List of works by Bruno Canard

3',5'Di-O-trityluridine inhibits in vitro flavivirus replication

scientific article published on 5 March 2013

3'-Deoxy phosphoramidate dinucleosides as improved inhibitors of hepatitis C virus subgenomic replicon and NS5B polymerase activity

scientific article published on September 2010

3′,5′di-O-Trityluridine Inhibits Flavivirus (Dengue and Yellow Fever Virus) Replication and Targets the Viral RNA Dependent RNA Polymerase

article by Tine De Burghgraeve et al published May 2011 in Antiviral Research

A closed-handed affair: positive-strand RNA virus polymerases

A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

scientific article published on 02 February 2022

A loss of viral replicative capacity correlates with altered DNA polymerization kinetics by the human immunodeficiency virus reverse transcriptase bearing the K65R and L74V dideoxynucleoside resistance substitutions

scientific article published on 23 March 2004

A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase

scientific article

A practical overview of protein disorder prediction methods

scientific article

A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.

scientific article

A relaxed discrimination of 2'-O-methyl-GTP relative to GTP between de novo and Elongative RNA synthesis by the hepatitis C RNA-dependent RNA polymerase NS5B.

scientific article published on 22 November 2004

A second, non-canonical RNA-dependent RNA polymerase in SARS Coronavirus

scientific article

A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate.

scientific article published on 19 May 2004

Activity inhibition and crystal polymorphism induced by active-site metal swapping

scientific article published on 28 July 2017

Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication

scientific article

Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.

scientific article published in April 2008

Alkylated flavanones from the bark of Cryptocarya chartacea as dengue virus NS5 polymerase inhibitors

scientific article published on 3 November 2011

An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization

scientific article (publication date: 3 June 2002)

An integrated system to study multiply substituted human immunodeficiency virus type 1 reverse transcriptase.

scientific article published in May 2001

Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieri

scientific article published on 29 August 2012

Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens.

scientific article published on 19 September 2006

Approved drugs screening against the nsP1 capping enzyme of Venezuelan equine encephalitis virus using an immuno-based assay

scientific article published on 11 January 2019

Arenaviridae exoribonuclease presents genomic RNA edition capacity

Arenaviruses and hantaviruses: from epidemiology and genomics to antivirals

scientific article published on 26 February 2011

Assessing protein disorder and induced folding

scientific article

Autolysis of Clostridium acetobutylicum ATCC 824

scientific article published on 01 May 1992

Biflavonoids of Dacrydium balansae with potent inhibitory activity on dengue 2 NS5 polymerase

scientific article published on 12 March 2012

Binding of RNA template to a complex of HIV-1 reverse transcriptase/primer/template

scientific article published on October 1997

Binding of the Methyl Donor S-Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2'-O-Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10.

scientific article published on 28 December 2016

Biochemical characterization of the (nucleoside-2'O)-methyltransferase activity of dengue virus protein NS5 using purified capped RNA oligonucleotides (7Me)GpppAC(n) and GpppAC(n).

scientific article

Biochemical principles and inhibitors to interfere with viral capping pathways

scientific article

Biodiversity as a Source of Potent and Selective Inhibitors of Chikungunya Virus Replication

Borano-nucleotides: new analogues to circumvent HIV-1 RT-mediated nucleoside drug-resistance

scientific article

C3P3-G1: first generation of a eukaryotic artificial cytoplasmic expression system

scientific article published on 01 March 2019

Catalytic editing properties of DNA polymerases.

scientific article

Chemical constituents of Anacolosa pervilleana and their antiviral activities

scientific article published on 14 May 2012

Comparative Virtual and Experimental Medium Throughput Screening for Hepatitis C Virus Polymerase Inhibitors

article published in 2008

Comparative mechanistic studies of de novo RNA synthesis by flavivirus RNA-dependent RNA polymerases.

