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List of works by Andrea Scozzafava

1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads

scientific article published on 11 July 2017

13C Nmr spectra of hexakis pyridine-N-oxide cobalt(II) and nickel(II) complexes

scholarly article by Ivano Bertini et al published January 1976 in Inorganica Chimica Acta

1H NMR ganglioside ceramide resonance region on the differential diagnosis of low and high malignancy of brain gliomas ⬇️

scientific article published on October 1, 1997

1H NMR studies of Chromatium vinosum cytochrome c′

scientific article published on 01 October 1990

1H NOE studies of oxidized high potential iron sulfur protein II from Ectothiorhodospira halophila

1H-NMR studies on partially and fully reduced 2(4Fe-4S) ferredoxin from Clostridium pasteurianum

scientific article published on March 1992

2D 1H NMR studies of oxidized 2(Fe4S4) ferredoxin from Clostridium pasteurianum

scientific article published in September 1991

3-phenyl-1H-indole-5-sulfonamides: structure-based drug design of a promising class of carbonic anhydrase inhibitors

scientific article published on January 2010

31P NMR spectra of paramagnetic MBr2 (OPPh3)2 complexes. A breakdown in the validity of the Solomon-Bloembergen equations

3D QSAR Selectivity Analyses of Carbonic Anhydrase Inhibitors: Insights for the Design of Isozyme Selective Inhibitors

scientific article published on 01 November 2006

4-Chlorocatechol 1,2-dioxygenase from the chlorophenol-utilizing Gram-positive Rhodococcus opacus 1CP: crystallization and preliminary crystallographic analysis

scientific article published on 29 May 2002

4-Toluenesulfonylureido derivatives of amines, amino acids and dipeptides: a novel class of potential antitumor agents

scientific article published on 01 October 2000

5- and 6-Membered (thio)lactones are prodrug type carbonic anhydrase inhibitors

scientific article published on 11 November 2011

6-Substituted 1,2-benzoxathiine-2,2-dioxides are isoform-selective inhibitors of human carbonic anhydrases IX, XII and VA

scientific article published on 01 January 2015

7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range

scientific article published on 25 October 2010

7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors.

scientific article published on 31 May 2013

A 31P NMR study of phosphate in presence of cobalt(II)- and copper(II)- substituted bovine carbonic anhydrase B.

scientific article

A Class of Sulfonamides with Strong Inhibitory Action against the α-Carbonic Anhydrase from Trypanosoma cruzi

scientific article published on 10 July 2013

A class of 4-sulfamoylphenyl-ω-aminoalkyl ethers with effective carbonic anhydrase inhibitory action and antiglaucoma effects.

scientific article

A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects

scientific article

A comment on the Jahn-Teller effect in the complex K2PbCu(NO2)6

A highly catalytically active γ-carbonic anhydrase from the pathogenic anaerobe Porphyromonas gingivalis and its inhibition profile with anions and small molecules

scientific article published on 28 May 2013

A new class of inhibitors capable of binding both the acidic and alkaline forms of carbonic anhydrase

scientific article published on 01 March 1981

A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth

scientific article published on 30 December 2010

A thermodynamic and spectroscopic study of the complexes of the undecapeptide Substance P, of its N-terminal fragment and of model pentapeptides containing two prolyl residues with copper ions

A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases

scientific article

Advances in the NMR investigation of paramagnetic molecules in solution

article published in 1992

Agents that target cysteine residues of biomolecules and their therapeutic potential

Aliphatic and aromatic inhibitors binding to the active site of catechol 2,3-dioxygenase from Pseudomonas putida mt-2

scientific article published on 01 April 1994

An inhibitor-like binding mode of a carbonic anhydrase activator within the active site of isoform II

scientific article published on 14 October 2010

An update in the development of HIV entry inhibitors

scientific article published on January 2007

An α-carbonic anhydrase from the thermophilic bacterium Sulphurihydrogenibium azorense is the fastest enzyme known for the CO2 hydration reaction

scientific article published on 29 September 2012

Anion inhibition studies of a β-carbonic anhydrase from Clostridium perfringens.

scientific article

Anion inhibition studies of an α-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1.

scientific article published on 9 July 2012

Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense

scientific article published on 27 September 2012

Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.

scientific article

Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease

scientific article published on 6 June 2013

Anion inhibition studies of two new β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila

scientific article published on 08 January 2014

Anion inhibition studies of two α-carbonic anhydrases from Lotus japonicus, LjCAA1 and LjCAA2.

scientific article published on 8 April 2014

Anion inhibition study of the β-carbonic anhydrase (CahB1) from the cyanobacterium Coleofasciculus chthonoplastes (ex-Microcoleus chthonoplastes).

scientific article published on 29 January 2014

Anion inhibition study of the β-class carbonic anhydrase (PgiCAb) from the oral pathogen Porphyromonas gingivalis

scientific article published on 12 August 2014

Antibacterial Co(II), Cu(II), Ni(II) and Zn(II) complexes of thiadiazole derived furanyl, thiophenyl and pyrrolyl Schiff bases

scientific article published in April 2002

Antibacterial Schiff bases of oxalyl-hydrazine/diamide incorporating pyrrolyl and salicylyl moieties and of their zinc(II) complexes

scientific article published in February 2002

Antibacterial cobalt(II), nickel(II) and zinc(II) complexes of nicotinic acid-derived Schiff-bases

scientific article published in April 2002

Anticancer and antiviral sulfonamides

scientific article

Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV

scientific article

Antifungal activity of Ag(I) and Zn(II) complexes of aminobenzolamide (5-sulfanilylamido-1,3,4-thiadiazole-2-sulfonamide) derivatives

scientific article

Antifungal activity of silver and zinc complexes of sulfadrug derivatives incorporating arylsulfonylureido moieties

scientific article published on 01 August 2000

Antiglaucoma Carbonic Anhydrase Inhibitors as Ophthalomologic Drugs

Antiglaucoma carbonic anhydrase inhibitors: a patent review

scientific article published on 30 April 2013

Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts.

scientific article published on 5 June 2012

Antimycobacterial activity of 3,4-dichlorophenyl-ureas, N,N-diphenyl-ureas and related derivatives

scientific article published in November 2001

Antimycobacterial activity of 9-sulfonylated/sulfenylated-6-mercaptopurine derivatives

scientific article

Antiobesity carbonic anhydrase inhibitors: a literature and patent review ⬇️

scientific article published on April 22, 2013

Antiviral sulfonamide derivatives

scientific article published on February 2004

Application of 2D 1H NMR spectroscopy to the study of the brain, spinal cord, and sciatic nerve

scientific article

Applications of carbonic anhydrase inhibitors and activators in therapy

Arylsulfonyl-N,N-dialkyl-dithiocarbamates as tumor cell growth inhibitors: novel agents targeting beta-tubulin?

scientific article

Arylsulfonyl-N,N-diethyl-dithiocarbamates: a novel class of antitumor agents

scientific article published on 01 August 2000

Bacterial protease inhibitors

scientific article

Bacterial proteases: current therapeutic use and future prospects for the development of new antibiotics

article

Benzolamide is not a membrane-impermeant carbonic anhydrase inhibitor

scientific article published in June 2004

Binding affinity of bicarboxylate ions for cobalt (II) bovine carbonic anhydrase

scientific article published on August 1978

Binding of fluoride to copper zinc superoxide dismutase

Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes.

scientific article

Biochemical characterization of the γ-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis, PgiCA.

scientific article published on 5 August 2013

Biochemical properties of a new α-carbonic anhydrase from the human pathogenic bacterium, Vibrio cholerae

scientific article published on 16 January 2013

Biodegradation of 2-naphthalensulfonic acid polymers by white-rot fungi: Scale-up into non-sterile packed bed bioreactors

scientific article

Biophysical investigation of bacterial aromatic extradiol dioxygenases involved in biodegradation processes

scholarly article by Ivano Bertini et al published October 1995 in Coordination Chemistry Reviews

