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List of works by Miroslaw Cygler

1.8 A refined structure of the lipase from Geotrichum candidum

scientific article

1H, 13C and 15N resonance assignments of human 5,10-methenyltetrahydrofolate synthetase

scientific article published on 01 August 2004

A case study on the treatment of protein SIRAS data

scientific article

A data management system for structural genomics

scientific article

Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis

scientific article

An atypical approach identifies TYR234 as the key base catalyst in chondroitin AC lyase

scientific article published in April 2006

Analogs of reaction intermediates identify a unique substrate binding site in Candida rugosa lipase

scientific article

Application of Dynamic Light Scattering in Protein Crystallization ⬇️

scientific article published on 01 August 2010

Application of the molecular replacement method to multidomain proteins. 1. Determination of the orientation of an immunoglobulin Fab fragment

scientific article published on 01 January 1988

Application of the molecular replacement method to multidomain proteins. 2. Comparison of various methods for positioning an oriented fragment in the unit cell

scientific article published on 01 May 1988

Asparagine 405 of heparin lyase II prevents the cleavage of glycosidic linkages proximate to a 3‐O‐sulfoglucosamine residue ⬇️

scientific article published on July 6, 2011

Bacillus thuringiensis CryIA(a) insecticidal toxin: crystal structure and channel formation

scientific article

Bacterial polysaccharide co-polymerases share a common framework for control of polymer length

scientific article

Bacterial structural genomics initiative: overview of methods and technologies applied to the process of structure determination

scientific article published in January 2008

Binding the atypical RA domain of Ste50p to the unfolded Opy2p cytoplasmic tail is essential for the high-osmolarity glycerol pathway.

scientific article published on December 2009

Biochemical and crystallographic studies reveal a specific interaction between TRAPP subunits Trs33p and Bet3p

scientific article

CS lyases: structure, activity, and applications in analysis and the treatment of diseases

scientific article

Catalytic Mechanism of Heparinase II Investigated by Site-directed Mutagenesis and the Crystal Structure with Its Substrate

scientific article

Channeling efficiency in the bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase domain: the effects of site-directed mutagenesis of NADP binding residues

article

Characterization of chondroitin sulfate lyase ABC from Bacteroides thetaiotaomicron WAL2926.

scientific article published in June 2008

Characterization of interactions between LPS transport proteins of the Lpt system.

scientific article published on 31 December 2010

Cloning, Baeyer-Villiger Biooxidations, and Structures of the Camphor Pathway 2-Oxo-Δ 3 -4,5,5-Trimethylcyclopentenylacetyl-Coenzyme A Monooxygenase of Pseudomonas putida ATCC 17453 ⬇️

scientific article published on January 20, 2012

Coiled-coil helix rotation selects repressing or activating state of transcriptional regulator DhaR

scientific article

Comparison of solid state and solution conformations of R and S epimers of 8,5'-cycloadenosine and their relevance to some enzymatic reactions

scientific article published on 01 May 1981

Composite active site of chondroitin lyase ABC accepting both epimers of uronic acid

scientific article

Computer modeling studies of the structure of a repressor

Conformational flexibility of PL12 family heparinases: structure and substrate specificity of heparinase III from Bacteroides thetaiotaomicron (BT4657)

scientific article

Contribution of structural genomics to understanding the biology of Escherichia coli

scientific article

Coverage of protein sequence space by current structural genomics targets

scientific article published on January 2003

Crystal Structure of Proteus vulgaris Chondroitin Sulfate ABC Lyase I at 1.9Å Resolution ⬇️

scientific article (publication date: 2 May 2003)

Crystal Structure of the Salmonella Typhimurium Effector GtgE.

scientific article

Crystal Structures of Apo and Metal-Bound Forms of the UreE Protein from Helicobacter pylori: Role of Multiple Metal Binding Sites, ⬇️

scientific article published on August 24, 2010

Crystal structure of D-ribose-5-phosphate isomerase (RpiA) from Escherichia coli

scientific article

Crystal structure of Escherichia coli PdxA, an enzyme involved in the pyridoxal phosphate biosynthesis pathway

scientific article

Crystal structure of Escherichia coli crotonobetainyl-CoA: carnitine CoA-transferase (CaiB) and its complexes with CoA and carnitinyl-CoA.

