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List of works by Alexander Wlodawer

1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors

scientific article published in July 2005

100 Years later: Celebrating the contributions of x-ray crystallography to allergy and clinical immunology

scientific article

A Crystallographic Study of Bright Far-Red Fluorescent Protein mKate Reveals pH-induced cis-trans Isomerization of the Chromophore

scientific article

A Structural Basis for Reversible Photoswitching of Absorbance Spectra in Red Fluorescent Protein rsTagRFP

scientific article

A brief history of macromolecular crystallography, illustrated by a family tree and its Nobel fruits

scientific article

A close look onto structural models and primary ligands of metallo-β-lactamases

A comparative study of the expression of serine proteinases in quiescent seeds and in developing Canavalia ensiformis plants

article

A comparison of the crystal structures of bacterial l-asparaginases

A family portrait of the RIO kinases

scientific article published on 22 September 2005

A general acid-base mechanism for the stabilization of a tetrahedral adduct in a serine-carboxyl peptidase: a computational study

scientific article published in November 2005

A model of the ternary complex of interleukin-10 with its soluble receptors

scientific article

A model of tripeptidyl-peptidase I (CLN2), a ubiquitous and highly conserved member of the sedolisin family of serine-carboxyl peptidases ⬇️

scientific article published on November 11, 2003

A new look at cytokine signaling

scientific article published on 01 January 2008

Activation mechanism of plasmepsins, pepsin-like aspartic proteases from Plasmodium, follows a unique trans-activation pathway

scientific article published on 09 May 2020

An unusual orientation for Tyr75 in the active site of the aspartic proteinase from Saccharomyces cerevisiae

scientific article

Antigenic Determinants of the Bilobal Cockroach Allergen Bla g 2.

scientific article

Application of InChI to curate, index, and query 3-D structures

scientific article (publication date: 28 April 2005)

Atomic resolution structure of Erwinia chrysanthemi L-asparaginase

scientific article

Atomic-resolution crystal structure of the antiviral lectin scytovirin

scientific article

Atomic-resolution crystal structure of the proteolytic domain of Archaeoglobus fulgidus lon reveals the conformational variability in the active sites of lon proteases

scientific article published in August 2005

Autophosphorylation of Archaeoglobus fulgidus Rio2 and crystal structures of its nucleotide-metal ion complexes

scientific article published in June 2005

Avoidable errors in deposited macromolecular structures: an impediment to efficient data mining

scientific article

Biophysical characterization of cyclic nucleotide phosphodiesterases

scientific article published in March 2002

Carbohydrates contribute to the interactions between cockroach allergen Bla g 2 and a monoclonal antibody

scientific article

Catalytic residues and substrate specificity of recombinant human tripeptidyl peptidase I (CLN2).

scientific article published on August 2005

Catalytic role of proton transfers in the formation of a tetrahedral adduct in a serine carboxyl peptidase

scientific article published on 01 August 2006

Characterization of the Recombinant Extracellular Domains of Human Interleukin-20 Receptors and Their Complexes with Interleukin-19 and Interleukin-20 ⬇️

scientific article published on November 4, 2003

Chemical compound navigator: a web-based chem-BLAST, chemical taxonomy-based search engine for browsing compounds

scientific article published on June 2006

Clarification of the mechanism of acylation reaction and origin of substrate specificity of the serine-carboxyl peptidase sedolisin through QM/MM free energy simulations

scientific article

Classification of ATP-dependent proteases Lon and comparison of the active sites of their proteolytic domains

scientific article

Cloning, expression, purification, crystallization and preliminary X-ray diffraction data of the Pyrococcus horikoshii RadA intein

scientific article

Comparison of the substrate specificity of two potyvirus proteases

scientific article

Complexes of neutralizing and non-neutralizing affinity matured Fabs with a mimetic of the internal trimeric coiled-coil of HIV-1 gp41

scientific article (publication date: 2013)

Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase

scientific article

Correcting the record of structural publications requires joint effort of the community and journal editors.

scientific article

Correction to "Inhibitor Complexes of the Pseudomonas Serine-Carboxyl Proteinase"

scientific article published on 13 November 2018

Covid-19.bioreproducibility.org: A web resource for SARS-CoV-2-related structural models

scientific article published on 27 September 2020

Crystal Structure of Crataeva tapia Bark Protein (CrataBL) and Its Effect in Human Prostate Cancer Cell Lines

scientific article

Crystal Structure of Human Interferon-λ1 in Complex with Its High-Affinity Receptor Interferon-λR1

scientific article

Crystal Structure of a Complex of the Intracellular Domain of Interferon λ Receptor 1 (IFNLR1) and the FERM/SH2 Domains of Human JAK1.

scientific article published on 7 October 2016

Crystal Structure of the Labile Complex of IL-24 with the Extracellular Domains of IL-22R1 and IL-20R2

scientific article published on 15 August 2018

Crystal Structures of Inhibitor Complexes of Human T-Cell Leukemia Virus (HTLV-1) Protease

scientific article

Crystal Structures of a Plant Trypsin Inhibitor from Enterolobium contortisiliquum (EcTI) and of Its Complex with Bovine Trypsin

scientific article

Crystal Structures of the Histo-Aspartic Protease (HAP) from Plasmodium falciparum

scientific article

Crystal structure of A. fulgidus Rio2 defines a new family of serine protein kinases

scientific article

Crystal structure of XMRV protease differs from the structures of other retropepsins

scientific article

Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody

scientific article

Crystal structure of a retroviral protease proves relationship to aspartic protease family

scientific article published in Nature

Crystal structure of a truncated version of the phage lambda protein gpD.

scientific article published in December 2004

Crystal structure of avian sarcoma virus integrase with bound essential cations

scholarly article published 1997

Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding aspartic protease with a novel mode of self-inhibition.

scientific article published in April 2005

Crystal structure of human T cell leukemia virus protease, a novel target for anticancer drug design

scientific article

Crystal structure of interleukin-19 defines a new subfamily of helical cytokines

scientific article

Crystal structure of the AAA+ alpha domain of E. coli Lon protease at 1.9A resolution

scientific article published on April 2004

Crystal structure of the N-terminal domain of E. coli Lon protease

scientific article

Crystal structure of the catalytic domain of avian sarcoma virus integrase

Crystal structures of the complex of a kallikrein inhibitor from Bauhinia bauhinioides with trypsin and modeling of kallikrein complexes

scientific article published on 07 January 2019

Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum

scientific article

Crystal structures of the reverse transcriptase-associated ribonuclease H domain of xenotropic murine leukemia-virus related virus ⬇️

scientific article published on February 16, 2012

Crystal structures of the semireduced and inhibitor-bound forms of cyclic nucleotide phosphodiesterase from Arabidopsis thaliana

scientific article

Crystallization and preliminary crystallographic analysis of histamine dehydrogenase from Natrinema gari BCC 24369.

scientific article

Crystallization of cyclase-associated protein from Dictyostelium discoideum

scientific article

Crystallographic and biochemical investigations of kumamolisin-As, a serine-carboxyl peptidase with collagenase activity.

scientific article published on 10 March 2004

Crystallographic and functional studies of a modified form of eosinophil-derived neurotoxin (EDN) with novel biological activities

scientific article

Crystallographic studies of the complexes of antiviral protein griffithsin with glucose and N-acetylglucosamine

scientific article

Crystallographic study of red fluorescent protein eqFP578 and its far-red variant Katushka reveals opposite pH-induced isomerization of chromophore

scientific article

Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin

scientific article

Crystallographically correct but confusing presentation of structural models deposited in the Protein Data Bank

scientific article published on 05 September 2018

Crystallography and chemistry should always go together: a cautionary tale of protein complexes with cisplatin and carboplatin

scientific article

Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights

scientific article published on 07 July 2018

Deposition of structural data redux

scientific article

Detect, correct, retract: How to manage incorrect structural models

scientific article published on 7 November 2017

Determination of protein structures--a series of fortunate events

scientific article

Do structures matter any more?

scientific article published on 01 September 2018

Domain-swapped structure of a mutant of cyanovirin-N

scientific article

Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding.

scientific article

Elucidation of the structure of retroviral proteases: a reminiscence

scientific article published on 10 August 2015

Enzymatic properties, evidence for in vivo expression, and intracellular localization of shewasin D, the pepsin homolog from Shewanella denitrificans

scientific article

Generalized enzymatic mechanism of catalysis by tetrameric L-asparaginases from mesophilic bacteria

scientific article published on 15 October 2020

Geometric considerations support the double-displacement catalytic mechanism of l-asparaginase

scientific article published on 29 August 2019

Giving credit where credit is due

scientific article published on 01 August 2005

Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus

scientific article published on 23 January 2015

HIVdb: a database of the structures of human immunodeficiency virus protease

scientific article published in December 2002

High-Resolution Cryo-EM Maps and Models: A Crystallographer's Perspective

scientific article published on 10 August 2017

How to kill an enzyme (in more ways than one).

scientific article published in July 2004

Impact of synchrotron radiation on macromolecular crystallography: a personal view

scientific article

Improved molecular replacement by density- and energy-guided protein structure optimization

scientific article (publication date: 26 May 2011)

Interfaces between allergen structure and diagnosis: know your epitopes

scientific article published on April 2015

Introduction: celebrating the international year of crystallography: introduction.

scientific article published in September 2014

Is too 'creative' language acceptable in crystallography?

scientific article published on 13 August 2010

Kinetic stability and crystal structure of the viral capsid protein SHP.

scientific article published in November 2004

Lessons learned fighting HIV can be applied to anti-cancer drug design

scientific article published in March 2006

Ligand-centered assessment of SARS-CoV-2 drug target models in the Protein Data Bank

scientific article published on 17 May 2020

Light chain somatic mutations change thermodynamics of binding and water coordination in the HyHEL-10 family of antibodies

scientific article

Limited proteolysis of E. coli ATP-dependent protease Lon - a unified view of the subunit architecture and characterization of isolated enzyme fragments

scientific article published on 26 May 2008

Localization of ASV integrase-DNA contacts by site-directed crosslinking and their structural analysis

scientific article

Mechanism of Catalysis by l-Asparaginase

scientific article published on 04 May 2020

Mechanisms of allergen-antibody interaction of cockroach allergen Bla g 2 with monoclonal antibodies that inhibit IgE antibody binding

scientific article

Molecular replacement with pseudosymmetry and model dissimilarity: a case study

scientific article published on 18 January 2006

Monomerization of Viral Entry Inhibitor Griffithsin Elucidates the Relationship between Multivalent Binding to Carbohydrates and anti-HIV Activity

scientific article

Mutational analysis of the DEAD-box RNA helicase eIF4AII characterizes its interaction with transformation suppressor Pdcd4 and eIF4GI.

scientific article

NMR and Crystal Structures of the Pyrococcus horikoshii RadA Intein Guide a Strategy for Engineering a Highly Efficient and Promiscuous Intein

scientific article

Nature's recipe for splitting inteins

scientific article

New insights into structural and functional relationships between LonA proteases and ClpB chaperones

scientific article published on 21 July 2019

Novel fold of VirA, a type III secretion system effector protein fromShigella flexneri

scientific article

Numerologyversusreality: a voice in a recent dispute

On the accuracy of unit-cell parameters in protein crystallography

scientific article

On the prompt update of literature references in the Protein Data Bank

scientific article published on 30 September 2014

Online tools for enhancing presentation, understanding, and retention of 3D structural data.

scientific article published in December 2017

Opportunistic complexes of E. coli L-asparaginases with citrate anions

scientific article published on 30 July 2019

Overexpression and purification of scytovirin, a potent, novel anti-HIV protein from the cultured cyanobacterium Scytonema varium

scientific article

Pathological crystallography: case studies of several unusual macromolecular crystals

scientific article published on 24 June 2005

Piecing together the structure of retroviral integrase, an important target in AIDS therapy

scientific article published on 14 April 2009

Plant annexins form calcium-independent oligomers in solution

scientific article published on August 2002

Plasma kallikrein enhances platelet aggregation response by subthreshold doses of ADP.

scientific article published on 20 January 2017

Potential of the Lectin/Inhibitor Isolated from Crataeva tapia Bark (CrataBL) for Controlling Callosobruchus maculatus Larva Development

scientific article published on 16 November 2015

Prior knowledge or freedom of interpretation? A critical look at a recently published classification of "novel" Zn binding sites

scientific article published on 23 February 2016

Processing, catalytic activity and crystal structures of kumamolisin-As with an engineered active site

scientific article published in June 2006

Progress in protein crystallography.

scientific article published on 6 January 2016

Protein crystallography for aspiring crystallographers or how to avoid pitfalls and traps in macromolecular structure determination

scientific article

Protein crystallography for non-crystallographers, or how to get the best (but not more) from published macromolecular structures.

scientific article

Proteins do not have strong spines after all

scientific article published on 01 October 2009

Proteins that bind high-mannose sugars of the HIV envelope

scientific article

Purification, crystallization and preliminary crystallographic studies of the complex of interferon-lambda1 with its receptor

scientific article

RC1339/APRc from Rickettsia conorii is a novel aspartic protease with properties of retropepsin-like enzymes

scientific article

Rapid response to emerging biomedical challenges and threats

Rational approach to AIDS drug design through structural biology

scientific article

Refined crystal structures of red and green fluorescent proteins from the button polyp Zoanthus

scientific article

Retroviral proteases

scientific article

Safeguarding Structural Data Repositories against Bad Apples

scientific article

Serendipity, politics, and crystal structures, or how I became a protein crystallographer.

scientific article published in January 2016

Slicing a protease: structural features of the ATP-dependent Lon proteases gleaned from investigations of isolated domains

scientific article

Species-specific inhibition of porphobilinogen synthase by 4-oxosebacic acid

scientific article

Specific Fluorine Labeling of the HyHEL10 Antibody Affects Antigen Binding and Dynamics ⬇️

scientific article published on July 16, 2012

Statistical Coupling Analysis of Aspartic Proteinases Based on Crystal Structures of the Trichoderma reesei Enzyme and Its Complex with Pepstatin A

scientific article

Stereochemical restraints revisited: how accurate are refinement targets and how much should protein structures be allowed to deviate from them?

scientific article

Stereochemistry and Validation of Macromolecular Structures

scientific article published on January 2017

Structural Basis for Phototoxicity of the Genetically Encoded Photosensitizer KillerRed

scientific article

Structural Basis for the Persistence of Homing Endonucleases in Transcription Factor IIB Inteins.

scientific article

Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41

scientific article

Structural Evidence for a Dehydrated Intermediate in Green Fluorescent Protein Chromophore Biosynthesis

scientific article

Structural Insights into the Activation and Inhibition of Histo-Aspartic Protease from Plasmodium falciparum

scientific article

Structural analysis and unique molecular recognition properties of a Bauhinia forficata lectin that inhibits cancer cell growth.

scientific article

Structural and biochemical characterization of the inhibitor complexes of xenotropic murine leukemia virus-related virus protease

scientific article

Structural and enzymatic properties of the sedolisin family of serine-carboxyl peptidases

scientific article

Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1

scientific article

Structural basis for bathochromic shift of fluorescence in far-red fluorescent proteins eqFP650 and eqFP670

scientific article

Structural basis for inhibition of translation by the tumor suppressor Pdcd4.

scientific article published on 23 October 2006

Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation

scientific article

Structural basis for the substrate specificity of tobacco etch virus protease

scientific article

Structural characterization of B and non-B subtypes of HIV-protease: insights into the natural susceptibility to drug resistance development

scientific article

Structural evidence for variable oligomerization of the N-terminal domain of cyclase-associated protein (CAP)

article

Structural investigations of proteins encoded by <scp>SARS‐CoV</scp> ‐2

Structural studies of algal lectins with anti-HIV activity.

scientific article

Structural studies of the interaction of Crataeva tapia bark protein with heparin and other glycosaminoglycans.

scientific article published on 14 March 2013

Structural studies of vacuolar plasmepsins ⬇️

scientific article published on April 20, 2011

Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis

scientific article published on 8 February 2016

Structure and Mechanism of the Saposin-like Domain of a Plant Aspartic Protease

scientific article

Structure and activity of the atypical serine kinase Rio1.

