List of works by Antonello Merlino

A case of extensive protein platination: the reaction of lysozyme with a Pt(ii)–terpyridine complex

scientific article published on 01 July 2018

A driving force for polypeptide and protein collapse.

scientific article published on 8 December 2016

A new RNase sheds light on the RNase/angiogenin subfamily from zebrafish

scientific article

A novel ErbB2 epitope targeted by human antitumor immunoagents

scientific article published on 01 March 2011

A novel germline mutation in peroxisome proliferator-activated receptor gamma gene associated with large intestine polyp formation and dyslipidemia.

scientific article

A novel interdomain interface in crystallins: structural characterization of the βγ-crystallin from Geodia cydonium at 0.99 Å resolution

scientific article

A novel method for detection of selenomethionine incorporation in protein crystals via Raman microscopy

scientific article published on 16 January 2008

A potential allosteric subsite generated by domain swapping in bovine seminal ribonuclease

scientific article

A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex

scientific article

ATP regulation of the ligand-binding properties in temperate and cold-adapted haemoglobins. X-ray structure and ligand-binding kinetics in the sub-Antarctic fish Eleginops maclovinus

scientific article

An Order-Disorder Transition Plays a Role in Switching Off the Root Effect in Fish Hemoglobins

scientific article

An evolutionary conserved motif is responsible for immunoglobulin heavy chain packing in the B cell membrane.

scientific article published on 16 October 2010

An overview of biological macromolecule crystallization.

scientific article published on 31 May 2013

Approximate values for force constant and wave number associated with a low-frequency concerted motion in proteins can be evaluated by a comparison of X-ray structures

scientific article published on 13 April 2007

Arsenoplatin-1 Is a Dual Pharmacophore Anticancer Agent

scientific article published on 15 April 2019

Biochemical and structural properties of gamma-glutamyl transpeptidase from Geobacillus thermodenitrificans: an enzyme specialized in hydrolase activity.

scientific article published on 4 February 2010

Bovine Seminal Ribonuclease and Its Special Features: When Two is Better Than One

Chain termini cross-talk in the swapping process of bovine pancreatic ribonuclease

scientific article

Cisplatin Binding Sites in Human H-Chain Ferritin

scientific article published on 24 July 2017

Cisplatin binding to human serum albumin: a structural study

scientific article

Cisplatin binding to proteins: molecular structure of the ribonuclease a adduct

scientific article

Cisplatin binding to β-lactoglobulin: a structural study

scientific article published on 27 August 2020

Cisplatin encapsulation within a ferritin nanocage: a high-resolution crystallographic study

scientific article

Combined crystallographic and spectroscopic analysis of Trematomus bernacchii hemoglobin highlights analogies and differences in the peculiar oxidation pathway of Antarctic fish hemoglobins

scientific article

Comments on structural studies of haemoglobin from pisces species shortfin mako shark (Isurus oxyrinchus) at 1.9 Å resolution by P. Ramesh et al. (2013). J. Synchrotron Rad.20, 843-847.

scientific article published on 12 June 2014

Correlation between Hemichrome Stability and the Root Effect in Tetrameric Hemoglobins

scientific article

Crystallization and Preliminary X-Ray Diffraction Studies of a Psychrophilic Iron Superoxide Dismutase from Pseudoalteromonas haloplanktis

scientific article published on 01 January 2008

Crystallization and preliminary X-ray analysis of the complex of human alpha-thrombin with a modified thrombin-binding aptamer

scientific article

Crystallization, preliminary X-ray diffraction studies and Raman microscopy of the major haemoglobin from the sub-Antarctic fish Eleginops maclovinus in the carbomonoxy form.

scientific article

Cytotoxic properties of a new organometallic platinum(II) complex and its gold(I) heterobimetallic derivatives

scientific article

Dissecting the contribution of thrombin exosite I in the recognition of thrombin binding aptamer

scientific article

Duplex-quadruplex motifs in a peculiar structural organization cooperatively contribute to thrombin binding of a DNA aptamer

scientific article

Effect of NaCl on the conformational stability of the thermophilic γ-glutamyltranspeptidase from Geobacillus thermodenitrificans: Implication for globular protein halotolerance.

scientific article published on 2 October 2012

Effect of temperature on the interaction of cisplatin with the model protein hen egg white lysozyme

scientific article

Encapsulation of the Dinuclear Trithiolato-Bridged Arene Ruthenium Complex Diruthenium-1 in an Apoferritin Nanocage: Structure and Cytotoxicity

scientific article published on 11 February 2019

Exploring the interactions between model proteins and Pd(ii) or Pt(ii) compounds bearing charged N,N-pyridylbenzimidazole bidentate ligands by X-ray crystallography

scientific article published on 01 July 2018

Exploring the unfolding mechanism of γ-glutamyltranspeptidases: the case of the thermophilic enzyme from Geobacillus thermodenitrificans.