scientific article published in April 2005

Crystal structure of Escherichia coli glucose-1-phosphate thymidylyltransferase (RffH) complexed with dTTP and Mg2+

scientific article

Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI.

scientific article published in August 2005

Crystal structure of StaL, a glycopeptide antibiotic sulfotransferase from Streptomyces toyocaensis ⬇️

scientific article

Crystal structure of a peptidyl pyridinium methyl ketone inhibitor with thrombin

scientific article

Crystal structure of a trimeric form of dephosphocoenzyme A kinase from Escherichia coli

scientific article

Crystal structure of chondroitin AC lyase, a representative of a family of glycosaminoglycan degrading enzymes

scientific article

Crystal structure of chondroitinase B from Flavobacterium heparinum and its complex with a disaccharide product at 1.7 A resolution

scientific article

Crystal structure of histidinol phosphate aminotransferase (HisC) from Escherichia coli, and its covalent complex with pyridoxal-5'-phosphate and l-histidinol phosphate

scientific article

Crystal structure of human grancalcin, a member of the penta-EF-hand protein family

scientific article

Crystal structure of human procathepsin X: a cysteine protease with the proregion covalently linked to the active site cysteine

scientific article

Crystal structure of the RluD pseudouridine synthase catalytic module, an enzyme that modifies 23S rRNA and is essential for normal cell growth of Escherichia coli

scientific article

Crystal structure of the YciO protein from Escherichia coli

scientific article

Crystal structure of the bb' domains of the protein disulfide isomerase ERp57

scientific article

Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6

scientific article

Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin

scientific article

Crystal structure of ureidoglycolate hydrolase (AllA) from Escherichia coli O157:H7.

scientific article

Crystal structure of wild-type human procathepsin K

scientific article

Crystal structures of Escherichia coli ATP-dependent glucokinase and its complex with glucose

scientific article

Crystallization and preliminary X-ray analysis of PaaAC, the main component of the hydroxylase of the Escherichia coli phenylacetyl-coenzyme A oxygenase complex ⬇️

scientific article published on August 26, 2010

Crystallization and preliminary X-ray analysis of chondroitin sulfate ABC lyases I and II from Proteus vulgaris

scientific article published on 01 July 2000

Crystallization and preliminary X-ray analysis of chondroitinase B from Flavobacterium heparinum

scientific article (publication date: May 1999)

Crystallization and preliminary X-ray analysis of heparinase II from Pedobacter heparinus

scientific article

Crystallization and preliminary X-ray analysis of human grancalcin, a novel cytosolic Ca2+-binding protein present in leukocytes

scientific article published on 01 June 2000

Crystallization and preliminary X-ray diffraction studies of human procathepsin L

scientific article published on 01 July 1996

Crystallization and preliminary analysis of chondroitinase AC fromFlavobacterium heparinum ⬇️

scientific article published on March 1, 1998

Crystallization and structural details of Ca(2+)-induced conformational changes in the EF-hand domain VI of calpain

scientific article published on 01 January 2002

Crystallographic trapping of the glutamyl-CoA thioester intermediate of family I CoA transferases.

scientific article

Defining substrate characteristics from 3D structure; perspective on EstA structure

scientific article published in April 2004

Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures

scientific article

Design of a data model for developing laboratory information management and analysis systems for protein production

scientific article

Design of a linker for trivalent thrombin inhibitors: interaction of the main chain of the linker with thrombin

scientific article published on 01 April 1993

Design of noncovalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides

scientific article

Domain organization and crystal structure of the catalytic domain of E.coli RluF, a pseudouridine synthase that acts on 23S rRNA.

scientific article

Essential roles of zinc ligation and enzyme dimerization for catalysis in the aminoacylase-1/M20 family

scientific article

Expression and characterization of Geotrichum candidum lipase I gene. Comparison of specificity profile with lipase II.

scientific article

Family of phenylacetyl-CoA monooxygenases differs in subunit organization from other monooxygenases

scientific article

Genetic selection designed to stabilize proteins uncovers a chaperone called Spy ⬇️

scientific article published on February 13, 2011

High-Level Production of RecombinantGeotrichum candidumLipases in YeastPichia pastoris ⬇️

scientific article published on 01 October 1997

High-resolution crystal structure of Arthrobacter aurescens chondroitin AC lyase: an enzyme-substrate complex defines the catalytic mechanism

scientific article published in March 2004

Identification of Residues Essential for Differential Fatty Acyl Specificity of Geotrichum candidum Lipases I and II ⬇️

scientific article published on 01 December 1997

Identification of an Escherichia coli O157:H7 heme oxygenase with tandem functional repeats

scientific article

Improvement of the Thermostability and Activity of a Pectate Lyase by Single Amino Acid Substitutions, Using a Strategy Based on Melting-Temperature-Guided Sequence Alignment

scientific article

Insights from protein-protein interaction studies on bacterial pathogenesis.