Biotransformation of chloroaromatics: the impact of bioavailability and substrate specificity

scientific article published on January 2004

CD and EXAFS study of the interaction between phosvitin and copper(II) ions

COX-2 selective inhibitors, carbonic anhydrase inhibition and anticancer properties of sulfonamides belonging to this class of pharmacological agents

scientific article

Carbon-13 longitudinal relaxation times of acetate ion in the presence of metal-substituted bovine carbonic anhydrases

Carbonic Anhydrase Activators. Part 19 Spectroscopic and Kinetic Investigations for the Interaction of Isozymes I and II With Primary Amines

scientific article published in January 1997

Carbonic Anhydrase Activators: Gold Nanoparticles Coated with Derivatized Histamine, Histidine, and Carnosine Show Enhanced Activatory Effects on Several Mammalian Isoforms

scientific article published on 03 February 2011

Carbonic Anhydrase Inhibitor Coated Gold Nanoparticles Selectively Inhibit the Tumor-Associated Isoform IX over the Cytosolic Isozymes I and II

scientific article published on 01 December 2008

Carbonic Anhydrase Inhibitors Part 72 Synthesis and Antiglaucoma Properties of Metal Complexes of p-Fluorobenzolamide

scientific article published on January 1999

Carbonic Anhydrase Inhibitors. Part 46 Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes

scientific article published in January 1997

Carbonic Anhydrase Inhibitors. Part 55 Metal Complexes of 1,3,4-Thiadiazole-2-Sulfonamide Derivatives: In Vitro Inhibition Studies With Carbonic Anhydrase Isozymes I, II and IV

scientific article published on January 1998

Carbonic Anhydrase Inhibitors. Synthesis of Water-Soluble, Topically Effective, Intraocular Pressure-Lowering Aromatic/Heterocyclic Sulfonamides Containing Cationic or Anionic Moieties: Is the Tail More Important than the Ring?1

scientific article published on 01 July 1999

Carbonic Anhydrase Inhibitors: Clash with Ala65 as a Means for Designing Inhibitors with Low Affinity for the Ubiquitous Isozyme II, Exemplified by the Crystal Structure of the Topiramate Sulfamide Analogue†

scientific article published on 01 November 2006

Carbonic Anhydrase Inhibitors: Hypoxia-Activatable Sulfonamides Incorporating Disulfide Bonds that Target the Tumor-Associated Isoform IX†

scientific article published on 01 September 2006

Carbonic Anhydrase Inhibitors: Inhibition of Isozymes I, II And IV with Heterocyclic Mercaptans, Sulfenamides, Sulfonamides and their Metal Complexes ⬇️

scientific article published on June 1, 1998

Carbonic Anhydrase Inhibitors: Perfluoroalkyl/Aryl-Substituted Derivatives of Aromatic/Heterocyclic Sulfonamides as Topical Intraocular Pressure-Lowering Agents with Prolonged Duration of Action

scientific article published on 01 November 2000

Carbonic Anhydrase Inhibitors: Synthesis and Inhibition of Cytosolic/Membrane-Associated Carbonic Anhydrase Isozymes I, II, and IX with Sulfonamides Incorporating Hydrazino Moieties

scientific article published on 01 March 2005

Carbonic Anhydrase Inhibitors: Synthesis of Water-Soluble, Aminoacyl/Dipeptidyl Sulfonamides Possessing Long-Lasting Intraocular Pressure-Lowering Properties via the Topical Route1

scientific article published on 01 September 1999

Carbonic Anhydrase Inhibitors: Water-Soluble 4-Sulfamoylphenylthioureas as Topical Intraocular Pressure-Lowering Agents with Long-Lasting Effects

scientific article published on 01 December 2000

Carbonic Anhydrase Inhibitors: X-ray and Molecular Modeling Study for the Interaction of a Fluorescent Antitumor Sulfonamide with Isozyme II and IX

article

Carbonic Anhydrase Interaction With Lipothioars Enites: A Novel Class of Isozymes I and II Inhibitors

scientific article published on January 1996

Carbonic Anhydrase and Matrix Metalloproteinase Inhibitors: Sulfonylated Amino Acid Hydroxamates with MMP Inhibitory Properties Act as Efficient Inhibitors of CA Isozymes I, II, and IV, andN-Hydroxysulfonamides Inhibit Both These Zinc Enzymes1

scientific article published on 01 October 2000

Carbonic anhydrase I and II activation with mono- and dihalogenated histamine derivatives

scientific article published on 22 June 2011

Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells

scientific article published on 08 May 2013

Carbonic anhydrase IX: a new druggable target for the design of antitumor agents.

scientific article published on May 2008

Carbonic anhydrase activation and the drug design

scientific article published on January 2008

Carbonic anhydrase activators

Carbonic anhydrase activators - part 21. Novel activators of isozymes I, II and IV incorporating carboxamido and ureido histamine moieties

scientific article

Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its cons

scientific article

Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme

scientific article published in September 2006

Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.

scientific article published on 12 May 2009

Carbonic anhydrase activators. Part 17. Synthesis and activation study of a series of 1-(1,2,4-triazole-(1H)-3-yl)-2,4,6-trisubstituted-pyridinium salts against isozymes I, II and IV

Carbonic anhydrase activators. Part 24. High affinity isozymes I, II and IV activators, derivatives of 4-(4-chlorophenylsulfonylureido-amino acyl)ethyl-1H-imidazole

scientific article

Carbonic anhydrase activators. The selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram are strong activators of isozymes I and II.

scientific article published in August 2003

Carbonic anhydrase activators: Activation of isozyme XIII with amino acids and amines

scientific article published on 30 May 2006

Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids

scientific article published on 20 January 2010

Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines

scientific article published on 28 June 2008

Carbonic anhydrase activators: The first X-ray crystallographic study of an adduct of isoform I

scientific article published on 25 July 2006

Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators

scientific article

Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine

scientific article

Carbonic anhydrase activators: activation of human isozymes I, II and IX with phenylsulfonylhydrazido l-histidine derivatives.

scientific article

Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines

scientific article

Carbonic anhydrase activators: activation of the beta-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids

scientific article published on 5 February 2009

Carbonic anhydrase activators: activation of the beta-carbonic anhydrases from the pathogenic fungi Candida albicans and Cryptococcus neoformans with amines and amino acids.

scientific article published on 4 January 2010

Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines

scientific article

Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines

scientific article

Carbonic anhydrase activators: amino acyl/dipeptidyl histamine derivatives bind with high affinity to isozymes I, II and IV and act as efficient activators

scientific article published on 01 December 1999

Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines

scientific article

Carbonic anhydrase activators: design of high affinity isozymes I, II, and IV activators, incorporating tri-/tetrasubstituted-pyridinium-azole moieties

scientific article published in January 2002

Carbonic anhydrase activators: high affinity isozymes I, II, and IV activators, incorporating a beta-alanyl-histidine scaffold

scientific article published in January 2002

Carbonic anhydrase activators: human isozyme II is strongly activated by oligopeptides incorporating the carboxyterminal sequence of the bicarbonate anion exchanger AE1.

scientific article

Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV

scientific article

Carbonic anhydrase activators: l-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV

scientific article published on 15 November 2006

Carbonic anhydrase activators: synthesis of high affinity isozymes I, II and IV activators, derivatives of 4-(arylsulfonylureido-amino acyl)ethyl-1H-imidazole

scientific article published in January 2000

Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines

scientific article published on 6 March 2007

Carbonic anhydrase activity modulators: synthesis of inhibitors and activators incorporating 2-substituted-thiazol-4-yl-methyl scaffolds.

scientific article published in October 2001

Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates

scientific article published in 2007

Carbonic anhydrase catalyzes cyanamide hydration to urea: is it mimicking the physiological reaction?

