List of works - Michael Groll

20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A

scientific article

A Minimal β-Lactone Fragment for Selective β5c or β5i Proteasome Inhibitors

scientific article

A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism

scientific article

Activity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cells

scientific article

Alternative bacterial two-component small heat shock protein systems ⬇️

scientific article published on November 26, 2012

Applied techniques for mining natural proteasome inhibitors ⬇️

scientific article published on January 27, 2013

Are Free Radicals Involved in IspH Catalysis? An EPR and Crystallographic Investigation ⬇️

scientific article published on June 28, 2012

Biosynthesis of isoprenoids: crystal structure of the [4Fe-4S] cluster protein IspG

scientific article

Biosynthesis of the 22nd Genetically Encoded Amino Acid Pyrrolysine: Structure and Reaction Mechanism of PylC at 1.5Å Resolution ⬇️

scientific article published on September 14, 2012

Bortezomib-resistant mutant proteasomes: structural and biochemical evaluation with carfilzomib and ONX 0914

scientific article

Characterization of a Cyanobacterial Haloperoxidase and Evaluation of its Biocatalytic Halogenation Potential

scientific article

Crystal Structure of Methylornithine Synthase (PylB): Insights into the Pyrrolysine Biosynthesis ⬇️

scientific article published on November 16, 2011

Crystal structures of mutant IspH proteins reveal a rotation of the substrate's hydroxymethyl group during catalysis

scientific article

DNA minor groove sensing and widening by the CCAAT-binding complex

scientific article

Differential global structural changes in the core particle of yeast and mouse proteasome induced by ligand binding

scientific article

Dimerized Linear Mimics of a Natural Cyclopeptide (TMC-95A) Are Potent Noncovalent Inhibitors of the Eukaryotic 20S Proteasome ⬇️

scientific article published on April 17, 2013

Discovery of acetylene hydratase activity of the iron–sulphur protein IspH

scientific article

Disruption of oligomerization and dehydroalanine formation as mechanisms for ClpP protease inhibition

scientific article

Elucidation of the α‐Keto‐Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition ⬇️

scientific article published on January 10, 2011

Ferredoxin:NADPH oxidoreductase is recruited to thylakoids by binding to a polyproline type II helix in a pH-dependent manner

scientific article

Flavoenzyme-catalyzed formation of disulfide bonds in natural products

scientific article

Functional and phylogenetic properties of the pore-forming beta-barrel transporters of the Omp85 family

scientific article

Harnessing the evolvability of tricyclic microviridins to dissect protease-inhibitor interactions

scientific article

Hedycaryol synthase in complex with nerolidol reveals terpene cyclase mechanism

scientific article

High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation

scientific article

Hydroxyureas as Noncovalent Proteasome Inhibitors ⬇️

scientific article published on November 21, 2011

Identification of a β1/β2-specific sulfonamide proteasome ligand by crystallographic screening

scientific article

Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity ⬇️

scientific article published on February 17, 2012

Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites

scientific article

Indolo-phakellins as β5-specific noncovalent proteasome inhibitors

scientific article

Induced-fit mechanism in class I terpene cyclases

scientific article

Insights into Structural Network Responsible for Oligomerization and Activity of Bacterial Virulence Regulator Caseinolytic Protease P (ClpP) Protein ⬇️

scientific article published on January 30, 2012

Insights into the Binding of Pyridines to the Iron–Sulfur Enzyme IspH

scientific article

Interactions of the natural product kendomycin and the 20S proteasome

scientific article

Investigations on the maturation and regulation of archaebacterial proteasomes

scientific article (publication date: 14 March 2003)

IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters

scientific article

Macyranones: Structure, Biosynthesis, and Binding Mode of an Unprecedented Epoxyketone that Targets the 20S Proteasome

scientific article

Navigation inside a protease: substrate selection and product exit in the tricorn protease from Thermoplasma acidophilum

scientific article

Omuralide and vibralactone: differences in the proteasome- β-lactone-γ-lactam binding scaffold alter target preferences

scientific article

One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitor ⬇️

scientific article published on October 22, 2012

Probing the reaction mechanism of IspH protein by x-ray structure analysis

scientific article

Proteasome inhibition by fellutamide B induces nerve growth factor synthesis

scientific article

Pseudilins: halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD

scientific article

Quinone reductase acts as a redox switch of the 20S yeast proteasome

scientific article

Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr)

scientific article

Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association

scientific article

Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism

scientific article

Sequential Inactivation of Gliotoxin by the S-Methyltransferase TmtA

scientific article

Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition

scientific article

Structural Analysis of Spiro β-Lactone Proteasome Inhibitors

scientific article

Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad ⬇️

scientific article published on June 24, 2013

Structure and Reaction Mechanism of Pyrrolysine Synthase (PylD) ⬇️

scientific article published on May 29, 2013

Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor

scientific article

Structure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reduction

scientific article

Structure of the Dioxygenase AsqJ: Mechanistic Insights into a One-Pot Multistep Quinolone Antibiotic Biosynthesis

scientific article

Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes

scientific article

Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes

scientific article

Structures of Fluoro, Amino, and Thiol Inhibitors Bound to the [Fe4S4] Protein IspH

scientific article

Structures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism

scientific article

Synthesis and biological activity of optimized belactosin C congeners

scientific article

Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition

scientific article

Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors

scientific article

Systematic comparison of peptidic proteasome inhibitors highlights the α-ketoamide electrophile as an auspicious reversible lead motif

