List of works - Boris Illarionov

13C Isotopologue editing of FMN bound to phototropin domains

scientific article

A high-throughput screen utilizing the fluorescence of riboflavin for identification of lumazine synthase inhibitors

scientific article published in March 2005

A high-throughput screening platform for inhibitors of the riboflavin biosynthesis pathway

scientific article published on 03 March 2007

A new series of 3-alkyl phosphate derivatives of 4,5,6,7-tetrahydro-1-D-ribityl-1H-pyrazolo[3,4-d]pyrimidinedione as inhibitors of lumazine synthase: design, synthesis, and evaluation

scientific article published on 18 August 2007

A novel lumazine synthase inhibitor derived from oxidation of 1,3,6,8-tetrahydroxy-2,7-naphthyridine to a tetraazaperylenehexaone derivative

scientific article published on 10 March 2007

A roadmap to the isotopolog space of flavocoenzymes

scientific article published on 01 January 2014

Arabidopsis RIBA proteins: two out of three isoforms have lost their bifunctional activity in riboflavin biosynthesis

scientific article published on 31 October 2012

Aryl Bis-Sulfonamide Inhibitors of IspF fromArabidopsis thalianaandPlasmodium falciparum

scholarly article by Jonas Thelemann et al published 5 October 2015 in ChemMedChem

Aryl bis-sulfonamides bind to the active site of a homotrimeric isoprenoid biosynthesis enzyme IspF and extract the essential divalent metal cation cofactor

scientific article published on 18 June 2018

Binding modes of reverse fosmidomycin analogs toward the antimalarial target IspC

scientific article

Biosynthesis of vitamin B2: diastereomeric reaction intermediates of archaeal and non-archaeal riboflavin synthases

scientific article published on 8 June 2005

Catalysis of an Essential Step in Vitamin B2 Biosynthesis by a Consortium of Broad Spectrum Hydrolases.

scientific article

Coupled Methyl Group Rotation in FMN Radicals Revealed by Selective Deuterium Labeling

scientific article published on 21 February 2020

Crystal structure of an archaeal pentameric riboflavin synthase in complex with a substrate analog inhibitor: stereochemical implications

scientific article published on 4 November 2005

Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors

scientific article

Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents

scientific article published on 4 June 2014

Design, synthesis, and biochemical evaluation of 1,5,6,7-tetrahydro-6,7-dioxo-9-D-ribitylaminolumazines bearing alkyl phosphate substituents as inhibitors of lumazine synthase and riboflavin synthase

scientific article published on September 2005

Design, synthesis, and evaluation of 9-D-ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones bearing alkyl phosphate and alpha,alpha-difluorophosphonate substituents as inhibitors of tiboflavin synthase and lumazine synthase

scientific article published in February 2004

Design, synthesis, and evaluation of acyclic C-nucleoside and N-methylated derivatives of the ribitylaminopyrimidine substrate of lumazine synthase as potential enzyme inhibitors and mechanistic probes

scientific article published in October 2004

Detecting a new source for photochemically induced dynamic nuclear polarization in the LOV2 domain of phototropin by magnetic-field dependent (13)C NMR spectroscopy

scientific article published on 26 September 2014

Discovery and development of a small molecule library with lumazine synthase inhibitory activity

scientific article published in August 2009

Discovery and development of the covalent hydrates of trifluoromethylated pyrazoles as riboflavin synthase inhibitors with antibiotic activity against Mycobacterium tuberculosis

scientific journal article

Enzymes from the haloacid dehalogenase (HAD) superfamily catalyse the elusive dephosphorylation step of riboflavin biosynthesis.

scientific article

Evolution of vitamin B2 biosynthesis: structural and functional similarity between pyrimidine deaminases of eubacterial and plant origin

scientific article

Excited State Vibrations of Isotopically Labeled FMN Free and Bound to a Light-Oxygen-Voltage (LOV) Protein

scientific article published on 10 August 2020

Femtosecond to Millisecond Dynamics of Light Induced Allostery in the Avena sativa LOV Domain

scientific article

Hindered rotation of a cofactor methyl group as a probe for protein-cofactor interaction

scientific article published in July 2010

Inhibitors of the herbicidal target IspD: allosteric site binding

scientific article

IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters

scientific article

Ligand binding properties of the N-terminal domain of riboflavin synthase from Escherichia coli.