scientific article

Carbonic anhydrase inhibitors

scientific article (publication date: March 2003)

Carbonic anhydrase inhibitors

scientific article published on 01 November 1999

Carbonic anhydrase inhibitors - Part 49: Synthesis of substituted ureido and thioureido derivatives of aromatic/heterocyclic sulfonamides with increased affinities for isozyme I

Carbonic anhydrase inhibitors - Part 94. 1,3,4-Thiadiazole-2-sulfonamide derivatives as antitumor agents?

scientific article published on 01 September 2000

Carbonic anhydrase inhibitors and activators and their use in therapy

Carbonic anhydrase inhibitors with strong topical antiglaucoma properties incorporating a 4-(2-aminopyrimidin-4-yl-amino)-benzenesulfonamide scaffold

scientific article published in February 2002

Carbonic anhydrase inhibitors – Part 78. Synthesis of water-soluble sulfonamides incorporating β-alanyl moieties, possessing long lasting-intraocular pressure lowering properties via the topical route

scientific article published on 01 March 2000

Carbonic anhydrase inhibitors – part 70. Synthesis and ocular pharmacology of a new class of water-soluble, topically effective intraocular pressure lowering agents derived from nicotinic acid and aromatic/heterocyclic sulfonamides

scholarly article by C Supuran published October 1999 in European Journal of Medicinal Chemistry

Carbonic anhydrase inhibitors — Part 29 1: Interaction of isozymes I, II and IV with benzolamide-like derivatives

Carbonic anhydrase inhibitors — Part 52. Metal complexes of heterocyclic sulfonamides: A new class of strong topical intraocular pressure-lowering agents in rabbits

Carbonic anhydrase inhibitors — Part 53. Synthesis of substituted-pyridinium derivatives of aromatic sulfonamides: The first non-polymeric membrane-impermeable inhibitors with selectivity for isozyme IV

article by Claudiu T. Supuran et al published July 1998 in European Journal of Medicinal Chemistry

Carbonic anhydrase inhibitors, interaction of boron derivatives with isozymes I and II: a new binding site for hydrophobic inhibitors at the entrance of the active site as shown by docking studies

scientific article

Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.

scientific article published in March 2002

Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.

scientific article published on 13 July 2010

Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.

scientific article

Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines

scientific article published on 20 October 2008

Carbonic anhydrase inhibitors. Cloning, characterization and inhibition studies of the cytosolic isozyme III with anions

scientific article published on 20 October 2008

Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis

scientific journal article

Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference

scientific article

Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference

scientific article

Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors

scientific article published in January 2007

Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties

scientific article published in December 2004

Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.

scientific article published on July 2005

Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX.

scientific article published in April 2004

Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the cytosolic isoforms I and II.

scientific article published on 6 September 2009

Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides

scientific article

Carbonic anhydrase inhibitors. Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic sulfonamides: towards antimalarials with a novel mechanism of action?

scientific article published in January 2005

Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I and II, and extracellular isoforms IV, IX, and XII with sulfamides incorporating sugar moieties

scientific article published on 13 July 2007

Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions

scientific article published on 26 February 2009

Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.

scientific article

Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with lipophilic sulfonamides

scientific article published in August 2003

Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors

scientific article published in May 2003

Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes

scientific article published in June 2005

Carbonic anhydrase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozymes I and II with some 1,3,4-oxadiazole-thiols

Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose–thioureido tails

scientific article published on 12 March 2007

Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides

scientific article

Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate

scientific article published in February 2005

Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides.

scientific article published in February 2004

Carbonic anhydrase inhibitors. Inhibition of red blood cell ostrich (Struthio camelus) carbonic anhydrase with a series of aromatic and heterocyclic sulfonamides

scientific article

Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides.

scientific article published on 22 July 2009

Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions

scientific article published in September 2004

Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II and IX with some 1,3,4-oxadiazole- and 1,2,4-triazole-thiols

scientific article published in January 2008

Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols

scientific article

Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors

scientific article published on 30 June 2006

Carbonic anhydrase inhibitors. Inhibition of the fungal β-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids

scientific article published on 05 April 2009

Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isoforms I and II and transmembrane, tumor-associated isoforms IX and XII with boronic acids

scientific article published on 5 April 2009

Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides

scientific article

Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.

scientific article

Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions

scientific article published in November 2004

Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides

scientific article published in December 2004

Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?

scientific article

Carbonic anhydrase inhibitors. Inhibition of the zinc and cobalt gamma-class enzyme from the archaeon Methanosarcina thermophila with anions

scientific article

Carbonic anhydrase inhibitors. Inhibition of the zinc and cobalt γ-class enzyme from the archaeon Methanosarcina thermophila with anions

scholarly article by Alessio Innocenti et al published June 2004 in Bioorganic & Medicinal Chemistry Letters

Carbonic anhydrase inhibitors. Inhibition of the β-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with branched aliphatic/aromatic carboxylates and their derivatives

scientific article published on 17 February 2011

Carbonic anhydrase inhibitors. Inhibition of transmembrane isoforms IX, XII, and XIV with less investigated anions including trithiocarbonate and dithiocarbamate

scientific article published on 21 January 2010

Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions

scientific article published on 13 January 2007

Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives

scientific article published in May 2003

Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.

scientific article

Carbonic anhydrase inhibitors. Inhibition studies of the human secretory isoform VI with anions

scientific article published on 15 November 2006

Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.

scientific article

Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies

scientific article

Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies

scientific article

Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct

scientific article

Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates

scientific article published in February 2005

Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates

scientific article

Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet

scientific article published in December 2004

Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies

scientific article

Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies

scientific article

Carbonic anhydrase inhibitors. N-Cyanomethylsulfonamides—a new zinc binding group in the design of inhibitors targeting cytosolic and membrane-anchored isoforms

Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.

scientific article published in January 2005

Carbonic anhydrase inhibitors. Part 37. Novel classes of isozyme I and II inhibitors and their mechanism of action. Kinetic and spectroscopic investigations on native and cobalt-substituted enzymes

scholarly article by F Briganti et al published January 1996 in European Journal of Medicinal Chemistry

Carbonic anhydrase inhibitors. Part 43. Schiff bases derived from aromatic sulfonamides: towards more specific inhibitors for membrane-bound versus cytosolic isozymes

article by CT Supuran et al published May 1997 in European Journal of Medicinal Chemistry

Carbonic anhydrase inhibitors. Part 54: metal complexes of heterocyclic sulfonamides: a new class of antiglaucoma agents.

scientific article published in January 1997

Carbonic anhydrase inhibitors. Part 71

article

Carbonic anhydrase inhibitors. Part 79

scientific article published on 01 December 1999

Carbonic anhydrase inhibitors. Part 91. Metal complexes of heterocyclic sulfonamides as potential pharmacological agents in the treatment of gastric Acid secretion imbalances

scientific article published in January 2000

Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors

scientific article published on 3 May 2009

Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails

scientific article published in June 2002

Carbonic anhydrase inhibitors. Selective inhibition of human tumor-associated isozymes IX and XII and cytosolic isozymes I and II with some substituted-2-mercapto-benzenesulfonamides

Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited--old leads for new applications?

scientific article published on 29 May 2008

Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of [...]

scientific article published in July 2005

Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII.

scientific article published on 22 April 2009

Carbonic anhydrase inhibitors. Synthesis of topically effective intraocular pressure lowering agents derived from 5-(omega-aminoalkylcarboxamido)-1,3,4-thiadiazole-2-sulfonamide

scientific article

Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors

scientific article

Carbonic anhydrase inhibitors. The beta-carbonic anhydrases from the fungal pathogens Cryptococcus neoformans and Candida albicans are strongly inhibited by substituted-phenyl-1H-indole-5-sulfonamides.