scientific article

Targeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide Conjugation

scientific article

The Chaperone Activity of the Developmental Small Heat Shock Protein Sip1 Is Regulated by pH-Dependent Conformational Changes

scientific article

The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop

scientific article

The formation of pyrroline and tetrahydropyridine rings in amino acids catalyzed by pyrrolysine synthase (PylD)

scientific article

The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins

scientific article

Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum

scientific journal article

Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction

scientific article

Versatile C(3)-symmetric scaffolds and their use for covalent stabilization of the foldon trimer

scientific article

α-Keto phenylamides as P1'-extended proteasome inhibitors

scientific article

List of works by Michael Groll

20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A

A Minimal β-Lactone Fragment for Selective β5c or β5i Proteasome Inhibitors

A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism

Activity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cells

Alternative bacterial two-component small heat shock protein systems ⬇️

Applied techniques for mining natural proteasome inhibitors ⬇️

Are Free Radicals Involved in IspH Catalysis? An EPR and Crystallographic Investigation ⬇️

Biosynthesis of isoprenoids: crystal structure of the [4Fe-4S] cluster protein IspG

Biosynthesis of the 22nd Genetically Encoded Amino Acid Pyrrolysine: Structure and Reaction Mechanism of PylC at 1.5Å Resolution ⬇️

Bortezomib-resistant mutant proteasomes: structural and biochemical evaluation with carfilzomib and ONX 0914

Characterization of a Cyanobacterial Haloperoxidase and Evaluation of its Biocatalytic Halogenation Potential

Crystal Structure of Methylornithine Synthase (PylB): Insights into the Pyrrolysine Biosynthesis ⬇️

Crystal structures of mutant IspH proteins reveal a rotation of the substrate's hydroxymethyl group during catalysis

DNA minor groove sensing and widening by the CCAAT-binding complex

Differential global structural changes in the core particle of yeast and mouse proteasome induced by ligand binding

Dimerized Linear Mimics of a Natural Cyclopeptide (TMC-95A) Are Potent Noncovalent Inhibitors of the Eukaryotic 20S Proteasome ⬇️

Discovery of acetylene hydratase activity of the iron–sulphur protein IspH

Disruption of oligomerization and dehydroalanine formation as mechanisms for ClpP protease inhibition

Elucidation of the α‐Keto‐Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition ⬇️

Ferredoxin:NADPH oxidoreductase is recruited to thylakoids by binding to a polyproline type II helix in a pH-dependent manner

Flavoenzyme-catalyzed formation of disulfide bonds in natural products

Functional and phylogenetic properties of the pore-forming beta-barrel transporters of the Omp85 family

Harnessing the evolvability of tricyclic microviridins to dissect protease-inhibitor interactions

Hedycaryol synthase in complex with nerolidol reveals terpene cyclase mechanism

High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation

Hydroxyureas as Noncovalent Proteasome Inhibitors ⬇️

Identification of a β1/β2-specific sulfonamide proteasome ligand by crystallographic screening

Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity ⬇️

Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites

Indolo-phakellins as β5-specific noncovalent proteasome inhibitors

Induced-fit mechanism in class I terpene cyclases

Insights into Structural Network Responsible for Oligomerization and Activity of Bacterial Virulence Regulator Caseinolytic Protease P (ClpP) Protein ⬇️

Insights into the Binding of Pyridines to the Iron–Sulfur Enzyme IspH

Interactions of the natural product kendomycin and the 20S proteasome

Investigations on the maturation and regulation of archaebacterial proteasomes

IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters

Macyranones: Structure, Biosynthesis, and Binding Mode of an Unprecedented Epoxyketone that Targets the 20S Proteasome

Navigation inside a protease: substrate selection and product exit in the tricorn protease from Thermoplasma acidophilum

Omuralide and vibralactone: differences in the proteasome- β-lactone-γ-lactam binding scaffold alter target preferences

One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitor ⬇️

Probing the reaction mechanism of IspH protein by x-ray structure analysis

Proteasome inhibition by fellutamide B induces nerve growth factor synthesis

Pseudilins: halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD

Quinone reductase acts as a redox switch of the 20S yeast proteasome

Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr)

Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association

Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism

Sequential Inactivation of Gliotoxin by the S-Methyltransferase TmtA

Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition

Structural Analysis of Spiro β-Lactone Proteasome Inhibitors

Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad ⬇️

Structure and Reaction Mechanism of Pyrrolysine Synthase (PylD) ⬇️

Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor

Structure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reduction

Structure of the Dioxygenase AsqJ: Mechanistic Insights into a One-Pot Multistep Quinolone Antibiotic Biosynthesis

Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes

Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes

Structures of Fluoro, Amino, and Thiol Inhibitors Bound to the [Fe4S4] Protein IspH

Structures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism

Synthesis and biological activity of optimized belactosin C congeners

Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition

Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors

Systematic comparison of peptidic proteasome inhibitors highlights the α-ketoamide electrophile as an auspicious reversible lead motif

Targeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide Conjugation

The Chaperone Activity of the Developmental Small Heat Shock Protein Sip1 Is Regulated by pH-Dependent Conformational Changes

The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop

The formation of pyrroline and tetrahydropyridine rings in amino acids catalyzed by pyrrolysine synthase (PylD)

The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins

Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum

Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction

Versatile C(3)-symmetric scaffolds and their use for covalent stabilization of the foldon trimer

α-Keto phenylamides as P1'-extended proteasome inhibitors