List of works - Karl Harlos

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

scientific article

A functional and structural basis for TCR cross-reactivity in multiple sclerosis

scientific article

A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization

scientific article (publication date: June 2005)

Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains

scientific article

Structural basis of substrate discrimination and integrin binding by autotaxin

scientific article

An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly

scientific article

T cell cross-reactivity and conformational changes during TCR engagement

scientific article

In situ macromolecular crystallography using microbeams

scientific article published on 17 April 2012

T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides

scientific article

Toremifene interacts with and destabilizes the Ebola virus glycoprotein

scientific article published on 29 June 2016

Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centered rearrangements

scientific article

Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47

scientific article

The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D

scientific article

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP

scientific article

Structure of a Pestivirus Envelope Glycoprotein E2 Clarifies Its Role in Cell Entry

scientific article

Initiation of T cell signaling by CD45 segregation at 'close contacts'

scientific article (publication date: May 2016)

Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy

scientific article

Structure of the integrin binding fragment from fibrillin-1 gives new insights into microfibril organization

scientific article

Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors

scientific article

Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors

scientific article

Structurally encoded intraclass differences in EphA clusters drive distinct cell responses

scientific article

FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development

scientific article published on 22 October 2014

Structural basis of fibrillar collagen trimerization and related genetic disorders

scientific article

Equine Rhinitis A Virus and Its Low pH Empty Particle: Clues Towards an Aphthovirus Entry Mechanism?

scientific article

Atomic resolution structure of Moloney murine leukemia virus matrix protein and its relationship to other retroviral matrix proteins

scientific article

Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1

scientific article published on 16 September 2014

High-resolution structure of the catalytic region of MICAL (molecule interacting with CasL), a multidomain flavoenzyme-signaling molecule

scientific article

Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur

scientific article

Carbohydrate and domain architecture of an immature antibody glycoform exhibiting enhanced effector functions

scientific article

Crystal Structure of the Herpesvirus Nuclear Egress Complex Provides Insights into Inner Nuclear Membrane Remodeling

scientific article

Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferase

scientific article

Structural basis for cell surface patterning through NetrinG-NGL interactions

scientific article

A tick protein with a modified Kunitz fold inhibits human tryptase

scientific article

High-speed fixed-target serial virus crystallography

scientific article

Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan

scientific article published on 9 July 2015

Structural basis of latrophilin-FLRT interaction

scientific journal article

The structure of the macrophage signal regulatory protein alpha (SIRPalpha) inhibitory receptor reveals a binding face reminiscent of that used by T cell receptors

scientific article

The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2.

scientific article

Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion

scientific article

An ion-channel modulator from the saliva of the brown ear tick has a highly modified Kunitz/BPTI structure

scientific article

Bacteriophage P23-77 Capsid Protein Structures Reveal the Archetype of an Ancient Branch from a Major Virus Lineage

scientific article

Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae

scientific article

Structure and Self-Assembly of the Calcium Binding Matrix Protein of Human Metapneumovirus

scientific article

Solution and Crystallographic Structures of the Central Region of the Phosphoprotein from Human Metapneumovirus

scientific article

Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions

scientific article

Shielding and activation of a viral membrane fusion protein

scientific article published on 24 January 2018

Semi-automated microseeding of nanolitre crystallization experiments

scientific article

A Molecular-Level Account of the Antigenic Hantaviral Surface

scientific article

Benefits of automated crystallization plate tracking, imaging, and analysis

scientific article

Crystal Structure of Venezuelan Hemorrhagic Fever Virus Fusion Glycoprotein Reveals a Class 1 Postfusion Architecture with Extensive Glycosylation

scientific article

List of works by Karl Harlos

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

A functional and structural basis for TCR cross-reactivity in multiple sclerosis

A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization

Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains

Structural basis of substrate discrimination and integrin binding by autotaxin

An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly

T cell cross-reactivity and conformational changes during TCR engagement

In situ macromolecular crystallography using microbeams

T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides

Toremifene interacts with and destabilizes the Ebola virus glycoprotein

Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centered rearrangements

Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47

The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP

Structure of a Pestivirus Envelope Glycoprotein E2 Clarifies Its Role in Cell Entry

Initiation of T cell signaling by CD45 segregation at 'close contacts'

Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy

Structure of the integrin binding fragment from fibrillin-1 gives new insights into microfibril organization

Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors

Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors

Structurally encoded intraclass differences in EphA clusters drive distinct cell responses

FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development

Structural basis of fibrillar collagen trimerization and related genetic disorders

Equine Rhinitis A Virus and Its Low pH Empty Particle: Clues Towards an Aphthovirus Entry Mechanism?

Atomic resolution structure of Moloney murine leukemia virus matrix protein and its relationship to other retroviral matrix proteins

Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1

High-resolution structure of the catalytic region of MICAL (molecule interacting with CasL), a multidomain flavoenzyme-signaling molecule

Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur

Carbohydrate and domain architecture of an immature antibody glycoform exhibiting enhanced effector functions

Crystal Structure of the Herpesvirus Nuclear Egress Complex Provides Insights into Inner Nuclear Membrane Remodeling

Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferase

Structural basis for cell surface patterning through NetrinG-NGL interactions

A tick protein with a modified Kunitz fold inhibits human tryptase

High-speed fixed-target serial virus crystallography

Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan

Structural basis of latrophilin-FLRT interaction

The structure of the macrophage signal regulatory protein alpha (SIRPalpha) inhibitory receptor reveals a binding face reminiscent of that used by T cell receptors

The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2.

Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion

An ion-channel modulator from the saliva of the brown ear tick has a highly modified Kunitz/BPTI structure

Bacteriophage P23-77 Capsid Protein Structures Reveal the Archetype of an Ancient Branch from a Major Virus Lineage

Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae

Structure and Self-Assembly of the Calcium Binding Matrix Protein of Human Metapneumovirus

Solution and Crystallographic Structures of the Central Region of the Phosphoprotein from Human Metapneumovirus

Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions

Shielding and activation of a viral membrane fusion protein

Semi-automated microseeding of nanolitre crystallization experiments

A Molecular-Level Account of the Antigenic Hantaviral Surface

Benefits of automated crystallization plate tracking, imaging, and analysis

Crystal Structure of Venezuelan Hemorrhagic Fever Virus Fusion Glycoprotein Reveals a Class 1 Postfusion Architecture with Extensive Glycosylation