scientific article published on 8 August 2017

Insights into function of PSI domains from structure of the Met receptor PSI domain

scientific article published in August 2004

Insights into interfacial activation from an open structure of Candida rugosa lipase

scientific article

Insights into the biology of Escherichia coli through structural proteomics.

scientific article

Interaction of the Ankyrin H Core Effector of Legionella with the Host LARP7 Component of the 7SK snRNP Complex

scientific article published on 27 August 2019

Interactions between Kinase Scaffold MP1/p14 and Its Endosomal Anchoring Protein p18 ⬇️

scientific article published on April 15, 2011

Lectin control of protein folding and sorting in the secretory pathway

scientific journal article

Legionella pneumophila effector Lem4 is a membrane-associated protein tyrosine phosphatase

scientific article published on 05 July 2018

Liquid chromatography-mass spectrometry to study chondroitin lyase action pattern

scientific article published on 17 October 2008

Lysine-based structure responsible for selective mannose phosphorylation of cathepsin D and cathepsin L defines a common structural motif for lysosomal enzyme targeting.

scientific article published in August 1998

Mechanism of action and NAD+-binding mode revealed by the crystal structure of L-histidinol dehydrogenase

scientific article

Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein.

scientific article

Molecular dynamics-solvated interaction energy studies of protein-protein interactions: the MP1-p14 scaffolding complex

scientific article

Molecules of Escherichia coli MobB assemble into densely packed hollow cylinders in a crystal lattice with 75% solvent content

scientific article

NMR structure of YcgL, a conserved protein from Escherichia coli representing the DUF709 family, with a novel alpha/beta/alpha sandwich fold

scientific article

New Ulvan-Degrading Polysaccharide Lyase Family: Structure and Catalytic Mechanism Suggests Convergent Evolution of Active Site Architecture.

scientific article

NleH defines a new family of bacterial effector kinases

scientific article

Polymorphism in the lipase genes of Geotrichum candidum strains

scientific article published in January 1994

Polysaccharide co-polymerases: the enigmatic conductors of the O-antigen assembly orchestra.

scientific article published on 24 October 2012

Preliminary studies on the crystallization of beef heart cytochrome c oxidase by vapor diffusion

scientific article published on 01 June 1990

Preparation and characterization of bacterial protein complexes for structural analysis

scientific article

Preparation, characterization and crystallization of an antibody Fab fragment that recognizes RNA. Crystal structures of native Fab and three Fab-mononucleotide complexes

scientific article

Progress in understanding the assembly process of bacterial O-antigen

scientific article published on 29 April 2014

Protein-Protein Interactions in the  -Oxidation Part of the Phenylacetate Utilization Pathway: CRYSTAL STRUCTURE OF THE PaaF-PaaG HYDRATASE-ISOMERASE COMPLEX

scientific article

Purification and characterization of a Penicillium sp. lipase which discriminates against diglycerides

scientific article published in April 1996

Quantitative continuous assay for hyaluronan synthase

scientific article

Quaternary structure of WzzB and WzzE polysaccharide copolymerases

scientific article

Recognition of a Cell-Surface Oligosaccharide of Pathogenic Salmonella by an Antibody Fab Fragment ⬇️

scientific article published on July 26, 1991

Recognition of a carbohydrate antigenic determinant of Salmonella by an antibody ⬇️

scientific article published on May 1, 1993

Recognition of carbohydrates by antibodies

scientific article published on January 1994

Redesigning the active site of Geotrichum candidum lipase

Regulation of Shigella Effector Kinase OspG through Modulation of Its Dynamic Properties.

