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List of works by Robert McKenna

A Short, Strong Hydrogen Bond in the Active Site of Human Carbonic Anhydrase II

scientific article

A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects

scientific article

Adeno-Associated Virus (AAV) Capsid Stability and Liposome Remodeling During Endo/Lysosomal pH Trafficking

scientific article published on 20 June 2020

Adeno-Associated Virus VP1u Exhibits Protease Activity.

scientific article

Adeno-associated Virus 9 Structural Rearrangements Induced by Endosomal Trafficking pH and Glycan Attachment

scientific article published on 14 July 2021

Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV

scientific article

Apo-Human Carbonic Anhydrase II Revisited: Implications of the Loss of a Metal in Protein Structure, Stability, and Solvent Network ,

scientific article

Aspirin: A Suicide Inhibitor of Carbonic Anhydrase II

scientific article published on 31 March 2020

Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: insights into the proton transfer mechanism

scientific article

Biophysical Characterization of Cancer-Related Carbonic Anhydrase IX

scientific article published on 25 July 2020

Biophysical, Biochemical, and Cell Based Approaches Used to Decipher the Role of Carbonic Anhydrases in Cancer and to Evaluate the Potency of Targeted Inhibitors

scientific article published on 16 July 2018

Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors

scientific article

Comparative analysis of adeno-associated virus capsid stability and dynamics

scientific article

Comparison of solution and crystal properties of Co(II)–substituted human carbonic anhydrase II

scientific article

Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms

scientific article

Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations

scientific article

Crystal Structure of Carbonic Anhydrase II in Complex with an Activating Ligand: Implications in Neuronal Function.

scientific article published on 8 February 2018

Crystallographic evidence for noncoplanar catalytic aspartic acids in plasmepsin II resides in the Protein Data Bank

scientific article

Crystallography and Its Impact on Carbonic Anhydrase Research

article

Design of a Carbonic Anhydrase IX Active-Site Mimic To Screen Inhibitors for Possible Anticancer Properties † ‡

scientific article

Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation

scientific article

Dithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in Vivo

scientific article

Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations

scientific article

Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII

scientific article

Emerging from pseudo-symmetry: the redetermination of human carbonic anhydrase II in monoclinicP21with a doubledaaxis ⬇️

scientific article published on July 9, 2010

Entrapment of Carbon Dioxide in the Active Site of Carbonic Anhydrase II

scientific article

High-resolution structure of human carbonic anhydrase II complexed with acetazolamide reveals insights into inhibitor drug design

scientific article

High-resolution structure of unbound human immunodeficiency virus 1 subtype C protease: implications of flap dynamics and drug resistance

scientific article

Human bocavirus capsid structure: insights into the structural repertoire of the parvoviridae

scientific article

In vitro evaluation of ESE-15-ol, an estradiol analogue with nanomolar antimitotic and carbonic anhydrase inhibitory activity

scientific article

Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study

scientific article

Insights into Mycoplasma genitalium metabolism revealed by the structure of MG289, an extracytoplasmic thiamine binding lipoprotein ⬇️

scientific article published on February 1, 2011

Kinetic analysis of multiple proton shuttles in the active site of human carbonic anhydrase

scientific article

Kinetic and crystallographic studies of the role of tyrosine 7 in the active site of human carbonic anhydrase II ⬇️

scientific article published on December 9, 2010

Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II ⬇️

scientific article published on June 12, 2012

Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates

scientific article

Molecular biology and structure of a novel penaeid shrimp densovirus elucidate convergent parvoviral host capsid evolution

scientific article published on 03 August 2020

Neutron Diffraction of Acetazolamide-Bound Human Carbonic Anhydrase II Reveals Atomic Details of Drug Binding

scientific article

Neutron Structure of Human Carbonic Anhydrase II: A Hydrogen-Bonded Water Network “Switch” Is Observed between pH 7.8 and 10.0 ⬇️

scientific article published on October 12, 2011

Non-Classical Inhibition of Carbonic Anhydrase

scientific article

Polylysine induces an antiparallel actin dimer that nucleates filament assembly: crystal structure at 3.5-A resolution

scientific article

Probing the surface of human carbonic anhydrase for clues towards the design of isoform specific inhibitors

