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List of works by Michael Gajhede

A binding site tyrosine shapes desensitization kinetics and agonist potency at GluR2. A mutagenic, kinetic, and crystallographic study

scientific article published on 15 August 2005

A flexible loop at the dimer interface is a part of the active site of the adjacent monomer of Escherichia coli orotate phosphoribosyltransferase

scientific article

A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils

scientific article (publication date: May 2007)

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

scientific article

A tetrazolyl-substituted subtype-selective AMPA receptor agonist

scientific article

A unique set of SH3-SH3 interactions controls IB1 homodimerization

scientific article

Acetylcholine-Binding Protein Engineered to Mimic the α4-α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity

scientific article

Allergy vaccine engineering: epitope modulation of recombinant Bet v 1 reduces IgE binding but retains protein folding pattern for induction of protective blocking-antibody responses

scientific article published in October 2004

Amylosucrase, a glucan-synthesizing enzyme from the alpha-amylase family

scientific article

Arabidopsis ATP A2 peroxidase. Expression and high-resolution structure of a plant peroxidase with implications for lignification

scientific article

Arabidopsis thaliana peroxidase N: structure of a novel neutral peroxidase

scientific article

Band-structure methods for incommensurably modulated crystals: Application to the low-temperature phase of tetrathiafulvalene-tetracyanoquinodimethane (TTF-TCNQ)

scientific article published on 01 February 1991

Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate

scientific article

Chaperone binding at the ribosomal exit tunnel

scientific article

Chemical and Thermal Unfolding of Calreticulin

scientific article published on 01 May 2013

Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters

scientific article

Conformational Stability of Calreticulin

article

Crystal Structure and Pharmacological Characterization of a Novel N-Methyl-D-aspartate (NMDA) Receptor Antagonist at the GluN1 Glycine Binding Site

scientific article

Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHβE Suggests a Unique Mode of Antagonism

scientific article

Crystal Structure of a Partly Self-Complementary Peptide Nucleic Acid (PNA) Oligomer Showing a Duplex−Triplex Network†

scientific article (publication date: February 2005)

Crystal structure of horseradish peroxidase C at 2.15 A resolution

scientific article

Crystal structure of sucrose phosphorylase from Bifidobacterium adolescentis

scientific article

Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping

scientific article

Crystal structure of the covalent intermediate of amylosucrase from Neisseria polysaccharea

scientific article

Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate

scientific article published in February 2005

Crystal structures of amylosucrase from Neisseria polysaccharea in complex with D-glucose and the active site mutant Glu328Gln in complex with the natural substrate sucrose

scientific article

Crystal structures of two peptide–HLA-B*1501 complexes; structural characterization of the HLA-B62 supertype

scientific article published on 18 October 2006

Crystallization and preliminary X-ray analysis of birch-pollen allergen Bet v 1 in complex with a murine monoclonal IgG Fab′ fragment

article

Crystallization and preliminary X-ray diffraction studies of a peroxidase from barley grain

scientific article published on 01 November 1992

Crystallization and preliminary X-ray diffraction studies on the Apo form of orotate phosphoribosyltransferase from Escherichia coli.

scientific article

Crystallization and preliminary X-ray investigation at 2.0 A resolution of Bet v 1, a birch pollen protein causing IgE-mediated allergy.

scientific article

Crystallization and preliminary X-ray studies of recombinant amylosucrase from Neisseria polysaccharea

scientific article published on 01 February 2000

Crystallization and preliminary X-ray studies of recombinant horseradish peroxidase

scientific article published in January 1995

Crystallization and preliminary crystallographic characterization of an SH3 domain from the IB1 scaffold protein

scientific article

Crystallization of a stringent response factor from Aquifex aeolicus

scientific article

Cyclic lipoundecapeptide amphisin from Pseudomonas sp. strain DSS73.

scientific article

Cyclic lipoundecapeptide tensin from Pseudomonas fluorescens strain 96.578

scientific article published on 01 January 2000

Differential activity and structure of highly similar peroxidases. Spectroscopic, crystallographic, and enzymatic analyses of lignifying Arabidopsis thaliana peroxidase A2 and horseradish peroxidase A2

scientific article

Dimerization effect of sucrose octasulfate on rat FGF1

scientific article

Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2

scientific article

Dominant epitopes and allergic cross-reactivity: complex formation between a Fab fragment of a monoclonal murine IgG antibody and the major allergen from birch pollen Bet v 1

scientific article

Dominating IgE-binding epitope of Bet v 1, the major allergen of birch pollen, characterized by X-ray crystallography and site-directed mutagenesis

scientific article

Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4-α4 interface.