scientific article published on 31 January 2012

Ferritin nanocages loaded with gold ions induce oxidative stress and apoptosis in MCF-7 human breast cancer cells

scientific article

First Crystal Structure for a Gold Carbene-Protein Adduct

scientific article

Five-Coordinate Platinum(II) Compounds Containing Sugar Ligands: Synthesis, Characterization, Cytotoxic Activity, and Interaction with Biological Macromolecules.

scientific article published on 6 March 2018

Free-energy profile for CO binding to separated chains of human and Trematomus newnesi hemoglobin: insights from molecular dynamics simulations and perturbed matrix method

scientific article published in May 2010

Fusion of raft-like lipid bilayers operated by a membranotropic domain of the HSV-type I glycoprotein gH occurs through a cholesterol-dependent mechanism

scientific article

Global and local motions in ribonuclease A: a molecular dynamics study.

scientific article published in November 2002

Gold-based drug encapsulation within a ferritin nanocage: X-ray structure and biological evaluation as a potential anticancer agent of the Auoxo3-loaded protein

scientific article

Heterogeneous nucleation helps the search for initial crystallization conditions of γ-glutamyl transpeptidase from Bacillus licheniformis.

scientific article published on 25 May 2013

High resolution crystal structure of deoxy hemoglobin from Trematomus bernacchii at different pH values: The role of histidine residues in modulating the strength of the root effect

scientific article published on 01 November 2006

High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity

scientific article

Identification of an active dimeric intermediate populated during the unfolding process of the cambialistic superoxide dismutase from Streptococcus mutans

scientific article published on 28 November 2011

Increasing the X-ray diffraction power of protein crystals by dehydration: the case of bovine serum albumin and a survey of literature data

scientific article

Interaction between proteins and Ir based CO releasing molecules: mechanism of adduct formation and CO release

scientific article

Interaction of anticancer Ru(III) complexes with single stranded and duplex DNA model systems.

scientific article

Interaction of anticancer ruthenium compounds with proteins: high-resolution X-ray structures and raman microscopy studies of the adduct between hen egg white lysozyme and AziRu

scientific article

Interactions between anticancer trans-platinum compounds and proteins: crystal structures and ESI-MS spectra of two protein adducts of trans-(dimethylamino)(methylamino)dichloridoplatinum(II)

scientific article

Interactions of carboplatin and oxaliplatin with proteins: Insights from X-ray structures and mass spectrometry studies of their ribonuclease A adducts

scientific article

Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound

scientific article

Interactions of gold-based drugs with proteins: the structure and stability of the adduct formed in the reaction between lysozyme and the cytotoxic gold(III) compound Auoxo3

scientific article

Investigating the ruthenium metalation of proteins: X-ray structure and Raman microspectroscopy of the complex between RNase A and AziRu

scientific article

Label-free quantitative proteomics of the MCF-7 cellular response to a ferritin-metallodrug complex

scientific article published on 04 February 2020

Low resolution X-ray structure of γ-glutamyltranspeptidase from Bacillus licheniformis: opened active site cleft and a cluster of acid residues potentially involved in the recognition of a metal ion

scientific article

Mapping the protein-binding sites for iridium(iii)-based CO-releasing molecules

scientific article

Minimal structural requirements for root effect: crystal structure of the cathodic hemoglobin isolated from the antarctic fish Trematomus newnesi

scientific article

Missing gold atoms in lysozyme crystals used to grow gold nanoparticles

scientific article published on 01 April 2015

Modulation of Amyloidogenic Peptide Aggregation by Photoactivatable CO-Releasing Ruthenium(II) Complexes

scientific article published on 29 July 2020

Occurrence and formation of endogenous histidine hexa-coordination in cold-adapted hemoglobins.

scientific article published on 13 April 2011

On the pH-Modulated Ru-Based Prodrug Activation Mechanism

scientific article published on 07 January 2019

Oxaliplatin vs. cisplatin: competition experiments on their binding to lysozyme

scientific article

Peculiar features in the crystal structure of the adduct formed between cis-PtI2(NH3)2 and hen egg white lysozyme

scientific article

Platinated oligomers of bovine pancreatic ribonuclease: Structure and stability

scientific article

Platinum(II) Complexes with O,S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding

scientific article

Polyglutamine repeats and β-helix structure: Molecular dynamics study

article

Principles and methods used to grow and optimize crystals of protein-metallodrug adducts, to determine metal binding sites and to assign metal ligands.

scientific article

Protein Recognition of Gold-Based Drugs: 3D Structure of the Complex Formed When Lysozyme Reacts with Aubipy(c.).

scientific article published on 31 July 2014

Protein interactions of dirhodium tetraacetate: a structural study

scientific article published on 01 February 2020

Protein metalation by metal-based drugs: X-ray crystallography and mass spectrometry studies.

