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List of works by Julien Lescar

A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability and de Novo Initiation Activities

scientific article

A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication

scientific article

A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease.

scientific article

A multi-step strategy to obtain crystals of the dengue virus RNA-dependent RNA polymerase that diffract to high resolution

scientific article

A scintillation proximity assay for dengue virus NS5 2'-O-methyltransferase-kinetic and inhibition analyses.

scientific article published on 20 September 2008

A structural hypothesis for the transition between bent and extended conformations of the leukocyte beta2 integrins

scientific article

Amino acid residues critical for RNA-binding in the N-terminal domain of the nucleocapsid protein are essential determinants for the infectivity of coronavirus in cultured cells

scientific article published on 13 September 2006

Antibodies targeting the PfRH1 binding domain inhibit invasion of Plasmodium falciparum merozoites ⬇️

scientific article published on 11 July 2008

Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery

scientific article

Biochemical and genetic characterization of dengue virus methyltransferase

scientific article

Biochemical and structural analysis of Helix pomatia agglutinin. A hexameric lectin with a novel fold

scientific article published on 16 May 2006

Bioorthogonal cleavage and exchange of major histocompatibility complex ligands by employing azobenzene-containing peptides

scientific article

Chikungunya virus nsP4 RNA-dependent RNA polymerase core domain displays detergent-sensitive primer extension and terminal adenylyltransferase activities

scientific article

Conformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an Inhibitor

scientific article

Conventional and unconventional mechanisms for capping viral mRNA.

scientific article published on 05 December 2011

Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 Complex

scientific article

Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis

scientific article

Crystal Structure of the Dengue Virus Methyltransferase Bound to a 5′-Capped Octameric RNA

scientific article

Crystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom Resolution

scientific article (publication date: May 2007)

Crystal Structure of the NS3 Protease-Helicase from Dengue Virus

scientific article

Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD from Pseudomonas aeruginosa

scientific article published on 09 August 2019

Crystal structure of the FK506 binding domain of Plasmodium falciparum FKBP35 in complex with FK506

scientific article

Crystallization and diffraction analysis of the SARS coronavirus nsp10-nsp16 complex

scientific article

Crystallization and preliminary crystallographic analysis of human aquaporin 1 at a resolution of 3.28 Å.

scientific article

Crystallographic structure of ubiquitin in complex with cadmium ions

scientific article

Dengue Virus Non-Structural Protein 5

scientific article (publication date: 24 April 2017)

Dimerization of flavivirus NS4B protein

scientific article published on 03 January 2014

Discovery and characterization of pseudocyclic cystine-knot α-amylase inhibitors with high resistance to heat and proteolytic degradation

scientific article

Discovery of Dengue Virus NS4B Inhibitors

scientific article published on 27 May 2015

Expression, purification and preliminary crystallographic analysis of Pseudomonas aeruginosa RocR protein

scientific article published on 25 September 2009

Expression, purification, crystallization and preliminary X-ray analysis of full-length human RIG-I.

scientific article published on 22 January 2014

Expression, purification, crystallization and preliminary X-ray analysis ofPlasmodium falciparumGTP:AMP phosphotransferase ⬇️

scientific article published on May 23, 2012

Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications

scientific article

Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication

scientific article

Functional Evolution in Orthologous Cell-encoded RNA-dependent RNA Polymerases

scientific article published on 23 February 2016

Functional analysis of two cavities in flavivirus NS5 polymerase

scientific article

Generation and characterization of mouse monoclonal antibodies against NS4B protein of dengue virus

scientific article

Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2'-O methyltransferase activity in dengue virus

scientific article published on 29 March 2010

Induced-fit upon ligand binding revealed by crystal structures of the hot-dog fold thioesterase in dynemicin biosynthesis

scientific article

Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein

scientific article

Isolectins I-A and I-B of Griffonia (Bandeiraea) simplicifolia. Crystal structure of metal-free GS I-B(4) and molecular basis for metal binding and monosaccharide specificity

scientific article

Lyso-myristoyl phosphatidylcholine micelles sustain the activity of Dengue non-structural (NS) protein 3 protease domain fused with the full-length NS2B.