scientific article

Comparative production analysis of three phlebovirus nucleoproteins under denaturing or non-denaturing conditions for crystallographic studies

scientific article

Conformational disorder.

scientific article published in January 2010

Conformational plasticity of the VEEV macro domain is important for binding of ADP-ribose

scientific article published on 27 February 2019

Conventional and unconventional mechanisms for capping viral mRNA.

scientific article published on 05 December 2011

Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes

scientific article

Coronavirus nonstructural protein 16 is a cap-0 binding enzyme possessing (nucleoside-2'O)-methyltransferase activity

scientific article published on 16 April 2008

Correction to 3′-Deoxy Phosphoramidate Dinucleosides as Improved Inhibitors of Hepatitis C Virus Subgenomic Replicon and NS5B Polymerase Activity

scholarly article published in Journal of Medicinal Chemistry

Correction: In Vitro Reconstitution of SARS-Coronavirus mRNA Cap Methylation

scholarly article published by Isabelle Imbert in 2010

Corrigendum to “Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2′O)-methyltransferase” [Bioorg. Med. Chem. 15 (2007) 7795–7802]

scholarly article published in Bioorganic & Medicinal Chemistry

Coxsackievirus B3 protease 3C: expression, purification, crystallization and preliminary structural insights

scientific article

Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 Complex

scientific article

Crystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom Resolution

scientific article (publication date: May 2007)

Crystal structure and activity of Kunjin virus NS3 helicase; protease and helicase domain assembly in the full length NS3 protein

scientific article

Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family

scholarly article

Crystal structure of a methyltransferase from a no-known-vector Flavivirus

scientific article

Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5

scientific article

Crystal structure of the measles virus phosphoprotein domain responsible for the induced folding of the C-terminal domain of the nucleoprotein

scientific article

Crystal structures of Lymphocytic choriomeningitis virus endonuclease domain complexed with diketo-acid ligands.

scientific article

Crystallization and diffraction analysis of the SARS coronavirus nsp10-nsp16 complex

scientific article

Crystallization and preliminary X-ray diffraction analysis of Nsp15 from SARS coronavirus

scientific article

DNA polymerase fluorescent substrates with reversible 3′-tags

article

De Novo Initiation of RNA Synthesis by the Arterivirus RNA-Dependent RNA Polymerase

scientific article (publication date: August 2007)

Dengue virus replicons: production of an interserotypic chimera and cell lines from different species, and establishment of a cell-based fluorescent assay to screen inhibitors, validated by the evaluation of ribavirin's activity

scientific article published on 20 March 2010

Development of specific dengue virus 2'-O- and N7-methyltransferase assays for antiviral drug screening.

scientific article published on 12 June 2013

Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis

scholarly article

Effects of HIV Q151M-associated multi-drug resistance mutations on the activities of (-)-beta-D-1',3'-dioxolan guanine

scientific article published on 26 April 2005

Enhanced binding of azidothymidine-resistant human immunodeficiency virus 1 reverse transcriptase to the 3'-azido-3'-deoxythymidine 5'-monophosphate-terminated primer

scientific article

Enzymatic synthesis of acyclic nucleoside thiophosphonate diphosphates: effect of the α-phosphorus configuration on HIV-1 RT activity

scientific article

Essential amino acids of the hantaan virus N protein in its interaction with RNA.

scientific article

Ester prodrugs of acyclic nucleoside thiophosphonates compared to phosphonates: synthesis, antiviral activity and decomposition study

scientific article published on 14 March 2013

Evaluation of Adamantane Derivatives as Inhibitors of Dengue Virus mRNA Cap Methyltransferase by Docking and Molecular Dynamics Simulations

scientific article

Expression, purification and crystallization of the SARS-CoV macro domain.

