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List of works by Udo Oppermann

---Inhibition of histone H3K27 demethylase selectively modulates inflammatory phenotypes of natural killer cells.

scientific article published on 4 January 2018

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

scientific article published on August 2013

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

scientific article

A Chemical Probe For Tudor Domain Protein Spindlin1 to Investigate Chromatin Functions

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function

scientific article published on 15 October 2019

A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase

scientific article published on 01 March 2019

A germline mutation of CDKN2A and a novel RPLP1-C19MC fusion detected in a rare melanotic neuroectodermal tumor of infancy: a case report ⬇️

scientific article

A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics

scientific article

A miniaturized screen for inhibitors of Jumonji histone demethylases

scientific article

A non-enzymatic function of 17beta-hydroxysteroid dehydrogenase type 10 is required for mitochondrial integrity and cell survival

scientific article

A novel INS mutation in a family with MODY: variable insulin secretion and putative mechanisms

scientific article published on 6 April 2018

A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases

scientific article

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

scientific article

A structural mapping of mutations causing succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency

scientific article

AF10 (MLLT10) prevents somatic cell reprogramming through regulation of DOT1L-mediated H3K79 methylation

scientific article published on 02 July 2021

AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells

scientific article published on 12 February 2019

Active site variability of type 1 11beta-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons

scientific article published on 20 January 2006

Advances and challenges in epigenomic single-cell sequencing applications

scientific article published on 15 April 2020

Advances and challenges in understanding histone demethylase biology.

scientific article

Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress

scientific article

Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions

scientific article published on 30 January 2020

Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis

scientific article

Animal Models of Epigenetic Regulation in Neuropsychiatric Disorders ⬇️

scientific article published on 01 January 2011

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern

scientific article published on 28 October 2019

Assessing histone demethylase inhibitors in cells: lessons learned.

scientific article

Author Correction: Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions

scientific article published on 24 March 2020

Biochemical characterization of TASSELSEED 2, an essential plant short-chain dehydrogenase/reductase with broad spectrum activities

scientific article

Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy

scientific article

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming

scientific article published on 08 April 2019

Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology

scientific article published on January 2007

Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase

scientific article

Classification of the short-chain dehydrogenase/reductase superfamily using hidden Markov models

scientific article published in May 2010

Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study.

scientific article published on 26 January 2008

Codon optimization reveals critical factors for high level expression of two rare codon genes in Escherichia coli: RNA stability and secondary structure but not tRNA abundance.

scientific article

Coenzyme-based functional assignments of short-chain dehydrogenases/reductases (SDRs).

scientific article

Comparative enzymology of 11 beta -hydroxysteroid dehydrogenase type 1 from glucocorticoid resistant (Guinea pig) versus sensitive (human) species

scientific article published on 22 October 2002

Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis

scientific article

Critical residues for structure and catalysis in short-chain dehydrogenases/reductases

scientific article

Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6

scientific article

Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations

scientific article

Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase

scientific article published on 21 April 2011

Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing

scientific article

Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase

scientific article

Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor development

scientific article

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

scientific article

Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design

scientific article

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

scientific article

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

scientific article published on 07 December 2018

Development and application of a fluoride-detection-based fluorescence assay for γ-butyrobetaine hydroxylase

scientific article

Development of homogeneous luminescence assays for histone demethylase catalysis and binding.

scientific article

Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity

Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1)

scientific article published on 24 July 2015

Discovery of Orally Bioavailable, Quinoline-based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.

scientific article published on 16 May 2018

Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1)

scientific article published on 24 July 2019

Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone

scientific article

Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function

scientific article published on 26 February 2021

Divergent roles of prostacyclin and PGE2 in human tendinopathy

scientific article published on 13 March 2019

Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors.

scientific article published on 23 December 2015

Evaluation of micro-parallel liquid chromatography as a method for HTS-coupled actives verification

scientific article published in December 2007

GGPS1 Mutations Cause Muscular Dystrophy/Hearing Loss/Ovarian Insufficiency Syndrome

scientific article published on 13 May 2020

Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile.