scientific article published on 3 March 2010

Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors

scientific article published in December 2005

Carbonic anhydrase inhibitors. The nematode alpha-carbonic anhydrase of Caenorhabditis elegans CAH-4b is highly inhibited by 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides

scientific article published on 27 January 2009

Carbonic anhydrase inhibitors. X-ray crystal studies of the carbonic anhydrase II-trithiocarbonate adduct--an inhibitor mimicking the sulfonamide and urea binding to the enzyme

scientific article

Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.

scientific article

Carbonic anhydrase inhibitors. inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with anions

scientific article published in October 2003

Carbonic anhydrase inhibitors: 2-Substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV

scientific article published on 01 November 2008

Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties

scientific article

Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs

scientific article published in March 2006

Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.

scientific article published in January 2004

Carbonic anhydrase inhibitors: Gd(iii) complexes of DOTA- and TETA-sulfonamide conjugates targeting the tumor associated carbonic anhydrase isozymes IX and XII

Carbonic anhydrase inhibitors: Inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties

scientific article published on 08 January 2007

Carbonic anhydrase inhibitors: Inhibition of the cytosolic human isozyme VII with anions

scientific article published on 18 April 2006

Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols

scientific article published on 4 May 2008

Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with polyfluorinated aromatic/heterocyclic sulfonamides

scientific article published in June 2005

Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits

scientific article published in January 2004

Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.

scientific article

Carbonic anhydrase inhibitors: Schiff's bases of aromatic and heterocyclic sulfonamides and their metal complexes

scientific article published in June 2004

Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides

scientific article published on 13 July 2007

Carbonic anhydrase inhibitors: The β-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors

scientific article published on 25 April 2007

Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib

scientific article

Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II.

scientific article

Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase

scientific article published in January 2004

Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a bis-sulfonamide-two heads are better than one?

scientific article published in August 2003

Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a topically acting antiglaucoma sulfonamide

scientific article published in May 2004

Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride

scientific article published in January 2004

Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the perfluorobenzoyl analogue of methazolamide. Implications for the drug design of fluorinated inhibitors

scientific article published in August 2003

Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1,3,4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide to human isoform II

scientific article published on 26 September 2006

Carbonic anhydrase inhibitors: aliphatic N-phosphorylated sulfamates--a novel zinc-anchoring group leading to nanomolar inhibitors

scientific article published in June 2004

Carbonic anhydrase inhibitors: allylsulfonamide, styrene sulfonamide, N-allyl sulfonamides and some of their Si, Ge, and B derivatives

scientific article published in December 2001

Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties

scientific article published in January 2002

Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity

scientific article published in May 2004

Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties

scientific article

Carbonic anhydrase inhibitors: binding of indanesulfonamides to the human isoform II

scientific article

Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII

scientific article

Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori

scientific article published on 3 February 2006

Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides

scientific article

Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.

scientific article published on 13 November 2007

Carbonic anhydrase inhibitors: design of membrane-impermeant copper(II) complexes of DTPA-, DOTA-, and TETA-tailed sulfonamides targeting the tumor-associated transmembrane isoform IX.

scientific article published in November 2008

Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes.

scientific article published on 17 May 2008

Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma

scientific article published in September 2005

Carbonic anhydrase inhibitors: guaiacol and catechol derivatives effectively inhibit certain human carbonic anhydrase isoenzymes (hCA I, II, IX and XII)

scientific article published on 06 November 2014

Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives

scientific article

Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides

scientific article published in November 2005

Carbonic anhydrase inhibitors: inhibition of human and murine mitochondrial isozymes V with anions

scientific journal article

Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives

scientific article published in November 2004

Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.

scientific article

Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies

scientific article

Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid

scientific article published on 13 June 2008

Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates

scientific article published on 24 December 2008

Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.

scientific article

Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides

scientific article published on 3 October 2005

Carbonic anhydrase inhibitors: inhibition of the human transmembrane isozyme XIV with a library of aromatic/heterocyclic sulfonamides

scientific article published on 11 July 2005

Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.

scientific article published in December 2004

Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides

scientific article published in September 2005

Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides

scientific article published in March 2003

Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered

scientific article published in May 2004

Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides

scientific article published in November 2005

Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates

scientific article

Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions

scientific article

Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).

scientific article

Carbonic anhydrase inhibitors: metal complexes of a sulfanilamide derived Schiff base and their interaction with isozymes I, II and IV.

scientific article published in December 2001

Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.

scientific article published in June 2005

Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II.

scientific article published in September 2005

Carbonic anhydrase inhibitors: sulfonamides as antitumor agents?

scientific article published in March 2001

Carbonic anhydrase inhibitors: sulfonamides incorporating furan-, thiophene- and pyrrole-carboxamido groups possess strong topical intraocular pressure lowering properties as aqueous suspensions

scientific article published on 01 August 2000

Carbonic anhydrase inhibitors: synthesis and inhibition against isozymes I, II and IV of topically acting antiglaucoma sulfonamides incorporating cis-5-norbornene-endo-3-carboxy-2-carboxamido moieties

scientific article

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.

scientific article

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates

scientific article

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.

scientific article published in December 2004

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties

scientific article

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.

scientific article

Carbonic anhydrase inhibitors: synthesis and inhibition studies against mammalian isoforms I-XV with a series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides.

scientific article published on 13 September 2008

Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity

scientific article

Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.

scientific article published in May 2000

Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes

scientific article

Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.

scientific article

Carbonic anhydrase inhibitors: synthesis of water soluble sulfonamides incorporating a 4-sulfamoylphenylmethylthiourea scaffold, with potent intraocular pressure lowering properties

scientific article published in October 2002

Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors

scientific article

Carbonic anhydrase inhibitors: the X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors

scientific article

Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides

scientific article

Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library

scientific article

Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.

scientific article published in February 2004

Carbonic anhydrase inhibitors: the inhibition profiles of the human mitochondrial isoforms VA and VB with anions are very different

scientific article published on 15 August 2007

Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.

scientific article published on 25 December 2008

Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.

scientific article

Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?

scientific article published on 12 June 2008

Carbonic anhydrase inhibitors: topical sulfonamide antiglaucoma agents incorporating secondary amine moieties

scientific article

Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide

scientific article published in September 2003

Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating phthaloyl and phthalimido moieties.

scientific article published in January 2001

Carbonic anhydrase inhibitors: transepithelial transport of thioureido sulfonamide inhibitors of the cancer-associated isozyme IX is dependent on efflux transporters

scientific article published in April 2006

Carbonic anhydrase inhibitors: ureido and thioureido derivatives of aromatic sulfonamides possessing increased affinities for isozyme I. A novel route to 2,5-disubstituted-1,3,4-thiadiazoles via thioureas, and their interaction with isozymes I, II a

scientific article published on April 1, 1998

Carbonic anhydrases as targets for medicinal chemistry

scientific article published on 19 April 2007

Catechol 1,2-dioxygenase from the Gram-positive Rhodococcus opacus 1CP: quantitative structure/activity relationship and the crystal structures of native enzyme and catechols adducts

scientific article

Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family

scientific journal article

Characterization of an intradiol dioxygenase involved in the biodegradation of the chlorophenoxy herbicides 2,4-D and 2,4,5-T

scientific article published on 01 April 1997

Characterization of oxovanadium(IV) substituted bovine carbonic anhydrase B

Characterization of the biological conversion of naphthalene to (+)-cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene in direct micellar systems

Characterization of the first beta-class carbonic anhydrase from an arthropod (Drosophila melanogaster) and phylogenetic analysis of beta-class carbonic anhydrases in invertebrates

scientific article

Cloning, Characterization, and Sulfonamide and Thiol Inhibition Studies of an α-Carbonic Anhydrase from Trypanosoma cruzi, the Causative Agent of Chagas Disease

Cloning, characterization and anion inhibition studies of a new γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis.

scientific article

Cloning, characterization and anion inhibition study of the δ-class carbonic anhydrase (TweCA) from the marine diatom Thalassiosira weissflogii

scientific article

Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis.

scientific article published in March 2010

Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease

Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.