scientific article

Favipiravir strikes the SARS-CoV-2 at its Achilles heel, the RNA polymerase

scientific article published on 16 May 2020

Filovirus proteins for antiviral drug discovery: A structure/function analysis of surface glycoproteins and virus entry

scientific article

Filovirus proteins for antiviral drug discovery: Structure/function bases of the replication cycle

scientific article published on 9 February 2017

Flacourtosides A-F, phenolic glycosides isolated from Flacourtia ramontchi

scientific article published on 22 March 2012

Flaviviral methyltransferase/RNA interaction: structural basis for enzyme inhibition

scientific article

Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen

scientific journal article

Functional Characterization of the Cleavage Specificity of the Sapovirus Chymotrypsin-Like Protease

scientific article (publication date: August 2008)

General Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide Analogues

scientific article (publication date: December 2006)

Genomics and structure/function studies of Rhabdoviridae proteins involved in replication and transcription.

scientific article published on 25 February 2010

Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues.

scientific article

Glutamic residue 438 within the protease-sensitive subdomain of HIV-1 reverse transcriptase is critical for heterodimer processing in viral particles.

scientific article published in November 2001

HIV-1-associated uracil DNA glycosylase activity controls dUTP misincorporation in viral DNA and is essential to the HIV-1 life cycle

scientific article

High yield synthesis, purification and characterisation of the RNase L activators 5'-triphosphate 2'-5'-oligoadenylates

scientific article published on 12 June 2010

High-yield production of short GpppA- and 7MeGpppA-capped RNAs and HPLC-monitoring of methyltransfer reactions at the guanine-N7 and adenosine-2'O positions

scientific article (publication date: 2007)

Hsp72 recognizes a P binding motif in the measles virus N protein C-terminus

scientific journal article

Human monocytes possess a serine protease activity capable of degrading HIV-1 reverse transcriptase in vitro.

scientific article published in July 2001

Identification of a Nidovirales Orf1a N7-guanine cap Methyltransferase signature-sequence as a genetic marker of large genome Tobaniviridae

scientific article published on 17 May 2019

Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step

scientific article

Improved crystallization of the coxsackievirus B3 RNA-dependent RNA polymerase

scientific article published on 12 May 2007

Improving the soluble expression of recombinant proteins by randomly shuffling 5' and 3' coding-sequence ends

scientific article

In vitro reconstitution of SARS-coronavirus mRNA cap methylation

scientific article

In vitro suppression of K65R reverse transcriptase-mediated tenofovir- and adefovir-5'-diphosphate resistance conferred by the boranophosphonate derivatives

scientific article

Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus

scientific article

Internal RNA 2′O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect

scientific article published on 10 November 2022

International research networks in viral structural proteomics: again, lessons from SARS.

scientific article published on November 2007

In vitro antiviral activities of extracts derived from Daucus maritimus seeds.

scientific article published on 6 September 2011

Isolation and mapping of three STSs on mouse chromosome 19

scientific article published on 01 June 1996

MeDor: a metaserver for predicting protein disorder

scientific article

Measles virus (MV) nucleoprotein binds to a novel cell surface receptor distinct from FcgammaRII via its C-terminal domain: role in MV-induced immunosuppression

scientific article published on November 2003

Measles virus nucleoprotein induces cell-proliferation arrest and apoptosis through NTAIL-NR and NCORE-FcgammaRIIB1 interactions, respectively.

scientific article

Mechanism-based suppression of dideoxynucleotide resistance by K65R human immunodeficiency virus reverse transcriptase using an alpha-boranophosphate nucleoside analogue.

scientific article

Mechanistic basis for reduced viral and enzymatic fitness of HIV-1 reverse transcriptase containing both K65R and M184V mutations

scientific article published on 9 October 2003

Mechanistic insights into the suppression of drug resistance by human immunodeficiency virus type 1 reverse transcriptase using alpha-boranophosphate nucleoside analogs

scientific article published on 17 November 2004

Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain

scientific article published on 14 December 2018

Mismatch repair in Xenopus egg extracts: DNA strand breaks act as signals rather than excision points.

scientific article published on September 1996

Molecular basis for nucleotide conservation at the ends of the dengue virus genome.

