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List of works by Karl-Peter Hopfner

5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I

scientific article

A Click‐Chemistry Linked 2′3′‐cGAMP Analogue

scientific article published on 17 January 2019

A modular and controllable T cell therapy platform for acute myeloid leukemia

scientific article published on 07 January 2021

ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex

scientific article

ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.

scientific article published on 26 November 2015

ATP puts the brake on DNA double-strand break repair: a new study shows that ATP switches the Mre11-Rad50-Nbs1 repair factor between signaling and processing of DNA ends

scientific article published on 11 September 2014

Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia

scientific article

Activity-based probes for detection of active MALT1 paracaspase in immune cells and lymphomas

scientific article

Binding of Fibrinogen Aα1–50-β-Galactosidase Fusion Protein to Thrombin Stabilizes the Slow Form

scientific article published in Journal of Biological Chemistry

Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2

scientific article

Bispecific digoxigenin-binding antibodies for targeted payload delivery

scientific article

BusR senses bipartite DNA binding motifs by a unique molecular ruler architecture

scientific article published in 2021

Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta

scientific article

CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells

scientific article published on 4 November 2016

Catalytic Mechanism of the INO80 Chromatin Remodeler Acting on the Nucleosome

Chapter 5. RIG-I-Like RNA Helicases: Multidomain Proteins in Antiviral Innate Immunity and Processing of Small Regulatory RNAs

Chemical compensation in macromolecular bridge-binding to thrombin

scientific article published on 01 March 1993

Chip-based platform for dynamic analysis of NK cell cytolysis mediated by a triplebody

scientific article published on 09 March 2016

Chromosome Cohesion: Closing Time ⬇️

scientific article published on November 11, 2003

Chromosome biology: the crux of the ring

scientific article

Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia.

scientific article

Converting blood coagulation factor IXa into factor Xa: dramatic increase in amidolytic activity identifies important active site determinants

scientific article published on November 1997

Correction to Reversible and Controllable Nanolocomotionof an RNA-Processing Machinery.

scientific article published on 22 March 2013

Correction: ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA

scientific article published on 2 March 2016

Correlating calcium binding, Förster resonance energy transfer, and conformational change in the biosensor TN-XXL.

scientific article

Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses

scientific article published on February 2014

Crystal Structure of Human TWEAK in Complex with the Fab Fragment of a Neutralizing Antibody Reveals Insights into Receptor Binding

scientific article

Crystal Structure of an Anti-Ang2 CrossFab Demonstrates Complete Structural and Functional Integrity of the Variable Domain

scientific article

Crystal and solution structure of the human RIG-I SF2 domain

scientific article

Crystal structure of the full Swi2/Snf2 remodeler Mot1 in the resting state

scientific article published on 05 October 2018

Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions

scientific article

Crystallization of mouse RIG-I ATPase domain: in situ proteolysis

scientific article published on January 2014

Cytosolic RNA:DNA hybrids activate the cGAS-STING axis

scientific article

Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA.

scientific article

DNA double-strand break repair from head to tail

scientific article

DNA double-strand breaks come into focus

scientific article published on 01 October 2009

DNA mismatch repair: the hands of a genome guardian.

scientific article

Differential arrangements of conserved building blocks among homologs of the Rad50/Mre11 DNA repair protein complex

scientific article published in June 2004

Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease

scientific article

Discrimination of cytosolic self and non-self RNA by RIG-I-like receptors

scientific article

Dissecting the Mechanism of the HerA NurA DNA Break Resection Complex using Native Mass Spectrometry

Dramatic enhancement of the catalytic activity of coagulation factor IXa by alcohols

scientific article published on 01 July 1997

Dual-targeting triplebody 33-3-19 mediates selective lysis of biphenotypic CD19+ CD33+ leukemia cells

scientific article published on 10 March 2016

Editorial overview: Macromolecular machines and assemblies

scholarly article by David Barford published in April 2016

Editorial overview: Theory and simulation: Macromolecular machines

scholarly article by Karl-Peter Hopfner published in April 2014

Energetics of thrombin-fibrinogen interaction.

scientific article

Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies

scientific article

Epitope interactions of monoclonal antibodies targeting CD20 and their relationship to functional properties

scientific article published on 4 December 2012

Establishment of sister chromatid cohesion at the S. cerevisiae replication fork

scientific article

Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia.

