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List of works by Adelbert Bacher

(15)N{(31)P} REDOR NMR studies of the binding of phosphonate reaction intermediate analogues to Saccharomyces cerevisiae lumazine synthase

scientific article published on December 2008

13C Isotopologue editing of FMN bound to phototropin domains

scientific article

13C isotopologue perturbation studies of Listeria monocytogenes carbon metabolism and its modulation by the virulence regulator PrfA

scholarly article

13C-, 15N- and 31P-NMR studies of oxidized and reduced low molecular mass thioredoxin reductase and some mutant proteins

scientific article published in April 2004

13CO2 as a universal metabolic tracer in isotopologue perturbation experiments

article

2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthases of fungi and archaea

scientific journal article

A bicyclic autotrophic CO2 fixation pathway in Chloroflexus aurantiacus

scientific article

A high-throughput screen utilizing the fluorescence of riboflavin for identification of lumazine synthase inhibitors

scientific article published in March 2005

A metastable prerequisite for the growth of lumazine synthase crystals

scientific article published in March 2005

A novel lumazine synthase inhibitor derived from oxidation of 1,3,6,8-tetrahydroxy-2,7-naphthyridine to a tetraazaperylenehexaone derivative

scientific article published on 10 March 2007

A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus

scientific article (publication date: 18 April 2003)

A tomato enzyme catalyzing the phosphorylation of 3,4-dihydroxy-2-butanone

scientific article

Advances of high-resolution NMR techniques in the structural and metabolic analysis of plant biochemistry

scientific article

Aerobic benzoyl-CoA catabolic pathway in Azoarcus evansii: studies on the non-oxygenolytic ring cleavage enzyme

scientific article

Are Free Radicals Involved in IspH Catalysis? An EPR and Crystallographic Investigation ⬇️

scientific article published on June 28, 2012

Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study

scientific article published on 22 November 2009

Aryl Bis-Sulfonamide Inhibitors of IspF fromArabidopsis thalianaandPlasmodium falciparum

scholarly article by Jonas Thelemann et al published 5 October 2015 in ChemMedChem

Atomic-Resolution Structures of Discrete Stages on the Reaction Coordinate of the [Fe4S4] Enzyme IspG (GcpE)

scientific article published on 11 April 2015

Atovaquone for Prophylaxis of Toxoplasmosis after Allogeneic Hematopoietic Stem Cell Transplantation

scientific article published on 5 May 2015

Binding modes of reverse fosmidomycin analogs toward the antimalarial target IspC

scientific article

Biochemical characterization of Bacillus subtilis type II isopentenyl diphosphate isomerase, and phylogenetic distribution of isoprenoid biosynthesis pathways

scientific article published on July 2004

Biochemistry of the non-mevalonate isoprenoid pathway ⬇️

scientific article published on 09 July 2011

Biosynthesis of benzofuran derivatives in root cultures of Tagetes patula via phenylalanine and 1-deoxy-D-xylulose 5-phosphate

scientific article

Biosynthesis of cannabinoids

scientific article published in 2001

Biosynthesis of flavocoenzymes

scientific article

Biosynthesis of gallic acid in Rhus typhina: discrimination between alternative pathways from natural oxygen isotope abundance

scientific article

Biosynthesis of hyperforin in Hypericum perforatum

scientific article published in October 2002

Biosynthesis of isoprenoids. purification and properties of IspG protein from Escherichia coli

scientific article published in November 2005

Biosynthesis of isoprenoids: Crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase

scientific article

Biosynthesis of isoprenoids: a bifunctional IspDF enzyme from Campylobacter jejuni

scientific article published on July 2004

Biosynthesis of isoprenoids: crystal structure of the [4Fe-4S] cluster protein IspG

scientific article

Biosynthesis of isoprenoids: studies on the mechanism of 2C-methyl-D-erythritol-4-phosphate synthase

scientific article published on 4 July 2008

Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I

scientific article (publication date: 14 February 2003)