scientific article published in March 2007

Long-Lived Hydrated FMN Radicals. EPR Characterization and Implications for Catalytic Variability in Flavoproteins

scientific article published on 26 November 2018

Lumazine proteins from photobacteria: localization of the single ligand binding site to the N-terminal domain

scientific article published in December 2007

Mechanism of Allosteric Inhibition of the Enzyme IspD by Three Different Classes of Ligands

scientific article

Mechanistic insights on riboflavin synthase inspired by selective binding of the 6,7-dimethyl-8-ribityllumazine exomethylene anion

scientific article

Methyl groups matter: Photo-CIDNP characterizations of the semiquinone radicals of FMN and demethylated FMN analogs

scientific article published on 01 December 2019

Novel reverse thia-analogs of fosmidomycin: Synthesis and antiplasmodial activity

scientific article published on 22 July 2019

O-Nucleoside, S-nucleoside, and N-nucleoside probes of lumazine synthase and riboflavin synthase

scientific article

One protein, two chromophores: comparative spectroscopic characterization of 6,7-dimethyl-8-ribityllumazine and riboflavin bound to lumazine protein

scientific article published on 10 November 2014

Phage Display on the Anti-infective Target 1-Deoxy-d-xylulose-5-phosphate Synthase Leads to an Acceptor-Substrate Competitive Peptidic Inhibitor

scientific article published on 8 November 2017

Pre-steady-state kinetic analysis of riboflavin synthase using a pentacyclic reaction intermediate as substrate

scientific article

Preparation of flavocoenzyme isotopologues by biotransformation of purines

scientific article published on 24 February 2015

Presteady State Kinetic Analysis of Riboflavin Synthase ⬇️

scientific article published on September 22, 2003

Prodrugs of reverse fosmidomycin analogues

scientific article published on 12 February 2015

Pseudilins: halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD

scientific article

Random isotopolog libraries for protein perturbation studies. 13C NMR studies on lumazine protein of Photobacterium leiognathi

scientific article

Rapid preparation of isotopolog libraries by in vivo transformation of 1)C-glucose. Studies on 6,7-dimethyl-8-ribityllumazine, a biosynthetic precursor of vitamin B2.

scientific article

Recent advances in riboflavin biosynthesis

scientific article published on January 2014

Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr)

scientific article

Riboflavin synthase of Schizosaccharomyces pombe. Protein dynamics revealed by 19F NMR protein perturbation experiments

scientific article

Strategy for Enhancement of (13)C-Photo-CIDNP NMR Spectra by Exploiting Fractional (13)C-Labeling of Tryptophan

scientific article published on 5 August 2015

Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis

scientific article published on 19 September 2006

Structural study and thermodynamic characterization of inhibitor binding to lumazine synthase fromBacillus anthracis

scientific article

Structure of GTP cyclohydrolase I from Listeria monocytogenes, a potential anti-infective drug target

scientific article published on 30 August 2019

Structure of lumazine protein, an optical transponder of luminescent bacteria

scientific article

Studies on the reaction mechanism of riboflavin synthase: X-ray crystal structure of a complex with 6-carboxyethyl-7-oxo-8-ribityllumazine

scientific article

Synthesis and enzyme inhibitory activity of the s-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase.

scientific article published on 16 August 2007

Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum

scientific journal article

Ultrafast Structural Dynamics of BlsA, a Photoreceptor from the Pathogenic Bacterium Acinetobacter baumannii.

scientific article

Ultrafast infrared spectroscopy of an isotope-labeled photoactivatable flavoprotein

scientific article published on 4 February 2011

Variation in LOV Photoreceptor Activation Dynamics Probed by Time-Resolved Infrared Spectroscopy.

scientific article

Vibrational assignment of the ultrafast infrared spectrum of the photoactivatable flavoprotein AppA.

scientific article published on 27 August 2012

Vibrational spectra of the ground and the singlet excited ππ* state of 6,7-dimethyl-8-ribityllumazine

scientific article published on 16 March 2011

Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase

scientific article

α-Substituted β-oxa isosteres of fosmidomycin: synthesis and biological evaluation.

scientific article published on 11 July 2012

List of works by Boris Illarionov

13C Isotopologue editing of FMN bound to phototropin domains

A high-throughput screen utilizing the fluorescence of riboflavin for identification of lumazine synthase inhibitors

A high-throughput screening platform for inhibitors of the riboflavin biosynthesis pathway

A new series of 3-alkyl phosphate derivatives of 4,5,6,7-tetrahydro-1-D-ribityl-1H-pyrazolo[3,4-d]pyrimidinedione as inhibitors of lumazine synthase: design, synthesis, and evaluation

A novel lumazine synthase inhibitor derived from oxidation of 1,3,6,8-tetrahydroxy-2,7-naphthyridine to a tetraazaperylenehexaone derivative

A roadmap to the isotopolog space of flavocoenzymes

Arabidopsis RIBA proteins: two out of three isoforms have lost their bifunctional activity in riboflavin biosynthesis

Aryl Bis-Sulfonamide Inhibitors of IspF fromArabidopsis thalianaandPlasmodium falciparum

Aryl bis-sulfonamides bind to the active site of a homotrimeric isoprenoid biosynthesis enzyme IspF and extract the essential divalent metal cation cofactor

Binding modes of reverse fosmidomycin analogs toward the antimalarial target IspC

Biosynthesis of vitamin B2: diastereomeric reaction intermediates of archaeal and non-archaeal riboflavin synthases

Catalysis of an Essential Step in Vitamin B2 Biosynthesis by a Consortium of Broad Spectrum Hydrolases.

