List of works - Eloise Mastrangelo

Combined in silico and in vitro approaches identified the antipsychotic drug lurasidone and the antiviral drug elbasvir as SARS-CoV2 and HCoV-OC43 inhibitors

scientific article published on 10 March 2021

Crystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral Replication

scientific article

Crystal structure and activity of Kunjin virus NS3 helicase; protease and helicase domain assembly in the full length NS3 protein

scientific article

Crystal structure of a methyltransferase from a no-known-vector Flavivirus

scientific article

Delivery of suramin as an antiviral agent through liposomal systems

scientific article

Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2

scientific article

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

scientific article

Ebolavirus and Marburgvirus: insight the Filoviridae family

scientific article

Ferredoxin-NADP+ reductase from Plasmodium falciparum undergoes NADP+-dependent dimerization and inactivation: functional and crystallographic analysis

scientific article

Flaviviral helicase: Insights into the mechanism of action of a motor protein ⬇️

scientific article published on November 19, 2011

Flaviviral methyltransferase/RNA interaction: structural basis for enzyme inhibition

scientific article

Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase

scientific article published on 11 November 2017

Gelsolin pathogenic Gly167Arg mutation promotes domain-swap dimerization of the protein

scientific article

Hemoprotein time-resolved X-ray crystallography.

scientific article

Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

scientific article published in 2012

Identification of a small molecule that compromises the structural integrity of viroplasms and rotavirus double-layered particles

scientific article published on 15 November 2017

Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug

scientific article

Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin

scientific article published on 08 May 2016

Modulation of Guanylate Cyclase Activating Protein 1 (GCAP1) Dimeric Assembly by Ca2+ or Mg2+: Hints to Understand Protein Activity

scientific article published on 05 October 2020

NF023 binding to XIAP-BIR1: searching drugs for regulation of the NF-κB pathway

scientific article

Naphthalene-sulfonate inhibitors of human norovirus RNA-dependent RNA-polymerase

scientific article

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

scientific article

One hundred years of X-ray diffraction, 50 years of structural biology

PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases

scientific article

Preliminary characterization of (nucleoside-2′-O-)-methyltransferase crystals from Meaban and Yokose flaviviruses

scientific article (publication date: August 2006)

Preliminary crystallographic characterization of an RNA helicase from Kunjin virus

scientific article

Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents

scientific article

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

scientific article

Recognition of RNA cap in the Wesselsbron virus NS5 methyltransferase domain: implications for RNA-capping mechanisms in Flavivirus

scientific article

Recognition of Smac-mimetic compounds by the BIR domain of cIAP1

scientific article

Role and inhibition of GLI1 protein in cancer.

scientific article

Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-Mimetic

scientific article

Structural bases for substrate recognition and activity in Meaban virus nucleoside-2′-O-methyltransferase

scientific article (publication date: June 2007)

Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds

scientific article

Structural bases of the altered catalytic properties of a pathogenic variant of apoptosis inducing factor

scientific article

Structural basis for bivalent Smac-mimetics recognition in the IAP protein family

scientific article

Structure and biochemical analysis of Kokobera virus helicase

scientific article

Structure and functionality in flavivirus NS-proteins: perspectives for drug design

scientific article

Structure-Activity Relationship of NF023 Derivatives Binding to XIAP-BIR1

scientific article published on 12 April 2019

Structure-based inhibition of Norovirus RNA-dependent RNA polymerases

scientific article

Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor

scientific article

Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles

scientific article

The activator of apoptosis Smac-DIABLO acts as a tetramer in solution

scientific article published on February 2015

List of works by Eloise Mastrangelo

Combined in silico and in vitro approaches identified the antipsychotic drug lurasidone and the antiviral drug elbasvir as SARS-CoV2 and HCoV-OC43 inhibitors

Crystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral Replication

Crystal structure and activity of Kunjin virus NS3 helicase; protease and helicase domain assembly in the full length NS3 protein

Crystal structure of a methyltransferase from a no-known-vector Flavivirus

Delivery of suramin as an antiviral agent through liposomal systems

Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2

Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization

Ebolavirus and Marburgvirus: insight the Filoviridae family

Ferredoxin-NADP+ reductase from Plasmodium falciparum undergoes NADP+-dependent dimerization and inactivation: functional and crystallographic analysis

Flaviviral helicase: Insights into the mechanism of action of a motor protein ⬇️

Flaviviral methyltransferase/RNA interaction: structural basis for enzyme inhibition

Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase

Gelsolin pathogenic Gly167Arg mutation promotes domain-swap dimerization of the protein

Hemoprotein time-resolved X-ray crystallography.

Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis

Identification of a small molecule that compromises the structural integrity of viroplasms and rotavirus double-layered particles

Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug

Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin

Modulation of Guanylate Cyclase Activating Protein 1 (GCAP1) Dimeric Assembly by Ca2+ or Mg2+: Hints to Understand Protein Activity

NF023 binding to XIAP-BIR1: searching drugs for regulation of the NF-κB pathway

Naphthalene-sulfonate inhibitors of human norovirus RNA-dependent RNA-polymerase

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

One hundred years of X-ray diffraction, 50 years of structural biology

PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases

Preliminary characterization of (nucleoside-2′-O-)-methyltransferase crystals from Meaban and Yokose flaviviruses

Preliminary crystallographic characterization of an RNA helicase from Kunjin virus

Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents

Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.

Recognition of RNA cap in the Wesselsbron virus NS5 methyltransferase domain: implications for RNA-capping mechanisms in Flavivirus

Recognition of Smac-mimetic compounds by the BIR domain of cIAP1

Role and inhibition of GLI1 protein in cancer.

Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-Mimetic

Structural bases for substrate recognition and activity in Meaban virus nucleoside-2′-O-methyltransferase

Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds

Structural bases of the altered catalytic properties of a pathogenic variant of apoptosis inducing factor

Structural basis for bivalent Smac-mimetics recognition in the IAP protein family

Structure and biochemical analysis of Kokobera virus helicase

Structure and functionality in flavivirus NS-proteins: perspectives for drug design

Structure-Activity Relationship of NF023 Derivatives Binding to XIAP-BIR1

Structure-based inhibition of Norovirus RNA-dependent RNA polymerases

Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor

Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles

The activator of apoptosis Smac-DIABLO acts as a tetramer in solution