Biosynthesis of riboflavin in archaea studies on the mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase of Methanococcus jannaschii

scientific article published on 27 August 2002

Biosynthesis of riboflavin in archaea. 6,7-dimethyl-8-ribityllumazine synthase of Methanococcus jannaschii

scientific article

Biosynthesis of riboflavin. Screening for an improved GTP cyclohydrolase II mutant

scientific article published on 3 July 2009

Biosynthesis of riboflavin. Single turnover kinetic analysis of 6,7-dimethyl-8-ribityllumazine synthase

scientific article published in April 2003

Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe

scientific article published in January 2002

Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii

scientific article

Biosynthesis of terpenes. Preparation of (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate, an intermediate of the deoxyxylulose phosphate pathway

scientific article

Biosynthesis of terpenes: studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase

scientific article

Biosynthesis of tetrahydrofolate in plants: crystal structure of 7,8-dihydroneopterin aldolase from Arabidopsis thaliana reveals a novel adolase class

scientific article

Biosynthesis of tetrahydrofolate. Stereochemistry of dihydroneopterin aldolase

scientific article published on 30 May 2002

Biosynthesis of the 22nd Genetically Encoded Amino Acid Pyrrolysine: Structure and Reaction Mechanism of PylC at 1.5Å Resolution ⬇️

scientific article published on September 14, 2012

Biosynthesis of vitamin B2.

scientific article published in November 2002

Biosynthesis of vitamin B2: Structure and mechanism of riboflavin synthase

scientific article

Biosynthesis of vitamin B2: a unique way to assemble a xylene ring

scientific article published on March 2011

Biosynthesis of vitamin B2: diastereomeric reaction intermediates of archaeal and non-archaeal riboflavin synthases

scientific article published on 8 June 2005

Biosynthesis of zeaxanthin via mevalonate in Paracoccus species strain PTA-3335. A product-based retrobiosynthetic study

scientific article published in February 2002

Biosynthetic origin of a branched chain analogue of the lipase inhibitor, lipstatin

scientific article published in September 2003

Biosynthetic precursors of the lipase inhibitor lipstatin

scientific article

Blue light perception in plants. Detection and characterization of a light-induced neutral flavin radical in a C450A mutant of phototropin

scientific article published on 13 January 2003

Carbon metabolism of Listeria monocytogenes growing inside macrophages

scientific article

Catalysis of an Essential Step in Vitamin B2 Biosynthesis by a Consortium of Broad Spectrum Hydrolases

scientific article

Changes in flux pattern of the central carbohydrate metabolism during kernel development in maize

scientific article published on 7 November 2005

Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery

scientific article

Characterization of the Saccharomyces cerevisiae Fol1 protein: starvation for C1 carrier induces pseudohyphal growth

scientific article

Crystal Structure of Methylornithine Synthase (PylB): Insights into the Pyrrolysine Biosynthesis ⬇️

scientific article published on November 16, 2011

Crystal structure of Schizosaccharomyces pombe riboflavin kinase reveals a novel ATP and riboflavin-binding fold

scientific article (publication date: 7 March 2003)

Crystal structure of an archaeal pentameric riboflavin synthase in complex with a substrate analog inhibitor: stereochemical implications

scientific article published on 4 November 2005

Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors

scientific article

Crystal structure of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Bacillus subtilis

scientific article

Crystal structures of mutant IspH proteins reveal a rotation of the substrate's hydroxymethyl group during catalysis

scientific article

Crystal structures of the antitermination factor NusB from Thermotoga maritima and implications for RNA binding

scientific article published on November 2004

Decoding Biosynthetic Pathways in Plants by Pulse-Chase Strategies Using (13)CO₂ as a Universal Tracer †

scientific article

Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents

scientific article published on 4 June 2014

Design, synthesis, and biochemical evaluation of 1,5,6,7-tetrahydro-6,7-dioxo-9-D-ribitylaminolumazines bearing alkyl phosphate substituents as inhibitors of lumazine synthase and riboflavin synthase

scientific article published on September 2005

Design, synthesis, and evaluation of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and lumazine synthase