scientific article

Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone

scientific article published on 27 October 2020

H3K27me3 demethylases regulate in vitro chondrogenesis and chondrocyte activity in osteoarthritis.

scientific article published on 07 July 2016

High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships

scientific article

High-level expression and rapid purification of rare-codon genes from hyperthermophilic archaea by the GST gene fusion system

scientific article

High-level production and optimization of monodispersity of 11beta-hydroxysteroid dehydrogenase type 1.

scientific article

High‐throughput structural biology of metabolic enzymes and its impact on human diseases ⬇️

scientific article published on February 22, 2011

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism

scientific article published on 02 March 2020

Hot spots in Tcf4 for the interaction with beta-catenin

scientific article published on 25 March 2003

Human UTY(KDM6C) Is a Male-specific N -Methyl Lysyl Demethylase

scientific article

Human prostaglandin reductase 1 (PGR1): Substrate specificity, inhibitor analysis and site-directed mutagenesis.

scientific article published on 22 January 2015

Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform.

scientific article published on 17 February 2016

Identification of the 2-Benzoxazol-2-yl-phenol Scaffold as New Hit for JMJD3 Inhibition

scientific article published on 25 February 2019

Immunophenotypic expression of UCP1 in hibernoma and other adipose/non adipose soft tissue tumours

Increased 15-PGDH expression leads to dysregulated resolution responses in stromal cells from patients with chronic tendinopathy.

scientific article published on 8 September 2017

Inflammation activation and resolution in human tendon disease

scientific article published on October 2015

Inhibition of histone H3K27 demethylases inactivates brachyury (TBXT) and promotes chordoma cell death

scientific article published on 27 August 2020

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases

scientific article

Insight into S -adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits

scientific article

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

scientific article

Interactive JIMD articles using the iSee concept: turning a new page on structural biology data

scientific article published on 21 April 2011

Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein

scientific article

Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition.

scientific article published on 29 November 2017

Investigating the genetic association between ERAP1 and ankylosing spondylitis

scientific article published on 18 August 2009

Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases

scientific article published on 19 March 2018

Kinetic and structural evidence of the alkenal/one reductase specificity of human ζ-crystallin.

scientific article

Kruidenier et al. reply

scientific article published in Nature

Ligand supplementation as a method to increase soluble heterologous protein production

scientific article published on February 2008

Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function

scientific article

Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases

Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases

scientific article

Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity.

scientific article

Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor

scientific article

MTR-12SUV39H1 INHIBITOR AND EPIGENETIC MODIFIER DRUG CHAETOCIN SENSITIZES GBM CELLS TO TRAIL-INDUCED APOPTOSIS.

scientific article

Mass cytometry analysis reveals a distinct immune environment in peritoneal fluid in endometriosis: a characterisation study

scientific article published on 07 January 2020

Mechanism and substrate recognition of human holo ACP synthase

scientific article

Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome

scientific article published on 01 September 2019

Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome

scientific article published on 11 July 2019

Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites

scientific article

Molecular mechanisms underlying WOX1 activation during apoptotic and stress responses ⬇️

scientific article published on October 15, 2003

Nanopore sequencing of single-cell transcriptomes with scCOLOR-seq

scientific article published on 01 July 2021

Novel patient missense mutations in the HSD17B10 gene affect dehydrogenase and mitochondrial tRNA modification functions of the encoded protein

scientific article published on 6 September 2017

Periostin expression in neoplastic and non-neoplastic diseases of bone and joint

scientific article published on 05 September 2018

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

scientific article

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

scientific article

Potent and selective inhibitors of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD)

Protein production and purification

scientific article

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

scientific article

Quantitative analysis of histone demethylase probes using fluorescence polarization

scientific article published on 13 June 2013

Quinone oxidoreductase-2-mediated prodrug cancer therapy

scientific article published on July 2010

Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria

scientific article

Ribosomal oxygenases are structurally conserved from prokaryotes to humans

scientific article

Role of protein structure in variant annotation: structural insight of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency

scientific article published on 08 March 2019

Role of short-chain hydroxyacyl CoA dehydrogenases in SCHAD deficiency

scientific article published on 26 November 2007

SALMON: solvent accessibility, ligand binding, and mapping of ligand orientation by NMR spectroscopy

scientific article

SDR-type human hydroxysteroid dehydrogenases involved in steroid hormone activation

scientific article published on 17 January 2007

Sclerostin expression in bone tumours and tumour-like lesions.