scientific article published in February 2009

Cloning, polymorphism, and inhibition of beta-carbonic anhydrase of Helicobacter pylori

scientific article

Combined action of a bacterial monooxygenase and a fungal laccase for the biodegradation of mono- and poly-aromatic hydrocarbons

scientific article published on 14 April 2008

Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies

scientific article

Complexes With Biologically Active Ligands. Part 10 Inhibition of Carbonic Anhydrase Isozymes I and II With Metal Complexes of Imidazo[2,1-b ]-1,3,4-Thiadiazole-2-Sulfonamide

scientific article published in January 1997

Complexes With Biologically Active Ligands. Part 6 Ni(II) Coordination Compounds of Hydrazine and Heterocyclic Sulfonamides as Inhibitors of the Zinc Enzyme Carbonic Anhydrase

scientific article published on January 1996

Complexes with biologically active ligands. Part 11. Synthesis and carbonic anhydrase inhibitory activity of metal complexes of 4,5-disubstituted-3-mercapto-1,2,4-triazole derivatives

scientific article published on January 1998

Complexes with biologically active ligands. Part 9 metal complexes of 5-benzoylamino- and 5-(3-nitrobenzoyl-amino)-1,3,4-thiadiazole-2-sulfonamide as carbonic anhydrase inhibitors

scientific article published in January 1997

Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms

scientific article

Cooperative phenomena in polynuclear metalloproteins

Correction to Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins.

scientific article published on 30 June 2015

Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations

scientific article

Crystal Structure of 3-Chlorocatechol 1,2-dioxygenase Key Enzyme of a New Modified Ortho-pathway from the Gram-positive Rhodococcus opacus 1CP Grown on 2-chlorophenol

scientific article published on 05 June 2006

Crystal analysis of aromatic sulfonamide binding to native and (Zn)2 adduct of human carbonic anhydrase I Michigan 1

Crystal structure of 4-chlorocatechol 1,2-dioxygenase from the chlorophenol-utilizing gram-positive Rhodococcus opacus 1CP.

scientific article published in April 2004

Crystal structure of a blue laccase from Lentinus tigrinus: evidences for intermediates in the molecular oxygen reductive splitting by multicopper oxidases

scientific article

Crystal structure of a zinc-activated variant of human carbonic anhydrase I, CA I Michigan 1: evidence for a second zinc binding site involving arginine coordination

scientific article published on 21 May 2002

Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide

scientific article

Crystal structure of the blue multicopper oxidase from the white-rot fungus Trametes trogii complexed with p-toluate

article by Irene Matera et al published October 2008 in Inorganica Chimica Acta

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

scientific article

Crystal structure of the hydroxyquinol 1,2-dioxygenase from Nocardioides simplex 3E, a key enzyme involved in polychlorinated aromatics biodegradation

scientific article

Crystal structures of salicylate 1,2-dioxygenase-substrates adducts: A step towards the comprehension of the structural basis for substrate selection in class III ring cleaving dioxygenases

scientific article

Crystallization and preliminary X-ray crystallographic analysis of hydroquinone dioxygenase from Sphingomonas sp. TTNP3.

scientific article published on 21 April 2012

Crystallization and preliminary X-ray crystallographic analysis of the small subunit of the heterodimeric laccase POXA3b from Pleurotus ostreatus

scientific article published on 24 December 2013

Crystallization and preliminary crystallographic analysis of the hydroxyquinol 1,2-dioxygenase from Nocardioides simplex 3E: a novel dioxygenase involved in the biodegradation of polychlorinated aromatic compounds

scientific article published on 01 April 1999

Crystallization and preliminary structure analysis of the blue laccase from the ligninolytic fungus Panus tigrinus

scientific article published on 20 January 2005

Cyclodextrin complexation highly enhances efficacy of arylsulfonylureido benzenesulfonamide carbonic anhydrase inhibitors as a topical antiglaucoma agents

scientific article published on 29 July 2015

Cyclodextrin complexes of sulfonamide carbonic anhydrase inhibitors as long-lasting topically acting antiglaucoma agents

scientific article

Cysteine-modifying agents: a possible approach for effective anticancer and antiviral drugs

scientific article

DNA Cloning, Characterization, and Inhibition Studies of an α-Carbonic Anhydrase from the Pathogenic Bacterium Vibrio cholerae

scientific article published on 04 December 2012

Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins

scientific article

Density Functional Description of the Early Stages of the Dioxygenation of [(MeC(CH2PPh2)3)M(catecholate)]+Complexes [M = Co(III), Ir(III)]: Toward a Rationalization of the Catalytic Mechanism of Ring-Opening Dioxygenases

scientific article published on 01 April 2000

Density functional characterization of the chemoselective oxidation of catechol by using molecular oxygen: thermodynamics of the reaction between [(triphos)Ir(dtbc)]+ and O2.

scientific article published in July 2003

Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis

scientific article published on 11 January 2017

Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: molecular and X-ray crystallographic studies

scientific article

Design of zinc binding functions for carbonic anhydrase inhibitors.

scientific article published on January 2008

Design, solid-phase synthesis, and biological evaluation of novel 1,5-diarylpyrrole-3-carboxamides as carbonic anhydrase IX inhibitors.

scientific article

Designing of novel carbonic anhydrase inhibitors and activators.

scientific article

Development and ex vivo evaluation of 5-aminolevulinic acid-loaded niosomal formulations for topical photodynamic therapy

article

Different behavior of sulfonamides with respect to copper-substituted bovine and human carbonic anhydrases

scientific article published on 01 April 1982

Differential decolorization of textile dyes in mixtures and the joint effect of laccase and cellobiose dehydrogenase activities present in extracellular extracts from Funalia trogii

scientific article published on 18 August 2011

Dihalogenated sulfanilamides and benzolamides are effective inhibitors of the three β-class carbonic anhydrases from Mycobacterium tuberculosis

scientific article published on 03 January 2012

Dioxygen, an unexpected carbonic anhydrase ligand.

scientific article published in December 2018

Dipotassium-trioxohydroxytetrafluorotriborate, K₂[B₃O₃F₄OH], is a potent inhibitor of human carbonic anhydrases

scientific article published on 18 June 2014

Direct micellar systems as a tool to improve the efficiency of aromatic substrate conversion for fine chemicals production

article

Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273

scientific journal article

Dithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in Vivo

scientific article

Dithiocarbamates are strong inhibitors of the beta-class fungal carbonic anhydrases from Cryptococcus neoformans, Candida albicans and Candida glabrata

scientific article published on 11 December 2011

Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations

scientific article

Drug Design Studies of Carbonic Anhydrase Activators

scholarly article

ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme

scientific article

EXAFS studies of Fe(III)-phosvitin at high metal to protein ratios

scientific article published on 01 April 1994

Effect of carbon source on the degradation of 2-naphthalenesulfonic acid polymers mixture by Pleurotus ostreatus in petrochemical wastewater

article by Laura Palli et al published December 2014 in Process Biochemistry

Efficient polycyclic aromatic hydrocarbons dihydroxylation in direct micellar systems

scientific article published in August 2001

Enzymatic decolorization of spent textile dyeing baths composed by mixtures of synthetic dyes and additives

scientific article published on 17 January 2012

Errata

scholarly article published in Cellular and Molecular Neurobiology

Evaluation of an FIA Operated Amperometric Bacterial Biosensor, Based on Pseudomonas Putida F1 for the Detection of Benzene, Toluene, Ethylbenzene, and Xylenes (BTEX)

Evidence of exchangeable protons in the acidic form of manganese(II) bovine carbonic anhydrase B.

scientific article published on March 1978

Evidence of exchangeable protons in the donor groups of the acidic form of cobalt bovine carbonic anhydrase B.