scientific article published in August 2002

Design, synthesis, and evaluation of 9-D-ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones bearing alkyl phosphate and alpha,alpha-difluorophosphonate substituents as inhibitors of tiboflavin synthase and lumazine synthase

scientific article published in February 2004

Design, synthesis, and evaluation of acyclic C-nucleoside and N-methylated derivatives of the ribitylaminopyrimidine substrate of lumazine synthase as potential enzyme inhibitors and mechanistic probes

scientific article published in October 2004

Detecting a new source for photochemically induced dynamic nuclear polarization in the LOV2 domain of phototropin by magnetic-field dependent (13)C NMR spectroscopy

scientific article published on 26 September 2014

Diagnosis of Toxoplasma gondii infection after allogeneic stem cell transplant can be difficult and requires intensive scrutiny

scientific article published in August 2010

Discovery and development of a small molecule library with lumazine synthase inhibitory activity

scientific article published in August 2009

Discovery of acetylene hydratase activity of the iron–sulphur protein IspH

scientific article

Enzyme catalysis via control of activation entropy: site-directed mutagenesis of 6,7-dimethyl-8-ribityllumazine synthase

scientific article

Enzymes from the haloacid dehalogenase (HAD) superfamily catalyse the elusive dephosphorylation step of riboflavin biosynthesis

scientific article

Evolution of vitamin B2 biosynthesis. A novel class of riboflavin synthase in Archaea

scientific article published on October 2004

Evolution of vitamin B2 biosynthesis: riboflavin synthase of Arabidopsis thaliana and its inhibition by riboflavin

scientific article published in May 2005

Evolution of vitamin B2 biosynthesis: structural and functional similarity between pyrimidine deaminases of eubacterial and plant origin

scientific article

Femtosecond to Millisecond Dynamics of Light Induced Allostery in the Avena sativa LOV Domain

scientific article

Fluorescent inhibitors for IspF, an enzyme in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy.

scientific article

Folate biosynthesis in higher plants. cDNA cloning, heterologous expression, and characterization of dihydroneopterin aldolases

scientific article published on 23 April 2004

Folate synthesis in plants: the first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase I

scientific article

Formation of metal nanoclusters on specific surface sites of protein molecules

scientific article published on August 2002

Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli

scientific article

Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis

scientific article published on 2 October 2004

Hindered rotation of a cofactor methyl group as a probe for protein-cofactor interaction

scientific article published in July 2010

Improvement of the quality of lumazine synthase crystals by protein engineering

scientific article published on 11 June 2008

Incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase vs lumazine synthase

scientific article published in October 2002

Inhibition of methyl-CoM Reductase from Methanobrevibacter ruminantium by 2-bromoethanesulfonate

Inhibitors of the Herbicidal Target IspD: Allosteric Site Binding ⬇️

scientific article published on July 18, 2011

Inhibitors of the kinase IspE: structure-activity relationships and co-crystal structure analysis

scientific article

Insights into the Binding of Pyridines to the Iron–Sulfur Enzyme IspH

scientific article

Isoprenoid biosynthesis in plants - 2C-methyl-D-erythritol-4-phosphate synthase (IspC protein) of Arabidopsis thaliana. ⬇️

scientific article

Isotopolog perturbation techniques for metabolic networks: metabolic recycling of nutritional glucose in Drosophila melanogaster

scientific article

IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters

scientific article

IspH protein of Escherichia coli: studies on iron-sulfur cluster implementation and catalysis

scientific article

Ligand binding properties of the N-terminal domain of riboflavin synthase from Escherichia coli.

scientific article published in March 2007

Light-induced activation of class II cyclobutane pyrimidine dimer photolyases

scientific article published on 15 March 2010

Light-induced reactions of Escherichia coli DNA photolyase monitored by Fourier transform infrared spectroscopy

scientific article

Localization of two enzymes of the tetrahydrobiopterin biosynthetic pathway in embryonic chick retina

scientific article published in February 2002

Lumazine proteins from photobacteria: localization of the single ligand binding site to the N-terminal domain

scientific article published in December 2007

Lumazine synthase from Candida albicans as an anti-fungal target enzyme: structural and biochemical basis for drug design

scientific article

Magnetic-field effect on the photoactivation reaction of Escherichia coli DNA photolyase

scholarly article

Mechanistic insights on riboflavin synthase inspired by selective binding of the 6,7-dimethyl-8-ribityllumazine exomethylene anion

scientific article

Metabolic flux analysis in complex isotopolog space. Recycling of glucose in tobacco plants

scientific article

Metal sites in 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with the substrate ribulose 5-phosphate

scientific article

NMR-Based Isotopologue Profiling of Microbial Carotenoids ⬇️

scientific article published on January 1, 2012

Natural abundance solution 13C NMR studies of a phototropin with photoinduced polarization

scientific article

New enzymes involved in aerobic benzoate metabolism in Azoarcus evansii

scientific article

Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods

scientific article

Nonphosphate inhibitors of IspE protein, a kinase in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy.

scientific article published in June 2007

Northern blot analysis of sepiapterin reductase mRNA in mammalian cell lines and tissues

scientific article

Nuphar lutea thioalkaloids inhibit the nuclear factor kappaB pathway, potentiate apoptosis and are synergistic with cisplatin and etoposide

scientific article

O-Nucleoside, S-Nucleoside, and N-Nucleoside Probes of Lumazine Synthase and Riboflavin Synthase ⬇️

scientific article published on July 10, 2012

On the reaction mechanism of adduct formation in LOV domains of the plant blue-light receptor phototropin

scientific article published in September 2004

Pathogenomics of Listeria spp.

scientific article

Perspectives in anti-infective drug design. The late steps in the biosynthesis of the universal terpenoid precursors, isopentenyl diphosphate and dimethylallyl diphosphate

scientific article published in October 2004

Phenylalanine-independent biosynthesis of 1,3,5,8-tetrahydroxyxanthone. A retrobiosynthetic NMR study with root cultures of Swertia chirata

scientific article published in July 2003

Photochemically induced dynamic nuclear polarization in a C450A mutant of the LOV2 domain of the Avena sativa blue-light receptor phototropin

scientific article

Potential anti-infective targets in pathogenic yeasts: structure and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans

scientific article

Pre-steady-state kinetic analysis of riboflavin synthase using a pentacyclic reaction intermediate as substrate

scientific article

Presteady State Kinetic Analysis of Riboflavin Synthase ⬇️

scientific article published on September 22, 2003

Probing the N(5)-H bond of the isoalloxazine moiety of flavin radicals by X- and W-band pulsed electron-nuclear double resonance

scientific article

Probing the reaction mechanism of IspH protein by x-ray structure analysis

scientific article

Prodrugs of reverse fosmidomycin analogues

scientific article published on 12 February 2015

Pseudilins: halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD

scientific article

RNA DNA discrimination by the antitermination protein NusB.

scientific article published in April 2003

Random isotopolog libraries for protein perturbation studies. 13C NMR studies on lumazine protein of Photobacterium leiognathi

scientific article published in November 2005

Rapid one-pot synthesis of riboflavin isotopomers

scientific article published in December 2002

Rapid preparation of isotopolog libraries by in vivo transformation of 1)C-glucose. Studies on 6,7-dimethyl-8-ribityllumazine, a biosynthetic precursor of vitamin B2.

scientific article published in August 2004

Reaction mechanism of GTP cyclohydrolase I: single turnover experiments using a kinetically competent reaction intermediate

scientific article published in February 2002

Recent advances in riboflavin biosynthesis

scientific article published on January 2014

Reductive Dehydroxylation of Allyl Alcohols by IspH Protein ⬇️

scientific article published on November 15, 2010

Resonance Raman spectroscopic study of the neutral flavin radical complex of DNA photolyase fromEscherichia coli

article published in 2001

Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr)

scientific article

Riboflavin synthase of Schizosaccharomyces pombe. Protein dynamics revealed by 19F NMR protein perturbation experiments

scientific article

Sexual Dimorphism in the Response of Mercurialis annua to Stress

scientific article published on 26 April 2016

Starch biosynthesis and intermediary metabolism in maize kernels. Quantitative analysis of metabolite flux by nuclear magnetic resonance

scientific article published in December 2002

Stereochemical studies on the making and unmaking of isopentenyl diphosphate in different biological systems.

