List of works by Andrea Mattevi

3-Hydroxybenzoate 6-Hydroxylase from Rhodococcus jostii RHA1 Contains a Phosphatidylinositol Cofactor

scientific article

8 Demethylation pathways for histone methyllysine residues

scientific article published in 2006

A 30 Å long U-shaped catalytic tunnel in the crystal structure of polyamine oxidase

A Monotopic Membrane Protein Goes Solo

A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors

scientific article published on 5 May 2017

A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex

scientific article published on 01 April 2019

A close look at NAD biosynthesis

A covalent modification of NADP+ revealed by the atomic resolution structure of FprA, a Mycobacterium tuberculosis oxidoreductase

scientific article

A highly specific mechanism of histone H3-K4 recognition by histone demethylase LSD1.

scientific article published on 20 September 2006

A novel mammalian flavin-dependent histone demethylase

scientific journal article

A novel oxidoreductase family sharing a conserved FAD-binding domain.

scientific article published on June 1998

Active site plasticity in D-amino acid oxidase: a crystallographic analysis

scientific article

Alternative splicing of the histone demethylase LSD1/KDM1 contributes to the modulation of neurite morphogenesis in the mammalian nervous system

scientific article

An Elegant Four-Helical Fold in NOX and STEAP Enzymes Facilitates Electron Transport across Biomembranes-Similar Vehicle, Different Destination

scientific article published on 20 August 2020

An unprecedented NADPH domain conformation in lysine monooxygenase NbtG provides insights into uncoupling of oxygen consumption from substrate hydroxylation

scientific article published on 23 March 2015

Ancestral reconstruction of mammalian FMO1 enables structural determination, revealing unique features that explain its catalytic properties

scientific article published on 25 December 2020

Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs

scientific article published on 23 December 2019

Antiviral strategies to control calicivirus infections

scientific article published on 21 May 2010

Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering

scientific article published on 31 March 2020

Asp-170 is crucial for the redox properties of vanillyl-alcohol oxidase

scientific article

At Long Last Potent and Selective KDM5 Inhibitors

scholarly article by Dante Rotili published in July 2016

Baeyer-Villiger Monooxygenase FMO5 as Entry Point in Drug Metabolism

scientific article published on 7 August 2017

Beyond the Protein Matrix: Probing Cofactor Variants in a Baeyer-Villiger Oxygenation Reaction

scientific article

Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis

scientific article

Biocatalytic Characterization of Human FMO5: Unearthing Baeyer–Villiger Reactions in Humans

Biocatalytic Properties and Structural Analysis of Eugenol Oxidase from Rhodococcus jostii RHA1: A Versatile Oxidative Biocatalyst

scientific article

Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2

scientific article

Characterization and Crystal Structure of a Robust Cyclohexanone Monooxygenase

Characterization and Crystal Structure of a Robust Cyclohexanone Monooxygenase.

scientific article

Characterization of a thermostable flavin-containing monooxygenase from Nitrincola lacisaponensis (NiFMO)

scientific article published on 04 January 2019

Characterization of immunoglobulin variable regions of two human pathogenic monoclonal cryocrystalglobulins

scientific article published on 18 October 2007

Competitive Inhibition of Swine Kidney Copper Amine Oxidase by Drugs: Amiloride, Clonidine, and Gabexate Mesylate

scholarly article by Rodolfo Federico et al published November 1997 in Biochemical and Biophysical Research Communications

Covalent flavinylation enhances the oxidative power of vanillyl-alcohol oxidase

article

Covalent flavinylation is essential for efficient redox catalysis in vanillyl-alcohol oxidase

scientific article

Cross-talk and ammonia channeling between active centers in the unexpected domain arrangement of glutamate synthase

scientific article

Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction

scientific article published in Nature Communications

Crystal Structure of 3-Hydroxybenzoate 6-Hydroxylase Uncovers Lipid-assisted Flavoprotein Strategy for Regioselective Aromatic Hydroxylation

scientific article

Crystal structure of Escherichia coli pyruvate kinase type I: molecular basis of the allosteric transition

scientific article

Crystal structure of a Baeyer-Villiger monooxygenase

scientific article

Crystal structure of human monoamine oxidase B, a drug target enzyme monotopically inserted into the mitochondrial outer membrane

scientific article published on April 2004

Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization

scientific article

Crystal structures and atomic model of NADPH oxidase

scientific article published on 12 June 2017

Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class

scientific article

Crystallization and preliminary X-ray analysis of an alditol oxidase from Streptomyces coelicolor A3(2).

scientific article published on 30 November 2006

Crystallization and preliminary X-ray analysis of polyamine oxidase from Zea mays L

scientific article published on 01 November 1998

Crystallization and preliminary X-ray analysis of pyruvate kinase type I from Escherichia coli

scientific article published in November 1995

Crystallization and preliminary X-ray analysis of the flavoenzyme vanillyl-alcohol oxidase from Penicillium simplicissimum.