scientific article published on September 1977

Experimental and theoretical affinity studies of substituted phenols to chlorocatechol 1,2-dioxygenases: A step toward the comprehension of inhibitor/substrate binding to intradiol dioxygenases

article published in 2010

External pH influences the transcriptional profile of the carbonic anhydrase, CAH-4b in Caenorhabditis elegans

scientific article published on 3 July 2008

Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins

scientific article published on 27 March 2012

Fluorescent sulfonamide carbonic anhydrase inhibitors incorporating 1,2,3-triazole moieties: Kinetic and X-ray crystallographic studies

scholarly article by Fabrizio Carta published in January 2016

Functionalized Derivatives of Benzo-Crown Ethers. Part 4. Antifungal Macrocyclic Supramolecular Complexes of Transition Metal Ions Acting as Lanosterol-14-alpha-Demethylase Ihibitors

scientific article published in January 1999

Fungal laccase, cellobiose dehydrogenase, and chemical mediators: combined actions for the decolorization of different classes of textile dyes

scientific article

Furazan and furoxan sulfonamides are strong α-carbonic anhydrase inhibitors and potential antiglaucoma agents

scientific article published on 17 June 2014

Gel sequestration of heavy metals by Klebsiella oxytoca isolated from iron mat

article published in 2001

Glaucoma and the applications of carbonic anhydrase inhibitors

scientific article published on January 2014

Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.

scientific article published on 22 November 2011

Heterocyclic compounds and their uses: a patent evaluation of WO2010151735A2 ⬇️

scientific article published on March 25, 2011

Heterocyclic urea derivatives and methods of use thereof (WO2010142978) ⬇️

scientific article published on January 20, 2012

Highly active antiretroviral therapy: current state of the art, new agents and their pharmacological interactions useful for improving therapeutic outcome

scientific article

Hydroxyurea is a carbonic anhydrase inhibitor

scientific article published in May 2003

Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.

scientific article

Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including acetazolamide in human glioblastoma.

scientific article published on 12 April 2013

Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model

scientific article published on 16 July 2009

Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors

scientific article published on 14 May 2007

Immunohistochemical study of carbonic anhydrase isozymes in human skin

scientific article published on September 2003

Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation

scientific article

Inhibition of V-ATPase and carbonic anhydrases as interference strategy with tumor acidification processes

scientific article published on January 2012

Inhibition of beta-carbonic anhydrases from the bacterial pathogen Brucella suis with inorganic anions

scientific article published on 24 February 2012

Inhibition of carbonic anhydrase IX: a new strategy against cancer

scientific article published on July 2009

Inhibition of human carbonic anhydrase isoforms I-XIV with sulfonamides incorporating fluorine and 1,3,5-triazine moieties

scientific article

Inhibition of the R1 fragment of the cadmium-containing zeta-class carbonic anhydrase from the diatom Thalassiosira weissflogii with anions.

scientific article published on July 2010

Inhibition of the alpha- and beta-carbonic anhydrases from the gastric pathogenHelycobacter pyloriwith anions

scientific article published on 03 February 2012

Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives?

scientific article published on 14 December 2010

Inhibition of the β-class carbonic anhydrases from Mycobacterium tuberculosis with carboxylic acids

scientific article published on 3 February 2012

Inhibition of tumor-associated human carbonic anhydrase isozymes IX and XII by a new class of substituted-phenylacetamido aromatic sulfonamides

scientific article published on 20 June 2013

Inhibition of α-class cytosolic human carbonic anhydrases I, II, IX and XII, and β-class fungal enzymes by carboxylic acids and their derivatives: new isoform-I selective nanomolar inhibitors

scientific article published on 2 August 2012

Inhibition of β-carbonic anhydrases with ureido-substituted benzenesulfonamides

article

Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides.

scientific article published on 21 February 2010

Inhibition studies of new ureido-substituted sulfonamides incorporating a GABA moiety against human carbonic anhydrase isoforms I–XIV

scientific article published on 01 December 2014

Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates

scientific article published on 24 June 2011

Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium

scientific article published on 28 April 2011

Inhibitors of HIV-1 protease: 10 years after

article

Inhibitors of HIV-1 protease: current state of the art 10 years after their introduction. From antiretroviral drugs to antifungal, antibacterial and antitumor agents based on aspartic protease inhibitors

scientific article published on January 2007

Interaction of cobalt(II) bovine carbonic anhydrase with aniline, benzoate, and anthranilate ⬇️

scientific article published on January 19, 1977

Interaction of cobalt-bovine carbonic anhydrase with the acetate ion

scientific article published on 01 November 1976

Interactions between alpha-amino acids and cobalt(II) bovine-carbonic anhydrase

scientific article published on January 1977

Intramolecular ring-stacking interaction between caffeine and bis(1,10-phenanthroline)copper(II) ion: 1H NMR and calorimetric investigations

Investigation of the coppermagnesiumalkaline phosphatase system

scholarly article by Ivano Bertini et al published January 1983 in Inorganica Chimica Acta

Investigation of zinc-deprived bovine superoxide dismutase

Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates

scientific article

Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine-benzenesulfonamides acting as carbonic anhydrase inhibitors

scientific article

Kinetic and anion inhibition studies of a β-carbonic anhydrase (FbiCA 1) from the C4 plant Flaveria bidentis

scientific article published on 30 January 2013

Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site

article

Laccase isoforms with unusual properties from the basidiomyceteSteccherinum ochraceumstrain 1833

scientific article published in 2008

Mechanism of cyanamide hydration catalyzed by carbonic anhydrase II suggested by cryogenic X-ray diffraction

scientific article

Metal binding and antibacterial activity of ciprofloxacin complexes

scientific article published in June 2005

Metal binding functions in the design of carbonic anhydrase inhibitors

scientific article published on January 2007

Metalloantibiotics: synthesis and antibacterial activity of cobalt(II), copper(II), nickel(II) and zinc(II) complexes of kefzol

scientific article

Metalloenzyme inhibitors for the treatment of Gram-negative bacterial infections: a patent review (2009 – 2012) ⬇️

scientific article published on 04 March 2013

Modulation of carbonic anhydrase 9 (CA9) in human brain cancer

scientific article published on January 2010

Modulation of carbonic anhydrase activity and its applications in therapy

Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target

scientific article published on 28 March 2012

Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate

scientific journal article

Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA.

scientific article published on 30 March 2007

Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators

scientific article published on 10 July 2014

Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV

scientific article published on 17 May 2012

Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma

scientific article published on 2 June 2016

Multinuclear NMR investigation of the metal binding sites of transferrins

N-Hydroxyurea—A versatile zinc binding function in the design of metalloenzyme inhibitors

scientific article published on 12 June 2006

New advances in HIV entry inhibitors development

scientific article

New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II

scientific article published on 06 February 2012

New selective carbonic anhydrase IX inhibitors: synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides.

scientific article

New zinc binding motifs in the design of selective carbonic anhydrase inhibitors.

scientific article published on August 2006

Non-peptidic chemokine receptors antagonists as emerging anti-HIV agents

scientific article

Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors

scientific article

Nonaromatic Sulfonamide Group as an Ideal Anchor for Potent Human Carbonic Anhydrase Inhibitors: Role of Hydrogen-Bonding Networks in Ligand Binding and Drug Design

scientific article published on 01 August 2002

Nonionic Micelles Promote Whole Cell Bioconversion of Aromatic Substrates in an Aqueous Environment

Novel aromatic/heterocyclic sulfonamides and their metal complexes as inhibitors of carbonic anhydrase isozymes I, II and IV.

scientific article

Novel carbonic anhydrase isozymes I, II and IV activators incorporating sulfonyl-histamino moieties

scientific article published on 01 July 1999

Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII

article

Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors

scientific article

Novel therapies for glaucoma: a patent review 2007 – 2011 ⬇️

scientific article published on December 23, 2011

Paramagnetic Metal Centers in Proteins Investigated through Heterocorrelated NMR Spectroscopy

Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors

scientific article published on 08 September 2014

Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II

scientific article published on 30 July 2011

Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I

scientific article

Phosphodiesterase 5 inhibitors--drug design and differentiation based on selectivity, pharmacokinetic and efficacy profiles

scientific article published on January 2006

Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule

scientific article

Polypharmacology of sulfonamides: pazopanib, a multitargeted receptor tyrosine kinase inhibitor in clinical use, potently inhibits several mammalian carbonic anhydrases.

scientific article published on 26 June 2012

Preliminary crystallographic analysis of 3-chlorocatechol 1,2-dioxygenase of a new modified ortho-pathway from the Gram-positive Rhodococcus opacus 1CP grown on 2-chlorophenol

scientific article

Preliminary crystallographic analysis of 3-chlorocatechol 1,2-dioxygenase of a new modifiedortho-pathway from the Gram-positiveRhodococcus opacus1CP grown on 2-chlorophenol

Protease inhibitors of the sulfonamide type: anticancer, antiinflammatory, and antiviral agents

scientific article

Protease inhibitors – Part 3. Synthesis of non-basic thrombin inhibitors incorporating pyridinium-sulfanilylguanidine moieties at the P1 site

scientific article published on 01 November 1999

Protease inhibitors – Part 5. Alkyl/arylsulfonyl- and arylsulfonylureido-/arylureido- glycine hydroxamate inhibitors of Clostridium histolyticum collagenase

scientific article published on 01 March 2000

Protease inhibitors, part 13: Specific, weakly basic thrombin inhibitors incorporating sulfonyl dicyandiamide moieties in their structure

scientific article published in January 2001

Protease inhibitors. Part 12. Synthesis of potent matrix metalloproteinase and bacterial collagenase inhibitors incorporating sulfonylated N-4-nitrobenzyl-beta-alanine hydroxamate moieties

scientific article

Protease inhibitors. Part 2. Weakly basic thrombin inhibitors incorporating sulfonyl-aminoguanidine moieties as S1 anchoring groups: synthesis and structure-activity correlations

scientific article

Protease inhibitors. Part 7

scientific article published on 01 March 2000

Protease inhibitors. Part 8: synthesis of potent Clostridium histolyticum collagenase inhibitors incorporating sulfonylated L-alanine hydroxamate moieties

scientific article

Protease inhibitors: Part 4. Synthesis of weakly basic thrombin inhibitors incorporating pyridinium-sulfanilylaminoguanidine moieties

scientific article

Protease inhibitors: synthesis and QSAR study of novel classes of nonbasic thrombin inhibitors incorporating sulfonylguanidine and O-methylsulfonylisourea moieties at P1

scientific article

Protease inhibitors: synthesis of a series of bacterial collagenase inhibitors of the sulfonyl amino acyl hydroxamate type

scientific article published in June 2001

Protease inhibitors: synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating arylsulfonylureido and 5-dibenzo-suberenyl/suberyl moieties

scientific article published in May 2003

Protease inhibitors: synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating succinyl hydroxamate and iminodiacetic acid hydroxamate moieties

scientific article published in June 2003

Protease inhibitors: synthesis of clostridium histolyticum collagenase inhibitors incorporating sulfonyl-L-alanine hydroxamate moieties

scientific article

Protease inhibitors: synthesis of matrix metalloproteinase and bacterial collagenase inhibitors incorporating 5-amino-2-mercapto-1,3,4-thiadiazole zinc binding functions

scientific article published in October 2002

Protease inhibitors: synthesis of potent bacterial collagenase and matrix metalloproteinase inhibitors incorporating N-4-nitrobenzylsulfonylglycine hydroxamate moieties

scientific article

Protein tyrosine kinase inhibitors as anticancer agents

article published in 2004

Protein–Protein Interactions: Inhibition of Mammalian Carbonic Anhydrases I–XV by the Murine Inhibitor of Carbonic Anhydrase and Other Members of the Transferrin Family

scientific article published on 18 May 2012

Proton NOE studies on dicopper(II) dicobalt(II) superoxide dismutase

Proton magnetic resonance spectra of six-coordinate iron(II), cobalt(II), and nickel(II) complexes with pyridine-n-oxide and benzamide

scholarly article by Ivano Bertini et al published January 1972 in Inorganica Chimica Acta

Proton relaxation of water solutions containing copper carbonic anhydrase

Purification and catalytic properties of two catechol 1,2-dioxygenase isozymes from benzoate-grown cells of Acinetobacter radioresistens

scientific article published on 01 November 2000

Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii

scientific article published on 13 February 2011

Purification, biochemical properties and substrate specificity of a catechol 1,2-dioxygenase from a phenol degrading Acinetobacter radioresistens

scientific article published on 01 October 1997

Pyridinium derivatives of histamine are potent activators of cytosolic carbonic anhydrase isoforms I, II and VII

scientific article published on 02 March 2011

QSAR studies for the inhibition of the transmembrane carbonic anhydrase isozyme XIV with sulfonamides using PRECLAV software

scientific article published in April 2009

Quantitative structure/activity relationship for the rate of conversion of C4-substituted catechols by catechol-1,2-dioxygenase from Pseudomonas putida (arvilla) C1.

scientific article published on October 1998

Reaction intermediates and redox state changes in a blue laccase from Steccherinum ochraceum observed by crystallographic high/low X-ray dose experiments

scientific article

Redox state and carbonic anhydrase isozyme IX expression in human renal cell carcinoma: biochemical and morphological investigations

scientific article published in June 2004

Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.

scientific article published on 9 November 2012

Role of surfactants in optimizing fluorene assimilation and intermediate formation by Rhodococcus rhodochrous VKM B-2469.

scientific article published on 23 August 2008

Salen and tetrahydrosalen derivatives act as effective inhibitors of the tumor-associated carbonic anhydrase XII--a new scaffold for designing isoform-selective inhibitors.

scientific article

Salicylate 1,2-dioxygenase from Pseudaminobacter salicylatoxidans: crystal structure of a peculiar ring-cleaving dioxygenase

scientific article

Secondary and tertiary sulfonamides: a patent review (2008 – 2012) ⬇️

scientific article published on November 14, 2012

Secondary/tertiary benzenesulfonamides with inhibitory action against the cytosolic human carbonic anhydrase isoforms I and II.

scientific article published in March 2012

Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency

scientific article

Selective interaction of ferricyanide with cluster I of Clostridium pasteurianum 2[Fe4 S4 ] ferredoxin

scientific article published on 01 October 1993

Serendipitous fragment-based drug discovery: ketogenic diet metabolites and statins effectively inhibit several carbonic anhydrases.

scientific article published in March 2012

Single crystal ESR study of the Cu(en)3SO4 complex

Single crystal polarized electronic spectra of a five-coordinate macrocyclic complex of nickel(II)

scholarly article by Dante Gatteschi & Andrea Scozzafava published January 1977 in Inorganica Chimica Acta

Single crystal polarized electronic spectra of the complex bis(N-t-butylpyrrole-2-carbaldimino)cobalt(II)

scholarly article by Ivano Bertini et al published January 1975 in Inorganica Chimica Acta

Six-coordinate copper complexes wlth g<g in the solid state

article published in 1979

Small molecule antagonists of chemokine receptors as emerging anti-HIV agents

article

Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.

scientific article published on 14 June 2011

Spectroscopic investigation of copper(II) bovine carbonic anhydrase and its inhibitor derivatives

scholarly article by Ivano Bertini et al published 1978 in Dalton transactions RSC

Static–dynamic distortions of the tris(1,2-diaminoethane)copper(II) cation [Cu(en)3]2+. Crystal structures of the salts [Cu(en)3][SO4] at 120 K and of [Cu(en)3]Cl2·0.75 en at 298 K

Stereochemistry of cobalt(II) in cobalt bovine carbonic anhydrase and its derivatives

scholarly article by Ivano Bertini et al published January 1977 in Inorganica Chimica Acta

