List of works - Stefan Steinbacher

(1R,2R)-N-(1-Cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): A Potent and Highly Selective Cathepsin K Inhibitor for the Treatment of Osteoarthritis ⬇️

scientific article published on July 10, 2012

A combined spectroscopic and crystallographic approach to probing drug–human serum albumin interactions ⬇️

scientific article published on September 24, 2010

Biosynthesis of riboflavin in archaea studies on the mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase of Methanococcus jannaschii

scientific article published on 27 August 2002

Crystal structure of Schizosaccharomyces pombe riboflavin kinase reveals a novel ATP and riboflavin-binding fold

scientific article (publication date: 7 March 2003)

Crystal structure of the plant PPC decarboxylase AtHAL3a complexed with an ene-thiol reaction intermediate

scientific article (publication date: 14 March 2003)

Crystal structure of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Bacillus subtilis

scientific article

Design of selective Cathepsin inhibitors

scientific article

Dipeptidyl nitrile inhibitors of Cathepsin L

scientific article

Discovery and Optimization of a Novel Series of Potent Mutant B-RafV600E Selective Kinase Inhibitors ⬇️

scientific article published on February 27, 2013

Identification of azabenzimidazoles as potent JAK1 selective inhibitors

scientific article

Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers ⬇️

scientific article published on September 6, 2011

Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors

scientific article

Metal sites in 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with the substrate ribulose 5-phosphate

scientific article

Potential anti-infective targets in pathogenic yeasts: structure and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans

scientific article

Riboflavin synthase of Schizosaccharomyces pombe. Protein dynamics revealed by 19F NMR protein perturbation experiments

scientific article

Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development

scientific article (publication date: 16 May 2003)

Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids

scientific article

Structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with divalent metal ions and the substrate ribulose 5-phosphate: implications for the catalytic mechanism

scientific article

Structure of the murine unglycosylated IgG1 Fc fragment

scientific article

The Crystal Structure of a Constitutively Active Mutant RON Kinase Suggests an Intramolecular Autophosphorylation Hypothesis ⬇️

scientific article published on September 21, 2010

The crystal structures of Zea mays and Arabidopsis 4-hydroxyphenylpyruvate dioxygenase

scientific article

The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase

scientific article

List of works by Stefan Steinbacher

(1R,2R)-N-(1-Cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): A Potent and Highly Selective Cathepsin K Inhibitor for the Treatment of Osteoarthritis ⬇️

A combined spectroscopic and crystallographic approach to probing drug–human serum albumin interactions ⬇️

Biosynthesis of riboflavin in archaea studies on the mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase of Methanococcus jannaschii

Crystal structure of Schizosaccharomyces pombe riboflavin kinase reveals a novel ATP and riboflavin-binding fold

Crystal structure of the plant PPC decarboxylase AtHAL3a complexed with an ene-thiol reaction intermediate

Crystal structure of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Bacillus subtilis

Design of selective Cathepsin inhibitors

Dipeptidyl nitrile inhibitors of Cathepsin L

Discovery and Optimization of a Novel Series of Potent Mutant B-RafV600E Selective Kinase Inhibitors ⬇️

Identification of azabenzimidazoles as potent JAK1 selective inhibitors

Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers ⬇️

Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors

Metal sites in 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with the substrate ribulose 5-phosphate

Potential anti-infective targets in pathogenic yeasts: structure and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans

Riboflavin synthase of Schizosaccharomyces pombe. Protein dynamics revealed by 19F NMR protein perturbation experiments

Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development

Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids

Structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with divalent metal ions and the substrate ribulose 5-phosphate: implications for the catalytic mechanism

Structure of the murine unglycosylated IgG1 Fc fragment

The Crystal Structure of a Constitutively Active Mutant RON Kinase Suggests an Intramolecular Autophosphorylation Hypothesis ⬇️

The crystal structures of Zea mays and Arabidopsis 4-hydroxyphenylpyruvate dioxygenase

The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase