List of works - Mikako Shirouzu

A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo

scientific article

A snapshot of the 30S ribosomal subunit capturing mRNA via the Shine-Dalgarno interaction

scientific article

An enzyme with a deep trefoil knot for the active-site architecture

scientific article

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

scientific article

Biochemical and biophysical properties of interactions between subunits of the peripheral stalk region of human V-ATPase

scientific article

Biochemical and structural studies on the high affinity of Hsp70 for ADP

scientific article

Cell-permeable Carboxyl-terminal p27Kip1 Peptide Exhibits Anti-tumor Activity by Inhibiting Pim-1 Kinase

scientific article

Conserved Neutralizing Epitope at Globular Head of Hemagglutinin in H3N2 Influenza Viruses

scientific article

Crystal Structure of Epstein-Barr Virus DNA Polymerase Processivity Factor BMRF1

scientific article

Crystal Structure of the Ca2+/Calmodulin-dependent Protein Kinase Kinase in Complex with the Inhibitor STO-609

scientific article

Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentation

scientific article

Crystal structure and RNA-binding analysis of the archaeal transcription factor NusA

scientific article

Crystal structure of MqnD (TTHA1568), a menaquinone biosynthetic enzyme from Thermus thermophilus HB8

scientific article

Crystal structure of a hypothetical protein, TT1725, from Thermus thermophilus HB8 at 1.7 A resolution

scientific article

Crystal structure of a novel polyisoprenoid-binding protein from Thermus thermophilus HB8

scientific article

Crystal structure of cucumisin, a subtilisin-like endoprotease from Cucumis melo L

scientific article

Crystal structure of elongation factor P from Thermus thermophilus HB8

scientific article

Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures

scientific article

Crystal structure of human ribosomal protein L10 core domain reveals eukaryote-specific motifs in addition to the conserved fold

scientific article

Crystal structure of nanoKAZ: The mutated 19 kDa component of Oplophorus luciferase catalyzing the bioluminescent reaction with coelenterazine

scientific article

Crystal structure of tRNA N2,N2-guanosine dimethyltransferase Trm1 from Pyrococcus horikoshii

scientific article

Crystal structure of the 2'-5' RNA ligase from Thermus thermophilus HB8

scientific article

Crystal structure of the Bruton's tyrosine kinase PH domain with phosphatidylinositol

scientific article

Crystal structure of the GAF-B domain from human phosphodiesterase 10A complexed with its ligand, cAMP

scientific article

Crystal structure of the Pyrococcus horikoshii DNA primase-UTP complex: implications for the mechanism of primer synthesis

scientific article

Crystal structure of the RNA 2'-phosphotransferase from Aeropyrum pernix K1

scientific article (publication date: 29 April 2005)

Crystal structure of the RUN domain of the RAP2-interacting protein x

scientific journal article

Crystal structure of the central axis DF complex of the prokaryotic V-ATPase

scientific article

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

scientific article

Crystal structure of the conserved protein TT1542 fromThermus thermophilusHB8

scientific article

Crystal structure of the eukaryotic light-driven proton-pumping rhodopsin, Acetabularia rhodopsin II, from marine alga

scientific article

Crystal structure of the guanylate kinase domain from discs large homolog 1 (DLG1/SAP97)

scientific article

Crystal structure of the human receptor activity-modifying protein 1 extracellular domain

scientific article

Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism

scientific article

Crystal structures of the S6K1 kinase domain in complexes with inhibitors

scientific article

Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of Sam68

scientific article

Crystallization of the archaeal transcription termination factor NusA: a significant decrease in twinning under microgravity conditions

scientific article

Crystallographic and mutational studies on the tRNA thiouridine synthetase TtuA

scientific article

Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis

scientific article

DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses

scientific article

Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state

scientific article

Expression, purification and characterization of isoforms of peripheral stalk subunits of human V-ATPase

scientific article

Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor

scientific article

Genetic encoding of 3-iodo-L-tyrosine in Escherichia coli for single-wavelength anomalous dispersion phasing in protein crystallography

scientific article

HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor

scientific article

High-resolution crystal structure of the catalytic domain of human dual-specificity phosphatase 26

scientific article

Identification of Critical Residues in G 13 for Stimulation of p115RhoGEF Activity and the Structure of the G 13-p115RhoGEF Regulator of G Protein Signaling Homology (RH) Domain Complex

scientific article

Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

scientific article

Interaction of Era with the 30S ribosomal subunit implications for 30S subunit assembly

scientific journal article

Investigating the Roles of the C-Terminal Domain of Plasmodium falciparum GyrA

scientific article

Mapping of the basic amino-acid residues responsible for tubulation and cellular protrusion by the EFC/F-BAR domain of pacsin2/Syndapin II

scientific article

Novel RNA recognition motif domain in the cytoplasmic polyadenylation element binding protein 3

scientific article

Novel dimerization mode of the human Bcl-2 family protein Bak, a mitochondrial apoptosis regulator

scientific article

Phosphorylation analysis of 90 kDa heat shock protein within the cytosolic arylhydrocarbon receptor complex

scientific journal article

RBFOX and SUP-12 sandwich a G base to cooperatively regulate tissue-specific splicing

scientific article

Real-time imaging of histone H4K12-specific acetylation determines the modes of action of histone deacetylase and bromodomain inhibitors

scientific article

Rotation mechanism of Enterococcus hirae V1-ATPase based on asymmetric crystal structures

scientific article

Solution structure of a BolA-like protein from Mus musculus

scientific article

Solution structure of a tmRNA-binding protein, SmpB, from Thermus thermophilus

scientific article (publication date: 30 January 2003)

Solution structure of an Arabidopsis WRKY DNA binding domain

scientific article

Solution structure of an atypical WW domain in a novel beta-clam-like dimeric form

scientific article

Solution structure of the B3 DNA binding domain of the Arabidopsis cold-responsive transcription factor RAV1

scientific article

Solution structure of the PWWP domain of the hepatoma-derived growth factor family

scientific journal article

Solution structure of the RNA binding domain in the human muscleblind-like protein 2

scientific article

Solution structure of the SEA domain from the murine homologue of ovarian cancer antigen CA125 (MUC16)

scientific article

Solution structure of the SWIRM domain of human histone demethylase LSD1

scientific article

Solution structure of the antifreeze-like domain of human sialic acid synthase

scientific article

Solution structure of the first RNA recognition motif domain of human spliceosomal protein SF3b49 and its mode of interaction with a SF3b145 fragment

scientific article (publication date: February 2017)

Solution structure of the second RNA recognition motif (RRM) domain of murine T cell intracellular antigen-1 (TIA-1) and its RNA recognition mode

scientific article

Solution structure of the zinc finger HIT domain in protein FON

scientific article

Solution structures of the double-stranded RNA-binding domains from RNA helicase A

scientific article

Structural Characterization of the Ribosome Maturation Protein, RimM

scientific article

Structural and functional differences of SWIRM domain subtypes

scientific article

Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain

scientific article

Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding

scientific article

Structural basis for functional mimicry of long-variable-arm tRNA by transfer-messenger RNA

scientific article

Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors

scientific article

Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms

scientific article

Structural basis for promoter specificity switching of RNA polymerase by a phage factor

scientific article

Structural basis for the dual RNA-recognition modes of human Tra2- RRM

scientific article

Structural basis for the exclusive specificity of Slac2-a/melanophilin for the Rab27 GTPases

scientific article

Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2

scientific article

Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3

scientific article

Structural basis for the slow photocycle and late proton release in Acetabularia rhodopsin I from the marine plant Acetabularia acetabulum

scientific article

Structural basis of CoA recognition by the Pyrococcus single-domain CoA-binding proteins

scientific article

Structural basis of interleukin-5 dimer recognition by its α receptor

scientific article

Structural basis of replication origin recognition by the DnaA protein

scientific article (publication date: 15 April 2003)

Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis

scientific article

Structure of a UPF0150-family protein fromThermus thermophilusHB8

scientific article

Structure of an N-terminally truncated selenophosphate synthetase fromAquifex aeolicus

scientific article

Structure of archaeal glyoxylate reductase from Pyrococcus horikoshii OT3 complexed with nicotinamide adenine dinucleotide phosphate

scientific article

Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)

scientific article

Structure of selenophosphate synthetase essential for selenium incorporation into proteins and RNAs

scientific article

Structure of the Rho-specific guanine nucleotide-exchange factor Xpln

scientific article

Structure of the human Tim44 C-terminal domain in complex with pentaethylene glycol: ligand-bound form

scientific article

Structure of the minimized α/β-hydrolase fold protein fromThermus thermophilusHB8

scientific article

Structure of the putative thioesterase protein TTHA1846 from Thermus thermophilus HB8 complexed with coenzyme A and a zinc ion

scientific article

Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives

scientific article

Structures of two archaeal diphthine synthases: insights into the post-translational modification of elongation factor 2

scientific article

The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange

scientific article

The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma

scientific article

The Cdc42 binding and scaffolding activities of the fission yeast adaptor protein Scd2.

scientific article

The RAC binding domain/IRSp53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation

scientific article

The RRM domain of poly(A)-specific ribonuclease has a noncanonical binding site for mRNA cap analog recognition

scientific article

The crystal structure of leucyl/phenylalanyl-tRNA-protein transferase from Escherichia coli

scientific article

The crystal structure of mouse Nup35 reveals atypical RNP motifs and novel homodimerization of the RRM domain

scientific journal article

The putative DNA-binding protein Sto12a from the thermoacidophilic archaeon Sulfolobus tokodaii contains intrachain and interchain disulfide bonds

scientific article

The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation

scientific article (publication date: 2014)

ZF21 Protein, a Regulator of the Disassembly of Focal Adhesions and Cancer Metastasis, Contains a Novel Noncanonical Pleckstrin Homology Domain

scientific article

List of works by Mikako Shirouzu

A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo

A snapshot of the 30S ribosomal subunit capturing mRNA via the Shine-Dalgarno interaction

An enzyme with a deep trefoil knot for the active-site architecture

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

Biochemical and biophysical properties of interactions between subunits of the peripheral stalk region of human V-ATPase

Biochemical and structural studies on the high affinity of Hsp70 for ADP

Cell-permeable Carboxyl-terminal p27Kip1 Peptide Exhibits Anti-tumor Activity by Inhibiting Pim-1 Kinase

Conserved Neutralizing Epitope at Globular Head of Hemagglutinin in H3N2 Influenza Viruses

Crystal Structure of Epstein-Barr Virus DNA Polymerase Processivity Factor BMRF1

Crystal Structure of the Ca2+/Calmodulin-dependent Protein Kinase Kinase in Complex with the Inhibitor STO-609

Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentation

Crystal structure and RNA-binding analysis of the archaeal transcription factor NusA

Crystal structure of MqnD (TTHA1568), a menaquinone biosynthetic enzyme from Thermus thermophilus HB8

Crystal structure of a hypothetical protein, TT1725, from Thermus thermophilus HB8 at 1.7 A resolution

Crystal structure of a novel polyisoprenoid-binding protein from Thermus thermophilus HB8

Crystal structure of cucumisin, a subtilisin-like endoprotease from Cucumis melo L

Crystal structure of elongation factor P from Thermus thermophilus HB8

Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures

Crystal structure of human ribosomal protein L10 core domain reveals eukaryote-specific motifs in addition to the conserved fold

Crystal structure of nanoKAZ: The mutated 19 kDa component of Oplophorus luciferase catalyzing the bioluminescent reaction with coelenterazine

Crystal structure of tRNA N2,N2-guanosine dimethyltransferase Trm1 from Pyrococcus horikoshii

Crystal structure of the 2'-5' RNA ligase from Thermus thermophilus HB8

Crystal structure of the Bruton's tyrosine kinase PH domain with phosphatidylinositol

Crystal structure of the GAF-B domain from human phosphodiesterase 10A complexed with its ligand, cAMP

Crystal structure of the Pyrococcus horikoshii DNA primase-UTP complex: implications for the mechanism of primer synthesis

Crystal structure of the RNA 2'-phosphotransferase from Aeropyrum pernix K1

Crystal structure of the RUN domain of the RAP2-interacting protein x

Crystal structure of the central axis DF complex of the prokaryotic V-ATPase

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

Crystal structure of the conserved protein TT1542 fromThermus thermophilusHB8

Crystal structure of the eukaryotic light-driven proton-pumping rhodopsin, Acetabularia rhodopsin II, from marine alga

Crystal structure of the guanylate kinase domain from discs large homolog 1 (DLG1/SAP97)

Crystal structure of the human receptor activity-modifying protein 1 extracellular domain

Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism

Crystal structures of the S6K1 kinase domain in complexes with inhibitors

Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of Sam68

Crystallization of the archaeal transcription termination factor NusA: a significant decrease in twinning under microgravity conditions

Crystallographic and mutational studies on the tRNA thiouridine synthetase TtuA

Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis

DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses

Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state

Expression, purification and characterization of isoforms of peripheral stalk subunits of human V-ATPase

Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor

Genetic encoding of 3-iodo-L-tyrosine in Escherichia coli for single-wavelength anomalous dispersion phasing in protein crystallography

HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor

High-resolution crystal structure of the catalytic domain of human dual-specificity phosphatase 26

Identification of Critical Residues in G 13 for Stimulation of p115RhoGEF Activity and the Structure of the G 13-p115RhoGEF Regulator of G Protein Signaling Homology (RH) Domain Complex

Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

Interaction of Era with the 30S ribosomal subunit implications for 30S subunit assembly

Investigating the Roles of the C-Terminal Domain of Plasmodium falciparum GyrA

Mapping of the basic amino-acid residues responsible for tubulation and cellular protrusion by the EFC/F-BAR domain of pacsin2/Syndapin II

Novel RNA recognition motif domain in the cytoplasmic polyadenylation element binding protein 3

Novel dimerization mode of the human Bcl-2 family protein Bak, a mitochondrial apoptosis regulator

Phosphorylation analysis of 90 kDa heat shock protein within the cytosolic arylhydrocarbon receptor complex

RBFOX and SUP-12 sandwich a G base to cooperatively regulate tissue-specific splicing

Real-time imaging of histone H4K12-specific acetylation determines the modes of action of histone deacetylase and bromodomain inhibitors

Rotation mechanism of Enterococcus hirae V1-ATPase based on asymmetric crystal structures

Solution structure of a BolA-like protein from Mus musculus

Solution structure of a tmRNA-binding protein, SmpB, from Thermus thermophilus

Solution structure of an Arabidopsis WRKY DNA binding domain

Solution structure of an atypical WW domain in a novel beta-clam-like dimeric form

Solution structure of the B3 DNA binding domain of the Arabidopsis cold-responsive transcription factor RAV1

Solution structure of the PWWP domain of the hepatoma-derived growth factor family

Solution structure of the RNA binding domain in the human muscleblind-like protein 2

Solution structure of the SEA domain from the murine homologue of ovarian cancer antigen CA125 (MUC16)

Solution structure of the SWIRM domain of human histone demethylase LSD1

Solution structure of the antifreeze-like domain of human sialic acid synthase

Solution structure of the first RNA recognition motif domain of human spliceosomal protein SF3b49 and its mode of interaction with a SF3b145 fragment

Solution structure of the second RNA recognition motif (RRM) domain of murine T cell intracellular antigen-1 (TIA-1) and its RNA recognition mode

Solution structure of the zinc finger HIT domain in protein FON

Solution structures of the double-stranded RNA-binding domains from RNA helicase A

Structural Characterization of the Ribosome Maturation Protein, RimM

Structural and functional differences of SWIRM domain subtypes

Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain

Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding

Structural basis for functional mimicry of long-variable-arm tRNA by transfer-messenger RNA

Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors

Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms

Structural basis for promoter specificity switching of RNA polymerase by a phage factor