scientific article

Crystallization of L-aspartate oxidase, the first enzyme in the bacterial de novo biosynthesis of NAD

article

Crystallographic and enzymatic investigations on the role of Ser558, His610, and Asn614 in the catalytic mechanism of Azotobacter vinelandii dihydrolipoamide acetyltransferase (E2p)

scientific article

Crystallographic snapshots of UDP-glucuronic acid 4-epimeraseligand binding, rotation and reduction

scientific article published on 13 July 2020

Cyclization in concert

scientific article

Dealing with oxygen using bare hands

scientific article (2015)

Deciphering the enzymatic mechanism of sugar ring contraction in UDP-apiose biosynthesis

scientific article published on 01 November 2019

Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors

scientific article published on 14 February 2005

Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells

scientific article published on 28 November 2018

Differential Properties of Transcriptional Complexes Formed by the CoREST Family

scientific article

Discovery and characterization of an F420-dependent glucose-6-phosphate dehydrogenase (Rh-FGD1) from Rhodococcus jostii RHA1.

scientific article published on 13 December 2016

Discovery of Inhibitors for the Ether Lipid-Generating Enzyme AGPS as Anti-Cancer Agents

scientific article published on 31 August 2015

Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent

scientific article published on 24 December 2015

Engineering of microheterogeneity-resistant p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens.

scientific article published in December 1990

Engineering stability in NADPH oxidases: a common strategy for enzyme production

article

Enzymes without borders: mobilizing substrates, delivering products

scientific article published on July 2008

Expanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatin

scientific article (publication date: 2013)

Expanding the structural biology toolbox with single-molecule holography

scientific article published on 2 February 2017

Exploring the Structural Basis of Substrate Preferences in Baeyer-Villiger Monooxygenases

scientific article

Finding the switch: turning a baeyer-villiger monooxygenase into a NADPH oxidase

scientific article

Flavins as Covalent Catalysts: New Mechanisms Emerge

scientific article published on 5 March 2017

Flavoenzymes: diverse catalysts with recurrent features

scientific article

Flavoprotein oxidases: classification and applications

scientific article published on 03 May 2013

Functional analysis of pyrimidine 5'-nucleotidase mutants causing nonspherocytic hemolytic anemia

scientific article

Functional role of the "aromatic cage" in human monoamine oxidase B: structures and catalytic properties of Tyr435 mutant proteins

scientific article published in April 2006

Glutamate synthase: a fascinating pathway from L-glutamine to L-glutamate.

scientific article published on March 2004

Histone deacetylases as an epigenetic pillar for the development of hybrid inhibitors in cancer

scientific article published on 12 April 2019

Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process

scientific article published in April 2005

Human histone demethylase LSD1 reads the histone code

scientific article

Identification of a gatekeeper residue that prevents dehydrogenases from acting as oxidases.

scientific article

Identifying a recombinant alkyldihydroxyacetonephosphate synthase suited for crystallographic studies

article

Impact of Mutations on NPAC Structural Dynamics: Mechanistic Insights from MD Simulations

scientific article published on 21 August 2019

Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues

scientific article published in March 2004

Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures

scientific article

Interactions of Monoamine Oxidases with the Antiepileptic Drug Zonisamide: Specificity of Inhibition and Structure of the Human Monoamine Oxidase B Complex

scientific article

Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation

scientific article

Isolation and characterization of a thermostable F420:NADPH oxidoreductase from Thermobifida fusca

scientific article published on 14 April 2017

Joint Functions of Protein Residues and NADP(H) in Oxygen Activation by Flavin-containing Monooxygenase

scientific article

Kinetic Resolution of sec-Thiols via Enantioselective Oxidation with Rationally Engineered 5-(Hydroxymethyl)furfural Oxidase.

scientific article

Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease

scientific article

LSD1: oxidative chemistry for multifaceted functions in chromatin regulation

scientific article published on 17 March 2008

Lights and shadows on monoamine oxidase inhibition in neuroprotective pharmacological therapies

scientific article

Limited Proteolysis and X-ray Crystallography Reveal the Origin of Substrate Specificity and of the Rate-Limiting Product Release during Oxidation ofd-Amino Acids Catalyzed by Mammaliand-Amino Acid Oxidase†,‡

article by Maria Antonietta Vanoni et al published May 1997 in Biochemistry

MCM5: a new actor in the link between DNA replication and Meier-Gorlin syndrome.