scientific article published on 20 February 2016

Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding

scientific article published on 08 January 2019

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

scientific article

Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β-thalassemia

scientific article published on 3 November 2016

Short-chain dehydrogenase/reductase (SDR) relationships: a large family with eight clusters common to human, animal, and plant genomes

scientific article

Short-chain dehydrogenases/reductases (SDR): the 2002 update

scientific article

Short-chain dehydrogenases/reductases (SDRs).

scientific article

Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms

scientific article published on 15 October 2008

Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy

scientific article published on 05 January 2021

Structural Basis for Different Specificities of Acyltransferases Associated with the Human Cytosolic and Mitochondrial Fatty Acid Synthases

scientific article

Structural analysis of human KDM5B guides histone demethylase inhibitor development

scientific article

Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family

scientific article

Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates

scientific article

Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity

scientific article

Structural and mechanistic studies on γ-butyrobetaine hydroxylase

scientific article

Structural basis for substrate specificity in human monomeric carbonyl reductases

scientific article

Structural basis of fumarate hydratase deficiency

scientific article

Structural genomics of histone tail recognition

scientific article

Structural impact of human and Escherichia coli biotin carboxyl carrier proteins on biotin attachment

scientific article

Structural insight into the human mitochondrial tRNA purine N1-methyltransferase and ribonuclease P complexes

scientific article published on 07 June 2018

Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A

scientific article

Structure and Mechanism of Human UDP-glucose 6-Dehydrogenase

scientific article

Structure and function of human 17beta-hydroxysteroid dehydrogenases

scientific article

Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS

scientific article

Structure and mechanism of human UDP-xylose synthase: evidence for a promoting role of sugar ring distortion in a three-step catalytic conversion of UDP-glucuronic acid

scientific article published on 18 July 2012

Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function

scientific article

Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family

scientific article

Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease

scientific article published on 9 December 2005

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.

scientific article published on 8 March 2008

Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.

scientific article published on 22 October 2008

Structures of the Human GTPase MMAA and Vitamin B 12 -dependent Methylmalonyl-CoA Mutase and Insight into Their Complex Formation

scientific article

Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates.

scientific article published on 18 August 2017

Superfamilies SDR and MDR: from early ancestry to present forms. Emergence of three lines, a Zn-metalloenzyme, and distinct variabilities

scientific article published on May 2010

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis

scientific article

The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative

scientific article

The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions

scientific article published on 12 November 2004

The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activity

scientific article

The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding

scientific article (publication date: 4 August 2006)

The first international workshop on the epigenetics of osteoarthritis

scientific article

The fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma

scientific article published on 26 November 2019

The human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summary

scientific article published on 17 November 2008

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants

scientific article published on 28 August 2015

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

scholarly article

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

scientific article published on 14 September 2016

The relationship between the chemistry and biological activity of the bisphosphonates.

scientific article published on 09 April 2011

The roles of Jumonji-type oxygenases in human disease

scientific article published on February 2014

Thermal unfolding of the archaeal DNA and RNA binding protein Ssh10.

scientific article published on 20 June 2008

Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3

scientific article

Tic32, an essential component in chloroplast biogenesis

scientific article published in October 2009

Tic32, an essential component in chloroplast biogenesis.

scientific article published on 5 June 2004

Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships

scientific article published on 16 December 2014

Towards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implications

scientific article

Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases?

scientific article published on September 2006

UDP-glucose dehydrogenase: structure and function of a potential drug target

scientific article published on October 2010

Virtual fragment screening identification of a novel Quinoline-5,8-dicarboxylic acid derivative as selective JMJD3 inhibitor.

scientific article published on 6 April 2018

Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases? ⬇️

scientific article published on 03 April 2013

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