scientific article

Protein-mediated disproportionation of Au(i): insights from the structures of adducts of Au(iii) compounds bearing N,N-pyridylbenzimidazole derivatives with lysozyme

scientific article published on 06 September 2019

Protonation of histidine 55 affects the oxygen access to heme in the alpha chain of the hemoglobin from the Antarctic fish Trematomus bernacchii

scientific article published in March 2011

Pt(II) versus Pt(IV) in Carbene Glycoconjugate Antitumor Agents: Minimal Structural Variations and Great Performance Changes

scientific article published on 04 March 2020

Reversible substrate-induced domain motions in ribonuclease A

scientific article

Role of tertiary structures on the Root effect in fish hemoglobins

scientific article

Role of the Metal Center in the Modulation of the Aggregation Process of Amyloid Model Systems by Square Planar Complexes Bearing 2-(2'-pyridyl)benzimidazole Ligands

scientific article published on 12 October 2019

Role of the tertiary and quaternary structure in the formation of bis-histidyl adducts in cold-adapted hemoglobins

scientific article published on 11 January 2012

Ru-Based CO releasing molecules with azole ligands: interaction with proteins and the CO release mechanism disclosed by X-ray crystallography.

scientific article published on 13 July 2017

Ruthenium metalation of proteins: the X-ray structure of the complex formed between NAMI-A and hen egg white lysozyme

scientific article

S-adenosylhomocysteine hydrolase from the archaeon Pyrococcus furiosus: biochemical characterization and analysis of protein structure by comparative molecular modeling.

scientific article

Selective X-ray-induced NO photodissociation in haemoglobin crystals: evidence from a Raman-assisted crystallographic study

scientific article

Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense state

scientific article

Structural Characterization of Ferric Hemoglobins from Three Antarctic Fish Species of the Suborder Notothenioidei

scientific article

Structural Characterization of a Gold/Serum Albumin Complex

scientific article published on 30 July 2019

Structural and denaturation studies of two mutants of a cold adapted superoxide dismutase point to the importance of electrostatic interactions in protein stability

scientific article

Structural and functional relationships of natural and artificial dimeric bovine ribonucleases: new scaffolds for potential antitumor drugs

scientific article published on 07 October 2013

Structural evidences for a secondary gold binding site in the hydrophobic box of lysozyme

scientific article

Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant

scientific article

Structure and dimerization of the teleost transmembrane immunoglobulin region

scientific article published on 22 July 2008

Structure and flexibility in cold-adapted iron superoxide dismutases: the case of the enzyme isolated from Pseudoalteromonas haloplanktis

scientific article

Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease: an enzyme tailored to evade ribonuclease protein inhibitor.

scientific article

Subtle functional collective motions in pancreatic-like ribonucleases: from ribonuclease A to angiogenin

scientific article published on 01 October 2003

The X-ray structure of the complex formed in the reaction between oxaliplatin and lysozyme

scientific article

The X-ray structure of the primary adducts formed in the reaction between cisplatin and cytochrome c

scientific article

The bis-histidyl complex in hemoproteins: A detailed conformational analysis of database protein structures and the case of Antarctic fish hemoglobins

scientific article published on 01 March 2009

The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme

scientific article

The first step of arsenoplatin-1 aggregation in solution unveiled by solving the crystal structure of its protein adduct

scientific article published on 15 December 2020

The importance of dynamic effects on the enzyme activity: X-ray structure and molecular dynamics of onconase mutants

scientific article published on 22 February 2005

The maturation mechanism of γ-glutamyl transpeptidases: Insights from the crystal structure of a precursor mimic of the enzyme from Bacillus licheniformis and from site-directed mutagenesis studies

scientific article

The mode of action of anticancer gold-based drugs: a structural perspective

scientific article

The multiple forms of bovine seminal ribonuclease: structure and stability of a C-terminal swapped dimer

scientific article

The structure of the CD3 ζζ transmembrane dimer in POPC and raft-like lipid bilayer: a molecular dynamics study.

scientific article

Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase

scientific article

Thrombin-aptamer recognition: a revealed ambiguity

scientific article

Toward an antitumor form of bovine pancreatic ribonuclease: the crystal structure of three noncovalent dimeric mutants

scientific article

Unusual mode of protein binding by a cytotoxic π-arene ruthenium(ii) piano-stool compound containing an O,S-chelating ligand

scientific article

Unusual structural features in the lysozyme derivative of the tetrakis(acetato)chloridodiruthenium(II,III) complex

scientific article

{Ru(CO)x}-Core complexes with benzimidazole ligands: synthesis, X-ray structure and evaluation of anticancer activity in vivo.

scientific article published on 16 February 2017

α-Thalassemia associated with hb instability: a tale of two features. the case of Hb Rogliano or α1 Cod 108(G15)Thr→Asn and Hb Policoro or α2 Cod 124(H7)Ser→Pro

scientific article

γ-Glutamyl transpeptidase architecture: Effect of extra sequence deletion on autoprocessing, structure and stability of the protein from Bacillus licheniformis.

scientific article published on 10 September 2014

γ-Glutamyltranspeptidases: sequence, structure, biochemical properties, and biotechnological applications.

scientific article published on 21 April 2012

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