scientific article published on 13 January 2015

Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases

article published in 2011

Epitope grafting, re-creating a conformational Bet v 1 antibody epitope on the surface of the homologous apple allergen Mal d 1.

scientific article

Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP.

scientific article published on April 2005

Expression, crystallization and preliminary X-ray analysis of extracellular modules of the neural cell-adhesion molecules NCAM and L1.

scientific article published on 25 February 2004

Expression, crystallization and preliminary X-ray analysis of the extracellular Ig modules I-IV and F3 modules I-III of the neural cell-adhesion molecule L1

scientific article published on 31 August 2005

Expression, purification and characterization of the human MTA2-RBBP7 complex

scientific article

Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine

scientific article

High resolution crystal structures of the p120 RasGAP SH3 domain

scientific article

High-resolution structure of HLA-A*1101 in complex with SARS nucleocapsid peptide

scientific article published on 20 July 2005

Human proton coupled folic acid transporter is a monodisperse oligomer in the lauryl maltose neopentyl glycol solubilized state.

scientific article published on 2 December 2017

Identification of catechols as histone-lysine demethylase inhibitors

scientific article

Increased amylosucrase activity and specificity, and identification of regions important for activity, specificity and stability through molecular evolution

scientific article published in February 2006

Inhibitors of histone demethylases

scientific article published on February 2011

Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy

scientific article

Intersubunit Bridge Formation Governs Agonist Efficacy at Nicotinic Acetylcholine  4 2 Receptors: UNIQUE ROLE OF HALOGEN BONDING REVEALED

scientific article

Ionotropic glutamate-like receptor  2 binds D-serine and glycine

scientific article

Kainate induces various domain closures in AMPA and kainate receptors

scientific article

L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain

scientific article

Lysine demethylase inhibition protects pancreatic β cells from apoptosis and improves β-cell function

scientific article

Major venom allergen of yellow jackets, Ves v 5: structural characterization of a pathogenesis-related protein superfamily

scientific article

Maltooligosaccharide disproportionation reaction: an intrinsic property of amylosucrase from Neisseria polysaccharea.

scientific article

Modulation of the dimer interface at ionotropic glutamate-like receptor delta2 by D-serine and extracellular calcium

scientific article

Molecular architecture of the Jumonji C family histone demethylase KDM5B

scientific article published on 11 March 2019

Molecular basis of allergic cross-reactivity between group 1 major allergens from birch and apple

scientific article

Molecular basis of the amylose-like polymer formation catalyzed by Neisseria polysaccharea amylosucrase.

scientific article published on 21 October 2003

Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors

scientific article published on 10 December 2012

Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4

scientific article

Molecular modelling of human red blood cell pyruvate kinase: structural implications of a novel G1091 to a mutation causing severe nonspherocytic hemolytic anemia

scientific article published on 01 December 1997

Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors

scientific article

Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand binding domain

scientific article

Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor

scientific article

Oligosaccharide and sucrose complexes of amylosucrase. Structural implications for the polymerase activity

scientific article

Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus

scientific article published on 13 January 2010

Pancreatic spasmolytic polypeptide: Crystallization, circular dichroism analysis, and preliminary X-ray diffraction studies

scholarly article by Michael Gajhede published in August 1992

Pancreatic spasmolytic polypeptide: first three-dimensional structure of a member of the mammalian trefoil family of peptides

scientific article

Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid

scientific article

Peptides Derived from Histone 3 and Modified at Position 18 Inhibit Histone Demethylase KDM6 Enzymes

scientific article published on 24 July 2018

Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors

scientific article

Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors

scientific article published on 10 December 2015

Plant peroxidases: substrate complexes with mechanistic implications

scientific article

Reversal of ABCG2/BCRP-Mediated Multidrug Resistance by 5,3',5'-Trihydroxy-3,6,7,4'-Tetramethoxyflavone Isolated from the Australian Desert Plant Chinnock

scientific article published in 2021

Role of CD3 gamma in T cell receptor assembly.

scientific article published on February 1996

Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR.