Structural Insights on Carbonic Anhydrase Inhibitory Action, Isoform Selectivity, and Potency of Sulfonamides and Coumarins Incorporating Arylsulfonylureido Groups

Structural basis for the substrate specificity and the absence of dehalogenation activity in 2-chloromuconate cycloisomerase from Rhodococcus opacus 1CP

scientific article

Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition

scientific article

Structural modulation of the biological activity of gold nanoparticles functionalized with a carbonic anhydrase inhibitor.

scientific article published on 17 May 2013

Substrate, substrate analogue, and inhibitor interactions with the ferrous active site of catechol 2,3-dioxygenase monitored through XAS studies

scientific article published on 01 August 1994

Sulfamates and their therapeutic potential

scientific article

Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases

scientific article

Sulfonamide carbonic anhydrase inhibitors: Zinc coordination and tail effects influence inhibitory efficacy and selectivity for different isoforms

Sulfonamide derivatives with protease inhibitory action as anticancer, anti-inflammatory and antiviral agents

article published in 2002

Sulfonamide inhibition studies of the β carbonic anhydrase from Drosophila melanogaster.

scientific article published on 9 May 2014

Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis.

scientific article

Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.

scientific article

Sulfonamide inhibition studies of the γ-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis.

scientific article published on 21 November 2013

Sulfonamide inhibition studies of the δ-carbonic anhydrase from the diatom Thalassiosira weissflogii.

scientific article

Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila

scientific article published on 13 April 2014

Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.

scientific article published on 7 August 2014

Sulfonamides and sulfonylated derivatives as anticancer agents

scientific article

Sulfonamides and their isosters as carbonic anhydrase inhibitors.

scientific article

Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies

scientific article

Sulfonamides incorporating boroxazolidone moieties are potent inhibitors of the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII

scientific article published on 21 March 2011

Sulfonamides incorporating fluorine and 1,3,5-triazine moieties are effective inhibitors of three β-class carbonic anhydrases from Mycobacterium tuberculosis

scientific article published on 24 October 2013

Sulfonamides: a patent review (2008 – 2012) ⬇️

scientific article published on June 15, 2012

Sulfonylamido derivatives of aminoglutethimide and their copper(II) complexes: a novel class of antifungal compounds

Sulphonamide inhibition studies of the β-carbonic anhydrase from the bacterial pathogen Clostridium perfringens

scientific article published in December 2018

Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action

scientific article

Synthesis and inhibition potency of novel ureido benzenesulfonamides incorporating GABA as tumor-associated carbonic anhydrase IX and XII inhibitors

scientific article published on 04 September 2015

Synthesis of Biologically Active Co(II), Cu(II), Ni(II) and Zn(II) Complexes of Symmetrically 1,1′‐Disubstituted Ferrocene‐Derived Compounds

Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action

scientific article published on 31 March 2015

Synthesis of rhodamine B-benzenesulfonamide conjugates and their inhibitory activity against human α- and bacterial/fungal β-carbonic anhydrases

scientific article published on 21 July 2011

Synthesis of sulfonamides with effective inhibitory action against Porphyromonas gingivalis γ-carbonic anhydrase

scientific article published on 18 June 2014

Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

scientific article published on April 2009

Targeting Bacterial Metalloenzymes: A New Strategy for the Development of Anti-Infective Agents

article

Targeting cysteine residues of biomolecules: new approaches for the design of antiviral and anticancer drugs

scientific article

Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

scientific article published on 17 March 2011

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

scientific article

The acid-base equilibria of carbonic anhydrase

The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides

scientific article published on 23 July 2012

The antifungal activity of 2,2'-diamino-4,4'-dithiazole derivatives is due to the possible inhibition of lanosterol-14-alpha-demethylase

scientific article published in January 1998

The antifungal activity of sulfonylamido derivatives of 2-aminophenoxathiin and related compounds

The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors

scientific article

The crystal structures of native hydroquinone 1,2-dioxygenase from Sphingomonas sp. TTNP3 and of substrate and inhibitor complexes

scientific article published on 19 February 2017

The development of topically acting carbonic anhydrase inhibitors as anti-glaucoma agents

scientific article published on January 2007

The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents

scientific article

The electronic spectra of cobalt(II) bovine carbonic anhydrase

scholarly article by D. Barzi et al published January 1979 in Inorganica Chimica Acta

The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines

scientific article published on 20 December 2012

The extremo-α-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium azorense is highly inhibited by sulfonamides

scientific article published on 31 May 2013

The first activation study of a bacterial carbonic anhydrase (CA). The thermostable α-CA from Sulfurihydrogenibium yellowstonense YO3AOP1 is highly activated by amino acids and amines.

scientific article published on 30 August 2012

The generation of a 1-hydroxy-2-naphthoate 1,2-dioxygenase by single point mutations of salicylate 1,2-dioxygenase--rational design of mutants and the crystal structures of the A85H and W104Y variants

scientific article

The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.

scientific article

The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors

scientific article published on 31 August 2009

The role of the active site amino acid residues on the catalytic activity of Cu2Zn2SOD.

scientific article

The salicylate 1,2-dioxygenase as a model for a conventional gentisate 1,2-dioxygenase: crystal structures of the G106A mutant and its adducts with gentisate and salicylate

scientific article published on 28 February 2013

The sulfamide motif in the design of enzyme inhibitors

scientific article published in January 2006

The unusual behavior of the inhibitor S(+)(1-amino-2-phenylethyl)phosphonic acid towards carboxypeptidase A

scientific article published on 01 November 1990

The β-carbonic anhydrases from Mycobacterium tuberculosis as drug targets.

scientific article published on January 2010

Therapeutic applications of serine protease inhibitors

Therapeutic applications of sulfamates

scholarly article by Jean-Yves Winum et al published September 2004 in Expert Opinion on Therapeutic Patents

Therapeutic potential of sulfamides as enzyme inhibitors.

scientific article

Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins

Transition metal acetylsalicylates and their anti-inflammatory activity

scientific article (publication date: April 2002)

Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line

scientific article published on September 2002

Tricyclic Sulfonamides Incorporating Benzothiopyrano[4,3-c]pyrazole and Pyridothiopyrano[4,3-c]pyrazole Effectively Inhibit α- and β-Carbonic Anhydrase: X-ray Crystallography and Solution Investigations on 15 Isoforms

article

Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition

scientific article

Unsymmetrical 1,1'-disubstituted ferrocenes: synthesis of Co(ii), Cu(ii), Ni(ii) and Zn(ii) chelates of ferrocenyl -1-thiadiazolo-1'-tetrazole, -1-thiadiazolo-1'-triazole and -1-tetrazolo-1'-triazole with antimicrobial properties

scientific article published in August 2002

Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.

scientific article

Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines.

scientific article

Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?

scientific article published in September 2009

X-ray and ESR investigation of an elongated octahedral tris-(1, 2-diaminoethane) copper (II) complex

X-ray crystallographic and molecular docking studies on a unique chloromuconolactone dehalogenase from Rhodococcus opacus 1CP

scientific article

X-ray structure of the first `extremo-α-carbonic anhydrase', a dimeric enzyme from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1

scientific article

X-ray structures of 4-chlorocatechol 1,2-dioxygenase adducts with substituted catechols: new perspectives in the molecular basis of intradiol ring cleaving dioxygenases specificity

scientific article published on 20 December 2012

XAS characterization of the active sites of novel intradiol ring-cleaving dioxygenases: hydroxyquinol and chlorocatechol dioxygenases

scientific article published on 01 August 1998

Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo.

scientific article published on 16 May 2013

Ytterbium(III) as a CD probe for the investigation of the metal binding sites of transferrins

Zinc Binding Functions in the Design of Carbonic Anhydrase Inhibitors

scholarly article

Zinc complexes of benzothiazole-derived Schiff bases with antibacterial activity

scientific article published in June 2003

α-Carbonic Anhydrases Possess Thioesterase Activity

scientific article published on 19 January 2015

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