scientific article published on 15 February 2017

Mechanistic aspects regarding the elimination of H2O2 from C(4a)-hydroperoxyflavin. The role of a proton shuttle required for H2O2 elimination

scientific article published on 12 August 2013

Mercuration of vanillyl-alcohol oxidase fromPenicillium simplicissimumgenerates inactive dimers

scientific article published on 01 January 1997

Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Antidiabetes Drugs

scientific article

Molecular Mimicry and Ligand Recognition in Binding and Catalysis by the Histone Demethylase LSD1-CoREST Complex

scientific article

Molecular and mechanistic properties of the membrane-bound mitochondrial monoamine oxidases

scientific article

Monoamine Oxidases, Oxidative Stress, and Altered Mitochondrial Dynamics in Cardiac Ageing

scientific article

Multiple pathways guide oxygen diffusion into flavoenzyme active sites

scientific article

NeuroLSD1: Splicing-Generated Epigenetic Enhancer of Neuroplasticity

scientific article published on 13 December 2016

New frontiers in structural flavoenzymology

scientific article published on 27 October 2006

New insights into the structures and functions of human monoamine oxidases A and B

New roles of flavoproteins in molecular cell biology: histone demethylase LSD1 and chromatin

scientific article published on 14 July 2009

New structures of allosteric proteins revealing remarkable conformational changes

scientific article published on December 1996

On the mechanism of calcium-dependent activation of NADPH oxidase 5 (NOX5)

scientific article published on 30 November 2019

One-Pot Biocatalytic Double Oxidation of α-Isophorone for the Synthesis of Ketoisophorone

Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.

scientific article

Phosphorylation of neuronal Lysine-Specific Demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1/2

scientific article

Photoinduced monooxygenation involving NAD(P)H-FAD sequential single-electron transfer

scientific article published on 25 May 2020

Polycyclic Ketone Monooxygenase from the Thermophilic Fungus Thermothelomyces thermophila: A Structurally Distinct Biocatalyst for Bulky Substrates.

scientific article published on 23 December 2016

Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features

scientific article

Polystyrene microbridges used in sitting-drop crystallization release 1,4-diphenyl-2-butene, a novel inhibitor of human MAO B.

scientific article

Potentiation of Ligand Binding through Cooperative Effects in Monoamine Oxidase B

scientific article

Precursor of ether phospholipids is synthesized by a flavoenzyme through covalent catalysis

scientific article

Probing the active site of L-aspartate oxidase by site-directed mutagenesis: role of basic residues in fumarate reduction

scientific article published in April 2001

Probing the interaction of the p53 C-terminal domain to the histone demethylase LSD1.

scientific article published on 4 August 2017

Properties of the recombinant ferredoxin-dependent glutamate synthase of Synechocystis PCC6803. Comparison with the Azospirillum brasilense NADPH-dependent enzyme and its isolated alpha subunit

scientific article

Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase

scientific article

Publisher Correction: Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs

scientific article published on 01 February 2020

Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies.

scientific article

Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts

article

Purification and crystallization of Kokobera virus helicase

scientific article

Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells

Recombinant human dihydroxyacetonephosphate acyl-transferase characterization as an integral monotopic membrane protein.

scientific article published on 8 November 2016

Refined crystal structure of lipoamide dehydrogenase from Azotobacter vinelandii at 2.2 Å resolution

article

Revealing the moonlighting role of NADP in the structure of a flavin-containing monooxygenase

scientific article

Role of the His57−Glu214 Ionic Couple Located in the Active Site ofMycobacterium tuberculosisFprA†,‡

scholarly article by Andrea Pennati et al published July 2006 in Biochemistry

Same Substrate, Many Reactions: Oxygen Activation in Flavoenzymes

scientific article

Side-Chain Pruning Has Limited Impact on Substrate Preference in a Promiscuous Enzyme

scientific article published on 30 October 2018

Snapshots of Enzymatic Baeyer-Villiger Catalysis: OXYGEN ACTIVATION AND INTERMEDIATE STABILIZATION

scientific article

Stabilization of C4a-hydroperoxyflavin in a two-component flavin-dependent monooxygenase is achieved through interactions at flavin N5 and C4a atoms

scientific article published on 16 June 2011

Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis

scientific article

Structural analysis of flavinylation in vanillyl-alcohol oxidase

scientific article

Structural analysis of the catalytic mechanism and stereoselectivity in Streptomyces coelicolor alditol oxidase

scientific article

Structural and Mechanistic Studies of Mofegiline Inhibition of Recombinant Human Monoamine Oxidase B ∥

scientific article

Structural and biochemical analysis of human pathogenic astrovirus serine protease at 2.0 A resolution

scientific article

Structural and biochemical insights into 7β-hydroxysteroid dehydrogenase stereoselectivity

scientific article

Structural and mechanistic studies of arylalkylhydrazine inhibition of human monoamine oxidases A and B

