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List of works by Mischa Machius

A Single Active-Site Mutation of P450BM-3 Dramatically Enhances Substrate Binding and Rate of Product Formation

scientific article

A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain α-Ketoacid Dehydrogenase

A proximal arginine R206 participates in switching of the Bradyrhizobium japonicum FixL oxygen sensor.

scientific article

A versatile conformational switch regulates reactivity in human branched-chain alpha-ketoacid dehydrogenase

scientific article

Activator Protein-1: redox switch controlling structure and DNA-binding

scientific article published on 7 September 2017

Artificial ligand binding within the HIF2  PAS-B domain of the HIF2 transcription factor

scientific article

Biophysical and bioinformatic analyses implicate the Treponema pallidum Tp34 lipoprotein (Tp0971) in transition metal homeostasis

scientific article

Changes at the KinA PAS-A dimerization interface influence histidine kinase function

scientific article

Computational Design of the Sequence and Structure of a Protein-Binding Peptide ⬇️

scientific article published on March 9, 2011

Computational design of a symmetric homodimer using β-strand assembly ⬇️

scientific article published on December 5, 2011

Correction to Discovery of Small Molecule Mer KinaseInhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia.

scientific article published on 15 August 2014

Cross-talk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain alpha-keto acid decarboxylase/dehydrogenase

scientific article

Crystal Structure of the Formin mDia1 in Autoinhibited Conformation

scientific article

Crystal structure of a 12 ANK repeat stack from human ankyrinR.

scientific article

Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations

scientific article

Crystal structure of inhibitor-bound P450BM-3 reveals open conformation of substrate access channel

scientific article

Crystal structure of the 47-kDa lipoprotein of Treponema pallidum reveals a novel penicillin-binding protein

scientific article

Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution

scientific article

Crystal structure of the RIM2 C2A-domain at 1.4 A resolution

scientific article

Crystal structure of the Tp34 (TP0971) lipoprotein of treponema pallidum: implications of its metal-bound state and affinity for human lactoferrin

scientific article

Crystal structures of the effector-binding domain of repressor Central glycolytic gene Regulator fromBacillus subtilisreveal ligand-induced structural changes upon binding of several glycolytic intermediates

scientific article

Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors

scientific article published on 13 September 2016

Diffraction data analysis in the presence of radiation damage

scientific article

Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors

scientific article

Discovery of Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia

scientific article

Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica ⬇️

scientific article published on November 15, 2012

Increasing Sequence Diversity with Flexible Backbone Protein Design: The Complete Redesign of a Protein Hydrophobic Core ⬇️

scientific article published on May 24, 2012

Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer

scientific article

Interactions of substrates at the surface of P450s can greatly enhance substrate potency

scientific article

Kinetic stabilization of Bacillus licheniformis alpha-amylase through introduction of hydrophobic residues at the surface

scientific article

Localization and Structure of the Ankyrin-binding Site on  2-Spectrin

scientific article

Metal-Mediated Affinity and Orientation Specificity in a Computationally Designed Protein Homodimer ⬇️

scientific article published on December 15, 2011

Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges

scientific article

Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation

scientific article

Monovalent cation dependence and preference of GHKL ATPases and kinases

scientific article (publication date: 5 June 2003)

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

scientific article

Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors

scientific article

Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase: refined phosphorylation loop structure in the active site

scientific article

Side chain and backbone contributions of Phe508 to CFTR folding

scientific article

Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein   Subunit Mutants

scientific article

Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme

scientific article

Structural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteases

scientific article

Structural and Biochemical Basis for Polyamine Binding to the Tp0655 Lipoprotein of Treponema pallidum: Putative Role for Tp0655 (TpPotD) as a Polyamine Receptor

scientific article

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

scientific article

Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase

scientific article published in August 2006

Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch

scientific article

Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops

scientific article

Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4

scientific journal article

Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine

scientific article

Structural basis of Rho GTPase-mediated activation of the formin mDia1.

scientific article published in April 2005

Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain

scientific article published on 5 January 2005

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

scientific article

Structural biology: a high-tech tool for biomedical research

scientific article

Structural evidence that the 32-kilodalton lipoprotein (Tp32) of Treponema pallidum is an L-methionine-binding protein

scientific article published on 15 October 2004

Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex

scientific article

Structure and Mechanism of a Eukaryotic FMN Adenylyltransferase

scientific article

Structure and Substrate Recruitment of the Human Spindle Checkpoint Kinase Bub1

scientific article

Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana

scholarly article

The Crystal Structure of a Self-Activating G Protein α Subunit Reveals Its Distinct Mechanism of Signal Initiation ⬇️

scientific article published on February 8, 2011

The PnrA (Tp0319; TmpC) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like operon in Treponema pallidum

scientific article

The two active sites in human branched-chain alpha-keto acid dehydrogenase operate independently without an obligatory alternating-site mechanism

scientific article

Three-dimensional structure of the complexin/SNARE complex

scientific article

p31comet blocks Mad2 activation through structural mimicry

scientific article

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