scientific article

Molecular genetic analysis of the nagH gene encoding a hyaluronidase of Clostridium perfringens.

scientific article published on April 1994

Molecular mapping of the RNA Cap 2'-O-methyltransferase activation interface between severe acute respiratory syndrome coronavirus nsp10 and nsp16.

scientific article

Monoclonal antibodies to the West Nile virus NS5 protein map to linear and conformational epitopes in the methyltransferase and polymerase domains

scientific article published on 26 August 2009

Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase

scientific article published on 29 December 2015

Nuclear localization of dengue virus nonstructural protein 5 does not strictly correlate with efficient viral RNA replication and inhibition of type I interferon signaling

scientific article published on 13 February 2013

Nucleotide analogue binding, catalysis and primer unblocking in the mechanisms of HIV-1 reverse transcriptase-mediated resistance to nucleoside analogues.

scientific article

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

scientific article

PHYTOCHIK: Biodiversity As A Source of Selective Inhibitors of CHIKV Replication

article published in 2011

Phosphoramidate dinucleosides as hepatitis C virus polymerase inhibitors

scientific article

Phosphorylation of AZT-resistant human immunodeficiency virus type 1 reverse transcriptase by casein kinase II in vitro: effects on inhibitor sensitivity

scientific article published in August 2000

Picornavirus non-structural proteins as targets for new anti-virals with broad activity

scientific article

Practical application of bioinformatics by the multidisciplinary VIZIER consortium

scientific article published on 11 February 2010

Predicting protein disorder and induced folding: from theoretical principles to practical applications.

scientific article

Preliminary characterization of (nucleoside-2′-O-)-methyltransferase crystals from Meaban and Yokose flaviviruses

scientific article (publication date: August 2006)

Preliminary characterization of (nucleoside-2′-O-)-methyltransferase crystals from Meaban and Yokose flaviviruses. Corrigendum.

scientific article published on 28 February 2007

Preliminary crystallographic characterization of an RNA helicase from Kunjin virus

scientific article

Primer-dependent and primer-independent initiation of double stranded RNA synthesis by purified Arabidopsis RNA-dependent RNA polymerases RDR2 and RDR6

scientific article

Purification and characterization of an extracellular muramidase of Clostridium acetobutylicum ATCC 824 that acts on non-N-acetylated peptidoglycan

scientific article

Purification and crystallization of Kokobera virus helicase

scientific article

RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex

scientific article

RNA-dependent RNA polymerases from flaviviruses and Picornaviridae

scientific article

Recognition of RNA cap in the Wesselsbron virus NS5 methyltransferase domain: implications for RNA-capping mechanisms in Flavivirus

scientific article

Regulation of Flavivirus RNA synthesis and replication

scientific article

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

scientific article

SARS-CoV ORF1b-encoded nonstructural proteins 12-16: replicative enzymes as antiviral targets.

scientific article

SPINE bioinformatics and data-management aspects of high-throughput structural biology

scientific article

Screening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication Inhibitors That Target Viral Protein 2C

scientific article (publication date: May 2016)

Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enteroviruses B and D by targeting viral protein 2C.

scientific article published on 18 January 2013

Single pH buffer refolding screen for protein from inclusion bodies.

scientific article

Solid-phase synthesis of 5’-capped mRNA with a methylene bridge within triphosphate chain

Solid-phase synthesis of 5’-capped mRNA with a phosphorothioate modification within triphosphate bridge

Stratégies de formation de la structure coiffe chez les virus à ARN

Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93

scientific article

Structural analysis of the activation of ribavirin analogs by NDP kinase: comparison with other ribavirin targets

scientific article (publication date: March 2003)