scientific article

Structural bases for inhibitor binding and catalysis in polyamine oxidase

scientific article

Structural basis of LSD1-CoREST selectivity in histone H3 recognition

scientific article

Structural characterization of l-aspartate oxidase and identification of an interdomain loop by limited proteolysis

scientific article published on 01 March 1999

Structural insight into the mechanism of oxygen activation and substrate selectivity of flavin-dependent N-hydroxylating monooxygenases

scientific article

Structural insights into the mechanism of amine oxidation by monoamine oxidases A and B

scientific article

Structural properties of human monoamine oxidases A and B

scientific article

Structural studies on flavin reductase PheA2 reveal binding of NAD in an unusual folded conformation and support novel mechanism of action

scientific article

Structural studies on the synchronization of catalytic centers in glutamate synthase

scientific article

Structure and biochemical analysis of Kokobera virus helicase

scientific article

Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia

scientific article

Structure and functionality in flavivirus NS-proteins: perspectives for drug design

scientific article

Structure and mechanisms of ROS generation by NADPH oxidases

scientific article published on 30 April 2019

Structure of D-amino acid oxidase: new insights from an old enzyme

scientific article published on December 1997

Structure of FAD-bound L-aspartate oxidase: insight into substrate specificity and catalysis

scientific article

Structure of L-aspartate oxidase: implications for the succinate dehydrogenase/fumarate reductase oxidoreductase family

scientific article

Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders

scientific article

Structure of the monooxygenase component of a two-component flavoprotein monooxygenase

scientific article

Structure, function and redesign of vanillyl-alcohol oxidase

Structure-Based Enzyme Tailoring of 5-Hydroxymethylfurfural Oxidase

article published in 2015

Structure-based engineering of Phanerochaete chrysosporium alcohol oxidase for enhanced oxidative power towards glycerol

scientific article published in 2018

Structure-based redesign of cofactor binding in putrescine oxidase

scientific article

Structure-function relationships in flavoenzyme-dependent amine oxidations: a comparison of polyamine oxidase and monoamine oxidase

scientific article

Structures of Michaelis and product complexes of plant cytokinin dehydrogenase: implications for flavoenzyme catalysis

scientific article

Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs

scientific article

Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A

scientific article

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors

scientific article published on 4 January 2018

Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation

scientific article published on 08 April 2020

The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis

scientific article published on 14 September 2013

The FAD binding sites of human monoamine oxidases A and B

scientific article (publication date: 2004)

The PHBH fold: Not only flavoenzymes

scientific article published on 01 March 1998

The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology.

scientific article

The VAO/PCMH flavoprotein family.

scientific article

The VIZIER project: preparedness against pathogenic RNA viruses

scientific article

The active conformation of glutamate synthase and its binding to ferredoxin

scientific article

The allosteric regulation of pyruvate kinase

scientific article

The allosteric regulation of pyruvate kinase

scientific article published on June 1996

The catalytic domain of the dihydrolipoyl transacetylase component of the pyruvate dehydrogenase complex from Azotobacter vinelandii and Escherichia coli. Expression, purification, properties and preliminary X-ray analysis.

scientific article published in November 1991

The crucial step in ether phospholipid biosynthesis: structural basis of a noncanonical reaction associated with a peroxisomal disorder

scientific article

The enigmatic reaction of flavins with oxygen

scientific article published on 20 July 2012

The extreme structural plasticity in the CYP153 subfamily of P450s directs development of designer hydroxylases

article

The growing structural and functional complexity of the LSD1/KDM1A histone demethylase

scientific article

The oxygen-binding vs. oxygen-consuming paradigm in biocatalysis: structural biology and biomolecular simulation

scientific article

The pyruvate dehydrogenase multienzyme complex

The refined crystal structure of Pseudomonas putida lipoamide dehydrogenase complexed with NAD+ at 2.45 A resolution

scientific article

The role of the proteome in catalysis and regulation

The ‘gating’ residues Ile199 and Tyr326 in human monoamine oxidase B function in substrate and inhibitor recognition

scientific article

ThermoFAD, a Thermofluor-adapted flavin ad hoc detection system for protein folding and ligand binding

scientific article

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration.

scientific article published on 10 February 2017

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.

scientific article published on 10 February 2017

Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B

scientific article

To be or not to be an oxidase: challenging the oxygen reactivity of flavoenzymes

scientific article

Touch, act and go: landing and operating on nucleosomes

scientific article published on 19 January 2016

Two tyrosine residues, Tyr-108 and Tyr-503, are responsible for the deprotonation of phenolic substrates in vanillyl-alcohol oxidase

scientific article published on 17 July 2017

Vanillyl-alcohol oxidase, a tasteful biocatalyst

article

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