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List of works by Felix Rohdich

2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19.

scientific article published on 28 March 2016

A high-throughput screening platform for inhibitors of the riboflavin biosynthesis pathway

scientific article published on 03 March 2007

A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors

scientific article published in Scientific Reports

A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.

scientific article

A tomato enzyme catalyzing the phosphorylation of 3,4-dihydroxy-2-butanone

scientific article

Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study

scientific article published on 22 November 2009

Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases

scientific article (publication date: 9 December 2016)

Biochemical characterization of Bacillus subtilis type II isopentenyl diphosphate isomerase, and phylogenetic distribution of isoprenoid biosynthesis pathways

scientific article published on July 2004

Biochemistry of the non-mevalonate isoprenoid pathway ⬇️

scientific article published on 09 July 2011

Biosynthesis of isoprenoids. purification and properties of IspG protein from Escherichia coli

scientific article published in November 2005

Biosynthesis of isoprenoids: Crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase

scientific article

Biosynthesis of isoprenoids: a bifunctional IspDF enzyme from Campylobacter jejuni

scientific article published on July 2004

Biosynthesis of isoprenoids: crystal structure of the [4Fe-4S] cluster protein IspG

scientific article

Biosynthesis of isoprenoids: studies on the mechanism of 2C-methyl-D-erythritol-4-phosphate synthase

scientific article published on 4 July 2008

Biosynthesis of terpenes. Preparation of (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate, an intermediate of the deoxyxylulose phosphate pathway

scientific article

Biosynthesis of terpenes: studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase

scientific article

Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery

scientific article

Crystal structure of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Bacillus subtilis

scientific article

Discovery and Optimization of 2-Arylquinazolin-4-ones into a Potent and Selective Tankyrase Inhibitor Modulating Wnt Pathway Activity

scientific article published on 20 August 2019

Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors

scientific article published on 02 May 2019

Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19

scientific article

Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore

scientific article published on 22 January 2016

Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.

scientific article published on 13 February 2015

Evolution of vitamin B2 biosynthesis: structural and functional similarity between pyrimidine deaminases of eubacterial and plant origin

scientific article

Fluorescent inhibitors for IspF, an enzyme in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy

scientific article

Fragment-Based Discovery of New Highly Substituted 1H-Pyrrolo[2,3-b]- and 3H-Imidazolo[4,5-b]-Pyridines as Focal Adhesion Kinase Inhibitors ⬇️

scientific article published on January 22, 2013

Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli

scientific article

Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis

scientific article published on 2 October 2004

Identification of Methionine Aminopeptidase-2 (MetAP-2) Inhibitor M8891: A Clinical Compound for the Treatment of Cancer

scientific article published on 03 December 2019

Inhibitors of the Herbicidal Target IspD: Allosteric Site Binding ⬇️

scientific article published on July 18, 2011

Inhibitors of the kinase IspE: structure-activity relationships and co-crystal structure analysis

scientific article

Isoprenoid biosynthesis in plants - 2C-methyl-D-erythritol-4-phosphate synthase (IspC protein) of Arabidopsis thaliana ⬇️

scientific article

IspH protein of Escherichia coli: studies on iron-sulfur cluster implementation and catalysis

scientific article

Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods

scientific article

Nonphosphate inhibitors of IspE protein, a kinase in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy

scientific article published in June 2007

Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates.

scientific article published on 8 December 2016

Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models

scientific article published on 13 July 2021

Perspectives in anti-infective drug design. The late steps in the biosynthesis of the universal terpenoid precursors, isopentenyl diphosphate and dimethylallyl diphosphate

scientific article published in October 2004

Phenylalanine-independent biosynthesis of 1,3,5,8-tetrahydroxyxanthone. A retrobiosynthetic NMR study with root cultures of Swertia chirata

scientific article published in July 2003

Probing the reaction mechanism of IspH protein by x-ray structure analysis

scientific article

Stereochemical studies on the making and unmaking of isopentenyl diphosphate in different biological systems

scientific article published in September 2004

Stimulation of Vgamma9/Vdelta2 T-lymphocyte proliferation by the isoprenoid precursor, (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate

scientific article published on 18 September 2006

Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development

scientific article (publication date: 16 May 2003)

Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids

scientific article

Structure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reduction

scientific article

Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening.

scientific article published on 4 August 2016

Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein

scientific article

Synthesis and antiplasmodial activity of highly active reverse analogues of the antimalarial drug candidate fosmidomycin

scientific article published on October 2010

Synthesis and characterization of cytidine derivatives that inhibit the kinase IspE of the non-mevalonate pathway for isoprenoid biosynthesis

scientific article

The crystal structure of a plant 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase exhibits a distinct quaternary structure compared to bacterial homologues and a possible role in feedback regulation for cytidine monophosphate.

scientific article

The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: studies on the mechanisms of the reactions catalyzed by IspG and IspH protein

scholarly article

The identification of isoprenoids that bind in the intersubunit cavity of Escherichia coli 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase by complementary biophysical methods.

scientific article published on 17 December 2004

Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum

scientific journal article

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