scientific article

Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins

scientific article

Role of arginine 292 in the catalytic activity of chondroitin AC lyase from Flavobacterium heparinum

scientific article

Salmonella Disrupts Host Endocytic Trafficking by SopD2-Mediated Inhibition of Rab7

scientific article

Salmonella Effectors SseK1 and SseK3 Target Death Domain Proteins in the TNF and TRAIL Signaling Pathways

scientific article published on 22 March 2019

Site-directed mutagenesis of the active site region in the quinate/shikimate 5-dehydrogenase YdiB of Escherichia coli

scientific article published on 13 December 2004

Solution structure of a trisaccharide-antibody complex: comparison of NMR measurements with a crystal structure

scientific article

Specificity determinants of human cathepsin s revealed by crystal structures of complexes

scientific article (publication date: 25 March 2003)

Specificity of Campylobacter jejuni adhesin PEB3 for phosphates and structural differences among its ligand complexes

scientific article

Structural Basis for Fe–S Cluster Assembly and tRNA Thiolation Mediated by IscS Protein–Protein Interactions

scientific article

Structural Characterization of Closely Related O-antigen Lipopolysaccharide (LPS) Chain Length Regulators ⬇️

scientific article published on March 21, 2012

Structural Mimicry by a Bacterial F Box Effector Hijacks the Host Ubiquitin-Proteasome System

scientific article published on 10 January 2017

Structural Organization of Enzymes of the Phenylacetate Catabolic Hybrid Pathway

scientific article published on 12 June 2015

Structural Snapshots of Heparin Depolymerization by Heparin Lyase I

scientific article

Structural and Functional Analysis of Campylobacter jejuni PseG: A UDP-SUGAR HYDROLASE FROM THE PSEUDAMINIC ACID BIOSYNTHETIC PATHWAY

scientific article

Structural and Functional Investigations of the Effector Protein LpiR1 from Legionella pneumophila

scientific article published on 17 May 2016

Structural and enzymatic characterization of NanS (YjhS), a 9‐O‐Acetyl N‐acetylneuraminic acid esterase from Escherichia coli O157:H7 ⬇️

scientific article published on May 31, 2011

Structural and functional characterization of PL28 family ulvan lyase NLR48 from Nonlabens ulvanivorans

scientific article published on 06 June 2018

Structural and functional characterization of PseC, an aminotransferase involved in the biosynthesis of pseudaminic acid, an essential flagellar modification in Helicobacter pylori

scientific article

Structural and functional studies of the Escherichia coli phenylacetyl-CoA monooxygenase complex

scientific article

Structural and functional study of Legionella pneumophila effector RavA

scientific article published on 09 March 2021

Structural and mechanistic classification of uronic acid-containing polysaccharide lyases

scientific article published on 30 August 2010

Structural and mechanistic insight into covalent substrate binding by Escherichia coli dihydroxyacetone kinase ⬇️

scientific article published on January 5, 2011

Structural basis for specificity of papain-like cysteine protease proregions toward their cognate enzymes ⬇️

scientific article published on September 1, 1998

Structural basis for the inhibition of host protein ubiquitination by Shigella effector kinase OspG

scientific article

Structural basis of the regulation of the CbpA co-chaperone by its specific modulator CbpM

scientific article

Structural context for proteinN-glycosylation in bacteria: The structure of PEB3, an adhesin fromCampylobacter jejuni

scientific article published in May 2007

Structural insight into effector proteins of Gram-negative bacterial pathogens that modulate the phosphoproteome of their host

scientific article published on 06 February 2015

Structural similarity of YbeD protein from Escherichia coli to allosteric regulatory domains

scientific article published on December 2004

Structural snapshots of Escherichia coli histidinol phosphate phosphatase along the reaction pathway

scientific article

Structurally unique interaction of RBD-like and PH domains is crucial for yeast pheromone signaling ⬇️

scientific article published on December 14, 2012

Structure and active site residues of PglD, an N-acetyltransferase from the bacillosamine synthetic pathway required for N-glycan synthesis in Campylobacter jejuni

scientific article

Structure and conformation of the potent antiherpes agent 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine) ⬇️

scientific article published on December 15, 1981

Structure and conformational flexibility of Candida rugosa lipase

scientific article

Structure and function of the glycopeptide N-methyltransferase MtfA, a tool for the biosynthesis of modified glycopeptide antibiotics

scientific article

Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex.

