List of works - Debra Dunaway-Mariano

Analysis of the Structural Determinants Underlying Discrimination between Substrate and Solvent in β-Phosphoglucomutase Catalysis † ‡

scientific article

Analysis of the substrate specificity loop of the HAD superfamily cap domain

scientific journal article

Characterization of the 4-Hydroxybenzoyl-Coenzyme A Thioesterase from Arthrobacter sp. Strain SU ⬇️

scientific article published on May 1, 2003

Characterization, kinetics, and crystal structures of fructose-1,6-bisphosphate aldolase from the human parasite, Giardia lamblia

scientific article

Co-evolution of HAD phosphatase and hotdog-fold thioesterase domain function in the menaquinone-pathway fusion proteins BF1314 and PG1653.

scientific article published on 10 July 2013

Conformational flexibility of PEP mutase

scientific article

Consequences of domain insertion on sequence-structure divergence in a superfold

scientific article published on 19 August 2013

Correlation of structure and function in the human hotdog-fold enzyme hTHEM4

scientific article

Crystal structure of human thioesterase superfamily member 2

scientific article

Crystal structure of the petal death protein from carnation flower

scientific article

Dissociative phosphoryl transfer in PEP mutase catalysis: structure of the enzyme/sulfopyruvate complex and kinetic properties of mutants

scientific article

Divergence of Structure and Function in the Haloacid Dehalogenase Enzyme Superfamily: Bacteroides thetaiotaomicron BT2127 Is an Inorganic Pyrophosphatase

scientific article

Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB).

scientific article

Divergence of substrate specificity and function in the Escherichia coli hotdog-fold thioesterase paralogs YdiI and YbdB.

scientific article

Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes

scientific article published on 7 July 2006

HAD superfamily phosphotransferase substrate diversification: structure and function analysis of HAD subclass IIB sugar phosphatase BT4131.

scientific article

Homo sapiens dullard protein phosphatase shows a preference for the insulin-dependent phosphorylation site of lipin1

scientific article

Human Brown Fat Inducible Thioesterase Variant 2 Cellular Localization and Catalytic Function ⬇️

scientific article published on August 23, 2012

Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN).

scientific article

Investigation of the Catalytic Mechanism of the Hotdog-Fold Enzyme Superfamily Pseudomonas sp. Strain CBS3 4-Hydroxybenzoyl-CoA Thioesterase ⬇️

scientific article published on January 13, 2012

Kinetic evidence for a substrate-induced fit in phosphonoacetaldehyde hydrolase catalysis

scientific article published in November 2002

Markers of fitness in a successful enzyme superfamily

scientific article

Mechanism of 4-chlorobenzoate:coenzyme a ligase catalysis

scientific article published on 12 July 2008

Mechanism of Substrate Recognition and Catalysis of the Haloalkanoic Acid Dehalogenase Family Member α-Phosphoglucomutase

scientific article published on 13 July 2018

Mechanisms of catalysis and inhibition operative in the arginine deiminase from the human pathogen Giardia lamblia

scientific article

Phosphoryl group transfer: evolution of a catalytic scaffold

scientific article published in September 2004

Pyruvate site of pyruvate phosphate dikinase: crystal structure of the enzyme-phosphonopyruvate complex, and mutant analysis

scientific article

Rational Redesign of the 4-Chlorobenzoate Binding Site of 4-Chlorobenzoate: Coenzyme A Ligase for Expanded Substrate Range † , ‡ , §

scientific article

Rational design of reversible inhibitors for trehalose 6-phosphate phosphatases

scientific article

Rational design, synthesis and evaluation of first generation inhibitors of the Giardia lamblia fructose-1,6-biphosphate aldolase

scientific article

Structural Basis for the Divergence of Substrate Specificity and Biological Function within HAD Phosphatases in Lipopolysaccharide and Sialic Acid Biosynthesis

scientific article

Structural Characterization of a 140° Domain Movement in the Two-Step Reaction Catalyzed by 4-Chlorobenzoate:CoA Ligase † ‡

scientific article

Structural Determinants of Substrate Recognition in the HAD Superfamily Member d - glycero - d - manno -Heptose-1,7-bisphosphate Phosphatase (GmhB),

scientific article

Structural insights into the substrate binding and stereoselectivity of giardia fructose-1,6-bisphosphate aldolase

scientific article

Structure and Catalysis in the Escherichia coli Hotdog-fold Thioesterase Paralogs YdiI and YbdB

scientific article

Structure and Function of PA4872 from Pseudomonas aeruginosa , a Novel Class of Oxaloacetate Decarboxylase from the PEP Mutase/Isocitrate Lyase Superfamily

scientific article

Structure and function of 2,3-dimethylmalate lyase, a PEP mutase/isocitrate lyase superfamily member

