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List of works by Frank Sicheri

A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein

scientific article

A Strategy for Modulation of Enzymes in the Ubiquitin System

scientific article

A substrate binding model for the KEOPS tRNA modifying complex

scientific article published on 04 December 2020

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

scientific article

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme

scientific article

Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase ⬇️

scientific article

Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular Machine

scientific article

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain

scientific article

Bone recognition mechanism of porcine osteocalcin from crystal structure ⬇️

scientific article published on October 30, 2003

CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization

scientific article

CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling

scientific article

Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase

scientific article

Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain

scientific article

Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation

scientific article

Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation

scientific article

Determination of the Plk4/Sak consensus phosphorylation motif using peptide spots arrays

scientific article

Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity

scientific article

Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1

scientific article

Functional characterization of a PROTAC directed against BRAF mutant V600E

scientific article published on 10 August 2020

Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization

scientific article

Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function

scientific article

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

scientific article

Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9

scientific article

OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function

scientific article

Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients

scientific article published on 01 October 2020

Potent and Selective Inhibitors of the Inositol-requiring Enzyme 1 Endoribonuclease ⬇️

scientific article published on February 8, 2011

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions

scientific article

Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system

scientific article

Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis

scientific article

Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease

scientific article

Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

scientific article

Structural basis for specificity of TGFβ family receptor small molecule inhibitors

scientific article

Structural basis for the recruitment of glycogen synthase by glycogenin

scientific article

Structural basis of Rad53 kinase activation by dimerization and activation segment exchange

scientific article

Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays

scientific article

Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors

scientific article (publication date: 28 August 2014)

Structure of an SspH1-PKN1 Complex Reveals the Basis for Host Substrate Recognition and Mechanism of Activation for a Bacterial E3 Ubiquitin Ligase

scientific article

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

scientific article

The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization

scientific article

The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis

scientific article

The structural basis of modified nucleosome recognition by 53BP1

scientific article

X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition

scientific article

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