List of works - Karl Harlos

A Molecular-Level Account of the Antigenic Hantaviral Surface

scientific article

A Molecular-Level Account of the Antigenic Hantaviral Surface

A Two-Tailed Phosphopeptide Crystallizes to Form a Lamellar Structure

scientific article

A Two-Tailed Phosphopeptide Crystallizes to Form a Lamellar Structure

A functional and structural basis for TCR cross-reactivity in multiple sclerosis

scientific article

A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization

scientific article (publication date: June 2005)

A tick protein with a modified Kunitz fold inhibits human tryptase

scientific article

An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly

scientific article

An ion-channel modulator from the saliva of the brown ear tick has a highly modified Kunitz/BPTI structure

scientific article

Atomic resolution structure of Moloney murine leukemia virus matrix protein and its relationship to other retroviral matrix proteins

scientific article

Author Correction: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

scientific article published in Nature Communications

Bacteriophage P23-77 Capsid Protein Structures Reveal the Archetype of an Ancient Branch from a Major Virus Lineage

scientific article

Benefits of automated crystallization plate tracking, imaging, and analysis

scientific article

Carbohydrate and domain architecture of an immature antibody glycoform exhibiting enhanced effector functions

scientific article

Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization

scientific article published on 19 June 2017

Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing

scientific article

Crystal Structure of Venezuelan Hemorrhagic Fever Virus Fusion Glycoprotein Reveals a Class 1 Postfusion Architecture with Extensive Glycosylation

scientific article

Crystal Structure of the Herpesvirus Nuclear Egress Complex Provides Insights into Inner Nuclear Membrane Remodeling

scientific article

Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy

scientific article

Crystal structure of a 3-oxoacyl-(acylcarrier protein) reductase (BA3989) from Bacillus anthracis at 2.4-A resolution

scientific article

Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centered rearrangements

scientific article

Crystal structure of equine rhinitis A virus in complex with its sialic acid receptor

scientific article

Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors

scientific article

Crystallization and preliminary crystallographic analysis of the major capsid proteins VP16 and VP17 of bacteriophage P23-77.

scientific article

Crystallization, dehydration and experimental phasing of WbdD, a bifunctional kinase and methyltransferase fromEscherichia coliO9a

scientific article

Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae

scientific article

Equine Rhinitis A Virus and Its Low pH Empty Particle: Clues Towards an Aphthovirus Entry Mechanism?

scientific article

Expression, purification and crystallization of the ectodomain of the envelope glycoprotein E2 from Bovine viral diarrhoea virus

scientific article

FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development ⬇️

scientific article published on 22 October 2014

Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states

scientific article

High-resolution structure of the catalytic region of MICAL (molecule interacting with CasL), a multidomain flavoenzyme-signaling molecule

scientific article

High-speed fixed-target serial virus crystallography ⬇️

scientific article

Humidity control as a strategy for lattice optimization applied to crystals of HLA-A*1101 complexed with variant peptides from dengue virus

scientific article

Improved crystallization and diffraction of caffeine-induced death suppressor protein 1 (Cid1).

scientific article published on 21 February 2015

In situ macromolecular crystallography using microbeams

scientific article published on 17 April 2012

Initiation of T cell signaling by CD45 segregation at 'close contacts'

scientific article (publication date: May 2016)

Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.

scientific article published on 22 March 2017

New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM

scientific article

Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47

scientific article

Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

scientific article published in Nature Communications

Pushing the limits of sulfur SAD phasing:de novostructure solution of the N-terminal domain of the ectodomain of HCV E1

scientific article

Semi-automated microseeding of nanolitre crystallization experiments

scientific article

Shielding and activation of a viral membrane fusion protein

scientific article published on 24 January 2018

Solution and Crystallographic Structures of the Central Region of the Phosphoprotein from Human Metapneumovirus

scientific article

Some lessons from the systematic production and structural analysis of soluble (alpha)(beta) T-cell receptors

scientific article published on 26 August 2009

Structural Insights into the Inhibition of Wnt Signaling by Cancer Antigen 5T4/Wnt-Activated Inhibitory Factor 1

scientific article

Structural basis for cell surface patterning through NetrinG-NGL interactions

scientific article

Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferase

scientific article

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

scientific article

Structural basis of fibrillar collagen trimerization and related genetic disorders

scientific article

Structural basis of latrophilin-FLRT interaction

scientific journal article

Structural basis of substrate discrimination and integrin binding by autotaxin

scientific article

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP

scientific article

Structural plasticity of Cid1 provides a basis for its distributive RNA terminal uridylyl transferase activity.

scientific article published on 20 February 2015

Structural transitions of the conserved and metastable hantaviral glycoprotein envelope

scientific article

Structurally encoded intraclass differences in EphA clusters drive distinct cell responses

scientific article

Structure and Self-Assembly of the Calcium Binding Matrix Protein of Human Metapneumovirus

scientific article

Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors

scientific article

Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan

scientific article published on 9 July 2015

Structure determination of human semaphorin 4D as an example of the use of MAD in non-optimal cases

scientific article

Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase from Plasmodium vivax sheds light on drug resistance

scientific article published in Journal of Biological Chemistry

Structure of Signal-regulatory Protein : A LINK TO ANTIGEN RECEPTOR EVOLUTION

scientific article

Structure of a Pestivirus Envelope Glycoprotein E2 Clarifies Its Role in Cell Entry

scientific article

Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur

scientific article

Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion

scientific article

Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development

scientific article published on 4 May 2016

Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions

scientific article

Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains

scientific article

Structure of the integrin binding fragment from fibrillin-1 gives new insights into microfibril organization

scientific article

Structures of an alanine racemase fromBacillus anthracis(BA0252) in the presence and absence of (R)-1-aminoethylphosphonic acid (L-Ala-P)

scientific article

T cell cross-reactivity and conformational changes during TCR engagement

scientific article

T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides

scientific article

Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis

scientific article

The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2.