scientific article published in September 2004

Strategy for Enhancement of (13)C-Photo-CIDNP NMR Spectra by Exploiting Fractional (13)C-Labeling of Tryptophan

scientific article published on 5 August 2015

Structural basis for the interaction of Escherichia coli NusA with protein N of phage lambda

scholarly article

Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase

scientific article

Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development

scientific article (publication date: 16 May 2003)

Structural study and thermodynamic characterization of inhibitor binding to lumazine synthase fromBacillus anthracis

scientific article

Structure and Properties of an Engineered Transketolase from Maize

scientific article

Structure and Reaction Mechanism of Pyrrolysine Synthase (PylD) ⬇️

scientific article published on May 29, 2013

Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids

scientific article

Structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with divalent metal ions and the substrate ribulose 5-phosphate: implications for the catalytic mechanism

scientific article

Structure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reduction

scientific article

Structure of lumazine protein, an optical transponder of luminescent bacteria

scientific article

Structure of the molybdenum-cofactor biosynthesis protein MoaB of Escherichia coli

scientific article

Structures and reaction mechanisms of GTP cyclohydrolases ⬇️

scientific article published on March 4, 2013

Structures of Fluoro, Amino, and Thiol Inhibitors Bound to the [Fe4S4] Protein IspH

scientific article

Studies of the intermediary metabolism in cultured cells of the insect Spodoptera frugiperda using 13C- or 15N-labelled tracers

scientific article

Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein

scientific article

Synthesis and antiplasmodial activity of highly active reverse analogues of the antimalarial drug candidate fosmidomycin

scientific article published on October 2010

Synthesis and characterization of cytidine derivatives that inhibit the kinase IspE of the non-mevalonate pathway for isoprenoid biosynthesis

scientific article

Synthesis and enzyme inhibitory activity of the s-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase.

scientific article published on 16 August 2007

Temperature-dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus

scientific article published on 16 July 2003

The crystal structure of a plant 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase exhibits a distinct quaternary structure compared to bacterial homologues and a possible role in feedback regulation for cytidine monophosphate.

scientific article

The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: studies on the mechanisms of the reactions catalyzed by IspG and IspH protein

scholarly article

The formation of pyrroline and tetrahydropyridine rings in amino acids catalyzed by pyrrolysine synthase (PylD)

scientific article

The lumazine synthase/riboflavin synthase complex: shapes and functions of a highly variable enzyme system ⬇️

scientific article published on April 24, 2013

The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase

scientific article

The structure of the N-terminal domain of riboflavin synthase in complex with riboflavin at 2.6A resolution

scientific article

Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum

scientific journal article

Transcriptional regulation by antitermination. Interaction of RNA with NusB protein and NusB/NusE protein complex of Escherichia coli

scientific article

Tryptophan 13C nuclear-spin polarization generated by intraprotein electron transfer in a LOV2 domain of the blue-light receptor phototropin

scientific article published on April 2009

Ultrafast infrared spectroscopy of an isotope-labeled photoactivatable flavoprotein

scientific article published on 4 February 2011

Unambiguous determination of the g-matrix orientation in a neutral flavin radical by pulsed electron-nuclear double resonance at 94 GHz.

scientific article published in August 2005

Vibrational assignment of the ultrafast infrared spectrum of the photoactivatable flavoprotein AppA.

scientific article published on 27 August 2012

Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase

scientific article

g-Tensor of the Neutral Flavin Radical Cofactor of DNA Photolyase Revealed by 360-GHz Electron Paramagnetic Resonance Spectroscopy

article

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