scientific article published on 3 November 2017

Structure of Ca2+-loaded human grancalcin ⬇️

scientific article published on November 21, 2001

Structure of CbpA J-domain bound to the regulatory protein Cbpm explains its specificity and suggests evolutionary link between Cbpm and transcriptional regulators

scientific article

Structure of GlgS from Escherichia coli suggests a role in protein-protein interactions

scientific article

Structure of L-Xylulose-5-Phosphate 3-Epimerase (UlaE) from the Anaerobic L-Ascorbate Utilization Pathway of Escherichia coli: Identification of a Novel Phosphate Binding Motif within a TIM Barrel Fold

scientific article

Structure of [NiFe] Hydrogenase Maturation Protein HypE from Escherichia coli and Its Interaction with HypF

scientific article

Structure of a calpain Ca2+-binding domain reveals a novel EF-hand and Ca2+-induced conformational changes

scientific article published on July 1, 1997

Structure of a single-chain antibody variable domain (Fv) fragment complexed with a carbohydrate antigen at 1.7-A resolution

scientific article

Structure of apoptosis-linked protein ALG-2: insights into Ca2+-induced changes in penta-EF-hand proteins

scientific article

Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment

scientific article

Structure of hydrogenase maturation protein HypF with reaction intermediates shows two active sites

scientific article

Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion

scientific article

Structure of the 16S rRNA pseudouridine synthase RsuA bound to uracil and UMP

scientific article

Structure of the N-terminal domain of the effector protein LegC3 from Legionella pneumophila

scientific article

Structure of the noncatalytic domains and global fold of the protein disulfide isomerase ERp72

scientific article

Structure of the pseudouridine synthase RsuA from Haemophilus influenzae.

scientific article

Structure-Function Analysis of Escherichia coli MnmG (GidA), a Highly Conserved tRNA-Modifying Enzyme

scientific article

Structure-function analyses of a PL24 family ulvan lyase reveal key features and suggest its catalytic mechanism

scientific article

Structure-guided investigation of lipopolysaccharide O-antigen chain length regulators reveals regions critical for modal length control

scientific article published on 3 June 2011

Structures of shikimate dehydrogenase AroE and its Paralog YdiB. A common structural framework for different activities

scientific article (publication date: 23 May 2003)

Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase

scientific article

Sulfonation of glycopeptide antibiotics by sulfotransferase StaL depends on conformational flexibility of aglycone scaffold

scientific article

Synthesis, structural, and biological studies on a pseudodisaccharide containing a bicyclic, bridged carba-sugar

scholarly article by Zsolt Fejes et al published July 2011 in Tetrahedron: Asymmetry

The 3-D structure of a folate-dependent dehydrogenase/cyclohydrolase bifunctional enzyme at 1.5 å resolution ⬇️

scientific article published on February 15, 1998

The KH domain facilitates the substrate specificity and unwinding processivity of DDX43 helicase

scientific article published on 16 November 2020

The Legionella kinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation

scientific article published on 08 June 2020

The Solution Structure of YbcJ from Escherichia coli Reveals a Recently Discovered L Motif Involved in RNA Binding

scientific article

The Structure of calnexin, an ER chaperone involved in quality control of protein folding

scientific article

The alpha/beta hydrolase fold

scientific article (publication date: April 1992)

The architecture of the multisubunit TRAPP I complex suggests a model for vesicle tethering

scientific article

The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation

scientific article

The crystal structure of Escherichia coli MoeA, a protein from the molybdopterin synthesis pathway

scientific article

The final player in the coenzyme A biosynthetic pathway

scientific article published in August 2003

The open conformation of a Pseudomonas lipase

scientific article

The structural genomics experimental pipeline: insights from global target lists.

scientific article published in August 2004

The structure of Legionella effector protein LpnE provides insights into its interaction with Oculocerebrorenal syndrome of Lowe (OCRL) protein

scientific article published on 20 December 2018

The structure of chondroitin B lyase complexed with glycosaminoglycan oligosaccharides unravels a calcium-dependent catalytic machinery

scientific article

The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling

scientific article

The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot

scientific article

The structure of the exopolyphosphatase (PPX) from Escherichia coli O157:H7 suggests a binding mode for long polyphosphate chains

scientific article

Three-dimensional structure of 2-amino-3-ketobutyrate CoA ligase from Escherichia coli complexed with a PLP-substrate intermediate: inferred reaction mechanism

scientific article

Trapping open and closed forms of FitE: a group III periplasmic binding protein

scientific article

Uronic polysaccharide degrading enzymes

scientific article

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