scientific article

Receptor Switching in Newly Evolved Adeno-associated Viruses

scientific article published on 09 September 2021

Recombinant Plasmepsin 1 from the Human Malaria Parasite Plasmodium falciparum : Enzymatic Characterization, Active Site Inhibitor Design, and Structural Analysis

scientific article

Role of Hydrophilic Residues in Proton Transfer during Catalysis by Human Carbonic Anhydrase II † ‡

scientific article

Role of a glutamate bridge spanning the dimeric interface of human manganese superoxide dismutase

scientific article

Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency

scientific article

Signaling pathways of ESE-16, an antimitotic and anticarbonic anhydrase estradiol analog, in breast cancer cells

scientific article

Speeding up proton transfer in a fast enzyme: kinetic and crystallographic studies on the effect of hydrophobic amino acid substitutions in the active site of human carbonic anhydrase II

scientific article

Structural Characterization of Cuta- and Tusavirus: Insight into Protoparvoviruses Capsid Morphology

scientific article published on 17 June 2020

Structural Characterization of H-1 Parvovirus: Comparison of Infectious Virions to Empty Capsids

scientific article

Structural Characterization of the Dual Glycan Binding Adeno-Associated Virus Serotype 6 ⬇️

scientific article published on September 22, 2010

Structural Insights into Adeno-Associated Virus Serotype 5

scientific article

Structural Insights into the Extracytoplasmic Thiamine-Binding Lipoprotein p37 of Mycoplasma hyorhinis

scientific article

Structural Studies of Adeno-Associated Virus Serotype 8 Capsid Transitions Associated with Endosomal Trafficking ⬇️

scientific article published on September 7, 2011

Structural and Kinetic Study of the Extended Active Site for Proton Transfer in Human Carbonic Anhydrase II

scientific article

Structural and biophysical characterization of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2: insights into engineering thermostable enzymes for CO2 sequestration

scientific article

Structural and catalytic characterization of a thermally stable and acid-stable variant of human carbonic anhydrase II containing an engineered disulfide bond

scientific article

Structural and catalytic effects of proline substitution and surface loop deletion in the extended active site of human carbonic anhydrase II

scientific article

Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III

scientific article

Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II

scientific article

Structural and kinetic study of differences between human and Escherichia coli manganese superoxide dismutases

scientific article

Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase

scientific article

Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition

scientific article

Structural elucidation of the hormonal inhibition mechanism of the bile acid cholate on human carbonic anhydrase II

scientific article

Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles

scientific article

Structural insights and functional implications of choline acetyltransferase

scientific journal article

Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases

scientific article

Structural study of the location of the phenyl tail of benzene sulfonamides and the effect on human carbonic anhydrase inhibition

scientific article

Structural, catalytic and stabilizing consequences of aromatic cluster variants in human carbonic anhydrase II

scientific article

Structure and catalysis by carbonic anhydrase II: Role of active-site tryptophan 5

scientific article

Structure and inhibition studies of a type II beta-carbonic anhydrase psCA3 from Pseudomonas aeruginosa

scientific article

Structure determination of the cancer-associated Mycoplasma hyorhinis protein Mh-p37

scientific article

Structure of Adeno-Associated Virus Serotype 8, a Gene Therapy Vector

scientific article

Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transfer

scientific article (publication date: 11 April 2003)

Structure of neurotropic adeno-associated virus AAVrh.8.

scientific article

Structure of the unbound form of HIV-1 subtype A protease: comparison with unbound forms of proteases from other HIV subtypes

scientific article

Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies

scientific article

Synchrotron Radiation Provides a Plausible Explanation for the Generation of a Free Radical Adduct of Thioxolone in Mutant Carbonic Anhydrase II ⬇️

scientific article published on October 7, 2010

The Escherichia coli Clamp Loader Can Actively Pry Open the β-Sliding Clamp ⬇️

scientific article published on October 4, 2011

The Structure of Carbonic Anhydrase IX Is Adapted for Low-pH Catalysis

scientific article

The contribution of naturally occurring polymorphisms in altering the biochemical and structural characteristics of HIV-1 subtype C protease

scientific article

The refined atomic structure of carbonic anhydrase II at 1.05 A resolution: implications of chemical rescue of proton transfer

scientific article

The structure of AAVrh32.33, a novel gene delivery vector

scientific article

Water Networks in Fast Proton Transfer during Catalysis by Human Carbonic Anhydrase II ⬇️

scientific article published on December 18, 2012

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