Coupled Methyl Group Rotation in FMN Radicals Revealed by Selective Deuterium Labeling

Crystal structure of an archaeal pentameric riboflavin synthase in complex with a substrate analog inhibitor: stereochemical implications

Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors

Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents

Design, synthesis, and biochemical evaluation of 1,5,6,7-tetrahydro-6,7-dioxo-9-D-ribitylaminolumazines bearing alkyl phosphate substituents as inhibitors of lumazine synthase and riboflavin synthase

Design, synthesis, and evaluation of 9-D-ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones bearing alkyl phosphate and alpha,alpha-difluorophosphonate substituents as inhibitors of tiboflavin synthase and lumazine synthase

Design, synthesis, and evaluation of acyclic C-nucleoside and N-methylated derivatives of the ribitylaminopyrimidine substrate of lumazine synthase as potential enzyme inhibitors and mechanistic probes

Detecting a new source for photochemically induced dynamic nuclear polarization in the LOV2 domain of phototropin by magnetic-field dependent (13)C NMR spectroscopy

Discovery and development of a small molecule library with lumazine synthase inhibitory activity

Discovery and development of the covalent hydrates of trifluoromethylated pyrazoles as riboflavin synthase inhibitors with antibiotic activity against Mycobacterium tuberculosis

Enzymes from the haloacid dehalogenase (HAD) superfamily catalyse the elusive dephosphorylation step of riboflavin biosynthesis.

Evolution of vitamin B2 biosynthesis: structural and functional similarity between pyrimidine deaminases of eubacterial and plant origin

Excited State Vibrations of Isotopically Labeled FMN Free and Bound to a Light-Oxygen-Voltage (LOV) Protein

Femtosecond to Millisecond Dynamics of Light Induced Allostery in the Avena sativa LOV Domain

Hindered rotation of a cofactor methyl group as a probe for protein-cofactor interaction

Inhibitors of the herbicidal target IspD: allosteric site binding

IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters

Ligand binding properties of the N-terminal domain of riboflavin synthase from Escherichia coli.

Long-Lived Hydrated FMN Radicals. EPR Characterization and Implications for Catalytic Variability in Flavoproteins

Lumazine proteins from photobacteria: localization of the single ligand binding site to the N-terminal domain

Mechanism of Allosteric Inhibition of the Enzyme IspD by Three Different Classes of Ligands

Mechanistic insights on riboflavin synthase inspired by selective binding of the 6,7-dimethyl-8-ribityllumazine exomethylene anion

Methyl groups matter: Photo-CIDNP characterizations of the semiquinone radicals of FMN and demethylated FMN analogs

Novel reverse thia-analogs of fosmidomycin: Synthesis and antiplasmodial activity

O-Nucleoside, S-nucleoside, and N-nucleoside probes of lumazine synthase and riboflavin synthase

One protein, two chromophores: comparative spectroscopic characterization of 6,7-dimethyl-8-ribityllumazine and riboflavin bound to lumazine protein

Phage Display on the Anti-infective Target 1-Deoxy-d-xylulose-5-phosphate Synthase Leads to an Acceptor-Substrate Competitive Peptidic Inhibitor

Pre-steady-state kinetic analysis of riboflavin synthase using a pentacyclic reaction intermediate as substrate

Preparation of flavocoenzyme isotopologues by biotransformation of purines

Presteady State Kinetic Analysis of Riboflavin Synthase ⬇️

Prodrugs of reverse fosmidomycin analogues

Pseudilins: halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD

Random isotopolog libraries for protein perturbation studies. 13C NMR studies on lumazine protein of Photobacterium leiognathi

Rapid preparation of isotopolog libraries by in vivo transformation of 1)C-glucose. Studies on 6,7-dimethyl-8-ribityllumazine, a biosynthetic precursor of vitamin B2.

Recent advances in riboflavin biosynthesis

Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr)

Riboflavin synthase of Schizosaccharomyces pombe. Protein dynamics revealed by 19F NMR protein perturbation experiments

Strategy for Enhancement of (13)C-Photo-CIDNP NMR Spectra by Exploiting Fractional (13)C-Labeling of Tryptophan

Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis

Structural study and thermodynamic characterization of inhibitor binding to lumazine synthase fromBacillus anthracis

Structure of GTP cyclohydrolase I from Listeria monocytogenes, a potential anti-infective drug target

Structure of lumazine protein, an optical transponder of luminescent bacteria

Studies on the reaction mechanism of riboflavin synthase: X-ray crystal structure of a complex with 6-carboxyethyl-7-oxo-8-ribityllumazine

Synthesis and enzyme inhibitory activity of the s-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase.

Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum

Ultrafast Structural Dynamics of BlsA, a Photoreceptor from the Pathogenic Bacterium Acinetobacter baumannii.

Ultrafast infrared spectroscopy of an isotope-labeled photoactivatable flavoprotein

Variation in LOV Photoreceptor Activation Dynamics Probed by Time-Resolved Infrared Spectroscopy.

Vibrational assignment of the ultrafast infrared spectrum of the photoactivatable flavoprotein AppA.

Vibrational spectra of the ground and the singlet excited ππ* state of 6,7-dimethyl-8-ribityllumazine

Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase

α-Substituted β-oxa isosteres of fosmidomycin: synthesis and biological evaluation.