scientific article

The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D

scientific article

The structure of the macrophage signal regulatory protein alpha (SIRPalpha) inhibitory receptor reveals a binding face reminiscent of that used by T cell receptors

scientific article

Toremifene interacts with and destabilizes the Ebola virus glycoprotein

scientific article published on 29 June 2016

Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1

scientific article published on 16 September 2014

List of works by Karl Harlos

A Molecular-Level Account of the Antigenic Hantaviral Surface

A Molecular-Level Account of the Antigenic Hantaviral Surface

A Two-Tailed Phosphopeptide Crystallizes to Form a Lamellar Structure

A Two-Tailed Phosphopeptide Crystallizes to Form a Lamellar Structure

A functional and structural basis for TCR cross-reactivity in multiple sclerosis

A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization

A tick protein with a modified Kunitz fold inhibits human tryptase

An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly

An ion-channel modulator from the saliva of the brown ear tick has a highly modified Kunitz/BPTI structure

Atomic resolution structure of Moloney murine leukemia virus matrix protein and its relationship to other retroviral matrix proteins

Author Correction: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

Bacteriophage P23-77 Capsid Protein Structures Reveal the Archetype of an Ancient Branch from a Major Virus Lineage

Benefits of automated crystallization plate tracking, imaging, and analysis

Carbohydrate and domain architecture of an immature antibody glycoform exhibiting enhanced effector functions

Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization

Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing

Crystal Structure of Venezuelan Hemorrhagic Fever Virus Fusion Glycoprotein Reveals a Class 1 Postfusion Architecture with Extensive Glycosylation

Crystal Structure of the Herpesvirus Nuclear Egress Complex Provides Insights into Inner Nuclear Membrane Remodeling

Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy

Crystal structure of a 3-oxoacyl-(acylcarrier protein) reductase (BA3989) from Bacillus anthracis at 2.4-A resolution

Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centered rearrangements

Crystal structure of equine rhinitis A virus in complex with its sialic acid receptor

Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors

Crystallization and preliminary crystallographic analysis of the major capsid proteins VP16 and VP17 of bacteriophage P23-77.

Crystallization, dehydration and experimental phasing of WbdD, a bifunctional kinase and methyltransferase fromEscherichia coliO9a

Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae

Equine Rhinitis A Virus and Its Low pH Empty Particle: Clues Towards an Aphthovirus Entry Mechanism?

Expression, purification and crystallization of the ectodomain of the envelope glycoprotein E2 from Bovine viral diarrhoea virus

FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development ⬇️

Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states

High-resolution structure of the catalytic region of MICAL (molecule interacting with CasL), a multidomain flavoenzyme-signaling molecule

High-speed fixed-target serial virus crystallography ⬇️

Humidity control as a strategy for lattice optimization applied to crystals of HLA-A*1101 complexed with variant peptides from dengue virus

Improved crystallization and diffraction of caffeine-induced death suppressor protein 1 (Cid1).

In situ macromolecular crystallography using microbeams

Initiation of T cell signaling by CD45 segregation at 'close contacts'

Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.

New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM

Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47

Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

Pushing the limits of sulfur SAD phasing:de novostructure solution of the N-terminal domain of the ectodomain of HCV E1

Semi-automated microseeding of nanolitre crystallization experiments

Shielding and activation of a viral membrane fusion protein

Solution and Crystallographic Structures of the Central Region of the Phosphoprotein from Human Metapneumovirus

Some lessons from the systematic production and structural analysis of soluble (alpha)(beta) T-cell receptors

Structural Insights into the Inhibition of Wnt Signaling by Cancer Antigen 5T4/Wnt-Activated Inhibitory Factor 1

Structural basis for cell surface patterning through NetrinG-NGL interactions

Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferase

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

Structural basis of fibrillar collagen trimerization and related genetic disorders

Structural basis of latrophilin-FLRT interaction

Structural basis of substrate discrimination and integrin binding by autotaxin

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP

Structural plasticity of Cid1 provides a basis for its distributive RNA terminal uridylyl transferase activity.

Structural transitions of the conserved and metastable hantaviral glycoprotein envelope

Structurally encoded intraclass differences in EphA clusters drive distinct cell responses

Structure and Self-Assembly of the Calcium Binding Matrix Protein of Human Metapneumovirus

Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors

Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan

Structure determination of human semaphorin 4D as an example of the use of MAD in non-optimal cases

Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase from Plasmodium vivax sheds light on drug resistance

Structure of Signal-regulatory Protein : A LINK TO ANTIGEN RECEPTOR EVOLUTION

Structure of a Pestivirus Envelope Glycoprotein E2 Clarifies Its Role in Cell Entry

Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur

Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion

Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development

Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions

Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains

Structure of the integrin binding fragment from fibrillin-1 gives new insights into microfibril organization

Structures of an alanine racemase fromBacillus anthracis(BA0252) in the presence and absence of (R)-1-aminoethylphosphonic acid (L-Ala-P)

T cell cross-reactivity and conformational changes during TCR engagement

T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides

Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis

The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2.

The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D

The structure of the macrophage signal regulatory protein alpha (SIRPalpha) inhibitory receptor reveals a binding face reminiscent of that used by T cell receptors

Toremifene interacts with and destabilizes the Ebola virus glycoprotein

Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1