Structural and Functional Basis of the Fidelity of Nucleotide Selection by Flavivirus RNA-Dependent RNA Polymerases

scientific article published on 30 January 2018

Structural and biochemical analysis of human pathogenic astrovirus serine protease at 2.0 A resolution

scientific article

Structural and biophysical analysis of sequence insertions in the Venezuelan Equine Encephalitis Virus macro domain

scientific article published on 25 February 2015

Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5

scientific article

Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains

scientific article

Structural and functional characterization of sapovirus RNA-dependent RNA polymerase

scientific article published on 22 November 2006

Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA.

scientific article published on 26 December 2017

Structural bases for substrate recognition and activity in Meaban virus nucleoside-2′-O-methyltransferase

scientific article (publication date: June 2007)

Structural basis for activation of α-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase

scientific article

Structural characterization of the N-terminal part of the MERS-CoV nucleocapsid by X-ray diffraction and small-angle X-ray scattering

scientific article

Structural disorder and modular organization in Paramyxovirinae N and P.

scientific article

Structural disorder within the replicative complex of measles virus: functional implications

scientific article

Structural genomics of the SARS coronavirus: cloning, expression, crystallization and preliminary crystallographic study of the Nsp9 protein.

scientific article published on 19 August 2003

Structure and Genetic Analysis of the Arterivirus Nonstructural Protein 7α

scientific article

Structure and biochemical analysis of Kokobera virus helicase

scientific article

Structure and functionality in flavivirus NS-proteins: perspectives for drug design

scientific article

Structure and oligomerization state of the C-terminal region of the Middle East respiratory syndrome coronavirus nucleoprotein

scientific article published in January 2019

Structure-activity relationship study of biflavonoids on the Dengue virus polymerase DENV-NS5 RdRp

scientific article published on 8 August 2013

Substitution of two residues in the measles virus nucleoprotein results in an impaired self-association

scientific article published in October 2002

Substrate selectivity of Dengue and Zika virus NS5 polymerase towards 2'-modified nucleotide analogues

scientific article published on 29 December 2016

Suppression of multidrug-resistant HIV-1 reverse transcriptase primer unblocking activity by alpha-phosphate-modified thymidine analogues.

scientific article published on 19 April 2005

Synthesis and anti-BVDV activity of acridones as new potential antiviral agents

scientific article published in April 2006

Synthesis and antiviral activity of boranophosphonate isosteres of AZT and d4T monophosphates

scientific article

Synthesis of 5' cap-0 and cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N⁷)-methyl transferase.

scientific article published on 14 February 2012

Synthesis of AZT-alpha-Borano-5'-diphospho-hexoses

scientific article

Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Novel α-Borano-Nucleotide Analogues of 9-[2-(Phosphonomethoxy)ethyl]adenine and (R)-9-[2-(Phosphonomethoxy)propyl]adenine

scientific article published on 01 December 2006

The 2C putative helicase of echovirus 30 adopts a hexameric ring-shaped structure.

scientific article

The C-terminal domain of measles virus nucleoprotein belongs to the class of intrinsically disordered proteins that fold upon binding to their physiological partner

scientific article published in February 2004

The C-terminal domain of the measles virus nucleoprotein is intrinsically disordered and folds upon binding to the C-terminal moiety of the phosphoprotein

scientific article published on 5 March 2003

The Crystal Structure of a Cardiovirus RNA-Dependent RNA Polymerase Reveals an Unusual Conformation of the Polymerase Active Site

scientific article

The Crystal Structures of Chikungunya and Venezuelan Equine Encephalitis Virus nsP3 Macro Domains Define a Conserved Adenosine Binding Pocket

scientific article (publication date: July 2009)

The Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral Replication

scientific article (publication date: October 2007)

The N-Terminal Domain of the Arenavirus L Protein Is an RNA Endonuclease Essential in mRNA Transcription

scientific article

The N-terminal domain of the phosphoprotein of Morbilliviruses belongs to the natively unfolded class of proteins

scientific article

The RNA helicase, nucleotide 5'-triphosphatase, and RNA 5'-triphosphatase activities of Dengue virus protein NS3 are Mg2+-dependent and require a functional Walker B motif in the helicase catalytic core.