scientific article

Functional and biochemical dissection of the structure-specific nuclease ARTEMIS

scientific article

GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia

scientific article published on 30 May 2012

Hexasome-INO80 complex reveals structural basis of noncanonical nucleosome remodeling

scientific article published on 29 June 2023

Human TGF-β1 deficiency causes severe inflammatory bowel disease and encephalopathy.

scientific article published on 26 February 2018

Impact of Heterogeneity and Lattice Bond Strength on DNA Triangle Crystal Growth

article published in 2016

In vivo ligands of MDA5 and RIG-I in measles virus-infected cells

scientific article

Invited review: Architectures and mechanisms of ATP binding cassette proteins

scientific article published on 31 March 2016

Lessons from structural and biochemical studies on the archaeal exosome

scientific article published on February 2009

MRE11/RAD50/NBS1: complex activities

scientific article published on 10 August 2004

Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress

scientific article published on 21 January 2016

Mechanism of replication blocking and bypass of Y-family polymerase   by bulky acetylaminofluorene DNA adducts

scientific article

Mechanisms of nucleic acid translocases: lessons from structural biology and single-molecule biophysics

scientific article published on 6 December 2006

Mechanistic insight into the assembly of the HerA-NurA helicase-nuclease DNA end resection complex

scientific article published in November 2017

MlaA, a hexameric ATPase linked to the Mre11 complex in archaeal genomes

scientific article

Modulation of protein properties in living cells using nanobodies

scientific article

Molecular architecture and regulation of BCL10-MALT1 filaments

scientific article published in Nature Communications

Molecular architecture of the HerA-NurA DNA double-strand break resection complex

scientific article published on 11 November 2014

Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth

scientific article

Molecular mechanisms and cellular functions of cGAS-STING signalling

scientific article published on 18 May 2020

Mre11 and Rad50 from Pyrococcus furiosus: cloning and biochemical characterization reveal an evolutionarily conserved multiprotein machine

scientific article

Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II.

scientific article

NK cells from an AML patient have recovered in remission and reached comparable cytolytic activity to that of a healthy monozygotic twin mediated by the single-chain triplebody SPM-2.

scientific article

New enzyme lineages by subdomain shuffling ⬇️

scientific article published on August 18, 1998

Nuclear actin-related proteins take shape

scientific article

Nuclear cGAS: guard or prisoner?

scientific article published in 2021

OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids

scientific article published on 18 July 2014

Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling

scientific article

Physiological fIXa activation involves a cooperative conformational rearrangement of the 99-loop

scientific article

Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML.

scientific article published on 12 January 2006

Processive RNA decay by the exosome: merits of a quantitative Bayesian sampling approach

scientific article

Quantitative analysis of processive RNA degradation by the archaeal RNA exosome

scientific article

RG7116, a therapeutic antibody that binds the inactive HER3 receptor and is optimized for immune effector activation

scientific article

RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids

scientific article published on 12 October 2012

RIG-I holds the CARDs in a game of self versus nonself

scientific article

RIG-I-Like Receptors: One STrEP Forward

scientific article published on 25 May 2016

RPA Mediates Recruitment of MRX to Forks and Double-Strand Breaks to Hold Sister Chromatids Together

scientific article

Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production

scientific article published on 28 April 2014

Rad50/SMC proteins and ABC transporters: unifying concepts from high-resolution structures.

scientific article

Response to: monoclonal antibodies targeting CD20.

scientific article published on 14 March 2013

Reversible and controllable nanolocomotion of an RNA-processing machinery

scientific article published on 17 November 2010

Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction

scholarly article

Ruler elements in chromatin remodelers set nucleosome array spacing and phasing

scientific article published in 2021

Rustless translation ⬇️

scientific article published on October 1, 2012

SIRPα-antibody fusion proteins stimulate phagocytosis and promote elimination of acute myeloid leukemia cells.

scientific article published on 4 January 2017

Sensing of viral nucleic acids by RIG-I: from translocation to translation

scientific article

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

scientific article

Serendipitous crystallization and structure determination of cyanase (CynS) from Serratia proteamaculans

scientific article

Single-molecule choreography between telomere proteins and G quadruplexes

scientific article published in June 2014

Single-molecule nucleosome remodeling by INO80 and effects of histone tails.

scientific article published on 13 January 2018

Snf2 family ATPases and DExx box helicases: differences and unifying concepts from high-resolution crystal structures

scientific article published on 25 August 2006

Species-specific detection of the antiviral small-molecule compound CMA by STING

scientific article

Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspase

scientific article

Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP

scientific article

Structural and biochemical characterization of human Schlafen 5

scientific article published on 01 January 2022

Structural and biochemical characterization of the cell fate determining nucleotidyltransferase fold protein MAB21L1.