scientific article published in July 2005

Structure of BbKI, a disulfide-free plasma kallikrein inhibitor

scientific article

Structure of RC1339/APRc from Rickettsia conorii, a retropepsin-like aspartic protease

scientific article

Structure of a lectin from the sea mussel Crenomytilus grayanus (CGL).

scientific article

Structure of cyclized green fluorescent protein

scientific article

Structure of the N-terminal fragment of Escherichia coli Lon protease ⬇️

scientific article published on July 9, 2010

Structure of the Taz2 domain of p300: insights into ligand binding

scientific article

Structure of the lamin A/C R482W mutant responsible for dominant familial partial lipodystrophy (FPLD)

scientific article

Structure of the red fluorescent protein from a lancelet (Branchiostoma lanceolatum): a novel GYG chromophore covalently bound to a nearby tyrosine

scientific article

Structure of the unbound form of HIV-1 subtype A protease: comparison with unbound forms of proteases from other HIV subtypes

scientific article

Structure-based design of AIDS drugs and the development of resistance.

scientific article

Structure-based engineering and comparison of novel split inteins for protein ligation

scientific article

Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides

scientific article

Structures of two highly homologous bacterial L-asparaginases: a case of enantiomorphic space groups

scientific article

The Convergence of the Hedgehog/Intein Fold in Different Protein Splicing Mechanisms

scientific article published on 07 November 2020

The DnaK Chaperone Uses Different Mechanisms To Promote and Inhibit Replication of Vibrio cholerae Chromosome 2.

scientific article

The QM/MM molecular dynamics and free energy simulations of the acylation reaction catalyzed by the serine-carboxyl peptidase kumamolisin-As

scientific article published on 28 February 2007

The RIO kinases: an atypical protein kinase family required for ribosome biogenesis and cell cycle progression

scientific article

The catalytic domain of Escherichia coli Lon protease has a unique fold and a Ser-Lys dyad in the active site

scientific article

The crystal structure of annexin Gh1 from Gossypium hirsutum reveals an unusual S3 cluster

scientific article (publication date: June 2003)

The crystal structure of the naturally split gp41-1 intein guides the engineering of orthogonal split inteins from cis-splicing inteins

scientific article published on 30 October 2019

The domain-swapped dimer of cyanovirin-N is in a metastable folded state: reconciliation of X-ray and NMR structures

scientific article

The expanding diversity of serine hydrolases

scientific article

The future of crystallography in drug discovery

scientific article

The importance of dynamics in substrate-assisted catalysis and specificity

scientific article published on May 2006

The quality and validation of structures from structural genomics

scientific article

The regulation of proteolysis around the world.

scientific article

The zymogen of plasmepsin V from Plasmodium falciparum is enzymatically active.

scientific article published on 25 October 2014

Topology of the disulfide bonds in the antiviral lectin scytovirin

scientific article

Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation

scientific article

Two inhibitor molecules bound in the active site of Pseudomonas sedolisin: a model for the bi-product complex following cleavage of a peptide substrate

scientific article

Understanding Blue-to-Red Conversion in Monomeric Fluorescent Timers and Hydrolytic Degradation of Their Chromophores

scientific article

Understanding the Autocatalytic Process of Pro‐kumamolisin Activation from Molecular Dynamics and Quantum Mechanical/Molecular Mechanical (QM/MM) Free‐Energy Simulations ⬇️

scientific article published on July 2, 2013

Unexpected Specificity of a Trypsin-like Enzyme

scientific article published on 01 April 2018

Unique Structural Fold of LonBA Protease from Bacillus subtilis, a Member of a Newly Identified Subfamily of Lon Proteases

scientific article published in 2022

Unmet challenges of structural genomics

scientific article

What happens when the signs of anomalous differences or the handedness of substructure are inverted?

scientific article published on 15 June 2007

Yellow fluorescent protein phiYFPv (Phialidium): structure and structure-based mutagenesis

scientific article

`Atomic resolution': a badly abused term in structural biology.

scientific article

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