scientific article published on October 2004

The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family

scientific article

The SARS-Coronavirus PLnc domain of nsp3 as a replication/transcription scaffolding protein

scientific article published on 5 February 2008

The VIZIER project: overview; expectations; and achievements

scientific article published on 10 March 2010

The VIZIER project: preparedness against pathogenic RNA viruses

scientific article

The WHO mission report struggles to trace the origins of the SARS-CoV-2 epidemic

scholarly article

The Y181C substitution in 3'-azido-3'-deoxythymidine-resistant human immunodeficiency virus, type 1, reverse transcriptase suppresses the ATP-mediated repair of the 3'-azido-3'-deoxythymidine 5'-monophosphate-terminated primer

scientific article

The Zika virus methyltransferase: structure and functions for drug design perspectives

scientific article (publication date: 28 December 2016)

The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases

scientific article

The enterotoxin gene (cpe) of Clostridium perfringens can be chromosomal or plasmid-borne

scientific article published on 01 February 1995

The flavivirus polymerase as a target for drug discovery.

scientific article published on 09 July 2008

The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes

scientific article

The intrinsically disordered C-terminal domain of the measles virus nucleoprotein interacts with the C-terminal domain of the phosphoprotein via two distinct sites and remains predominantly unfolded

scientific article published on August 2005

The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain

scientific article published on 10 September 2014

The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain

scientific article published on 17 November 2015

The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2'-O-methylation

scientific article published on 06 May 2021

The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure

article

The modeled structure of the RNA dependent RNA polymerase of GBV-C virus suggests a role for motif E in Flaviviridae RNA polymerases

scientific article

The molecular mechanism of multidrug resistance by the Q151M human immunodeficiency virus type 1 reverse transcriptase and its suppression using alpha-boranophosphate nucleotide analogues

scientific article published on 22 August 2002

The non-structural protein Nsp10 of mouse hepatitis virus binds zinc ions and nucleic acids

scientific article published on 30 June 2006

The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world.

scholarly article

The structure of the binary methyltransferase-SAH complex from Zika virus reveals a novel conformation for the mechanism of mRNA capping

scientific article published on 14 December 2017

The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C.

scientific article published on 12 March 2008

The translation of recombinant proteins in E. coli can be improved by in silico generating and screening random libraries of a -70/+96 mRNA region with respect to the translation initiation codon.

scientific article

The valine-to-threonine 75 substitution in human immunodeficiency virus type 1 reverse transcriptase and its relation with stavudine resistance.

scientific article

The viral RNA capping machinery as a target for antiviral drugs

scientific article published on 26 July 2012

The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection.

scientific article published on 22 August 2016

Toscana virus nucleoprotein oligomer organization observed in solution.

scientific article published on 28 July 2017

Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay

scientific article published on July 2017

Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target

scientific article published on 30 July 2008

Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase

scientific article published on 5 April 2017

Understanding the alphaviruses: recent research on important emerging pathogens and progress towards their control.

scientific article

VaZyMolO: a tool to define and classify modularity in viral proteins

scientific article published in March 2005

Viral Macro Domains Reverse Protein ADP-Ribosylation.

scientific article published on 20 July 2016

Viral RNA-polymerases -- a predicted 2'-O-ribose methyltransferase domain shared by all Mononegavirales

scientific article published on May 2002

Virologic and enzymatic studies revealing the mechanism of K65R- and Q151M-associated HIV-1 drug resistance towards emtricitabine and lamivudine

scientific article published in January 2006

Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2'O)-methyltransferase

scientific article

X-ray structure and activities of an essential Mononegavirales L-protein domain

scientific article

[Ebola virus L protein harbors a new enzymatic activity involved in the internal methylation of RNAs].

scientific article published on 01 November 2018

mRNA Capping by Venezuelan Equine Encephalitis Virus nsP1: Functional Characterization and Implications for Antiviral Research

scientific article

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