scientific article published on 8 June 2016

Structural and functional analysis of Mre11-3.

scientific article published on 26 March 2004

Structural basis for ATP-dependent chromatin remodelling by the INO80 complex.

scientific article published on 11 April 2018

Structural basis for DNA duplex separation by a superfamily-2 helicase

scientific article

Structural basis for adenylate kinase activity in ABC ATPases

scientific article

Structural basis for dodecameric assembly states and conformational plasticity of the full-length AAA+ ATPases Rvb1 · Rvb2

scientific article

Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1.

scientific article

Structural basis for sequestration and autoinhibition of cGAS by chromatin

scientific article published on 10 September 2020

Structural basis for transcription-coupled repair: the N terminus of Mfd resembles UvrB with degenerate ATPase motifs

scientific article published on 8 November 2005

Structural basis of highly conserved ribosome recycling in eukaryotes and archaea

scientific article

Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase

scientific article

Structural biochemistry of ATP-driven dimerization and DNA-stimulated activation of SMC ATPases

scientific article published in October 2004

Structural biochemistry of a bacterial checkpoint protein reveals diadenylate cyclase activity regulated by DNA recombination intermediates

scientific article

Structural biochemistry of nuclear actin-related proteins 4 and 8 reveals their interaction with actin

scientific article

Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

scientific article published in June 2000

Structural framework for the mechanism of archaeal exosomes in RNA processing

scientific article published on 01 November 2005

Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50.

scientific article

Structural mechanism of cytosolic DNA sensing by cGAS

scientific article

Structural studies of DNA end detection and resection in homologous recombination

scientific article published on 31 July 2014

Structure and DNA binding activity of the mouse condensin hinge domain highlight common and diverse features of SMC proteins

scientific article

Structure and DNA‐binding activity of the Pyrococcus furiosus SMC protein hinge domain ⬇️

scientific article published on February 1, 2011

Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBP

scientific article

Structure of Actin-related protein 8 and its contribution to nucleosome binding

scientific article

Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling

scientific article

Structure of the Rad50 DNA double-strand break repair protein in complex with DNA.

scientific article published on 27 October 2014

Structure of the catalytic domain of Mre11 from Chaetomium thermophilum.

scientific article published on 22 May 2015

Structure–Function Analysis of SWI2/SNF2 Enzymes

scientific article published on 01 January 2006

Swi2/Snf2 remodelers: hybrid views on hybrid molecular machines

scientific article published on 23 March 2012

Syk kinase-coupled C-type lectin receptors engage protein kinase C-σ to elicit Card9 adaptor-mediated innate immunity

scientific journal article

Symmetry conditions for binding processes.

scientific article published on April 1992

The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I

scientific article

The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair

scientific article

The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling

scientific article

The RNA Exosomes

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

scientific article

The bacterial Mre11-Rad50 homolog SbcCD cleaves opposing strands of DNA by two chemically distinct nuclease reactions

article

The chemistry of transcription through damaged DNA and of translesion synthesis at atomic resolution

scientific article published on 01 January 2007

The exosome, plugged

scientific article

The exosome: a macromolecular cage for controlled RNA degradation

scientific article

The influence of residue 190 in the S1 site of trypsin-like serine proteases on substrate selectivity is universally conserved

scientific article published in October 2002

The nuclear actin-containing Arp8 module is a linker DNA sensor driving INO80 chromatin remodeling

article

The rad50 signature motif: essential to ATP binding and biological function

scientific article

The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA

scientific article

The ternary microplasmin-staphylokinase-microplasmin complex is a proteinase-cofactor-substrate complex in action

scientific article

Theory of allosteric effects in serine proteases.

scientific article

Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants

Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity.

scientific article

X-Ray Structures of the Sulfolobus solfataricus SWI2/SNF2 ATPase Core and Its Complex with DNA

scientific article (publication date: May 2005)

X-ray structure of RLI, an essential twin cassette ABC ATPase involved in ribosome biogenesis and HIV capsid assembly

scientific article

X-ray structure of the complete ABC enzyme ABCE1 from Pyrococcus abyssi

scientific article

ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation.

scientific article published on 2 June 2016

c-di-AMP recognition by Staphylococcus aureus PstA

scientific article

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

scientific article

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders

scientific article published on 13 September 2017

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