scientific article

Structure and kinetics of phosphonopyruvate hydrolase from Variovorax sp. Pal2: new insight into the divergence of catalysis within the PEP mutase/isocitrate lyase superfamily

scientific article

Structure of 4-chlorobenzoyl coenzyme A dehalogenase determined to 1.8 A resolution: an enzyme catalyst generated via adaptive mutation

scientific article

Structure of YciA from Haemophilus influenzae (HI0827), a hexameric broad specificity acyl-coenzyme A thioesterase

scientific article

Structure of the trehalose-6-phosphate phosphatase from Brugia malayi reveals key design principles for anthelmintic drugs

scientific article

Structure-Function Analysis of 2-Keto-3-deoxy-D-glycero-D-galactonononate-9-phosphate Phosphatase Defines Specificity Elements in Type C0 Haloalkanoate Dehalogenase Family Members

scientific article

Swiveling domain mechanism in pyruvate phosphate dikinase

scientific article

The 2-aminoethylphosphonate-specific transaminase of the 2-aminoethylphosphonate degradation pathway

scientific article

The Akt C-terminal modulator protein is an acyl-CoA thioesterase of the Hotdog-Fold family

scientific article

The BH1999 protein of Bacillus halodurans C-125 is gentisyl-coenzyme A thioesterase

scientific article

The Catalytic Mechanism of the Hotdog-fold Enzyme Superfamily 4-Hydroxybenzoyl-CoA Thioesterase from Arthrobacter sp. Strain SU

scientific article

The Enzyme Function Initiative

scientific article

The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a

scientific article

The X-ray crystallographic structure and activity analysis of a Pseudomonas-specific subfamily of the HAD enzyme superfamily evidences a novel biochemical function

scientific article

The X‐ray crystallographic structure and specificity profile of HAD superfamily phosphohydrolase BT1666: Comparison of paralogous functions in B. thetaiotaomicron ⬇️

scientific article published on August 30, 2011

The catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition state

scientific article

The mechanism of domain alternation in the acyl-adenylate forming ligase superfamily member 4-chlorobenzoate: coenzyme A ligase

scientific article

The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis

scientific article

The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction

scientific article

The phosphonopyruvate decarboxylase from Bacteroides fragilis

scientific article

The structure of 4-hydroxybenzoyl-CoA thioesterase from arthrobacter sp. strain SU

scientific article

X-ray crystallographic analyses of inhibitor and substrate complexes of wild-type and mutant 4-hydroxybenzoyl-CoA thioesterase

scientific article

X-ray crystallographic and site-directed mutagenesis analysis of the mechanism of Schiff-base formation in phosphonoacetaldehyde hydrolase catalysis

scientific article

X-ray structure and characterization of carbamate kinase from the human parasiteGiardia lamblia

scientific article

X-ray structure and kinetic properties of ornithine transcarbamoylase from the human parasiteGiardia lamblia

scientific article

List of works by Debra Dunaway-Mariano

Analysis of the Structural Determinants Underlying Discrimination between Substrate and Solvent in β-Phosphoglucomutase Catalysis † ‡

Analysis of the substrate specificity loop of the HAD superfamily cap domain

Characterization of the 4-Hydroxybenzoyl-Coenzyme A Thioesterase from Arthrobacter sp. Strain SU ⬇️

Characterization, kinetics, and crystal structures of fructose-1,6-bisphosphate aldolase from the human parasite, Giardia lamblia

Co-evolution of HAD phosphatase and hotdog-fold thioesterase domain function in the menaquinone-pathway fusion proteins BF1314 and PG1653.

Conformational flexibility of PEP mutase

Consequences of domain insertion on sequence-structure divergence in a superfold

Correlation of structure and function in the human hotdog-fold enzyme hTHEM4

Crystal structure of human thioesterase superfamily member 2

Crystal structure of the petal death protein from carnation flower

Dissociative phosphoryl transfer in PEP mutase catalysis: structure of the enzyme/sulfopyruvate complex and kinetic properties of mutants

Divergence of Structure and Function in the Haloacid Dehalogenase Enzyme Superfamily: Bacteroides thetaiotaomicron BT2127 Is an Inorganic Pyrophosphatase

Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB).

Divergence of substrate specificity and function in the Escherichia coli hotdog-fold thioesterase paralogs YdiI and YbdB.

Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes

HAD superfamily phosphotransferase substrate diversification: structure and function analysis of HAD subclass IIB sugar phosphatase BT4131.

Homo sapiens dullard protein phosphatase shows a preference for the insulin-dependent phosphorylation site of lipin1

Human Brown Fat Inducible Thioesterase Variant 2 Cellular Localization and Catalytic Function ⬇️

Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN).

Investigation of the Catalytic Mechanism of the Hotdog-Fold Enzyme Superfamily Pseudomonas sp. Strain CBS3 4-Hydroxybenzoyl-CoA Thioesterase ⬇️

Kinetic evidence for a substrate-induced fit in phosphonoacetaldehyde hydrolase catalysis

Markers of fitness in a successful enzyme superfamily

Mechanism of 4-chlorobenzoate:coenzyme a ligase catalysis

Mechanism of Substrate Recognition and Catalysis of the Haloalkanoic Acid Dehalogenase Family Member α-Phosphoglucomutase

Mechanisms of catalysis and inhibition operative in the arginine deiminase from the human pathogen Giardia lamblia

Phosphoryl group transfer: evolution of a catalytic scaffold

Pyruvate site of pyruvate phosphate dikinase: crystal structure of the enzyme-phosphonopyruvate complex, and mutant analysis

Rational Redesign of the 4-Chlorobenzoate Binding Site of 4-Chlorobenzoate: Coenzyme A Ligase for Expanded Substrate Range † , ‡ , §

Rational design of reversible inhibitors for trehalose 6-phosphate phosphatases

Rational design, synthesis and evaluation of first generation inhibitors of the Giardia lamblia fructose-1,6-biphosphate aldolase

Structural Basis for the Divergence of Substrate Specificity and Biological Function within HAD Phosphatases in Lipopolysaccharide and Sialic Acid Biosynthesis

Structural Characterization of a 140° Domain Movement in the Two-Step Reaction Catalyzed by 4-Chlorobenzoate:CoA Ligase † ‡

Structural Determinants of Substrate Recognition in the HAD Superfamily Member d - glycero - d - manno -Heptose-1,7-bisphosphate Phosphatase (GmhB),

Structural insights into the substrate binding and stereoselectivity of giardia fructose-1,6-bisphosphate aldolase

Structure and Catalysis in the Escherichia coli Hotdog-fold Thioesterase Paralogs YdiI and YbdB

Structure and Function of PA4872 from Pseudomonas aeruginosa , a Novel Class of Oxaloacetate Decarboxylase from the PEP Mutase/Isocitrate Lyase Superfamily

Structure and function of 2,3-dimethylmalate lyase, a PEP mutase/isocitrate lyase superfamily member

Structure and kinetics of phosphonopyruvate hydrolase from Variovorax sp. Pal2: new insight into the divergence of catalysis within the PEP mutase/isocitrate lyase superfamily

Structure of 4-chlorobenzoyl coenzyme A dehalogenase determined to 1.8 A resolution: an enzyme catalyst generated via adaptive mutation

Structure of YciA from Haemophilus influenzae (HI0827), a hexameric broad specificity acyl-coenzyme A thioesterase

Structure of the trehalose-6-phosphate phosphatase from Brugia malayi reveals key design principles for anthelmintic drugs

Structure-Function Analysis of 2-Keto-3-deoxy-D-glycero-D-galactonononate-9-phosphate Phosphatase Defines Specificity Elements in Type C0 Haloalkanoate Dehalogenase Family Members

Swiveling domain mechanism in pyruvate phosphate dikinase

The 2-aminoethylphosphonate-specific transaminase of the 2-aminoethylphosphonate degradation pathway

The Akt C-terminal modulator protein is an acyl-CoA thioesterase of the Hotdog-Fold family

The BH1999 protein of Bacillus halodurans C-125 is gentisyl-coenzyme A thioesterase

The Catalytic Mechanism of the Hotdog-fold Enzyme Superfamily 4-Hydroxybenzoyl-CoA Thioesterase from Arthrobacter sp. Strain SU

The Enzyme Function Initiative

The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a

The X-ray crystallographic structure and activity analysis of a Pseudomonas-specific subfamily of the HAD enzyme superfamily evidences a novel biochemical function

The X‐ray crystallographic structure and specificity profile of HAD superfamily phosphohydrolase BT1666: Comparison of paralogous functions in B. thetaiotaomicron ⬇️

The catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition state

The mechanism of domain alternation in the acyl-adenylate forming ligase superfamily member 4-chlorobenzoate: coenzyme A ligase

The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis

The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction

The phosphonopyruvate decarboxylase from Bacteroides fragilis

The structure of 4-hydroxybenzoyl-CoA thioesterase from arthrobacter sp. strain SU

X-ray crystallographic analyses of inhibitor and substrate complexes of wild-type and mutant 4-hydroxybenzoyl-CoA thioesterase

X-ray crystallographic and site-directed mutagenesis analysis of the mechanism of Schiff-base formation in phosphonoacetaldehyde hydrolase catalysis

X-ray structure and characterization of carbamate kinase from the human parasiteGiardia lamblia

X-ray structure and kinetic properties of ornithine transcarbamoylase from the human parasiteGiardia lamblia