scientific article published on 29 September 2013

Mapping the Interactions between the NS4B and NS3 proteins of dengue virus

scientific article published on 14 January 2015

Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa.

scientific article published on 28 September 2016

Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

scientific article

NMR and crystallographic structures of the FK506 binding domain of human malarial parasite Plasmodium vivax FKBP35

scientific article

Plasmodium P36 determines host cell receptor usage during sporozoite invasion

scientific article

Polymerases of hepatitis C viruses and flaviviruses: structural and mechanistic insights and drug development

scientific article published on 19 February 2014

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

scientific article

RNA-dependent RNA polymerases from flaviviruses and Picornaviridae

scientific article

Rigidifying Acyl Carrier Protein Domain in Iterative Type I PKS CalE8 Does Not Affect Its Function ⬇️

scientific article published on September 5, 2012

Secondary Structure and Membrane Topology of the Full-Length Dengue Virus NS4B in Micelles

scientific article published on 24 August 2016

Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids

scientific article published on 21 September 2015

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

scientific article

Solution Structure of the PAS Domain of a Thermophilic YybT Protein Homolog Reveals a Potential Ligand-binding Site ⬇️

scientific article published on March 15, 2013

Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening

scientific article published on 18 April 2015

Structural Insights into Substrate Binding by PvFKBP35, a Peptidylprolyl cis-trans Isomerase from the Human Malarial Parasite Plasmodium vivax

scientific article

Structural basis for recognition of breast and colon cancer epitopes Tn antigen and Forssman disaccharide by Helix pomatia lectin

scientific article

Structural determinants for peptide-bond formation by asparaginyl ligases

scientific article published on 23 May 2019

Structural insights into the regulatory mechanism of the response regulator RocR from Pseudomonas aeruginosa in cyclic Di-GMP signaling

scientific article

Structural mimicry of the dengue virus envelope glycoprotein revealed by the crystallographic study of an idiotype-anti-idiotype Fab complex.

scientific article published on 21 June 2017

Structure and Catalytic Mechanism of the Thioesterase CalE7 in Enediyne Biosynthesis

scientific article

Structure of a diguanylate cyclase from Thermotoga maritima: insights into activation, feedback inhibition and thermostability

scientific article

Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation

scientific article

Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases

scientific article (publication date: May 2003)

Structure of human Rack1 protein at a resolution of 2.45 Å ⬇️

scientific article published on July 26, 2012

Structure of the Dengue Virus Helicase/Nucleoside Triphosphatase Catalytic Domain at a Resolution of 2.4 A

scientific article (publication date: August 2005)

Structure of the NS2B-NS3 protease from Zika virus after self-cleavage

scientific article (publication date: 15 November 2016)

Structure of the SARS coronavirus main proteinase as an active C2 crystallographic dimer

scientific article

Structure of the functional form of the mosquito larvicidal Cry4Aa toxin from Bacillus thuringiensis at a 2.8-angstrom resolution

scientific article

Structure-Based Mutational Analysis of the NS3 Helicase from Dengue Virus

scientific article (publication date: July 2006)

Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope

scientific article

Substrate Channel Flexibility in Pseudomonas aeruginosa MurB Accommodates Two Distinct Substrates

scientific article

Ten years of dengue drug discovery: progress and prospects

scientific article published on 27 September 2013

The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production

scientific article

The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replication

scientific article

The Crystal Structures of Chikungunya and Venezuelan Equine Encephalitis Virus nsP3 Macro Domains Define a Conserved Adenosine Binding Pocket

scientific article (publication date: July 2009)

The N-Terminal Domain of the Arenavirus L Protein Is an RNA Endonuclease Essential in mRNA Transcription

scientific article

The flavivirus NS2B-NS3 protease-helicase as a target for antiviral drug development

scientific article published on 02 April 2015

The flavivirus polymerase as a target for drug discovery.

scientific article published on 09 July 2008

The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes

scientific article

Thiazolidine-Masked α-Oxo Aldehyde Functionality for Peptide and Protein Modification

scientific article published on 27 December 2016

Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target

scientific article published on 30 July 2008

X-Ray Structures of the N- and C-Terminal Domains of a Coronavirus Nucleocapsid Protein: Implications for Nucleocapsid Formation

scientific article

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