scientific article published on 15 February 2017

Small angle X-ray studies reveal that Aspergillus niger glucoamylase has a defined extended conformation and can form dimers in solution

scientific article

Structural Basis of Histone Demethylase KDM6B Histone 3 Lysine 27 Specificity

scientific article

Structural Studies of Nicotinic Acetylcholine Receptors: Using Acetylcholine-Binding Protein as a Structural Surrogate.

scientific article

Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain

scientific article

Structural analysis of the two horseradish peroxidase catalytic residue variants H42E and R38S/H42E: implications for the catalytic cycle

scientific article

Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at α4β2 nicotinic acetylcholine receptors

scientific article

Structural characterization of the stringent response related exopolyphosphatase/guanosine pentaphosphate phosphohydrolase protein family

scientific article

Structural interactions between horseradish peroxidase C and the substrate benzhydroxamic acid determined by X-ray crystallography

scientific article

Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule

scientific article

Structural mutations of C-domains in members of the Ig superfamily. Consequences for the interactions between the T cell antigen receptor and the zeta 2 homodimer

scientific article

Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites

scientific article

Structural rearrangements of sucrose phosphorylase from Bifidobacterium adolescentis during sucrose conversion.

scientific article published on 21 September 2006

Structure analysis of modulated molecular crystals: The modulated phase of thiourea as described by a molecular displacement model

article

Structure and binding properties of a cameloid nanobody raised against KDM5B.

scientific article

Structure of HLA-A*1101 in complex with a hepatitis B peptide homologue.

scientific article published on 4 November 2006

Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501

scientific article

Structure of barley grain peroxidase refined at 1.9-A resolution. A plant peroxidase reversibly inactivated at neutral pH

scientific article published on 23 January 1998

Structure of porcine pancreatic spasmolytic polypeptide at 1.95 A resolution.

scientific article published in July 1996

Structure of rat acidic fibroblast growth factor at 1.4 Å resolution

scientific article

Structure of recombinant Ves v 2 at 2.0 Angstrom resolution: structural analysis of an allergenic hyaluronidase from wasp venom.

scientific article

Structure of soybean seed coat peroxidase: A plant peroxidase with unusual stability and haem-apoprotein interactions

scientific article

Structure of the PPX/GPPA phosphatase from Aquifex aeolicus in complex with the alarmone ppGpp

scientific article

Structure of the first PDZ domain of human PSD-93

scientific article

Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity

scientific article

Structure-Based Design of a New Scaffold for Cell-Penetrating Peptidic Inhibitors of the Histone Demethylase PHF8.

scientific article published on 21 April 2017

Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency

scientific article

Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor

scientific article

Synthesis, pharmacology, and biostructural characterization of novel α4β2 nicotinic acetylcholine receptor agonists

scientific article

Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors

scientific article published on 25 August 2011

The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP

scientific article published on 04 March 2020

The SAXS solution structure of RF1 differs from its crystal structure and is similar to its ribosome bound cryo-EM structure

scientific article published on December 2005

The apo structure of sucrose hydrolase from Xanthomonas campestris pv. campestris shows an open active-site groove

scientific article

The crystal structure of recombinant proDer p 1, a major house dust mite proteolytic allergen

scientific article

The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization

scientific article

The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region.

scientific article published on 7 April 2017

The metal binding site of the major house dust mite allergen Der p 1

scientific article published on 28 August 2006

The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells

scientific article published on 17 November 2017

The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209.

scientific article published on 31 January 2006

The structure of amylosucrase fromDeinococcus radioduranshas an unusual open active-site topology

scientific article

The structure of the complex between a branched pentasaccharide and Thermobacillus xylanilyticus GH-51 arabinofuranosidase reveals xylan-binding determinants and induced fit

scientific article

The structure of the mite allergen Blo t 1 explains the limited antibody cross-reactivity to Der p 1.

scientific article

The structures of the horseradish peroxidase C-ferulic acid complex and the ternary complex with cyanide suggest how peroxidases oxidize small phenolic substrates

scientific article

Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2

scientific article

Three-dimensional structure and epitopes of Bet v 1

article

Towards the molecular understanding of glycogen elongation by amylosucrase

scientific article published on January 2007

Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors.

scientific article published on 29 October 2013

Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2.

scientific article published on 9 December 2004

X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy

scientific article

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