analysis of tyrosine aminotransferase from Trypanosoma cruzi epimastigotes

Crystallization and preliminary crystal structure analysis of the ligand-binding domain of PqsR (MvfR), the Pseudomonas quinolone signal (PQS) responsive quorum-sensing transcription factor of Pseudomonas aeruginosa

Crystallographic proof for an extended hydrogen-bonding network in small prolyl isomerases

Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors

Destructive twisting of neutral metalloproteases: the catalysis mechanism of the Dispase autolysis-inducing protein from Streptomyces mobaraensis DSM 40487

Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex

Development of selective, potent RabGGTase inhibitors

Directed evolution of Mycobacterium tuberculosis β-lactamase reveals gatekeeper residue that regulates antibiotic resistance and catalytic efficiency

Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds

Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo

Diversity and evolution of the phenazine biosynthesis pathway

Ergothioneine biosynthetic methyltransferase EgtD reveals the structural basis of aromatic amino acid betaine biosynthesis

Expression, purification and crystal structure determination of a ferredoxin reductase from the actinobacterium Thermobifida fusca

Flexible Fragment Growing Boosts Potency of Quorum-Sensing Inhibitors against Pseudomonas aeruginosa Virulence

Formation of the pyruvoyl-dependent proline reductase Prd from Clostridioides difficile requires the maturation enzyme PrdH

High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA

High-resolution structures of RmlC from Streptococcus suis in complex with substrate analogs locate the active site of this class of enzyme

Inhibition and Regulation of the Ergothioneine Biosynthetic Methyltransferase EgtD.

Insights into ssDNA recognition by the OB fold from a structural and thermodynamic study of Sulfolobus SSB protein

Insights into the Cnx1E catalyzed MPT-AMP hydrolysis

Insights into the Dual Activity of a Bifunctional Dehydratase-Cyclase Domain.

Large‐scale production, purification and refolding of the full‐length cellular prion protein from Syrian golden hamster in Escherichia coli using the glutathione S‐transferase‐fusion system ⬇️

Ligand Binding Induces an Ammonia Channel in 2-Amino-2-desoxyisochorismate (ADIC) Synthase PhzE

Mechanisms and Specificity of Phenazine Biosynthesis Protein PhzF.

Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef

NAD(H)-mediated tetramerization controls the activity of phospholipase PlaB

Noncompaction of the ventricular myocardium is associated with a de novo mutation in the beta-myosin heavy chain gene

Novel correlations between the genotype and the phenotype of hypertrophic and dilated cardiomyopathy: results from the German Competence Network Heart Failure

Of two make one: the biosynthesis of phenazines.

Organization and Function of the Rab Prenylation and Recycling Machinery

Overexpression, purification and crystallization of PhzA, the first enzyme of the phenazine biosynthesis pathway of Pseudomonas fluorescens 2-79.

Overexpression, purification, crystallization and data collection of a single-stranded DNA-binding protein from Sulfolobus solfataricus.

Phenazine compounds in fluorescent Pseudomonas spp. biosynthesis and regulation

PhzA/B catalyzes the formation of the tricycle in phenazine biosynthesis

Position 123 of halohydrin dehalogenase HheG plays an important role in stability, activity, and enantioselectivity

Protein-Templated Hit Identification via an Ugi Four-Component Reaction

Protein-Templated Hit Identification via an Ugi Four-Component Reaction

Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase

Purification and crystallization of human Cu/Zn superoxide dismutase recombinantly produced in the protozoanLeishmania tarentolae

RabGDI displacement by DrrA from Legionella is a consequence of its guanine nucleotide exchange activity

Recent developments in the isolation, biological function, biosynthesis, and synthesis of phenazine natural products

Recent insights into the diversity, frequency and ecological roles of phenazines in fluorescent Pseudomonas spp.

Recombinant tyrosine aminotransferase from Trypanosoma cruzi: structural characterization and site directed mutagenesis of a broad substrate specificity enzyme

Revisiting the planarity of nucleic acid bases: Pyramidilization at glycosidic nitrogen in purine bases is modulated by orientation of glycosidic torsion.

RhoG and Cdc42 can contribute to Rac-dependent lamellipodia formation through WAVE regulatory complex-binding

Sequential additions of nucleophiles to tricarbonyl(η4-cycloheptadienyl)iron tetrafluoroborate

Structural basis for the relaxed substrate selectivity of Leishmania mexicana broad specificity aminotransferase

Structural insights into antigen recognition of an anti-β-(1,6)-β-(1,3)-D-glucan antibody

Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus

Structure and dynamics of a stabilized coiled-coil domain in the P-TEFb regulator Hexim1

Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens